WO2008144507A3 - Spirooxindole inhibitors of aurora kinase - Google Patents
Spirooxindole inhibitors of aurora kinase Download PDFInfo
- Publication number
- WO2008144507A3 WO2008144507A3 PCT/US2008/063893 US2008063893W WO2008144507A3 WO 2008144507 A3 WO2008144507 A3 WO 2008144507A3 US 2008063893 W US2008063893 W US 2008063893W WO 2008144507 A3 WO2008144507 A3 WO 2008144507A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhibitors
- spirooxindole
- compounds
- aurora
- kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Abstract
Aurora kinases have been found to be overexpressed in many tumors including breast, colon, and pancreatic cancers. The present invention provides novel inhibitors and/or binders of Aurora kinases. Certain of the spirooxindole compounds are specific inhibitors or binders of Aurora A, B, or C kinases. The compounds are useful in both the diagnosis and treatment of proliferative diseases such as cancer. Pharmaceutical compositions and method of using the compounds to treat proliferative diseases are also provided.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93836207P | 2007-05-16 | 2007-05-16 | |
US60/938,362 | 2007-05-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008144507A2 WO2008144507A2 (en) | 2008-11-27 |
WO2008144507A3 true WO2008144507A3 (en) | 2009-05-14 |
Family
ID=39708725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/063893 WO2008144507A2 (en) | 2007-05-16 | 2008-05-16 | Spirooxindole inhibitors of aurora kinase |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008144507A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263547B2 (en) | 2008-05-28 | 2012-09-11 | Massachusetts Institute Of Technology | DISC-1 pathway activators in the control of neurogenesis |
GB201603779D0 (en) | 2016-03-04 | 2016-04-20 | Mission Therapeutics Ltd | Novel compounds |
CN106008532B (en) * | 2016-07-20 | 2019-06-07 | 贵州大学 | Alcoxyl yl pyrimidines splice 3- pyrroles's loop coil oxoindole derivative and preparation method and application |
US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
US11858945B2 (en) | 2021-11-12 | 2024-01-02 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
US20230159546A1 (en) * | 2021-11-18 | 2023-05-25 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091646A2 (en) * | 2005-02-22 | 2006-08-31 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
WO2007047579A2 (en) * | 2005-10-14 | 2007-04-26 | Virginia Tech Intellectual Properties, Inc. | A novel therapeutic target for protozoal diseases |
WO2008027990A1 (en) * | 2006-08-29 | 2008-03-06 | Trustees Of Boston University | Therapeutic methods using wrn binding molecules |
-
2008
- 2008-05-16 WO PCT/US2008/063893 patent/WO2008144507A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091646A2 (en) * | 2005-02-22 | 2006-08-31 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
WO2007047579A2 (en) * | 2005-10-14 | 2007-04-26 | Virginia Tech Intellectual Properties, Inc. | A novel therapeutic target for protozoal diseases |
WO2008027990A1 (en) * | 2006-08-29 | 2008-03-06 | Trustees Of Boston University | Therapeutic methods using wrn binding molecules |
Non-Patent Citations (6)
Title |
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CHRIS V. GALLIFORD ET AL: "A highly diastereoselective, catalytic three-component assembly reaction for the synthesis of spiropyrrolidinyloxindoles", CHEMICAL COMMUNICATIONS, vol. 6, 2007, pages 631 - 633, XP002517188 * |
CHUO CHEN ET AL: "Convergent diversity-oriented synthesis of small-molecule hybrids", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 44, no. 15, 2005, pages 2249 - 2252, XP002517187 * |
IMRE FEJES ET AL: "2-Oxoindolin-3-ylidene derivatives as 2Pi components in 1,3-dipolar cycloadditions of azomethine ylides", TETRAHEDRON, vol. 57, no. 6, 2001, pages 1129 - 1137, XP004316545, ISSN: 0040-4020 * |
MICHAEL M.-C. LO ET AL: "A library of spirooxindoles based on a stereoselective three-component coupling reaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 49, 2004, pages 16077 - 16086, XP002517186 * |
MIKLOS NYERGES ET AL: "2-Oxoindolin-3-ylidene derivatives as 2Pi components in 1,3-dipolar cycloadditions of azomethine ylides", SYNLETT, no. 1, 1999, pages 111 - 113, XP002517184 * |
PAUL R. SEBAHAR AND ROBERT M. WILLIAMS: "The synthesis of spirooxindole pyrrolidines via an asymmetric azomethine ylide [1,3]-dipolar cycloaddition reaction", HETEROCYCLES, vol. 58, 2002, pages 563 - 575, XP001539206 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008144507A2 (en) | 2008-11-27 |
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