EA201690598A1 - Аминогетероарил бензамиды в качестве ингибиторов киназы - Google Patents

Аминогетероарил бензамиды в качестве ингибиторов киназы

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Publication number
EA201690598A1
EA201690598A1 EA201690598A EA201690598A EA201690598A1 EA 201690598 A1 EA201690598 A1 EA 201690598A1 EA 201690598 A EA201690598 A EA 201690598A EA 201690598 A EA201690598 A EA 201690598A EA 201690598 A1 EA201690598 A1 EA 201690598A1
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EA
Eurasian Patent Office
Prior art keywords
aminogeteroaril
benzamides
kinase inhibitors
compounds
relates
Prior art date
Application number
EA201690598A
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English (en)
Other versions
EA032754B1 (ru
Inventor
Джеффри Т. Багданофф
Юй Дин
Усок Хан
Цилинь Хуан
Цюнь Цзян
Джефф Сяньмин Цзинь
Сян Коу
Патрик Ли
Мика Линдвалль
Чжунчэн Минь
Юэ Пань
Сабина Пекки
Кейт Брюс Пфистер
Дэниел Пун
Вивек Раунияр
Сяолин Майкл Ван
Цюн Чжан
Цзяньгуан Чжоу
Шэцзинь Чжу
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201690598A1 publication Critical patent/EA201690598A1/ru
Publication of EA032754B1 publication Critical patent/EA032754B1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Настоящее изобретение относится к соединению формулы (I) или его солии терапевтическим применениям этих соединений. Настоящее изобретение также относится к фармацевтическим композициям, включающим эти соединения, и композициям, включающим эти соединения с дополнительным терапевтическим агентом.
EA201690598A 2013-11-01 2014-10-29 Аминогетероарил бензамиды в качестве ингибиторов киназы EA032754B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361898761P 2013-11-01 2013-11-01
CN2014088409 2014-10-11
PCT/US2014/062913 WO2015066188A1 (en) 2013-11-01 2014-10-29 Aminoheteroaryl benzamides as kinase inhibitors

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EA201690598A1 true EA201690598A1 (ru) 2016-10-31
EA032754B1 EA032754B1 (ru) 2019-07-31

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