EA201790395A1 - Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы - Google Patents
Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназыInfo
- Publication number
- EA201790395A1 EA201790395A1 EA201790395A EA201790395A EA201790395A1 EA 201790395 A1 EA201790395 A1 EA 201790395A1 EA 201790395 A EA201790395 A EA 201790395A EA 201790395 A EA201790395 A EA 201790395A EA 201790395 A1 EA201790395 A1 EA 201790395A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aminotriazin
- tank
- kinase inhibitors
- derivatives suitable
- binding kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Предложены соединения следующей формулы (I) и способы их применения и получения.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462056358P | 2014-09-26 | 2014-09-26 | |
US201562165005P | 2015-05-21 | 2015-05-21 | |
PCT/US2015/051757 WO2016049211A1 (en) | 2014-09-26 | 2015-09-23 | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
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EA201790395A1 true EA201790395A1 (ru) | 2017-08-31 |
Family
ID=54251749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790395A EA201790395A1 (ru) | 2014-09-26 | 2015-09-23 | Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы |
Country Status (17)
Country | Link |
---|---|
US (2) | US10040781B2 (ru) |
EP (2) | EP3517536B1 (ru) |
JP (2) | JP6499282B2 (ru) |
KR (1) | KR101949624B1 (ru) |
CN (1) | CN106715419A (ru) |
AU (1) | AU2015320675B2 (ru) |
BR (1) | BR102015024618A2 (ru) |
CA (1) | CA2962578C (ru) |
EA (1) | EA201790395A1 (ru) |
ES (2) | ES2881195T3 (ru) |
IL (1) | IL250875A0 (ru) |
MX (1) | MX2017003930A (ru) |
NZ (1) | NZ729618A (ru) |
SG (1) | SG11201701724VA (ru) |
TW (1) | TW201629046A (ru) |
UY (1) | UY36330A (ru) |
WO (1) | WO2016049211A1 (ru) |
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ES2881195T3 (es) | 2014-09-26 | 2021-11-29 | Gilead Sciences Inc | Derivados de aminotriazina útiles como compuestos inhibidores de quinasas que se unen a TANK |
BR112017002594A2 (pt) | 2015-12-17 | 2017-12-19 | Gilead Sciences Inc | compostos inibidores de cinase de ligação de tank |
MX2018008974A (es) | 2016-01-22 | 2018-11-09 | Janssen Pharmaceutica Nv | Nuevos derivados de cianoindolina sustituida como inhibidores de nik. |
EP3478673B1 (en) | 2016-06-30 | 2020-09-16 | Janssen Pharmaceutica NV | Cyanoindoline derivatives as nik inhibitors |
CN109641882B (zh) * | 2016-06-30 | 2022-10-28 | 杨森制药有限公司 | 作为nik抑制剂的杂芳族衍生物 |
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JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
CN109305944B (zh) * | 2017-07-28 | 2022-09-02 | 深圳睿熙生物科技有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
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CN109776513A (zh) * | 2019-03-18 | 2019-05-21 | 福建省医学科学研究院 | 一类4-苯基-1,3,5-三嗪-2-胺类抗肿瘤化合物及其制备方法 |
CN110357863B (zh) * | 2019-08-27 | 2023-04-14 | 药雅科技(上海)有限公司 | 一种三嗪双芳香环衍生物表皮生长因子抑制剂及其制备方法与用途 |
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2015
- 2015-09-23 ES ES19160625T patent/ES2881195T3/es active Active
- 2015-09-23 CA CA2962578A patent/CA2962578C/en not_active Expired - Fee Related
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- 2015-09-23 US US14/863,108 patent/US10040781B2/en active Active
- 2015-09-23 EP EP15775054.8A patent/EP3197884B1/en active Active
- 2015-09-23 EA EA201790395A patent/EA201790395A1/ru unknown
- 2015-09-23 SG SG11201701724VA patent/SG11201701724VA/en unknown
- 2015-09-23 KR KR1020177010833A patent/KR101949624B1/ko active IP Right Grant
- 2015-09-23 CN CN201580052292.6A patent/CN106715419A/zh active Pending
- 2015-09-23 AU AU2015320675A patent/AU2015320675B2/en not_active Ceased
- 2015-09-23 JP JP2017516318A patent/JP6499282B2/ja not_active Expired - Fee Related
- 2015-09-23 WO PCT/US2015/051757 patent/WO2016049211A1/en active Application Filing
- 2015-09-23 ES ES15775054T patent/ES2727376T3/es active Active
- 2015-09-23 NZ NZ729618A patent/NZ729618A/en not_active IP Right Cessation
- 2015-09-23 MX MX2017003930A patent/MX2017003930A/es unknown
- 2015-09-25 UY UY0001036330A patent/UY36330A/es not_active Application Discontinuation
- 2015-09-25 BR BR102015024618A patent/BR102015024618A2/pt not_active Application Discontinuation
- 2015-09-25 TW TW104131856A patent/TW201629046A/zh unknown
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2017
- 2017-03-01 IL IL250875A patent/IL250875A0/en unknown
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2018
- 2018-06-25 JP JP2018120056A patent/JP2018158942A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
KR101949624B1 (ko) | 2019-02-18 |
ES2727376T3 (es) | 2019-10-15 |
JP2018158942A (ja) | 2018-10-11 |
CA2962578A1 (en) | 2016-03-31 |
EP3197884A1 (en) | 2017-08-02 |
CN106715419A (zh) | 2017-05-24 |
US20180370955A1 (en) | 2018-12-27 |
WO2016049211A1 (en) | 2016-03-31 |
NZ729618A (en) | 2018-07-27 |
ES2881195T3 (es) | 2021-11-29 |
US20160096827A1 (en) | 2016-04-07 |
AU2015320675A1 (en) | 2017-03-23 |
CA2962578C (en) | 2019-01-08 |
JP2017529373A (ja) | 2017-10-05 |
EP3517536A1 (en) | 2019-07-31 |
JP6499282B2 (ja) | 2019-04-10 |
EP3517536B1 (en) | 2021-05-05 |
AU2015320675B2 (en) | 2018-10-18 |
TW201629046A (zh) | 2016-08-16 |
BR102015024618A2 (pt) | 2016-08-23 |
SG11201701724VA (en) | 2017-04-27 |
UY36330A (es) | 2016-04-29 |
US10253019B2 (en) | 2019-04-09 |
KR20170049609A (ko) | 2017-05-10 |
MX2017003930A (es) | 2017-06-30 |
EP3197884B1 (en) | 2019-03-06 |
IL250875A0 (en) | 2017-04-30 |
US10040781B2 (en) | 2018-08-07 |
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