BR112012006062A2 - novel compounds and their therapeutic use for protein kinase inhibition - Google Patents

novel compounds and their therapeutic use for protein kinase inhibition

Info

Publication number
BR112012006062A2
BR112012006062A2 BR112012006062A BR112012006062A BR112012006062A2 BR 112012006062 A2 BR112012006062 A2 BR 112012006062A2 BR 112012006062 A BR112012006062 A BR 112012006062A BR 112012006062 A BR112012006062 A BR 112012006062A BR 112012006062 A2 BR112012006062 A2 BR 112012006062A2
Authority
BR
Brazil
Prior art keywords
protein kinase
novel compounds
therapeutic
kinase inhibition
methods
Prior art date
Application number
BR112012006062A
Other languages
English (en)
Inventor
Zhanggui Wu
Original Assignee
Zhanggui Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US24354909P priority Critical
Application filed by Zhanggui Wu filed Critical Zhanggui Wu
Priority to PCT/US2010/049199 priority patent/WO2011035077A1/en
Publication of BR112012006062A2 publication Critical patent/BR112012006062A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

novos compostos e respectivo uso terapêutico para inibição de proteína quinase. novos compostos tendo a fórmula: em que y é n, o ou s. adicionalmente, são divulgadas composições farmacêuticas compreendendo os mesmos, métodos para tratar câncer usando os mesmos e métodos para a síntese dos mesmos. os novos compostos da presente invenção inibem proteína quinase, especialmente a ckeckpoint quinase chk1/ chk2.novel compounds and their therapeutic use for protein kinase inhibition. new compounds having the formula: wherein y is n, o or s. In addition, pharmaceutical compositions comprising the same, methods for treating cancer using them and methods for their synthesis are disclosed. the novel compounds of the present invention inhibit protein kinase, especially ckeckpoint kinase chk1 / chk2.
BR112012006062A 2009-09-18 2010-09-17 novel compounds and their therapeutic use for protein kinase inhibition BR112012006062A2 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US24354909P true 2009-09-18 2009-09-18
PCT/US2010/049199 WO2011035077A1 (en) 2009-09-18 2010-09-17 Novel compounds and therapeutic use thereof for protein kinase inhibition

Publications (1)

Publication Number Publication Date
BR112012006062A2 true BR112012006062A2 (pt) 2015-09-08

Family

ID=43759014

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012006062A BR112012006062A2 (pt) 2009-09-18 2010-09-17 novel compounds and their therapeutic use for protein kinase inhibition

Country Status (14)

Country Link
US (2) US8815863B2 (pt)
EP (2) EP2826780B1 (pt)
JP (1) JP6155026B2 (pt)
CN (2) CN104628741A (pt)
AU (2) AU2010295492B2 (pt)
BR (1) BR112012006062A2 (pt)
CA (1) CA2774367C (pt)
ES (2) ES2481791T3 (pt)
HK (1) HK1170908A1 (pt)
IN (1) IN2012DN03127A (pt)
MX (1) MX2012003286A (pt)
NZ (1) NZ599453A (pt)
RU (1) RU2012109220A (pt)
WO (1) WO2011035077A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2826780B1 (en) * 2009-09-18 2016-06-01 Zhanggui Wu Thieno[2,3-d]pyridazine derivatives and therapeutic use thereof for protein kinase inhibition
AU2014293011A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene
WO2021141974A2 (en) * 2020-01-07 2021-07-15 Fan Wu Combination cancer therapy using chk inhibitor
WO2021208055A1 (zh) * 2020-04-17 2021-10-21 浙江医药股份有限公司新昌制药厂 一种噻吩并哒嗪类化合物的晶型及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029241A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
WO2003028731A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
US7199119B2 (en) * 2002-10-31 2007-04-03 Amgen Inc. Antiinflammation agents
BRPI0418351A (pt) 2004-01-05 2007-05-08 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, métodos de limitar a proliferação celular em um humano ou animal, de tratamento de um humano ou animal sofrendo de cáncer, de tratamento de profilaxia de cáncer, de tratamento de um humano ou animal sofrendo de uma doença neoplásica, de tratamento de um humano ou animal sofrendo de uma doença prolifetativa de tratamento de cáncer, para o tratamento de infecções associadas com cáncer, para o tratamento profilático de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método de inibir a chk1 quinase, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo
MXPA06012682A (es) * 2004-05-04 2007-01-16 Hoffmann La Roche Tienopiridinas como inhibidores ikk.
AU2005238178A1 (en) 2004-05-04 2005-11-10 F. Hoffmann-La Roche Ag Thienopyridazines as IKK inhibitors
BRPI0608659A2 (pt) * 2005-04-06 2010-11-30 Astrazeneca Ab composto, métodos para limitar a proliferação celular, de tratamento de um ser humano ou animal sofrendo de uma doença, e de tratamento de profilaxia do cáncer, para tratar cáncer, de tratamento de infecções associadas com cáncer, e de profilaxia de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para inibir chk1 cinase, e um pak cinase, e para limitar a tumorigênese em um ser humano ou animal, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo
CN101189243A (zh) * 2005-04-06 2008-05-28 阿斯利康(瑞典)有限公司 取代的杂环及其作为chk1、pdk1和pak抑制剂的应用
WO2007124181A2 (en) 2006-04-21 2007-11-01 Amgen Inc. Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
KR20090027754A (ko) 2006-07-03 2009-03-17 코닌클리케 필립스 일렉트로닉스 엔.브이. 신선도 표시기를 갖는 음료 분배장치
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
EP2826780B1 (en) * 2009-09-18 2016-06-01 Zhanggui Wu Thieno[2,3-d]pyridazine derivatives and therapeutic use thereof for protein kinase inhibition

Also Published As

Publication number Publication date
AU2016204867B2 (en) 2017-02-16
US20120232082A1 (en) 2012-09-13
EP2826780A1 (en) 2015-01-21
CN102711475B (zh) 2015-01-28
AU2010295492B2 (en) 2016-05-05
EP2477496B1 (en) 2014-04-16
AU2016204867A1 (en) 2016-07-28
CN102711475A (zh) 2012-10-03
JP6155026B2 (ja) 2017-06-28
MX2012003286A (es) 2012-06-19
US8815863B2 (en) 2014-08-26
NZ599453A (en) 2014-03-28
IN2012DN03127A (pt) 2015-09-18
EP2826780B1 (en) 2016-06-01
EP2477496A1 (en) 2012-07-25
CA2774367C (en) 2018-07-10
RU2012109220A (ru) 2013-10-27
US20150072987A1 (en) 2015-03-12
JP2013505254A (ja) 2013-02-14
EP2477496A4 (en) 2013-02-27
ES2481791T3 (es) 2014-07-31
CN104628741A (zh) 2015-05-20
AU2010295492A1 (en) 2012-05-03
WO2011035077A1 (en) 2011-03-24
ES2587509T3 (es) 2016-10-25
US9487539B2 (en) 2016-11-08
CA2774367A1 (en) 2011-03-24
HK1170908A1 (zh) 2013-03-15

Similar Documents

Publication Publication Date Title
BR112012012404A2 (pt) mon 87427 transgenic maize event and the relative development range
BR112012009424A2 (pt) humidifier, sterilization chamber for a humidifier and method for sterilizing water
AR078399A1 (es) Etiqueta de alarma para la vigilancia electronica de articulos con identificacion por radio frecuencia
AR070418A1 (es) Metodo y aparato para determinar la dilatacion de un material mediante un dispositivo sensor de error de foco
AR079314A1 (es) PROCESS OF FLUID CATALYTIC CRACHING WITH REDUCED CARBON DIOXIDE ISSUANCE
IN2012DN03127A (pt)
AR070368A2 (es) Procedimiento para la preparacion de una composicion de vacuna que comprende un inmunoestimulante un antigeno y una sal metalica y uso de dicha composicion para preparar un medicamento.composicion de vacuna
AR073249A1 (es) VACCINE AGAINST VIRUS OF BOVINE VIRAL DIARRHEA (VDVB), IMMUNIZATION PROCEDURES AND METHODS
AR072183A4 (es) Dispositivo de coccion de alimentos con conveccion orientada
AR072456A1 (es) Sistema de elevacion fijo y permanente
AR070483A1 (es) Motor rotativo con camaras de expansion perifericas de seccion variable
AR070499A4 (es) Ruedas de vehiculos tradicionales con camaras de aire inflables
AR070472A1 (es) Cano o ducto plano
AR070462A1 (es) Metodo y composicion para tratar una afeccion diabetica. proceso para preparar dicha composicion. uso.
AR070435A1 (es) DISPOSITIVO GENERADOR DE ENERGíA A PARTIR DE CORRIENTES DE AGUA
AR070444A4 (es) Secador de pelo cuyo circuito electronico de control comprende un motor de cc sin escobillas
AR070445A4 (es) Elemento laminar para el colgado de articulos personales
AR070426A4 (es) Separador de bultos paralelepipedicos adyacentes palletizados
AR070428A1 (es) Envase para productos de la industria del tabaco
AR070425A4 (es) Dispositivo de acople para envases plasticos
AR070399A2 (es) Anticuerpos anti- erbb2 humanizados y tratamiento con anticuerpos anti-erb2. articulo de fabricacion. composicion. inmunoconjugado. acido nucleico. vector. celula huesped. proceso para preparar anticuerpo humanizado.
AR070396A1 (es) Lampara para semaforo
AR070423A1 (es) Derivados de arilsulfonas sustituidas como bloqueantes de canales de calcio
AR070419A1 (es) Procedimiento para el monitoreo y centrado de uno o mas haces de particulas energeticas
AR070417A1 (es) Horno de seguridad desmontable

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B07E Notice of approval relating to section 229 industrial property law

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure
B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal
B12B Appeal: appeal against refusal