MX2017003930A - Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank. - Google Patents
Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank.Info
- Publication number
- MX2017003930A MX2017003930A MX2017003930A MX2017003930A MX2017003930A MX 2017003930 A MX2017003930 A MX 2017003930A MX 2017003930 A MX2017003930 A MX 2017003930A MX 2017003930 A MX2017003930 A MX 2017003930A MX 2017003930 A MX2017003930 A MX 2017003930A
- Authority
- MX
- Mexico
- Prior art keywords
- tank
- kinase inhibitor
- inhibitor compounds
- derivatives useful
- binding kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se divulgan compuestos que tienen la siguiente fórmula (I) y métodos para su preparación y uso: (ver Fórmula).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462056358P | 2014-09-26 | 2014-09-26 | |
US201562165005P | 2015-05-21 | 2015-05-21 | |
PCT/US2015/051757 WO2016049211A1 (en) | 2014-09-26 | 2015-09-23 | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017003930A true MX2017003930A (es) | 2017-06-30 |
Family
ID=54251749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017003930A MX2017003930A (es) | 2014-09-26 | 2015-09-23 | Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank. |
Country Status (17)
Country | Link |
---|---|
US (2) | US10040781B2 (es) |
EP (2) | EP3197884B1 (es) |
JP (2) | JP6499282B2 (es) |
KR (1) | KR101949624B1 (es) |
CN (1) | CN106715419A (es) |
AU (1) | AU2015320675B2 (es) |
BR (1) | BR102015024618A2 (es) |
CA (1) | CA2962578C (es) |
EA (1) | EA201790395A1 (es) |
ES (2) | ES2727376T3 (es) |
IL (1) | IL250875A0 (es) |
MX (1) | MX2017003930A (es) |
NZ (1) | NZ729618A (es) |
SG (1) | SG11201701724VA (es) |
TW (1) | TW201629046A (es) |
UY (1) | UY36330A (es) |
WO (1) | WO2016049211A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
KR101949624B1 (ko) | 2014-09-26 | 2019-02-18 | 길리애드 사이언시즈, 인코포레이티드 | Tank-결합 키나제 억제제 화합물로서 유용한 아미노트리아진 유도체 |
CR20180320A (es) | 2015-12-17 | 2018-08-21 | Gilead Sciences Inc | Compuestos inhibidores de la quinasa de union a tank |
LT3405196T (lt) | 2016-01-22 | 2020-02-25 | Janssen Pharmaceutica Nv | Naujieji pakeistieji cianoindolino dariniai kaip nik inhibitoriai |
WO2018002219A1 (en) * | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
ES2805976T3 (es) * | 2016-06-30 | 2021-02-16 | Janssen Pharmaceutica Nv | Derivados heteroaromáticos en calidad de inhibidores de NIK |
WO2018124001A1 (ja) | 2016-12-27 | 2018-07-05 | 国立研究開発法人理化学研究所 | Bmpシグナル阻害化合物 |
JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
CN109305944B (zh) * | 2017-07-28 | 2022-09-02 | 深圳睿熙生物科技有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
RU2020115295A (ru) * | 2017-10-17 | 2021-11-18 | Мерк Патент Гмбх | ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ΤΒΚ/ΙΚΚε И ИХ ПРИМЕНЕНИЕ |
PL3752501T3 (pl) | 2018-02-13 | 2023-08-21 | Gilead Sciences, Inc. | Inhibitory pd-1/pd-l1 |
JP7242702B2 (ja) | 2018-04-19 | 2023-03-20 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
MX2020012137A (es) | 2018-05-14 | 2021-01-29 | Gilead Sciences Inc | Inhibidores de mcl-1. |
KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
CN111377850B (zh) * | 2018-12-31 | 2022-10-18 | 艾琪康医药科技(上海)有限公司 | 一种手性n-取代-3,3-二氟-4-羟基哌啶衍生物及其制备方法 |
CN109776513A (zh) * | 2019-03-18 | 2019-05-21 | 福建省医学科学研究院 | 一类4-苯基-1,3,5-三嗪-2-胺类抗肿瘤化合物及其制备方法 |
CN110357863B (zh) * | 2019-08-27 | 2023-04-14 | 药雅科技(上海)有限公司 | 一种三嗪双芳香环衍生物表皮生长因子抑制剂及其制备方法与用途 |
CN110862380A (zh) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
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TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
KR101949624B1 (ko) | 2014-09-26 | 2019-02-18 | 길리애드 사이언시즈, 인코포레이티드 | Tank-결합 키나제 억제제 화합물로서 유용한 아미노트리아진 유도체 |
US9994547B2 (en) | 2014-10-06 | 2018-06-12 | Takeda Pharmaceutical Company Limited | Heteroarylamide inhibitors of TBK1 |
JP2018524350A (ja) | 2015-06-29 | 2018-08-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | TBK/IKKε阻害剤化合物及びその用途 |
CR20180320A (es) | 2015-12-17 | 2018-08-21 | Gilead Sciences Inc | Compuestos inhibidores de la quinasa de union a tank |
-
2015
- 2015-09-23 KR KR1020177010833A patent/KR101949624B1/ko active IP Right Grant
- 2015-09-23 ES ES15775054T patent/ES2727376T3/es active Active
- 2015-09-23 EA EA201790395A patent/EA201790395A1/ru unknown
- 2015-09-23 JP JP2017516318A patent/JP6499282B2/ja not_active Expired - Fee Related
- 2015-09-23 EP EP15775054.8A patent/EP3197884B1/en active Active
- 2015-09-23 ES ES19160625T patent/ES2881195T3/es active Active
- 2015-09-23 AU AU2015320675A patent/AU2015320675B2/en not_active Ceased
- 2015-09-23 WO PCT/US2015/051757 patent/WO2016049211A1/en active Application Filing
- 2015-09-23 MX MX2017003930A patent/MX2017003930A/es unknown
- 2015-09-23 CA CA2962578A patent/CA2962578C/en not_active Expired - Fee Related
- 2015-09-23 NZ NZ729618A patent/NZ729618A/en not_active IP Right Cessation
- 2015-09-23 EP EP19160625.0A patent/EP3517536B1/en active Active
- 2015-09-23 CN CN201580052292.6A patent/CN106715419A/zh active Pending
- 2015-09-23 SG SG11201701724VA patent/SG11201701724VA/en unknown
- 2015-09-23 US US14/863,108 patent/US10040781B2/en active Active
- 2015-09-25 UY UY0001036330A patent/UY36330A/es not_active Application Discontinuation
- 2015-09-25 TW TW104131856A patent/TW201629046A/zh unknown
- 2015-09-25 BR BR102015024618A patent/BR102015024618A2/pt not_active Application Discontinuation
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2017
- 2017-03-01 IL IL250875A patent/IL250875A0/en unknown
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2018
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- 2018-06-27 US US16/020,777 patent/US10253019B2/en active Active
Also Published As
Publication number | Publication date |
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EA201790395A1 (ru) | 2017-08-31 |
UY36330A (es) | 2016-04-29 |
WO2016049211A1 (en) | 2016-03-31 |
JP2017529373A (ja) | 2017-10-05 |
CA2962578A1 (en) | 2016-03-31 |
SG11201701724VA (en) | 2017-04-27 |
NZ729618A (en) | 2018-07-27 |
EP3517536A1 (en) | 2019-07-31 |
JP2018158942A (ja) | 2018-10-11 |
US10040781B2 (en) | 2018-08-07 |
EP3197884B1 (en) | 2019-03-06 |
JP6499282B2 (ja) | 2019-04-10 |
AU2015320675B2 (en) | 2018-10-18 |
EP3197884A1 (en) | 2017-08-02 |
ES2881195T3 (es) | 2021-11-29 |
BR102015024618A2 (pt) | 2016-08-23 |
AU2015320675A1 (en) | 2017-03-23 |
CN106715419A (zh) | 2017-05-24 |
US20160096827A1 (en) | 2016-04-07 |
EP3517536B1 (en) | 2021-05-05 |
US10253019B2 (en) | 2019-04-09 |
TW201629046A (zh) | 2016-08-16 |
US20180370955A1 (en) | 2018-12-27 |
KR20170049609A (ko) | 2017-05-10 |
KR101949624B1 (ko) | 2019-02-18 |
IL250875A0 (en) | 2017-04-30 |
ES2727376T3 (es) | 2019-10-15 |
CA2962578C (en) | 2019-01-08 |
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