PL3762368T3 - ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ - Google Patents

ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ

Info

Publication number
PL3762368T3
PL3762368T3 PL19768926T PL19768926T PL3762368T3 PL 3762368 T3 PL3762368 T3 PL 3762368T3 PL 19768926 T PL19768926 T PL 19768926T PL 19768926 T PL19768926 T PL 19768926T PL 3762368 T3 PL3762368 T3 PL 3762368T3
Authority
PL
Poland
Prior art keywords
aminopyrazine
pi3k
inhibitors
diol compounds
diol
Prior art date
Application number
PL19768926T
Other languages
English (en)
Inventor
Stacey Shepard
Andrew P. Combs
Nikoo Falahatpisheh
Lixin Shao
Original Assignee
Incyte Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corporation filed Critical Incyte Corporation
Publication of PL3762368T3 publication Critical patent/PL3762368T3/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
PL19768926T 2018-03-08 2019-03-07 ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ PL3762368T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862640276P 2018-03-08 2018-03-08
US201862702230P 2018-07-23 2018-07-23
US201862745873P 2018-10-15 2018-10-15
PCT/US2019/021186 WO2019226213A2 (en) 2018-03-08 2019-03-07 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS
EP19768926.8A EP3762368B1 (en) 2018-03-08 2019-03-07 Aminopyrazine diol compounds as pi3k-y inhibitors

Publications (1)

Publication Number Publication Date
PL3762368T3 true PL3762368T3 (pl) 2022-06-06

Family

ID=67844335

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19768926T PL3762368T3 (pl) 2018-03-08 2019-03-07 ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ

Country Status (30)

Country Link
US (3) US10669262B2 (pl)
EP (2) EP3762368B1 (pl)
JP (2) JP7268049B2 (pl)
KR (1) KR20200142508A (pl)
CN (1) CN112074505B (pl)
AU (1) AU2019272342B2 (pl)
BR (1) BR112020018094A2 (pl)
CA (1) CA3093445A1 (pl)
CL (1) CL2020002275A1 (pl)
CO (1) CO2020012169A2 (pl)
CR (1) CR20200464A (pl)
DK (1) DK3762368T3 (pl)
EC (1) ECSP20061378A (pl)
ES (1) ES2910071T3 (pl)
HR (1) HRP20220331T1 (pl)
HU (1) HUE057970T2 (pl)
IL (2) IL302529A (pl)
LT (1) LT3762368T (pl)
MA (1) MA54133B1 (pl)
MD (1) MD3762368T2 (pl)
MX (2) MX2020009228A (pl)
PE (1) PE20210641A1 (pl)
PH (1) PH12020551390A1 (pl)
PL (1) PL3762368T3 (pl)
PT (1) PT3762368T (pl)
RS (1) RS63124B1 (pl)
SG (1) SG11202008560VA (pl)
SI (1) SI3762368T1 (pl)
TW (1) TWI827583B (pl)
WO (1) WO2019226213A2 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7401439B2 (ja) 2018-01-19 2023-12-19 サイトキネティックス， インコーポレイテッド 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
TWI707849B (zh) 2018-02-13 2020-10-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
MA54133B1 (fr) 2018-03-08 2022-01-31 Incyte Corp Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP4143158A1 (en) * 2020-04-29 2023-03-08 Basf Se Preparation of aromatic carboxyamides by palladium-catalyzed carbonylation reaction
CN112341437A (zh) * 2020-12-21 2021-02-09 李寒 一种取代的吡嗪衍生物及其应用
CA3209557A1 (en) 2021-03-04 2022-09-09 Bradley P. Morgan Cardiac sarcomere inhibitors

Family Cites Families (810)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2190837B1 (pl) 1972-06-29 1974-12-27 Rhone Progil
US4705853A (en) 1982-09-30 1987-11-10 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
US5025096A (en) 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
US4861884A (en) 1985-10-15 1989-08-29 The Dow Chemical Company Compositions prepared from amino substituted pyrazines and carboxylic acids, carboxylic acid anhydrides, carboxylic acid esters or carboxylic acid halides
GB8718445D0 (en) 1987-08-04 1987-09-09 Wyeth John & Brother Ltd Pyridyl-ethers
JP2691986B2 (ja) 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
NL9001162A (nl) 1990-05-18 1991-12-16 Stamicarbon Werkwijze ter bereiding van 2-n-acylaminopyridines en 2-aminopyridines uit 5-oxoalkaannitriloximmen alsmede deze 5-oxoalkaannitriloximmen, 2-n-acylaminopyridines en 2-aminopyridines.
US5155117A (en) 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
JPH0558997A (ja) 1991-09-04 1993-03-09 Mitsubishi Kasei Corp チオカルバモイルアセトニトリル誘導体
EP0553009B1 (fr) 1992-01-23 1997-06-04 Institut Francais Du Petrole Catalyseur d'alkylation de paraffines
US5315043A (en) 1992-02-05 1994-05-24 E. I. Du Pont De Nemours And Company Aromatic nucleophilic fluorination
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5252737A (en) 1992-05-22 1993-10-12 Monsanto Company Process for preparing N-aliphatic substituted p-phenylenediamines
JPH061776A (ja) 1992-06-18 1994-01-11 Nippon Soda Co Ltd 置換ピラジンカルボニトリルの製造方法
US5232945A (en) 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
JPH06256327A (ja) 1993-03-03 1994-09-13 Nippon Soda Co Ltd ４−置換アゼチジノン誘導体の製造方法
JP4327911B2 (ja) 1993-03-03 2009-09-09 日本曹達株式会社 イミド化合物の製造方法
WO1994022853A1 (en) 1993-03-26 1994-10-13 Shell Internationale Research Maatschappij B.V. Herbicidal 1-heteroaryl pyrazolidin-3,5-diones
US5436134A (en) 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
US5545535A (en) 1993-04-13 1996-08-13 Molecular Probes, Inc. Fluorescent assay for bacterial gram reaction
US5534416A (en) 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5451702A (en) 1993-04-26 1995-09-19 Monsanto Company Process for preparing substituted aromatic amines
TW266206B (pl) 1993-04-28 1995-12-21 Takeda Pharm Industry Co Ltd
JPH0782249A (ja) 1993-06-30 1995-03-28 Nippon Soda Co Ltd ４−置換アゼチジノン誘導体の製造法
US5744492A (en) 1993-09-17 1998-04-28 United States Of America Method for inhibiting angiogenesis
US5602156A (en) 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
US5430123A (en) 1994-02-04 1995-07-04 Hoechst Celanese Corporation Polymer compositions containing substituted pyrazines
US5393860A (en) 1994-02-04 1995-02-28 Hoechst Celanese Corporation Polymer compositions containing substituted pyrazines
US5459266A (en) 1994-02-04 1995-10-17 Hoechst Celanese Corporation Substituted pyrazines
EP0749423B1 (en) 1994-03-09 2003-06-18 Novo Nordisk A/S Piperidines and pyrrolidines
US5863903A (en) 1994-03-09 1999-01-26 Novo Nordisk A/S Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
DE19509353A1 (de) 1994-03-31 1995-10-05 Basf Ag 4-Aminopiperidine
SE9401353D0 (sv) 1994-04-21 1994-04-21 Pharmacia Ab Novel antitumour compounds with antimitotic activity
DE4417746A1 (de) 1994-05-20 1995-11-23 Bayer Ag Neue Farbstoffe zum Massefärben von Kunststoffen
KR0151819B1 (ko) 1994-06-11 1998-10-15 강박광 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법
GB9412522D0 (en) 1994-06-22 1994-08-10 Ici Plc Optical recording media
DE4427529A1 (de) 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von 1,2,4-Triazin-3,5-dionen
FR2725718B1 (fr) 1994-10-14 1997-01-24 Virbac Lab Bis-2-aminopyridines, leur procede de preparation et leurs applications
US5883106A (en) 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
SK281577B6 (sk) 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
DK0788496T3 (da) 1994-10-27 2001-06-18 Janssen Pharmaceutica Nv Inhibitorer for syntese af apolipoprotein-B
JPH08175994A (ja) 1994-10-27 1996-07-09 Takeda Chem Ind Ltd 脂質代謝改善剤
US5723477A (en) 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5677459A (en) 1994-11-10 1997-10-14 Sibia Neurosciences, Inc. Methods for the preparation of modulators of acetylcholine receptors
US5705512A (en) 1994-11-10 1998-01-06 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5703100A (en) 1994-11-10 1997-12-30 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6057346A (en) 1994-12-12 2000-05-02 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of retroviral LTR promoters by calcium response modifiers
US5521056A (en) 1995-01-10 1996-05-28 Eastman Kodak Company Photographic peracid bleaching composition and processing method using ternary iron carboxylate complexes as catalysts in peracid bleaching solutions
US5639776A (en) 1995-01-12 1997-06-17 Otsuka Kagaku Kabushiki Kaisha 4, 5-dihydropyrazole-5-thione derivatives and miticides comprising the same
US5656449A (en) 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
JPH08337583A (ja) 1995-04-13 1996-12-24 Takeda Chem Ind Ltd 複素環化合物およびその製造法
GB9520355D0 (en) 1995-10-05 1995-12-06 Zeneca Ltd Chemical process
ES2167563T3 (es) 1995-05-23 2002-05-16 Janssen Pharmaceutica Nv Derivados de (2-morfolinilmetil)benzamida.
ES2162074T3 (es) 1995-06-28 2001-12-16 Syngenta Ltd Procedimiento para la preparacion de 2-(6-sustituido pirid-2-iloximetil)fenilacetato.
WO1997011943A1 (fr) 1995-09-26 1997-04-03 Nippon Soda Co., Ltd. Composes de pyrazole, procede de preparation et bactericide agrohorticole
AU7528696A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Muscarine antagonists
AU7478496A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Muscarine antagonists
US5756508A (en) 1995-10-31 1998-05-26 Merck & Co., Inc. Muscarine antagonists
GB9525296D0 (en) 1995-12-11 1996-02-07 Merck Sharp & Dohme Therapeutic agents
WO1997026258A1 (en) 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
GB9605331D0 (en) 1996-03-13 1996-05-15 Glaxo Group Ltd Chemical compounds
US5880137A (en) 1996-04-19 1999-03-09 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
EP0914318A1 (en) 1996-05-11 1999-05-12 Kings College London Pyrazines
DE19620508A1 (de) 1996-05-22 1997-11-27 Hoechst Ag Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
US5672592A (en) 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
FR2751969B1 (fr) 1996-08-01 1998-12-04 Centre Nat Rech Scient Composes activateurs du canal cftr, et compositions pharmaceutiques les contenant
JP4278008B2 (ja) 1996-08-23 2009-06-10 興和株式会社 ジアミド化合物及びこれを含有する医薬
TW382127B (en) 1996-08-30 2000-02-11 Sony Corp Magnetic recording medium and cleaning tape
DE69707907T2 (de) 1996-09-26 2002-05-16 Syngenta Participations Ag Herbizid wirkende zusammensetzung
DE69724630T2 (de) 1996-10-02 2004-07-29 Bristol-Myers Squibb Pharma Co. 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv-reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung
DE69719775T2 (de) 1996-10-24 2004-02-05 Merck & Co., Inc. Thrombin inhibitoren
US5869487A (en) 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
US20020115678A1 (en) 1996-10-28 2002-08-22 Ellis William Y. Compounds, compositions and methods for treating antibiotic-resistant infections
US6274598B1 (en) 1996-10-28 2001-08-14 The United States Of America As Represented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
EP0936866A4 (en) 1996-10-28 2001-04-11 Dept Of The Army Us Government COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS
US6147080A (en) 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
JPH10188264A (ja) 1996-12-24 1998-07-21 Sony Corp 磁気記録媒体及びその製造方法
WO1998029114A1 (en) 1996-12-30 1998-07-09 Bar-Ilan University Tricarboxylic acid-containing oxyalkyl esters and uses thereof
AU6161198A (en) 1997-02-18 1998-09-08 E.I. Du Pont De Nemours And Company Herbicidal tetrazolinones
JPH10324687A (ja) 1997-02-19 1998-12-08 Nippon Soda Co Ltd ピロール化合物、製法および農園芸用殺菌剤
US5811442A (en) 1997-02-21 1998-09-22 Bencherif; Merouane Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow
DE19718742A1 (de) 1997-05-02 1998-11-05 Hoechst Ag Verfahren zur Herstellung von aromatischen Aldehyden durch katalytische Gasphasenhydrierung der Carbonsäuren
FR2763334A1 (fr) 1997-05-13 1998-11-20 Lipha Derives anthraniliques
FR2763588B1 (fr) 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
GB9711753D0 (en) 1997-06-06 1997-08-06 Merck Sharp & Dohme Therapeutic agents
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
KR20010014030A (ko) 1997-06-19 2001-02-26 더글라스이.리디치 퀴놀린-인돌 항균제, 이들의 용도 및 조성물
WO1999001453A1 (en) 1997-07-02 1999-01-14 F. Hoffmann-La Roche Ag A process for the manufacture of optically active chromanylpyridine derivatives
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
EP1017383A4 (en) 1997-09-23 2001-11-28 Merck & Co Inc THROMBIN INHIBITORS
AU741766B2 (en) 1997-12-01 2001-12-06 Merck & Co., Inc. Thrombin inhibitors
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
DK1043995T3 (da) 1997-12-22 2007-03-05 Bayer Pharmaceuticals Corp Inhibering af p38 kinaseaktivitet ved anvendelse af aryl- og heteroaryl-substituerede, heterocykliske urinstoffer
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
BR9814361A (pt) 1997-12-22 2001-11-27 Bayer Ag Inibição de quinase raf usando uréiasheterocìclicas substituìdas por arila eheteroarila
AU1685999A (en) 1997-12-24 1999-07-19 Ihara Chemical Industry Co. Ltd. Pyridyloxy(thio)alkanoic acid amide derivatives and agricultural/horticultural bactericides
DK0930302T3 (da) 1998-01-16 2003-07-21 Hoffmann La Roche Benzosulfonderivater
JP3929700B2 (ja) 1998-01-28 2007-06-13 塩野義製薬株式会社 新規三環式化合物
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
JPH11292883A (ja) 1998-04-07 1999-10-26 Yoshitomi Fine Chemical Kk トリフェニルボロンアミン付加化合物の製造方法
EE200000796A (et) 1998-04-27 2002-06-17 Janssen Pharmaceutica N.V. Ravimkuulike, selle valmistamismeetod ja farmatseutiline doseerimisvorm, ravimkuulikeste kasutaminefarmatseutilise doseerimisvormi valmistamiseks ning farmatseutiline pakend
ATE282610T1 (de) 1998-05-02 2004-12-15 Astrazeneca Ab Heterozyklische verbindungen mit faktor xa hemmender wirkung
CA2319153A1 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel sodium channel drugs and uses
US6197798B1 (en) 1998-07-21 2001-03-06 Novartis Ag Amino-benzocycloalkane derivatives
CO5090829A1 (es) 1998-07-21 2001-10-30 Novartis Ag Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b.
HUP0103464A3 (en) 1998-08-10 2002-11-28 U S Government Represented By Prodrugs of proton pump inhibitors and pharmaceutical compositions containing them
AU5620299A (en) 1998-08-11 2000-03-06 Novartis Ag Isoquinoline derivatives with angiogenesis inhibiting activity
JP2000073094A (ja) 1998-08-28 2000-03-07 Lion Corp カビ取り剤組成物
JP2000076642A (ja) 1998-08-31 2000-03-14 Sony Corp 磁気記録再生装置
JP2000076643A (ja) 1998-08-31 2000-03-14 Sony Corp 磁気ディスク装置
JP2000076640A (ja) 1998-08-31 2000-03-14 Sony Corp 磁気記録再生装置
PT1114030E (pt) 1998-09-15 2005-09-30 Syngenta Participations Ag Piridina cetonas uteis como herbicidas
JP2002528723A (ja) 1998-10-27 2002-09-03 モレキュラー・プロウブズ・インコーポレーテッド 遷移金属錯体を含有する発光タンパク質染色剤
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
CN1335847A (zh) 1998-12-04 2002-02-13 藤泽药品工业株式会社 磺酰胺化合物及其药物用途
EP1135365A1 (en) 1998-12-04 2001-09-26 American Home Products Corporation 4-3-substituted-amino-cyclobut-3-ene-1,2-diones and use for influencing smooth muscle contraction
US20020103141A1 (en) 1998-12-23 2002-08-01 Mckearn John P. Antiangiogenic combination therapy for the treatment of cancer
AR023071A1 (es) 1998-12-23 2002-09-04 Syngenta Participations Ag Compuestos de piridincetona, compuestos intermediarios, composicion herbicida e inhibidora del crecimiento de plantas, metodo para controlar la vegetacion indeseada, metodo para inhibir el crecimiento de las plantas, y uso de la composicion para controlar el crecimiento indeseado de plantas.
GB9901253D0 (en) 1999-01-20 1999-03-10 Isis Innovation Bis-terpyridine-platinum(II) complexes
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
DE19932571A1 (de) 1999-07-13 2001-01-18 Clariant Gmbh Verfahren zur Herstellung von Biarylen unter Palladophosphacyclobutan-Katalyse
CA2376961A1 (en) 1999-07-26 2001-02-01 Bristol-Myers Squibb Pharma Company Lactam inhibitors of hepatitis c virus ns3 protease
US7122627B2 (en) 1999-07-26 2006-10-17 Bristol-Myers Squibb Company Lactam inhibitors of Hepatitis C virus NS3 protease
EP1214304B1 (en) 1999-08-31 2005-08-24 Incyte San Diego Incorporated Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
JP2001072660A (ja) 1999-09-08 2001-03-21 Welfide Corp ＴＮＦ−α産生抑制剤および／またはＩＬ−１０産生促進剤
JP4523093B2 (ja) 1999-09-20 2010-08-11 広栄化学工業株式会社 ２−アミノ−ブロモピラジン類の製造方法
AU1053501A (en) 1999-11-02 2001-05-14 Ajinomoto Co., Inc. Polyazanaphthalene compound and medicinal use thereof
CA2386318A1 (en) 1999-11-18 2001-05-25 Pierre Ducray Pesticidal aminoheterocyclamide compounds
EP1242379A1 (en) 1999-12-03 2002-09-25 Emory University Curcumin analogues for treating cancer
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
JP4388189B2 (ja) 2000-03-08 2009-12-24 独立行政法人科学技術振興機構 ピリジン誘導体及びその製造方法
AU2001259130A1 (en) 2000-04-24 2001-11-07 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6768008B2 (en) 2000-04-24 2004-07-27 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US20040034225A1 (en) 2000-05-17 2004-02-19 Jacqueline Marchand-Brynaert Aryl-substituted n, n-heterocyclic compounds, method for their preparationand their use in therapeutics and diagnostics
WO2003024441A1 (fr) 2001-09-14 2003-03-27 Shionogi & Co., Ltd. Nouvelle utilisation de composes tricycliques
US6958353B2 (en) 2000-06-28 2005-10-25 Hisamitsu Medical Co., Ltd. Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts
PL202623B1 (pl) 2000-06-28 2009-07-31 Smithkline Beecham Plc Sposób wytwarzania drobno zmielonego preparatu substancji leczniczej, drobno zmielona substancja lecznicza wytworzona tym sposobem i zawierająca ją kompozycja farmaceutyczna
WO2002006271A1 (en) 2000-07-19 2002-01-24 F. Hoffmann-La Roche Ag Pyrimidine derivatives
US6541639B2 (en) 2000-07-26 2003-04-01 Bristol-Myers Squibb Pharma Company Efficient ligand-mediated Ullmann coupling of anilines and azoles
WO2002009759A2 (en) 2000-07-27 2002-02-07 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
AU2001294673A1 (en) 2000-09-21 2002-04-02 Aryx Therapeutics Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis
WO2002046249A2 (en) 2000-11-07 2002-06-13 Symyx Technologies, Inc. Methods of copolymerizing ethylene and isobutylene and polymers made thereby
EP1351686A2 (en) 2000-11-20 2003-10-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
FR2816942B1 (fr) 2000-11-23 2003-05-09 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
DE10060807A1 (de) 2000-12-07 2002-06-20 Aventis Pharma Gmbh Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
KR100844062B1 (ko) 2001-02-21 2008-07-07 미쓰이 가가쿠 가부시키가이샤 올레핀 중합용 촉매 및 이 촉매를 사용하는 올레핀중합체의 제조방법
CA2438813C (en) 2001-03-02 2008-07-29 F. Hoffmann-La Roche Ag Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists
FR2821718B1 (fr) 2001-03-08 2003-06-13 Aventis Cropscience Sa Nouvelles compositions fongicides a base de derives de pyridylmethylbenzamide et d'imidazoline ou d'oxazolidine
WO2002072543A2 (en) 2001-03-08 2002-09-19 Maxia Pharmaceuticals, Inc. Rxr activating molecules
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
OA12553A (en) 2001-03-28 2006-06-07 Pfizer N-Phenpropylcyclopentyl-substituted glutaramide derivatives as NEP inhibitors for FSAD.
AU2002305450A1 (en) 2001-05-08 2002-11-18 Yale University Proteomimetic compounds and methods
JP2002338537A (ja) 2001-05-16 2002-11-27 Mitsubishi Pharma Corp アミド化合物およびその医薬用途
JP2002338837A (ja) 2001-05-16 2002-11-27 Fuji Photo Film Co Ltd 新規化合物、色素、インク組成物、インクジェット用インク、インクジェット記録方法、及び熱転写色素
EP1400178A1 (en) 2001-06-08 2004-03-24 Japan Tobacco Inc. Fluid body coater
JP4180254B2 (ja) 2001-06-29 2008-11-12 独立行政法人科学技術振興機構 窒素含有６員環の製造方法
SE0102438D0 (sv) 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
JP4340404B2 (ja) 2001-07-23 2009-10-07 独立行政法人科学技術振興機構 不飽和６員環の製造方法
MXPA04002243A (es) 2001-09-19 2004-06-29 Aventis Pharma Sa Compuestos quimicos.
FR2830194B1 (fr) 2001-09-28 2003-12-19 Oreal Composition contenant un derive de pyrazine et utilisation pour la teinture directe ou d'oxydation et/ou l'eclaircissement optique des fibres keratiniques
FR2831022B1 (fr) 2001-10-23 2004-01-23 Aventis Cropscience Sa Composition fongicide a base d'au moins un derive de pyridylmethylbenzamide et d'au moins un derive dithiocarbamate
DE60213842T2 (de) 2001-10-30 2007-09-06 Novartis Ag Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung
US7166368B2 (en) 2001-11-07 2007-01-23 E. I. Du Pont De Nemours And Company Electroluminescent platinum compounds and devices made with such compounds
US7361671B2 (en) 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
JP4416998B2 (ja) 2001-11-19 2010-02-17 日本エンバイロケミカルズ株式会社 微生物防除剤
DE10238113A1 (de) 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
US7091357B2 (en) 2001-12-26 2006-08-15 University Of Kentucky Research Foundation Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
JP2005162612A (ja) 2002-01-09 2005-06-23 Ajinomoto Co Inc アシルスルホンアミド誘導体
JP2005525309A (ja) 2002-01-10 2005-08-25 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 医薬品としての使用のためのＭＴＰインヒビター又はａｐｏＢ分泌インヒビターとフィブレートの組み合わせ
WO2003059348A1 (en) 2002-01-11 2003-07-24 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
EP1470108B1 (en) 2002-01-18 2016-08-24 Vittal Mallya Scientific Research Foundation 1,4-dihydropyridine and pyridine compounds as calcium channel blockers
CA2474322A1 (en) 2002-01-25 2003-07-31 Kylix Pharmaceuticals B.V. 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
AU2003213184A1 (en) 2002-02-22 2003-09-09 Pharmacia And Upjohn Company Pyridyl sulfone derivatives as 5-ht receptor antagonists
AU2003213642A1 (en) 2002-02-28 2003-09-16 Rensselaer Polytechnic Institute High-affinity, low-molecular-mass displacers for ion-exchange chromatography
US20040127719A1 (en) 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same
US20090011991A1 (en) 2002-03-08 2009-01-08 Emory University Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis
US20050069551A1 (en) 2002-03-08 2005-03-31 Emory University Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis
CN1374306A (zh) 2002-03-27 2002-10-16 江苏省农药研究所 改良的杀虫剂中间体制备方法
JP2005320249A (ja) 2002-05-01 2005-11-17 Banyu Pharmaceut Co Ltd ２−アミノピラジン誘導体の製造方法
AU2003233228A1 (en) 2002-05-03 2003-11-17 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolyl-cis/trans-isomerases
US6806265B2 (en) 2002-05-16 2004-10-19 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
PE20040522A1 (es) 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
AU2003218176A1 (en) 2002-06-11 2003-12-22 Bristol-Myers Squibb Company Asymetric synthesis of amino-pyrrolidinones
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
EP1528921A2 (en) 2002-08-02 2005-05-11 Pharmacia Corporation Methods for treatment and prevention of gastrointestinal conditions
JP4178008B2 (ja) 2002-08-02 2008-11-12 日本エンバイロケミカルズ株式会社 藻類防除剤および藻類防除方法
JP2003292408A (ja) 2002-08-13 2003-10-15 Takeda Chem Ind Ltd 微生物防除剤
SE0202429D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel Compounds
EP1542948A4 (en) 2002-08-23 2008-12-17 Univ Connecticut NEW BIPHENYL AND BIPHENYLENE CANNABINOIDS
WO2004019863A2 (en) 2002-08-28 2004-03-11 Intermune, Inc. Combination therapy for treatment of fibrotic disorders
JP4513569B2 (ja) 2002-08-29 2010-07-28 日本ゼオン株式会社 遷移金属化合物、共役ジエン重合用触媒、共役ジエン重合体の製造方法、ならびにポリイソプレンとその環化物およびそれらの製造方法
JP4566540B2 (ja) 2002-10-03 2010-10-20 日本エンバイロケミカルズ株式会社 工業用殺菌剤、塗料、インク、樹脂エマルション、金属加工油剤、湿し水
JP2004123617A (ja) 2002-10-03 2004-04-22 Japan Enviro Chemicals Ltd 微生物防除剤
RU2005110062A (ru) 2002-10-07 2006-01-10 Артезиан Терапьютикс, Инк. (US) Дигидропиридиновые соединения, обладающие одновременной способностью к блокированию кальциевых каналов l-типа и к ингибированию активности фосфодиэстеразы типа 3
US20070066619A1 (en) 2002-10-07 2007-03-22 Artesian Therapeutics, Inc. Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
JP3587839B2 (ja) 2002-10-23 2004-11-10 日本エンバイロケミカルズ株式会社 ビス四級アンモニウム塩化合物の安定化方法
US20040082641A1 (en) 2002-10-28 2004-04-29 Rytved Klaus Asger Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
FR2846657B1 (fr) 2002-11-05 2004-12-24 Servier Lab Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ITMI20022389A1 (it) 2002-11-12 2004-05-13 Nicox Sa Farmaci per le disfunzioni sessuali.
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
US7135472B2 (en) 2002-11-22 2006-11-14 Bristol-Myers Squibb Company 3-Heterocyclic benzylamide derivatives as potassium channel openers
DE10254596A1 (de) 2002-11-22 2004-06-03 Merck Patent Gmbh Indolderivate
EP1575951B1 (en) 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
US20040127519A1 (en) 2002-12-12 2004-07-01 Pharmacia Corporation Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
US20040142978A1 (en) 2002-12-12 2004-07-22 Pharmacia Corporation Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
JP2006512338A (ja) 2002-12-12 2006-04-13 ファルマシア・コーポレーション マイトジェン活性化プロテインキナーゼ−活性化プロテインキナーゼ−２阻害剤としてのアミノシアノピリジンの使用法
JP4473503B2 (ja) 2002-12-16 2010-06-02 日本エンバイロケミカルズ株式会社 微生物防除剤
SE0203752D0 (sv) 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
JP3502629B1 (ja) 2002-12-26 2004-03-02 日本エンバイロケミカルズ株式会社 微生物防除剤および安定化方法
GB0300783D0 (en) 2003-01-14 2003-02-12 Btg Int Ltd Treatment of neurodegenerative conditions
GB0301350D0 (en) 2003-01-21 2003-02-19 Merck Sharp & Dohme Therapeutic agents
TW200418791A (en) 2003-01-23 2004-10-01 Bristol Myers Squibb Co Pharmaceutical compositions for inhibiting proteasome
US7329678B2 (en) 2003-01-28 2008-02-12 Smithkline Beecham Corporation Chemical compounds
PE20040945A1 (es) 2003-02-05 2004-12-14 Warner Lambert Co Preparacion de quinazolinas substituidas
US20060160864A1 (en) 2003-02-07 2006-07-20 Mitsuru Shiraishi Acrylamide derivative, process for producing the same, and use
CA2515235A1 (en) 2003-02-10 2004-08-19 Bayer Healthcare Ag Bis(hetero)aryl carboxamide derivatives for use as pgi2 antagonists
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
DE10315573A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
US7129264B2 (en) 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
CA2464604A1 (en) 2003-04-17 2004-10-17 Queen's University At Kingston Organic luminescent compounds and methods of making and using same
DE10318610A1 (de) 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
DE10318609A1 (de) 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318611A1 (de) 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
EP1837330B1 (en) 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
GB0311081D0 (en) 2003-05-14 2003-06-18 Btg Internat Limted Treatment of neurodegenerative conditions
US7507782B2 (en) 2003-05-21 2009-03-24 Basell Polyolefine Gmbh Transition-metal complexes with tridentate, nitrogen-containing ligands
AU2003902860A0 (en) 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
WO2004108673A2 (en) 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
WO2004113258A1 (ja) 2003-06-20 2004-12-29 Shionogi & Co., Ltd. 炭素−炭素結合生成反応
WO2004113277A2 (en) 2003-06-23 2004-12-29 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
WO2005005382A2 (en) 2003-07-02 2005-01-20 Cytokinetics, Inc. Compounds, compositions and methods
JP4363098B2 (ja) 2003-07-11 2009-11-11 三菱化学株式会社 ビスイミダゾピラジノン誘導体及びビスアミノピラジン誘導体
WO2005025623A2 (en) 2003-07-28 2005-03-24 Emory University Ef-24-factor vii conjugates
WO2005012298A1 (en) 2003-07-30 2005-02-10 Cyclacel Limited Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors
US7198730B2 (en) 2003-08-28 2007-04-03 E. I. Du Pont De Nemours And Company Phosphorescent material
US7504401B2 (en) 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
WO2005026166A1 (fr) 2003-09-16 2005-03-24 'chemical Diversity Research Institute', Ltd. Composition physiologiquement active, composition pharmaceutique, 1,2-dihydro[2,7]naphtyridine, procedes de fabrication et application
ES2360152T3 (es) 2003-09-22 2011-06-01 Euro-Celtique S.A. Compuestos de fenil-carboxamida útiles para el tratamiento del dolor.
AR045944A1 (es) 2003-09-24 2005-11-16 Novartis Ag Derivados de isoquinolina 1.4-disustituidas
JP2005126586A (ja) 2003-10-24 2005-05-19 Konica Minolta Holdings Inc ポリメチン色素、光電変換材料用半導体、光電変換素子及び太陽電池
RU2388747C2 (ru) 2003-11-07 2010-05-10 Тайсо Фармасьютикал Ко., Лтд. Способы получения производных бицикло [3.1.0]гексана и промежуточные соединения для этой цели
FR2862304A1 (fr) 2003-11-14 2005-05-20 Centre Nat Rech Scient Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
WO2005058876A1 (en) 2003-12-16 2005-06-30 Gpc Biotech Ag Pyrazine derivatives as effective compounds against infectious diseases
US20080188527A1 (en) 2003-12-23 2008-08-07 Cashman John R Synthetic Compounds and Derivatives as Modulators of Smoking or Nicotine Ingestion and Lung Cancer
ATE450263T1 (de) 2004-02-04 2009-12-15 Neurosearch As Diazabicyclische aryl-derivate als cholinerge rezeptor-modulatoren
DE102004005785A1 (de) 2004-02-06 2005-08-25 Bayer Cropscience Ag 2-Halogenfuryl/thienyl-3-carboxamide
JP2007524682A (ja) 2004-02-12 2007-08-30 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体−５の調節物質としてのビピリジルアミド
CA2557794A1 (en) 2004-03-15 2005-10-06 Eli Lilly And Company Opioid receptor antagonists
US7596407B2 (en) 2004-03-26 2009-09-29 Solvay Pharmaceuticals, B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
EP2522670A1 (en) 2004-04-07 2012-11-14 Takeda Pharmaceutical Company Limited Heterocyclic CRF receptor antagonists
US20050239826A1 (en) 2004-04-14 2005-10-27 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
MY143245A (en) 2004-04-28 2011-04-15 Mitsubishi Tanabe Pharma Corp 4- 2-(cycloalkylamino)pyrimidin-4-yl-(phenyl)-imidazolin-2-one derivatives as p38 map-kinase inhibitors for the treatment of inflammatory diseases
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
WO2005123719A1 (en) 2004-06-10 2005-12-29 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1756087B1 (en) 2004-06-16 2009-10-07 Wyeth Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase
WO2006009655A1 (en) 2004-06-16 2006-01-26 Wyeth Diphenylimidazopyrimidine and -imidazole amines as inhibitors of b-secretase
EP1841460A2 (en) 2004-06-18 2007-10-10 Neurochem (International) Limited Therapeutic formulations for the treatment of beta-amyloid related diseases
DE102004032651A1 (de) 2004-07-06 2006-02-16 Bayer Healthcare Ag Verwendung von substituierten 2-Thio-3,5-dicyano-4-phenyl-6-aminopyriden bei der Behandlung von Übelkeit und Erbrechen
JP5050312B2 (ja) 2004-07-23 2012-10-17 コニカミノルタホールディングス株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
RU2374239C2 (ru) 2004-07-28 2009-11-27 Ф.Хоффманн-Ля Рош Аг Производные арилпиридина
WO2006038606A1 (ja) 2004-10-05 2006-04-13 Shionogi & Co., Ltd. ビアリール誘導体
CA2584794A1 (en) 2004-10-26 2006-05-04 Third-Order Nanotechnologies, Inc. Tricyclic spacer systems for nonlinear optical devices
DK1805158T3 (en) 2004-10-29 2018-08-06 Kalypsys Inc SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
JPWO2006051937A1 (ja) 2004-11-15 2008-05-29 塩野義製薬株式会社 ヘテロ５員環誘導体
RU2007122351A (ru) 2004-11-15 2008-12-20 Тайсо Фармасьютикал Ко. Иминовое соединение
AU2005307735A1 (en) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Substituted amino acids as protein Tyrosine phosphatase inhibitors
US20090239865A1 (en) 2004-11-23 2009-09-24 George Chang Dibenzyl amine compounds and derivatives
CN101106983A (zh) 2004-11-24 2008-01-16 诺瓦提斯公司 JAK抑制剂与至少一种Bcr-Abl、Flt-3、FAK或RAF激酶抑制剂的组合
US20080015223A1 (en) 2004-12-03 2008-01-17 Arena Pharmaceuticals, Inc. Pyrazole Derivatives as Modulators of the 5-Ht2a Serotonin Receptor Useful for the Treatment of Disorders Related Thereto
US20080086006A1 (en) 2004-12-22 2008-04-10 Nelson Todd D Process for Making Substituted Piperidines
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
EP1833819A1 (en) 2004-12-30 2007-09-19 Astex Therapeutics Limited Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases
US20080146612A1 (en) 2005-01-27 2008-06-19 Astrazeneca Ab Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor
SI1848694T1 (sl) 2005-02-07 2010-01-29 Hoffmann La Roche Heterocikliäśni substituirani fenil metanoni kot inhibitorji glicinskega transporterja 1
KR20130089671A (ko) 2005-02-11 2013-08-12 바이엘 크롭사이언스 아게 피리딜메틸벤즈아미드 유도체 및 티아졸카르복사미드 유도체를 포함하는 살진균성 조성물
MX2007010068A (es) 2005-02-16 2007-10-10 Schering Corp Piperazino-piperidinas con actividad antagonista de cxcr3.
WO2006103254A1 (en) 2005-04-01 2006-10-05 Clariant International Ltd Betaines of squaric acid for use in optical layers for optical data recording
US7820699B2 (en) 2005-04-27 2010-10-26 Hoffmann-La Roche Inc. Cyclic amines
WO2006124874A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Inhibitors of b-raf kinase
DE102005025315A1 (de) 2005-06-02 2006-12-14 Merck Patent Gmbh Ionische Flüssigkeiten mit niedriger Viskosität
US7312331B2 (en) 2005-06-17 2007-12-25 The Regents Of The University Of California Stable cyclic (alkyl)(amino) carbenes as ligands for transition metal catalysts
DE102005030400A1 (de) 2005-06-27 2006-12-28 Archimica Gmbh Verfahren zur Herstellung von Arylaminen, Arylethern und Arylthioethern
DE102005032332A1 (de) 2005-07-08 2007-01-11 Merck Patent Gmbh Metallkomplexe
US20090176837A1 (en) 2005-07-12 2009-07-09 Sony Corporation Compounds with activity at retinoic acid receptors
WO2007011721A1 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
CN100562514C (zh) 2005-07-22 2009-11-25 中国科学院上海药物研究所 一类取代丙酰胺衍生物、其制备方法和用途
JP2009503103A (ja) 2005-08-02 2009-01-29 レキシコン・ファーマシューティカルズ・インコーポレーテッド アリールピリジン及びその使用方法
JP4799073B2 (ja) 2005-08-04 2011-10-19 日本エンバイロケミカルズ株式会社 微生物防除剤
KR100696636B1 (ko) 2005-08-18 2007-03-19 삼성에스디아이 주식회사 염료감응 태양 전지용 염료 및 이로부터 제조된 염료감응태양 전지
CA2618770A1 (en) 2005-08-25 2007-03-01 Emory University Hif inhibitors
MX2008002723A (es) 2005-08-26 2008-03-26 Serono Lab Derivados de pirazina y uso como inhibidores de p13k.
US20090215857A1 (en) 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
US8044173B2 (en) 2005-09-13 2011-10-25 University Of Reading Asymmetric synthesis of peptides
US7732613B2 (en) 2005-09-14 2010-06-08 Bristol-Myers Squibb Company Met kinase inhibitors
DE102005045132A1 (de) 2005-09-22 2007-03-29 Archimica Gmbh Verfahren zur Herstellung von 2-Arylcarbonylverbindungen, 2-Arylestern und 2-Arylnitrilen sowie ihrer heteroaromatischen Analoga
GT200600430A (es) 2005-09-27 2007-05-21 Compuestos de carboxiamina y metodos de uso de los mismos
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2007145819A (ja) 2005-10-28 2007-06-14 Tanabe Seiyaku Co Ltd 医薬組成物
TW200732320A (en) 2005-10-31 2007-09-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
TW200734304A (en) 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
US7531008B2 (en) 2005-11-30 2009-05-12 L'oreal S.A. Use of at least one cationic cyanin derivative for dyeing the hair, composition containing it, process for treating keratin fibers using the composition, and device therefor
WO2007064914A2 (en) 2005-12-01 2007-06-07 Elan Pharmaceuticals, Inc. 5-(arylsulfonyl)-pyrazolopiperidines
WO2007063935A1 (ja) 2005-12-02 2007-06-07 Mitsubishi Tanabe Pharma Corporation 芳香族化合物
JP2007161674A (ja) 2005-12-16 2007-06-28 Tanabe Seiyaku Co Ltd ピペリジン化合物およびその製法
WO2007073855A1 (en) 2005-12-23 2007-07-05 Bayer Healthcare Ag Use of adenosine a1 receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases
US7855291B2 (en) 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
JP5474354B2 (ja) 2005-12-30 2014-04-16 アステックス、セラピューティックス、リミテッド 医薬化合物
DE102006000649A1 (de) 2006-01-03 2007-07-05 Degussa Gmbh Universell einsetzbare Zusammensetzungen
DE102006000651A1 (de) 2006-01-03 2007-07-12 Degussa Gmbh Präparation aus Ionischen Flüssigkeiten und Harzen
FR2896798A1 (fr) 2006-01-27 2007-08-03 Sanofi Aventis Sa Derives de sulfonamides, leur preparation et leur application en therapeutique
HUP0600101A2 (en) 2006-02-09 2007-09-28 Univ Szegedi Resolution process for the preparation of cyclic beta-amino acids esters there of
US8227093B2 (en) 2006-02-11 2012-07-24 Samsung Mobile Display Co., Ltd. Cyclometalated transition metal complex and organic electroluminescence device using the same
CN101384586A (zh) * 2006-02-14 2009-03-11 诺华公司 Pi-3激酶抑制剂及其应用方法
DE102006009813A1 (de) 2006-03-01 2007-09-06 Bayer Healthcare Ag Verwendung von A2b/A1 Rezeptor Agonisten zur Modulation der Lipidspiegel
RU2008141368A (ru) 2006-03-21 2010-04-27 Шеринг Корпорейшн (US) Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3
KR20090007347A (ko) 2006-03-22 2009-01-16 버텍스 파마슈티칼스 인코포레이티드 증식성 장애의 치료를 위한 ｃ-ＭＥＴ 단백질 키나제 억제제
CA2644643C (en) 2006-03-22 2015-05-19 Janssen Pharmaceutica N.V. Inhibitors of the interaction between mdm2 and p53
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8163927B2 (en) 2006-04-03 2012-04-24 Glaxo Group Limited Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors
US7795265B2 (en) 2006-04-14 2010-09-14 Merck Sharp & Dohme Corp. Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators
JP2009533449A (ja) 2006-04-14 2009-09-17 メルク エンド カムパニー インコーポレーテッド コレシストキニン−１受容体モジュレーターとしての置換イミダゾール４−カルボキサミド類
CN101058577A (zh) 2006-04-18 2007-10-24 中国科学院化学研究所 1,4－二氢吡啶类化合物及其制备方法
KR101390239B1 (ko) 2006-04-27 2014-04-30 사노피-아벤티스 도이칠란트 게엠베하 Ｔａｓｋ-1 및 ｔａｓｋ-3 이온 채널 억제제
WO2007125061A1 (en) 2006-04-27 2007-11-08 Glaxo Group Limited Spirocompounds useful as modulators for dopamine d3 receptors
WO2007129664A1 (ja) 2006-05-02 2007-11-15 National University Corporation Nagoya University 不斉触媒作用用キラル四座配位子並びにその使用
ITMI20060895A1 (it) 2006-05-08 2007-11-09 Kemon S P A Intermedi primari per la colorazione ossidativa dei capelli
DE102006025316A1 (de) 2006-05-31 2007-12-06 Bayer Healthcare Ag Isoindolin-1-on-, Isoindolin-3-on- und Isoindolin-1,3-dion-Derivate und ihre Verwendung
ES2340093T3 (es) 2006-06-22 2010-05-28 Biovitrum Ab (Publ) Derivados pirazina y piridina como inhibidores de cinasa mnk.
US20080280891A1 (en) 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
JP5564251B2 (ja) 2006-06-29 2014-07-30 キネックス ファーマシューティカルズ， エルエルシー キナーゼカスケードを調節するためのビアリール組成物および方法
WO2008002676A2 (en) 2006-06-29 2008-01-03 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
EP2034839B1 (en) 2006-06-30 2017-08-23 Sloan-Kettering Institute for Cancer Research Treatment of neurodegenerative diseases through inhibition of hsp90
MX2008016557A (es) 2006-07-04 2009-02-06 Astrazeneca Ab Analogos de piridina nuevos.
CA2656810C (en) 2006-07-11 2012-03-13 Daewoong Pharmaceutical Co., Ltd. Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
ITMI20061368A1 (it) 2006-07-14 2008-01-15 Acraf Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
CN101516869A (zh) 2006-07-14 2009-08-26 先灵公司 具有cxcr3拮抗剂活性的杂环取代的哌嗪化合物
CA2659747C (en) 2006-08-03 2015-09-08 Trustees Of Tufts College Non-flushing niacin analogues, and methods of use thereof
EP1900727A1 (en) 2006-08-30 2008-03-19 Cellzome Ag Aminopyridine derivatives as kinase inhibitors
BRPI0717097A2 (pt) 2006-09-21 2013-11-26 Novartis Ag Derivados de pirrol úteis para o tratamento de doenças mediadas por citocina
KR100932093B1 (ko) 2006-09-27 2009-12-16 주식회사종근당 미세소관 형성 저해제로서 유용한 벤조페논 유도체
GB0619342D0 (en) 2006-09-30 2006-11-08 Vernalis R&D Ltd New chemical compounds
WO2008044713A1 (fr) 2006-10-10 2008-04-17 Nihon Nohyaku Co., Ltd. Dérivé de pyridinecarboxanilide substitué ou un de ses sels, agent agricole ou horticole et utilisation de celui-ci
DE102006048042A1 (de) 2006-10-11 2008-04-17 Bayer Healthcare Ag Acylaminoimidazole und Acylaminothiazole
DE102006048924A1 (de) 2006-10-17 2008-04-24 Bayer Healthcare Ag Acylaminopyrazole
US7820605B2 (en) 2006-10-27 2010-10-26 Chevron Oronite Company Llc Lubricating oil additive composition and method of making the same
US20090318410A1 (en) 2006-10-30 2009-12-24 Novartis Ag Imidazopyridazines as lipid kinase inhibitors
KR101146875B1 (ko) 2006-11-01 2012-05-16 에스케이이노베이션 주식회사 전이금속 촉매계 및 이를 이용한 에틸렌 단독중합체 또는에틸렌과 올레핀의 공중합체 제조방법
JP2009023986A (ja) 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
WO2008070908A1 (en) 2006-12-11 2008-06-19 Bionomics Limited Chemical compounds and processes
WO2008073480A1 (en) 2006-12-11 2008-06-19 Irm Llc Compounds and compositions as kinase inhibitors
GB0624689D0 (en) 2006-12-11 2007-01-17 Glaxo Group Ltd Novel fluorescent kinase ligands and methods employing the same
UA99270C2 (en) 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
FR2910298A1 (fr) 2006-12-20 2008-06-27 Oreal Composition tinctoriale contenant une silicone reactive, un colorant fluorescent ou azurant optique, procede de coloration utilisant la composition
GB0625659D0 (en) 2006-12-21 2007-01-31 Cancer Rec Tech Ltd Therapeutic compounds and their use
TW200840566A (en) 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
EP1938686A1 (de) 2006-12-29 2008-07-02 Bayer CropScience AG Substituierte 1-(3-Pyridinyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
FR2911876B1 (fr) 2007-01-29 2009-03-06 Rhodia Recherches & Tech Nouveaux complexes organometalliques mixtes a base de carbenes a motif alkyllaminocyclique.
JP2010518014A (ja) 2007-01-31 2010-05-27 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤として有用な２−アミノピリジン誘導体
US20080269241A1 (en) 2007-02-15 2008-10-30 Darin Allen Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
EP1975159A1 (en) 2007-03-27 2008-10-01 Bayer Schering Pharma Aktiengesellschaft 2,3,4,9-Tetrahydro-1H-carbazoles
EP1974729A1 (en) 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
BRPI0808241B8 (pt) 2007-04-03 2017-06-13 Du Pont composto, composições fungicidas e método de controle de doenças das plantas
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
US7482492B2 (en) 2007-04-12 2009-01-27 Xerox Corporation Cost effective method for synthesis of triarylamine compounds
US20100256147A1 (en) 2007-04-13 2010-10-07 Hangauer Jr David G Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders
EP1985445B1 (en) 2007-04-27 2011-07-20 Agfa Graphics N.V. A lithographic printing plate precursor
WO2008137128A2 (en) 2007-05-03 2008-11-13 Northeastern University Methods of treating fungal infections
US8263585B2 (en) 2007-05-04 2012-09-11 Novartis Ag Organic compounds
WO2008143440A1 (en) 2007-05-17 2008-11-27 Lg Chem, Ltd. New anthracene derivatives and organic electronic device using the same
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
TW200846319A (en) 2007-05-28 2008-12-01 China Petrochemical Dev Corp Method for preparing carbonate diester
EP1997493A1 (en) 2007-05-28 2008-12-03 Laboratorios del Dr. Esteve S.A. Combination of a 5-HT7 receptor ligand and an opioid receptor ligand
WO2008150899A1 (en) 2007-05-29 2008-12-11 Emory University Combination therapies for treatment of cancer and inflammatory diseases
KR20080106130A (ko) 2007-05-30 2008-12-04 제일모직주식회사 유기 광전 소자 및 이에 사용되는 재료
JP2009007342A (ja) 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
EP2155711A1 (en) 2007-06-05 2010-02-24 Sanofi-Aventis Substituted benzoylamino-indan-2-carboxylic acids and related compounds
JP5104060B2 (ja) 2007-06-25 2012-12-19 コニカミノルタホールディングス株式会社 有機エレクトロルミネッセンス素子材料、有機エレクトロルミネッセンス素子、表示装置及び照明装置
CN101969952A (zh) 2007-06-26 2011-02-09 莱西肯医药有限公司 包含色氨酸羟化酶抑制剂的组合物
GB0713259D0 (en) 2007-07-09 2007-08-15 Astrazeneca Ab Pyrazine derivatives 954
US8293747B2 (en) 2007-07-19 2012-10-23 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
CN101765591B (zh) 2007-07-26 2013-11-27 诺华股份有限公司 用于治疗炎性或过敏性病症的嘧啶衍生物
TWI388566B (zh) 2007-08-29 2013-03-11 Nat Univ Tsing Hua 含有碳烯配位基之過渡金屬錯合物及其在有機電激發光元件之應用
WO2009039181A2 (en) 2007-09-17 2009-03-26 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of Or. State Univ. Sulfonamide-based organocatalysts and method for their use
WO2009051705A1 (en) 2007-10-18 2009-04-23 Merck & Co., Inc. Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
FR2922550B1 (fr) 2007-10-19 2009-11-27 Sanofi Aventis Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
WO2009054941A1 (en) 2007-10-25 2009-04-30 Merck & Co., Inc. Therapeutic compounds
KR100957620B1 (ko) 2007-11-01 2010-05-13 제일모직주식회사 유기광전소자용 재료, 및 이를 이용한 유기광전소자
US7960547B2 (en) 2007-12-03 2011-06-14 Chien-Hong Cheng Transition metal complexes with carbene ligands and their application
CN101450939B (zh) 2007-12-05 2013-06-19 沈阳药科大学 新型苯并咪唑类化合物
WO2009073246A1 (en) 2007-12-06 2009-06-11 Universal Display Corporation Method for the synthesis of iridium (iii) complexes with sterically demanding ligands
PT2231636E (pt) 2007-12-07 2012-01-02 Novartis Ag Derivados de pirazole e a sua utilização a título de inibidores de quinases dependentes de ciclina
JP2009185020A (ja) 2008-01-11 2009-08-20 Ishihara Sangyo Kaisha Ltd ピリジルアミジン誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤
GB0801199D0 (en) 2008-01-23 2008-02-27 Acal Energy Ltd Fuel cells
CN102924412A (zh) 2008-01-25 2013-02-13 先正达参股股份有限公司 用作杀虫剂的2-氰基苯基磺酰胺衍生物
MX2010008376A (es) 2008-02-04 2011-02-22 Mercury Therapeutics Inc Moduladores ampk.
EP2252299B1 (en) 2008-02-15 2014-03-19 Merck Sharp & Dohme Corp. Fused pyridone m1 receptor positive allosteric modulators
CN102007126A (zh) 2008-02-22 2011-04-06 Irm责任有限公司 作为gpr119活性调控剂的化合物和组合物
GB0804067D0 (en) 2008-03-04 2008-04-09 Syngenta Participations Ag Chemical compounds
CA2718241A1 (en) 2008-03-11 2009-09-17 Neurosearch A/S Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors
GB0804701D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
GB0804702D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
EP2280966A1 (en) 2008-03-14 2011-02-09 Exelixis, Inc. Azabicyclo [3.2.1]octyl derivatives as 11 beta-hsd1 modulators
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
FR2928922B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
US8236446B2 (en) 2008-03-26 2012-08-07 Ada Technologies, Inc. High performance batteries with carbon nanomaterials and ionic liquids
JP5627453B2 (ja) 2008-03-31 2014-11-19 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター−１阻害剤
US8277691B2 (en) 2008-05-05 2012-10-02 Ada Technologies, Inc. High performance carbon nanocomposites for ultracapacitors
RU2529484C2 (ru) 2008-05-05 2014-09-27 Санофи-Авентис Ациламино-замещенные производные конденсированных циклопентанкарбоновых кислот и их применение в качестве фармацевтических средств
FR2930939B1 (fr) 2008-05-09 2010-07-30 Sanofi Aventis Derives de pyrrole, leur preparation et leur application en therapeutique
NZ589504A (en) 2008-05-29 2012-07-27 Kowa Co Substituted carbinol compound having cyclic linker
CN101591332B (zh) 2008-05-30 2014-04-16 莱西肯医药有限公司 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法
DK2292592T3 (da) 2008-06-05 2012-10-08 Asahi Kasei Pharma Corp Sulfonamidforbindelse og anvendelse deraf
ES2383246T3 (es) 2008-06-05 2012-06-19 Glaxo Group Limited 4-amino-indazoles
WO2009158467A2 (en) 2008-06-25 2009-12-30 Envivo Pharmaceuticals, Inc. Di-substituted phenyl compounds
KR101015858B1 (ko) 2008-06-26 2011-02-23 제일모직주식회사 유기 화합물, 및 이를 포함하는 유기 광전 소자
TW201002202A (en) 2008-06-27 2010-01-16 Du Pont Fungicidal pyridines
CN101619056B (zh) 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
TWI436973B (zh) 2008-08-07 2014-05-11 China Petrochemical Dev Corp 碳氫化合物之液相氧化方法
WO2010019930A1 (en) 2008-08-15 2010-02-18 Locus Pharmaceuticals, Inc. Urea derivatives as inhibitors of map kinases
ME01291A (me) 2008-09-02 2013-06-20 Novartis Ag Derivati prikolinamida kao inhibitori kinaze
WO2010027583A1 (en) 2008-09-03 2010-03-11 Universal Display Corporation Phosphorescent materials
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
WO2010029300A1 (en) 2008-09-12 2010-03-18 Biolipox Ab Bis aromatic compounds for use in the treatment of inflammation
WO2010033168A2 (en) 2008-09-18 2010-03-25 Renovis, Inc. Amide compounds, compositions and uses thereof
EP2168965A1 (en) 2008-09-25 2010-03-31 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine, imidazopyrazine, imidazopyridazine and imidazopyrimidine derivatives as melanocortin-4 receptor antagonists
US20120022070A1 (en) 2008-10-06 2012-01-26 Emory University Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
WO2010042799A2 (en) 2008-10-09 2010-04-15 Howard Hughes Medical Institute Novel chimeric ligand-gated ion channels and methods of use thereof
US8435911B2 (en) 2008-10-16 2013-05-07 Basell Polyolefine Gmbh Hybrid catalyst composition for polymerization of olefins
FR2937262B1 (fr) 2008-10-17 2010-11-05 Inst Francais Du Petrole Procede de preparation d'une composition catalytique pour la dimerisation, la co-dimerisation et l'oligomerisation des olefines.
CA2740583A1 (en) 2008-10-21 2010-04-29 Vertex Pharmaceuticals Incorporated C-met protein kinase inhibitors
KR20110074875A (ko) 2008-10-24 2011-07-04 렉시컨 파마슈티컬스 인코퍼레이티드 치환된 페닐알라닌의 제조 방법
RU2011123647A (ru) 2008-11-10 2012-12-20 Вертекс Фармасьютикалз Инкорпорейтед Соединения, полезные в качестве ингибиторов atr киназы
US8614222B2 (en) 2008-11-13 2013-12-24 The Trustees Of Columbia University In The City Of New York Methods of preventing and treating low bone mass diseases
TW201028399A (en) * 2008-11-27 2010-08-01 Shionogi & Co Pyrimidine derivative and pyridine derivative both having pi3k inhibitory activity
WO2010065333A1 (en) 2008-12-01 2010-06-10 Lexicon Pharmaceuticals, Inc. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis
JP2010143829A (ja) 2008-12-16 2010-07-01 Dainippon Sumitomo Pharma Co Ltd 新規なイミダゾキノリン誘導体
WO2010080488A1 (en) 2008-12-18 2010-07-15 E. I. Du Pont De Nemours And Company Continuous liquid-phase process for the synthesis of diaminopyridines from glutaronitriles
CN106496210B (zh) 2008-12-19 2020-06-09 沃泰克斯药物股份有限公司 用作atr激酶抑制剂的化合物
DE102009055828A1 (de) 2008-12-19 2010-07-01 Merck Patent Gmbh Verfahren zur Herstellung metallbeschichteter Partikel
TW201024259A (en) 2008-12-24 2010-07-01 China Petrochemical Dev Corp Method for preparing organic carboxylic acid ester
CN101781200B (zh) 2009-01-20 2013-04-03 中国石油化学工业开发股份有限公司 有机羧酸酯的制造方法
US8802687B2 (en) 2009-02-09 2014-08-12 Georgetown University Cadherin-11 inhibitors and methods of use thereof
BRPI1008325A2 (pt) 2009-02-11 2020-08-25 Merck Patent Gmbh carboxamidas azaeterocíclicas de amino
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
CN101513584B (zh) 2009-03-04 2011-11-09 中国科学院过程工程研究所 一种基于碱性离子液体催化剂的氧化脱硫方法
WO2010111573A1 (en) 2009-03-27 2010-09-30 Abbott Laboratories Compounds as cannabinoid receptor ligands
MX2011010915A (es) * 2009-04-16 2012-01-27 Ct Nac Investigaciones Oncologicas Cnio Imidazopirazinas para usarse como inhibidores decinasa.
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
JP2012162460A (ja) 2009-05-27 2012-08-30 Nippon Soda Co Ltd 含窒素ヘテロアリール誘導体および農園芸用殺菌剤
WO2010138901A1 (en) 2009-05-29 2010-12-02 Biogen Idec Ma Inc Carboxylic acid-containing compounds, derivatives thereof, and related methods of use
WO2010148351A1 (en) 2009-06-18 2010-12-23 Cylene Pharmaceuticals, Inc. Rhodanines and related heterocycles as kinase inhibitors
EP2445879A1 (en) 2009-06-25 2012-05-02 Institut Univ. de Ciència i Tecnologia, S.A. N-(2-oxo-1-phenylpiperidin-3-yl) sulfonamides for the identification of biological and pharmacological activity
ES2354550B1 (es) 2009-06-26 2011-11-15 Institut Univ. De Ciència I Tecnologia, S.A. Biblioteca de n-(1-fenil-2-oxo-3-piperidil)sulfonamidas para el descubrimiento de fármacos.
ES2354551B1 (es) 2009-07-01 2011-11-15 Institut Univ. De Ciencia I Tecnologia S.A. Bibliotecas de n-(1-fenil-2-oxo-3-piperidil)sulfonamidas para la identificación de actividad biológica y farmacológica.
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
CA2767231A1 (en) 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Cell-based bioprocessing
BR112012000421A2 (pt) 2009-07-06 2019-09-24 Alnylam Pharmaceuticals Inc composições e métodos para intensificar a produção de um produto biológico.
US8999969B2 (en) 2009-07-09 2015-04-07 Gilead Sciences, Inc. Anti-RSV compounds
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
JP4590020B1 (ja) 2009-07-31 2010-12-01 富士フイルム株式会社 電荷輸送材料及び有機電界発光素子
JP4599469B1 (ja) 2009-08-31 2010-12-15 富士フイルム株式会社 有機電界発光素子用材料及び有機電界発光素子
FR2949465B1 (fr) 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
US8993535B2 (en) 2009-09-04 2015-03-31 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
WO2011032034A2 (en) 2009-09-10 2011-03-17 University Of Idaho Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
US20110230465A1 (en) 2009-09-18 2011-09-22 Boehringer Ingleheim International Gmbh Viral polymerase inhibitors
EP2480549B1 (en) 2009-09-24 2015-04-08 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Fused imidazo[3,2-d]pyrazines as PI3 kinase inhibitors
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
KR20120104534A (ko) 2009-10-06 2012-09-21 브리스톨-마이어스 스큅 컴퍼니 피롤리딘 ｇｐｒ40 조절제
WO2011049150A1 (en) 2009-10-22 2011-04-28 Sumitomo Chemical Company, Limited Pyrone compound and its use for pest control
EP3492483A1 (en) 2009-10-22 2019-06-05 The Washington University Compounds and methods for treating bacterial infections
CN101712809A (zh) 2009-10-30 2010-05-26 上海拓引数码技术有限公司 一种有机染料、其制备方法及含该有机染料的可录式光学信息记录介质
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2011071860A2 (en) 2009-12-07 2011-06-16 Alnylam Pharmaceuticals, Inc. Compositions for nucleic acid delivery
WO2011072064A1 (en) 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
US20120245155A1 (en) 2009-12-11 2012-09-27 Shionogi & Co., Ltd. Fused heterocyclic compound having amino group
KR20120093428A (ko) 2009-12-14 2012-08-22 메르크 파텐트 게엠베하 스핑고신 키나아제 저해제
WO2011081945A2 (en) 2009-12-14 2011-07-07 Cornell University Activation and activators of sirt6
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
US20110190267A1 (en) 2010-01-05 2011-08-04 Shire Pharmaceuticals, Inc. Prodrugs of opioids and uses thereof
WO2011082488A1 (en) 2010-01-06 2011-07-14 British Columbia Cancer Agency Branch Bisphenol derivative therapeutics and methods for their use
ES2551875T3 (es) 2010-01-18 2015-11-24 Mmv Medicines For Malaria Venture Agentes nuevos contra la malaria
NZ600637A (en) 2010-01-27 2014-07-25 Boehringer Ingelhelheim Internat Gmbh Pyrazole compounds as crth2 antagonists
WO2011095196A1 (en) 2010-02-05 2011-08-11 Merck Patent Gmbh Hetaryl-[1,8]naphthyridine derivatives
AU2011227417A1 (en) 2010-03-16 2012-10-11 Aventis Pharmaceuticals Inc. Substituted pyrimidines as prostaglandin D2 receptor antagonists
EA201290957A1 (ru) 2010-04-07 2013-04-30 Ф.Хоффманн-Ля Рош Аг Пиразол-4-илгетероциклилкарбоксамидные соединения и способы их применения
CN102905700A (zh) 2010-04-16 2013-01-30 金克斯医药品有限公司 用于预防和治疗癌症的组合物以及方法
FR2959944B1 (fr) 2010-05-12 2012-06-08 Inst Francais Du Petrole Solution absorbante contenant un inhibiteur de degradation derive de la pyridine et procede d'absorption de composes acides contenus dans un effluent gazeux.
EP2568984A1 (en) 2010-05-12 2013-03-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2011143422A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated 2 -aminopyridine derivatives useful as inhibitors of atr kinase
NZ603876A (en) 2010-05-13 2015-02-27 Amgen Inc Nitrogen heterocyclic compounds useful as pde10 inhibitors
TWI428343B (zh) 2010-05-14 2014-03-01 Nat Univ Tsing Hua 無硫氰酸根配基的光敏錯合物及敏化染料太陽能電池
WO2011147038A1 (en) 2010-05-28 2011-12-01 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
CN102947270B (zh) 2010-06-22 2015-04-08 巴斯夫欧洲公司 制备4-羟基吡啶的方法
UY33469A (es) 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
BR112012033658A2 (pt) 2010-07-05 2016-11-29 Merck Patent Gmbh derivados bipiridílicos úteis para o tratamento de doenças induzidas por quinases
US8772343B2 (en) 2010-07-12 2014-07-08 Pfizer Limited Chemical compounds
US9102621B2 (en) 2010-07-12 2015-08-11 Pfizer Limited Acyl sulfonamide compounds
DK2592934T3 (en) 2010-07-16 2015-10-26 Nivalis Therapeutics Inc NOVEL dihydropyridin-2 (1H) -one compounds as S-NITROSOGLUTATHIONREDUKTASEINHIBITORER and neurokinin-3 receptor antagonists
JP5587701B2 (ja) 2010-08-06 2014-09-10 日本エンバイロケミカルズ株式会社 実験用水循環／収容装置用微生物防除剤、および実験用水循環／収容装置の微生物防除方法
ES2602972T3 (es) 2010-09-08 2017-02-23 Glaxosmithkline Intellectual Property Development Limited Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe
JPWO2012036278A1 (ja) 2010-09-17 2014-02-03 大正製薬株式会社 グリシントランスポーター阻害物質
ES2379919B1 (es) 2010-10-06 2013-03-19 Consejo Superior De Investigaciones Científicas (Csic) SÍNTESIS DE PIRIDONAS BICÍCLICAS QUE CONTIENEN EL SISTEMA HETEROCÍCLICO DE IMIDAZOL(1,2-a)PIRIDINA, A PARTIR DE 2-AMINO-6-(PROP-2-IN-1-IL AMINO) PIRIDINAS.
WO2012074869A1 (en) 2010-11-24 2012-06-07 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
GB201020161D0 (en) 2010-11-26 2011-01-12 Almac Discovery Ltd Pharmaceutical compounds
IT1402842B1 (it) 2010-11-30 2013-09-27 Annunziato 7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine.
KR101728898B1 (ko) 2010-12-07 2017-04-21 광주과학기술원 신규한 하이드라진 유도체 및 이의 용도
DE102010054892A1 (de) 2010-12-17 2012-06-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung eines Polyesters sowie Zusammensetzung und Formkörper umfassend einen derartigen Polyester
CN102125875B (zh) 2011-01-20 2012-09-05 郑州大学 二茂铁亚胺环钯-膦加合物在不对称联芳化合物合成中的应用
KR20140043043A (ko) 2011-02-11 2014-04-08 유니버셜 디스플레이 코포레이션 유기 발광 디바이스 및 이것에 사용되는 재료
IT1404379B1 (it) 2011-02-11 2013-11-22 Lembo Eterocicli ad attivita' antiipertensiva
JP2014511563A (ja) 2011-02-11 2014-05-15 ユニバーサル ディスプレイ コーポレイション 有機発光素子及び該有機発光素子に使用されるための材料
WO2012112956A2 (en) 2011-02-19 2012-08-23 The Broad Institute, Inc Compounds and methods for targeting leukemic stem cells
US20140171525A1 (en) 2011-02-21 2014-06-19 Honeywell International Inc. Polyurethane foam premixes containing halogenated olefin blowing agents and foams made from same
US11179500B2 (en) 2011-02-24 2021-11-23 Emory University JAB1 inhibitory compositions for ossification and methods related thereto
WO2012121939A2 (en) 2011-03-04 2012-09-13 Locus Pharmaceuticals, Inc. Aminopyrazine compounds
US9108984B2 (en) * 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
CN103097367B (zh) 2011-04-02 2014-12-03 中国人民解放军军事医学科学院毒物药物研究所 苯丙酸化合物、其制备方法及其医药用途
KR20140027974A (ko) 2011-04-05 2014-03-07 버텍스 파마슈티칼스 인코포레이티드 Ｔｒａ 키나제의 억제제로서 유용한 아미노피라진 화합물
US9371294B2 (en) 2011-04-12 2016-06-21 Chong Kun Dang Pharmaceutical Corp. Cycloalkenyl aryl derivatives for CETP inhibitor
AU2012250788B2 (en) 2011-05-03 2017-03-02 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US20120289481A1 (en) 2011-05-13 2012-11-15 O'neil Jennifer Compositions and methods for treating cancer
EP2524918A1 (en) 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
WO2012162334A1 (en) 2011-05-24 2012-11-29 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
KR20140034256A (ko) 2011-05-31 2014-03-19 메르크 파텐트 게엠베하 히드리도-트리시아노-보레이트 음이온을 포함하는 화합물
AR086653A1 (es) 2011-06-03 2014-01-15 Bristol Myers Squibb Co COMPUESTOS PARA LA REDUCCION DE PRODUCCION DE b-AMILOIDE
CN102260218B (zh) 2011-06-07 2013-05-08 北京理工大学 一种胺基吡嗪香料的合成方法
WO2012177639A2 (en) 2011-06-22 2012-12-27 Alnylam Pharmaceuticals, Inc. Bioprocessing and bioproduction using avian cell lines
WO2012178125A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US8822469B2 (en) 2011-06-22 2014-09-02 Vertex Pharmaceuticals Incorporated Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
CN102850328B (zh) 2011-07-01 2014-12-24 苏州东南药业股份有限公司 吡啶类化合物、其制备方法、包含该化合物的药物组合物及其用途
KR101502500B1 (ko) 2011-07-01 2015-03-16 주식회사 엘지화학 비수 전해액 및 이를 이용한 리튬 이차전지
EP2543673A1 (de) 2011-07-08 2013-01-09 cynora GmbH Kupfer(I)komplexe für opto-elektronische Vorrichtungen
MX2014001457A (es) 2011-08-05 2014-08-21 Abbvie Deutschland Derivados de aminocromano, de aminotiocromano y de amino-1,2,3,4-tetrahidroquinolina composiciones farmaceuticas que los contienen, y su uso en terapia.
AU2012293417A1 (en) 2011-08-10 2013-05-02 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
JP2014522872A (ja) 2011-08-12 2014-09-08 ビーエーエスエフ ソシエタス・ヨーロピア Ｎ−チオ−アントラニルアミド化合物、及び殺有害生物剤としてのそれらの使用
EA201400214A1 (ru) 2011-08-12 2014-07-30 Басф Се Антраниламидные соединения и их применение в качестве пестицидов
SG2014009609A (en) 2011-08-15 2014-05-29 Univ Utah Res Found Substituted (e)-n'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhiitors
JP2014524432A (ja) 2011-08-18 2014-09-22 ビーエーエスエフ ソシエタス・ヨーロピア 有害無脊椎動物を駆除するためのカルバモイルメトキシベンズアミドおよびカルバモイルメチルチオベンズアミドおよびカルバモイルメチルアミノベンズアミド
CL2014000498A1 (es) 2011-08-29 2014-12-19 Infinity Pharmaceuticals Inc Compuestos heterociclicos, inhibidores selectivos de isoformas de pi3k de clase i; composicion farmaceutica que los comprende; y metodo para tratar un trastorno selccionado de cancer, una enfermedad antiinflamaoria o una enfermedad autoinmune.
MX2020004502A (es) 2011-09-02 2022-01-20 Incyte Holdings Corp Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k).
CN102977150B (zh) 2011-09-06 2016-07-06 郑建鸿 含有碳烯配位基的过渡金属错合物结构及其在发光材料的应用
US9233996B2 (en) 2011-09-13 2016-01-12 California Institute Of Technology Multi-metallic organometallic complexes, and related polymers, compositions, methods and systems
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
US20140187783A1 (en) 2011-09-20 2014-07-03 Dow Corning Corporation Hafnium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts
US20140225027A1 (en) 2011-09-20 2014-08-14 Dow Corning Corporation Silver Containing Hydrosilylation Catalysts And Compositions Containing The Catalysts
CN104024267A (zh) 2011-09-20 2014-09-03 道康宁公司 含铁硅氢加成催化剂及含有该催化剂的组合物
EP2758410A2 (en) 2011-09-20 2014-07-30 Dow Corning Corporation Vanadium containing hydrosilylation catalysts and compositions containing the catalysts
WO2013043767A2 (en) 2011-09-20 2013-03-28 Dow Corning Corporation Rhenium containing hydrosilylation catalysts and compositions containing the catalysts
EP2758412A2 (en) 2011-09-20 2014-07-30 Dow Corning Corporation Manganese containing hydrosilylation catalysts and compositions containing the catalysts
EP2758408A1 (en) 2011-09-20 2014-07-30 Dow Corning Corporation Metal containing hydrosilylation catalysts and compositions containing the catalysts
US20140228573A1 (en) 2011-09-20 2014-08-14 Dow Corning Corporation Zirconium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts
US20140182483A1 (en) 2011-09-20 2014-07-03 Dow Corning Corporation Titanium Containing Hydrosilylation Catalysts And Compositions Containing The Catalysts
RU2677292C2 (ru) 2011-09-30 2019-01-16 Вертекс Фармасьютикалз Инкорпорейтед Способы получения соединений, которые можно использовать в качестве ингибиторов киназы atr
US9006444B2 (en) 2011-10-05 2015-04-14 Merck Sharp & Dohme Corp. Phenyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
CN103857671A (zh) 2011-10-14 2014-06-11 保土谷化学工业株式会社 新型苯并三唑衍生物和使用该衍生物的有机电致发光器件
CA2852914C (en) 2011-10-17 2019-11-26 The Johns Hopkins University Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors
CN105749294A (zh) 2011-10-26 2016-07-13 凯姆制药公司 氢吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
CN103087050A (zh) 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 芳基激酶抑制剂
ES2604958T3 (es) 2011-10-28 2017-03-10 Vanderbilt University Análogos de 2-(4-heterociclilbencil)isoindolin-1-ona sustituidos como moduladores alostéricos positivos del receptor muscarínico de acetilcolina M1
JPWO2013069242A1 (ja) 2011-11-07 2015-04-02 出光興産株式会社 有機エレクトロルミネッセンス素子用材料及びそれを用いた有機エレクトロルミネッセンス素子
WO2013071088A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP2776422A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013071093A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
EP2776429A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US9133131B2 (en) 2011-11-15 2015-09-15 Purdue Pharma L.P. Pyrimidine diol amides as sodium channel blockers
CN103958496B (zh) 2011-11-21 2017-05-24 巴斯夫欧洲公司 制备n‑取代的1h‑吡唑‑5‑甲酸盐化合物及其衍生物的方法
JP2013129653A (ja) 2011-11-22 2013-07-04 Nissan Chem Ind Ltd トリアゾ−ル誘導体および有害生物防除剤
JP2013129651A (ja) 2011-11-22 2013-07-04 Nissan Chem Ind Ltd チアゾール誘導体および有害生物防除剤
CN103998042B (zh) 2011-12-15 2016-12-28 诺华股份有限公司 Pi3k的活性或功能的抑制剂的应用
EP2791108B1 (en) 2011-12-15 2016-07-27 Pfizer Limited Sulfonamide derivatives
CN103159738B (zh) 2011-12-19 2016-09-07 上海泓博智源医药股份有限公司 炔基桥连的杂芳香化合物及其应用
WO2013096223A1 (en) 2011-12-19 2013-06-27 Abbvie Inc. Trpv1 antagonists
US8969325B2 (en) 2011-12-19 2015-03-03 Abbvie Inc. TRPV1 antagonists
WO2013092936A2 (en) 2011-12-20 2013-06-27 Galderma Research & Development Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne
US20130190356A1 (en) 2011-12-22 2013-07-25 Genentech, Inc. Benzyl sulfonamide derivatives as rorc modulators
JP2014015447A (ja) 2011-12-22 2014-01-30 Nissan Chem Ind Ltd ピラゾール誘導体および有害生物防除剤
US20150001516A1 (en) 2011-12-27 2015-01-01 Konica Minolta, Inc. Transparent electrode, electronic device, organic electroluminescence element, and method for manufacturing organic electroluminescence elements
EP2800740A1 (en) 2012-01-04 2014-11-12 Pfizer Limited N-aminosulfonyl benzamides
IN2012DE00110A (pl) 2012-01-11 2015-05-08 Syngenta Ltd
DK2810937T3 (en) 2012-01-31 2017-03-13 Daiichi Sankyo Co Ltd PYRIDONE DERIVATIVES
WO2013117649A1 (en) 2012-02-10 2013-08-15 Galapagos Nv Imidazo [4, 5 -c] pyridine derivatives useful for the treatment of degenerative and inflammatory diseases
US9138492B2 (en) 2012-02-23 2015-09-22 Canon Kabushiki Kaisha Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle
US9340549B2 (en) 2012-03-05 2016-05-17 Amgen Inc. Oxazolidinone compounds and derivatives thereof
US20150119394A1 (en) 2012-03-28 2015-04-30 Merck Sharp & Dohme Corp. Insulin-Like Growth Factor-1 Receptor Inhibitors
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
DE102012006896A1 (de) 2012-04-05 2013-10-10 Merck Patent Gmbh Silikate mit organischen Kationen
US8940742B2 (en) * 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013152727A1 (en) 2012-04-12 2013-10-17 The University Of Hong Kong Platinum(ii) complexes for oled applications
WO2013161929A1 (ja) 2012-04-26 2013-10-31 塩野義製薬株式会社 ピリジニルモルホリノン誘導体およびそれらを含有する医薬組成物
WO2013162061A1 (ja) 2012-04-26 2013-10-31 第一三共株式会社 二環性ピリミジン化合物
KR101383239B1 (ko) 2012-04-30 2014-04-10 한국화학연구원 베타-세크리테아제 활성을 억제하는 4-(벤즈이미다졸-2-일아미노)피롤리딘 유도체 및 이를 유효성분으로 함유하는 약제학적 조성물
IN2014MN02126A (pl) 2012-05-02 2015-09-11 Lupin Ltd
JP2014001205A (ja) 2012-05-22 2014-01-09 Nissan Chem Ind Ltd 動物の寄生虫防除剤
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds
WO2013184794A2 (en) 2012-06-05 2013-12-12 Cara Therapeutics, Inc. Peripheral kappa receptor agonists for reducing pain and inflammation
EP2676947A1 (de) 2012-06-18 2013-12-25 LANXESS Deutschland GmbH Verfahren zur Isomerisierung von subsituierten Aromaten unter Verwendung einer Salzschmelze
CN103524372B (zh) 2012-07-03 2015-06-10 南京圣和药业股份有限公司 一种组蛋白去乙酰化酶抑制剂
JP2014111559A (ja) 2012-07-04 2014-06-19 Nissan Chem Ind Ltd ピラゾール誘導体および有害生物防除剤
WO2014007395A1 (ja) 2012-07-06 2014-01-09 日産化学工業株式会社 ピラゾール若しくはチアゾール誘導体又はその塩及び有害生物防除剤
JP2015003895A (ja) 2012-07-06 2015-01-08 日産化学工業株式会社 チアゾール誘導体および有害生物防除剤
WO2014011768A1 (en) 2012-07-10 2014-01-16 Adispell, Inc. Anti-anxiety treatment
WO2014018741A1 (en) 2012-07-27 2014-01-30 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
US20150197513A1 (en) 2012-08-09 2015-07-16 Neuropore Therapies, Inc. Aryl- and heteroaryl-substituted benzene derivatives as modulators of pi3-kinase signalling pathways
JP2014037382A (ja) 2012-08-17 2014-02-27 Nissan Chem Ind Ltd 殺虫、殺ダニ、殺線虫、殺軟体動物、殺菌又は殺バクテリア剤組成物及び病害虫の防除方法
WO2014033631A1 (en) 2012-08-31 2014-03-06 Novartis Ag N-(3-pyridyl) biarylamides as kinase inhibitors
ES2889757T3 (es) 2012-09-06 2022-01-13 Plexxikon Inc Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos
CN103664878A (zh) 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 杂芳环及其衍生物类酪氨酸激酶抑制剂
US9328106B2 (en) 2012-09-26 2016-05-03 Genentech, Inc. Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
JP6127436B2 (ja) 2012-10-10 2017-05-17 コニカミノルタ株式会社 白色エレクトロルミネッセンスデバイス及び白色エレクトロルミネッセンスデバイスの製造方法
JP5994551B2 (ja) 2012-10-10 2016-09-21 コニカミノルタ株式会社 エレクトロルミネッセンスデバイス
TWI598325B (zh) 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類
JP6231009B2 (ja) 2012-10-22 2017-11-15 コニカミノルタ株式会社 透明電極、電子デバイスおよび有機エレクトロルミネッセンス素子
WO2014065073A1 (ja) 2012-10-22 2014-05-01 コニカミノルタ株式会社 透明電極、電子デバイスおよび有機エレクトロルミネッセンス素子
WO2014065209A1 (ja) 2012-10-23 2014-05-01 日本曹達株式会社 ピリジン化合物またはその塩、有害生物防除剤、殺虫剤または殺ダニ剤、および外部寄生虫防除剤
KR102000211B1 (ko) 2012-10-29 2019-09-30 삼성디스플레이 주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
KR20150082194A (ko) 2012-11-14 2015-07-15 데이진 화-마 가부시키가이샤 피리딘 유도체
US20140148484A1 (en) 2012-11-23 2014-05-29 Boehringer Ingelheim International Gmbh Pyrazole compounds for treating hairloss
WO2014090147A1 (zh) 2012-12-14 2014-06-19 上海恒瑞医药有限公司 嘧啶类衍生物及其可药用盐、其制备方法及其在医药上的应用
EP2934518B1 (en) 2012-12-19 2020-02-19 Merck Sharp & Dohme Corp. Spirocyclic cetp inhibitors
EP2935256B1 (en) 2012-12-19 2018-01-24 Bristol-Myers Squibb Company 4,6-diarylaminothiazines as bace1 inhibitors and their use for the reduction of beta-amyloid production
EP2934519B1 (en) 2012-12-20 2021-05-12 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
KR20140083620A (ko) 2012-12-26 2014-07-04 제일모직주식회사 차광층용 감광성 수지 조성물 및 이를 이용한 차광층
JP5911419B2 (ja) 2012-12-27 2016-04-27 キヤノン株式会社 有機発光素子及び表示装置
CN103896946B (zh) 2012-12-28 2018-04-03 浙江导明医药科技有限公司 用于预防及治疗多种自身免疫疾病的新化合物
WO2013171729A2 (en) 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
TW201443037A (zh) 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
EP2945939B1 (en) 2013-01-15 2020-03-04 Incyte Holdings Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
CN103694236B (zh) 2013-01-15 2017-05-31 苏州开拓药业股份有限公司 一种嘧啶骨架具有刺猬通路拮抗剂活性的抗肿瘤化合物
KR101791762B1 (ko) 2013-02-02 2017-11-20 치아타이 티안큉 파마수티컬 그룹 주식회사 치환된 2-아미노피리딘 단백질 키나제 억제제
EP2958897B1 (en) 2013-02-19 2019-01-09 Senomyx, Inc. Compounds useful as modulators of trpm8
MY177476A (en) 2013-02-22 2020-09-16 Pfizer Pyrrolo [2,3-d]pyrimidine derivatives as inhibitors of janus kinases (jak)
CN103923085B (zh) 2013-02-25 2016-08-24 苏州云轩医药科技有限公司 具有刺猬通路拮抗剂活性的吡啶杂环化合物及其用途
TWI687220B (zh) 2013-03-01 2020-03-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
EP2774919A1 (en) 2013-03-06 2014-09-10 Pharmeste S.R.L. In Liquidazione Novel sulfonamide TRPA1 receptor antagonists
JP6362367B2 (ja) 2013-03-12 2018-07-25 花王株式会社 酸化性組成物
JP6279358B2 (ja) 2013-03-12 2018-02-14 花王株式会社 酸化性組成物
JP2014198841A (ja) 2013-03-12 2014-10-23 花王株式会社 酸化性組成物
WO2014165128A2 (en) 2013-03-12 2014-10-09 Novira Therapeutics, Inc. Hepatitis b antiviral agents
US9505781B2 (en) 2013-03-13 2016-11-29 The Regents Of The University Of Michigan Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
AU2014239542A1 (en) 2013-03-15 2015-10-01 Araxes Pharma Llc Covalent inhibitors of KRas G12C
US9346802B2 (en) 2013-03-15 2016-05-24 Epizyme, Inc. CARM1 inhibitors and uses thereof
MX2015013348A (es) 2013-03-20 2016-01-20 Bayer Pharma AG Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos.
KR101599009B1 (ko) 2013-03-29 2016-03-14 동아에스티 주식회사 Cetp 억제 활성을 갖는 신규한 옥사졸리디논 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물
AR096022A1 (es) 2013-04-11 2015-12-02 Basf Se Compuestos de pirimidinio sustituido, útiles para combatir plagas de animales
CN103193702B (zh) 2013-04-18 2014-12-24 陕西师范大学 含氮杂环化合物官能团化的方法
ITMI20130647A1 (it) 2013-04-19 2014-10-20 Univ Bologna Alma Mater Composti con attività inibente sulle sirtuine
US9783550B2 (en) 2013-05-14 2017-10-10 The Board Of Regents Of The University Of Texas System Highly potent inhibitors of porcupine
CN105189477A (zh) 2013-05-17 2015-12-23 巴斯夫欧洲公司 制备n-取代的1h-吡唑-5-甲酸化合物及其衍生物的方法
JP6468186B2 (ja) 2013-05-31 2019-02-13 コニカミノルタ株式会社 透明電極、電子デバイス及び有機エレクトロルミネッセンス素子
US9193736B2 (en) 2013-06-11 2015-11-24 Janssen Pharmaceutica, Nv PDE 10a inhibitors for the treatment of type II diabetes
JP6184830B2 (ja) 2013-06-14 2017-08-23 花王株式会社 漂白洗浄剤組成物
MX2015016543A (es) 2013-06-27 2017-07-27 Lg Chemical Ltd Derivados de biarilo como agonistas de gpr120.
WO2015004029A1 (en) 2013-07-08 2015-01-15 Technische Universität München 18f-labeling of aromatic and heteroaromatic molecules with unprotected carboxylic acid groups
WO2015014900A1 (en) 2013-07-31 2015-02-05 Minoryx Therapeutics S.L. Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof
JPWO2015015993A1 (ja) 2013-08-01 2017-03-02 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子
WO2015023664A2 (en) 2013-08-12 2015-02-19 Adispell, Inc. Therapeutic treatment for drug poisoning and addiction
WO2015025172A1 (en) 2013-08-22 2015-02-26 Mark David Charles 5-aryl-thiazol-2-yl-amine compounds and their therapeutic use
WO2015025962A1 (ja) 2013-08-23 2015-02-26 富山化学工業株式会社 アミジン化合物またはその塩
US9359330B2 (en) 2013-08-26 2016-06-07 Purdue Pharma L.P. Substituted piperidines as sodium channel blockers
WO2015031561A1 (en) 2013-08-30 2015-03-05 Bp Corporation North America Inc. Catalytic conversion of alcohols
DE102013016324A1 (de) 2013-10-04 2015-04-09 Merck Patent Gmbh Perfluoralkylfluor- oder Perfluoralkylchlorgermanate
US10005746B2 (en) 2013-10-04 2018-06-26 Academia Sinica Molecular catalysts capable of catalyzing oxidation of hydrocarbons and method for oxidizing hydrocarbons
EP3063143B1 (en) 2013-11-01 2018-05-16 Novartis AG Aminoheteroaryl benzamides as kinase inhibitors
WO2015066697A1 (en) 2013-11-04 2015-05-07 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US10033000B2 (en) 2013-11-15 2018-07-24 Universal Display Corporation Organic electroluminescent materials and devices
US9340504B2 (en) 2013-11-21 2016-05-17 Purdue Pharma L.P. Pyridine and piperidine derivatives as novel sodium channel blockers
US9708278B2 (en) 2013-11-27 2017-07-18 Vanderbilt University Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1
CA2930148C (en) 2013-12-02 2023-04-11 Chemocentryx, Inc. Quinoline-8-carboxylic acid derivatives and their use to treat diseases and conditions modulated by ccr6
US10355227B2 (en) 2013-12-16 2019-07-16 Universal Display Corporation Metal complex for phosphorescent OLED
GB201322334D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
TN2016000203A1 (en) 2013-12-20 2017-10-06 Esteve Labor Dr Piperazine derivatives having multimodal activity against pain.
CN106659715A (zh) 2013-12-20 2017-05-10 药物发现研究所 取代的氨基三唑及其使用方法
JP6340788B2 (ja) 2013-12-25 2018-06-13 コニカミノルタ株式会社 透明電極及び電子デバイス
JP2015125845A (ja) 2013-12-26 2015-07-06 コニカミノルタ株式会社 透明電極及び電子デバイス
US10266515B2 (en) 2013-12-30 2019-04-23 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
CN105899491B (zh) 2014-01-17 2019-04-02 诺华股份有限公司 用于抑制shp2活性的1-哒嗪-/三嗪-3-基-哌(-嗪)/啶/吡咯烷衍生物及其组合物
CN103848838A (zh) 2014-01-23 2014-06-11 中国药科大学 一类c-Met与VEGFR-2双重拮抗剂、其制备方法及其医疗用途
JP2015141806A (ja) 2014-01-28 2015-08-03 出光興産株式会社 有機エレクトロルミネッセンス素子の製造方法、組成物、有機エレクトロルミネッセンス素子、および電子機器
CN103804312B (zh) 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
US9673407B2 (en) 2014-02-28 2017-06-06 Universal Display Corporation Organic electroluminescent materials and devices
US9775839B2 (en) 2014-03-13 2017-10-03 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
BR112016015365A8 (pt) 2014-03-17 2020-06-02 Hoffmann La Roche composto, composição farmacêutica e uso de um composto
WO2015142903A2 (en) 2014-03-17 2015-09-24 Genentech, Inc. Method of controlling lactate production with piperdine-dione derivatives
WO2015139621A1 (zh) 2014-03-18 2015-09-24 北京韩美药品有限公司 4-杂芳基取代的苯甲酸或苯甲酰胺类化合物
EP3119761B1 (en) 2014-03-19 2023-06-07 Amydis Diagnostics, Inc. Amyloid targeting agents and methods of using the same
CN104926801B (zh) 2014-03-22 2019-06-04 浙江大学 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用
JP6269260B2 (ja) 2014-03-31 2018-01-31 宇部興産株式会社 ビアリール化合物の製造方法
EP2933849A1 (de) 2014-04-15 2015-10-21 cynora GmbH Hostmaterialien für OLEDs
EP3131897B8 (en) 2014-04-16 2022-08-03 Merck Sharp & Dohme LLC Factor ixa inhibitors
CN106458966B (zh) * 2014-04-24 2019-05-07 诺华股份有限公司 作为磷脂酰肌醇3-激酶抑制剂的吡嗪衍生物
MX2016013812A (es) 2014-04-24 2017-03-09 Novartis Ag Derivados de amino-pirazina como inhibidores de fosfatidil-inositol-3-cinasa.
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
US9981972B2 (en) 2014-05-22 2018-05-29 Abide Therapeutics, Inc. N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
CN105461738B (zh) 2014-06-03 2019-03-08 中国人民解放军军事医学科学院毒物药物研究所 一种雷帕霉素衍生物、其制备方法、其药物组合物及用途
CN104004026A (zh) 2014-06-09 2014-08-27 江西冠能光电材料有限公司 一种电负性磷光材料
RS59054B1 (sr) 2014-06-17 2019-08-30 Vertex Pharma Postupak za lečenje raka korišćenjem kombinacije chk1 i atr inhibitora
CN106573931A (zh) 2014-06-18 2017-04-19 拜耳医药股份有限公司 抑制BET蛋白的具有间位取代的芳族氨基或醚基的3，4‑二氢吡啶并[2，3‑b]吡嗪酮
GB201411239D0 (en) 2014-06-25 2014-08-06 Takeda Pharmaceutical Novel compounds
GB201411236D0 (en) 2014-06-25 2014-08-06 Takeda Pharmaceutical Novel compounds
WO2016006512A1 (ja) 2014-07-07 2016-01-14 富士フイルム株式会社 光電変換素子、色素増感太陽電池、金属錯体色素、色素溶液、およびターピリジン化合物またはそのエステル化物
KR101982945B1 (ko) 2014-07-07 2019-05-27 후지필름 가부시키가이샤 광전 변환 소자, 색소 증감 태양 전지, 금속 착체 색소, 색소 용액, 및 터피리딘 화합물 또는 그 에스터화물
CN105315199B (zh) 2014-07-14 2020-11-20 湖南化工研究院有限公司 N-吡啶芳氧苯氧羧酸衍生物及其制备方法与应用
US9878982B2 (en) 2014-07-14 2018-01-30 Cisen Pharmaceutical Co., Ltd. Pyridine derivatives and anti-mycobacterial use thereof
WO2016012958A1 (en) 2014-07-23 2016-01-28 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
US10273230B2 (en) 2014-07-25 2019-04-30 Piramal Enterprises Limited Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
RU2017106742A (ru) 2014-08-05 2018-09-06 Элиос Биофарма, Инк. Комбинированная терапия для лечения парамиксовируса
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
KR101887213B1 (ko) 2014-08-12 2018-08-09 삼성에스디아이 주식회사 화합물, 이를 포함하는 유기 광전자 소자 및 표시장치
JP6625638B2 (ja) 2014-08-18 2019-12-25 ハドソン・バイオファーマ・インコーポレイテッド Ｍｄｍ２阻害薬としてのスピロピロリジン
WO2016040305A1 (en) 2014-09-08 2016-03-17 Temple University-Of The Commonwealth System Of Higher Education Pcsk9 inhibitors and methods of use thereof
US10669635B2 (en) 2014-09-18 2020-06-02 Baker Hughes, A Ge Company, Llc Methods of coating substrates with composite coatings of diamond nanoparticles and metal
JP2017528498A (ja) 2014-09-25 2017-09-28 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
WO2016049565A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions and methods for inhibition of ras
EP3201187A4 (en) 2014-10-01 2018-04-11 The Brigham and Women's Hospital, Inc. Compositions and methods for inhibiting bmp
JP6100745B2 (ja) 2014-10-01 2017-03-22 ユー・ディー・シー アイルランド リミテッド 有機電界発光素子
HUE046914T2 (hu) 2014-10-08 2020-04-28 Redx Pharma Plc N-piridinil-acetamid-származékok, mint a WNT jelátviteli út inhibitorai
PL3204381T3 (pl) 2014-10-08 2022-08-29 Redx Pharma Plc Pochodne n-pirydynyloacetamidu jako inhibitory ścieżki sygnalizacji wnt
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US10174012B2 (en) 2014-11-04 2019-01-08 The University Of Kansas LKB1-AMPK activators for therapeutic use in polycystic kidney disease
WO2016073623A2 (en) 2014-11-04 2016-05-12 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
WO2016074757A1 (de) 2014-11-11 2016-05-19 Merck Patent Gmbh Verfahren zur herstellung von mono- und bis(perfluoralkyl)fluorophosphatsalzen und deren säuren
WO2016088354A1 (ja) 2014-12-05 2016-06-09 出光興産株式会社 金属錯体化合物、有機エレクトロルミネッセンス素子用材料、組成物、有機エレクトロルミネッセンス素子及び電子機器
CN104557863B (zh) 2014-12-18 2017-03-15 中国科学院广州生物医药与健康研究院 一种新型烟酰胺磷酸核糖转移酶抑制剂及其合成方法与应用
ES2746839T3 (es) 2014-12-18 2020-03-09 Pfizer Derivados de pirimidina y triazina y su uso como inhibidores de AXL
EA032473B1 (ru) 2014-12-23 2019-05-31 Аксикин Фармасьютикалз, Инк. 3,5-диаминопиразоловые ингибиторы киназы
JP6502091B2 (ja) 2014-12-26 2019-04-17 国立研究開発法人産業技術総合研究所 高圧水素製造法および製造システム
US10544361B2 (en) 2015-01-20 2020-01-28 Cynora Gmbh Pyridines and derivatives thereof as components for use in optoelectronic components
CN105845831B (zh) 2015-01-30 2019-07-05 三星显示有限公司 有机发光装置
US20180022990A1 (en) 2015-02-03 2018-01-25 Sumitomo Chemical Company, Limited Composition and light emitting device using the same
US9586949B2 (en) 2015-02-09 2017-03-07 Incyte Corporation Aza-heteroaryl compounds as PI3K-gamma inhibitors
CN104744348B (zh) 2015-02-13 2018-01-09 华侨大学 多取代吡啶衍生物及其制备方法
US9701671B2 (en) 2015-02-20 2017-07-11 Canon Kabushiki Kaisha Organic compound, electrochromic element containing the same, optical filter, lens unit, imaging device, and window component
NZ734993A (en) 2015-02-27 2024-03-22 Incyte Holdings Corp Salts of pi3k inhibitor and processes for their preparation
US10577349B2 (en) 2015-03-02 2020-03-03 Sanford Burnham Prebys Medical Discovery Institute Quinolinones as inhibitors of translation initiation complex
CN107624110B (zh) 2015-03-06 2021-01-26 法玛克亚公司 赖氨酰氧化酶样2抑制剂及其用途
WO2016161145A1 (en) 2015-03-31 2016-10-06 Dana-Farber Cancer Institute, Inc. Stk4 inhibitors for treatment of hematologic malignancies
EP3283479B1 (en) 2015-04-01 2022-12-14 Rigel Pharmaceuticals, Inc. Tgf-beta inhibitors
SG11201708140RA (en) 2015-04-08 2017-11-29 Torrent Pharmaceuticals Ltd Novel pyridinium compounds
KR101953175B1 (ko) 2015-04-24 2019-02-28 주식회사 엘지화학 함질소 다환 화합물 및 이를 이용하는 유기 발광 소자
CN106083823A (zh) 2015-04-30 2016-11-09 中国科学院上海药物研究所 一类具有激酶抑制活性的化合物、制备方法和用途
CA2984183C (en) 2015-05-01 2021-11-09 Pfizer Inc. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof
GB201507753D0 (en) 2015-05-06 2015-06-17 Biolipox Ab New compounds and uses
JP7083247B2 (ja) 2015-05-08 2022-06-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 発光材料、発光性薄膜、有機エレクトロルミネッセンス素子、表示装置及び照明装置
CN107426998A (zh) 2015-05-22 2017-12-01 美国陶氏益农公司 铃木偶联后钯催化剂的回收和/或再利用
US11925102B2 (en) 2015-06-04 2024-03-05 Universal Display Corporation Organic electroluminescent materials and devices
CN104927742B (zh) 2015-06-23 2017-05-17 上海东和胶粘剂有限公司 聚氨酯木结构胶及其制备方法
JP2017019789A (ja) 2015-07-13 2017-01-26 大阪ガスケミカル株式会社 微生物防除剤
EP3322420B1 (en) 2015-07-13 2021-12-29 Merck Sharp & Dohme Corp. Bicyclic heterocycles as inhibitors of cholesterol ester transfer protein
CN105175202B (zh) 2015-07-14 2018-09-07 绍兴文理学院 由芳香肼制备联芳烃的方法
TWI608132B (zh) 2015-08-06 2017-12-11 羅門哈斯電子材料有限公司 自含有吡啶基烷基胺及雙環氧化物之反應產物的銅電鍍覆浴液電鍍覆光阻劑限定之特徵的方法
KR101735687B1 (ko) 2015-09-23 2017-05-15 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계 및 이를 이용한 올레핀 올리고머화 방법
KR101832448B1 (ko) 2015-09-24 2018-02-26 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계, 및 이를 이용한 올레핀 올리고머화 방법
US20170092880A1 (en) 2015-09-25 2017-03-30 Universal Display Corporation Organic electroluminescent materials and devices
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
WO2017059434A1 (en) 2015-10-02 2017-04-06 Esanex, Inc. Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of cancer
US9981945B2 (en) 2015-10-07 2018-05-29 NuBridge BioSciences Pyrimidine derivatives as CFTR modulators
US10174002B2 (en) 2015-10-07 2019-01-08 NuBridge BioSciences Pyridine derivatives as CFTR modulators
US9890149B2 (en) 2015-10-07 2018-02-13 NuBridge BioSciences Isothiazole derivatives as CFTR modulators
WO2017061581A1 (ja) 2015-10-08 2017-04-13 株式会社神鋼環境ソリューション ビピリジン化合物の合成方法およびピリジン化合物の製造方法
US10526316B2 (en) 2015-10-09 2020-01-07 Janssen Pharmaceutica Nv Quinoxaline and pyridopyrazine derivatives as PI3Kβ inhibitors
WO2017070003A1 (en) 2015-10-20 2017-04-27 Kiacta Sárl Use of prodrugs of 1,3-propanedisulfonic acid or pharmaceutically acceptable salts thereof for the treatment of sarcoidosis
JP6917989B2 (ja) 2015-11-06 2021-08-11 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 神経学的疾患を処置するためのムスカリン受容体４（ｍ４）アンタゴニストとしての、ｎ−［２−（１−ベンジルピペリジン−４−イル）エチル］−４−（ピラジン−２−イル）−ピペラジン−１−カルボキサミド誘導体および関連化合物
CA3005614A1 (en) 2015-11-17 2017-05-26 Taipei Medical University Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases
WO2017097216A1 (zh) 2015-12-07 2017-06-15 杭州雷索药业有限公司 五元杂环酰胺类wnt通路抑制剂
EP3377053A4 (en) 2015-12-09 2019-07-03 Case Western Reserve University PROCESS FOR MODULATING THE RIBONUCLEOTIDE REDUCTASE
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物
KR102396293B1 (ko) 2015-12-29 2022-05-11 삼성디스플레이 주식회사 유기 발광 소자
KR102419178B1 (ko) 2015-12-29 2022-07-11 삼성디스플레이 주식회사 유기 발광 소자
TW201734003A (zh) 2016-01-05 2017-10-01 英塞特公司 作為ＰＩ３Ｋ-γ抑制劑之吡啶及嘧啶化合物
AU2017205101B2 (en) 2016-01-08 2023-05-04 Breast Cancer Now Inhibitors of ataxia-telangiectasia mutated and Rad3-related protein kinase (ATR) for use in methods of treating cancer
SG11201803725SA (en) 2016-01-22 2018-06-28 Chevron Oronite Co Synergistic lubricating oil composition containing a mixture of olefin copolymer dispersant-type viscosity improver and amine compound
EP3883345A1 (en) 2016-01-28 2021-09-22 Sumitomo Chemical Company Limited Film production method
KR20170093273A (ko) 2016-02-03 2017-08-16 주식회사 동진쎄미켐 유기발광소자
WO2017170765A1 (ja) 2016-03-30 2017-10-05 田辺三菱製薬株式会社 新規含窒素複素環化合物
US10236456B2 (en) 2016-04-11 2019-03-19 Universal Display Corporation Organic electroluminescent materials and devices
CA3020543A1 (en) 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use
WO2017189569A1 (en) 2016-04-25 2017-11-02 Trustees Of Tufts College Multimediator dpp4 and fap inhibitors, and uses related thereto
US20170305861A1 (en) 2016-04-25 2017-10-26 Immunomet Therapeutics, Inc Heteroaryl compounds comprising nitrogen and use thereof
US20170320875A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
US10138248B2 (en) 2016-06-24 2018-11-27 Incyte Corporation Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors
NZ750414A (en) 2016-07-05 2023-02-24 Guangzhou Maxinovel Pharmaceuticals Co Ltd Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
CN107759614B (zh) 2016-08-16 2023-01-24 中国科学院上海药物研究所 一类噁唑并吡啶季铵盐类化合物、其制备方法及用途
WO2018037058A1 (en) 2016-08-24 2018-03-01 F. Hoffmann-La Roche Ag 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
WO2018042362A1 (en) 2016-09-02 2018-03-08 Suven Life Sciences Limited Muscarinic m1 receptor positive allosteric modulators
CN109790081A (zh) 2016-09-21 2019-05-21 乐天化学株式会社 烯烃低聚的催化剂体系和使用其制备烯烃低聚物的方法
WO2018056643A1 (ko) 2016-09-21 2018-03-29 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계 및 이를 이용한 올레핀 올리고머 제조방법
CA3037118C (en) 2016-09-28 2021-12-14 Dong-A St Co., Ltd. Tetrahydropyridine derivatives and their use as antibacterial agents
TWI734861B (zh) 2016-12-19 2021-08-01 瑞典商指紋卡公司 包括顯示功能之電容式指紋感測裝置
CN106831735B (zh) 2017-01-23 2019-10-11 牡丹江医学院 一种治疗骨质疏松的杂环化合物及其制备方法和用途
CN106905299B (zh) 2017-02-28 2019-04-02 牡丹江医学院 一种治疗胰腺炎的药物及其制备方法
WO2019079469A1 (en) 2017-10-18 2019-04-25 Incyte Corporation CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED WITH HYDROXY TERTIARY GROUPS AS INHIBITORS OF PI3K-GAMMA
MA54133B1 (fr) 2018-03-08 2022-01-31 Incyte Corp Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

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