ES2167563T3 - Derivados de (2-morfolinilmetil)benzamida. - Google Patents
Derivados de (2-morfolinilmetil)benzamida.Info
- Publication number
- ES2167563T3 ES2167563T3 ES96916121T ES96916121T ES2167563T3 ES 2167563 T3 ES2167563 T3 ES 2167563T3 ES 96916121 T ES96916121 T ES 96916121T ES 96916121 T ES96916121 T ES 96916121T ES 2167563 T3 ES2167563 T3 ES 2167563T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- rent
- sup
- hydrogen
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- -1 AMINO Chemical class 0.000 abstract 3
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000030136 gastric emptying Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000032258 transport Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Abstract
LA PRESENTE INVENCION TRATA DE NUEVOS DERIVADOS DE (2 MORFOLINILMETIL)BENZAMIDA QUE POSEEN LA FORMULA (I), LAS FORMAS DE N Y LAS FORMAS ESTEREOQUIMICAMENTE ISOMERAS DE LOS MISMOS, EN LA CUAL R SUP,1} ES ALQUILO C SUB,1-6}, ALQUENILO C SUB,2-6} O ALQUINILO C SUB,2-6}; R SUP,2} ES HIDROGENO, HALO O ALQUILSULFONILAMINO C SUB,1-6}; R SUP,3} ES HIDROGENO O ALQUILO C SUB,1-6}; L ES UN RADICAL DE FORMULA R SUP,4} 5} LQ IILO C SUB,1-12}; R SUP,4} ES HIDROGENO, HIDROXI, ALQUILO C SUB,1-6}, ALQUILOXI C SUB,1-6}, AMINO, MONO 1-6})AMINO O UN ANILLO HETEROCICLICO OPCIONALMENTE SUSTITUIDO; R SUP,5} Y R SUP,7} SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, ALQUILO C SUB,1-6}, ALQUILOXI C SUB,1-6}, AMINO, MONO LQUIL C SUB,1-6})AMINO O UN ANILLO HETEROCICLICO OPCIONALMENTE SUSTITUIDO; R SUP,6} ES HIDROGENO O ALQUILO C SUB,1-6}; Y ARILO ES FENILO O FENILO SUSTITUIDO CON 1, 2 O 3 SUSTITUYENTES SELECCIONADOS ENTRE HALO, ALQUILO C SUB,1-6} O ALQUILOXI C SUB,1-6}. ADEMAS TRATA DE COMPOSICIONES FARMACEUTICAS QUE LOSCONTIENEN, DE PROCEDIMIENTOS PARA PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES, Y EL USO DE LOS MISMOS COMO MEDICINA, EN PARTICULAR EN TRASTORNOS QUE IMPLICAN UN VACIADO GASTRICO DISMINUIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95201350 | 1995-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2167563T3 true ES2167563T3 (es) | 2002-05-16 |
Family
ID=8220318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96916121T Expired - Lifetime ES2167563T3 (es) | 1995-05-23 | 1996-05-15 | Derivados de (2-morfolinilmetil)benzamida. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6100262A (es) |
EP (1) | EP0827500B1 (es) |
JP (1) | JPH11505815A (es) |
KR (1) | KR100446099B1 (es) |
AT (1) | ATE208766T1 (es) |
AU (1) | AU710037B2 (es) |
CA (1) | CA2220140C (es) |
DE (1) | DE69617001T2 (es) |
DK (1) | DK0827500T3 (es) |
ES (1) | ES2167563T3 (es) |
IL (1) | IL118379A (es) |
MY (1) | MY117938A (es) |
NO (1) | NO309900B1 (es) |
NZ (1) | NZ309065A (es) |
PT (1) | PT827500E (es) |
TW (1) | TW505639B (es) |
WO (1) | WO1996037486A1 (es) |
ZA (1) | ZA964100B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1324990B1 (en) * | 2000-09-29 | 2014-10-29 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
UA77515C2 (en) * | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
ES2910071T3 (es) | 2018-03-08 | 2022-05-11 | Incyte Corp | Compuestos de aminopirazina diol como inhibidores de PI3K-Y |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
CN110938068B (zh) * | 2019-11-06 | 2022-12-23 | 广东东阳光药业有限公司 | N-(吗啉-2-基甲基)酰胺衍生物及其用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870074A (en) * | 1986-04-30 | 1989-09-26 | Dainippon Pharmaceutical Co., Ltd. | Substituted benzamide derivatives, for enhancing gastrointestinal motility |
WO1995026953A1 (fr) * | 1994-03-30 | 1995-10-12 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose d'acide benzoïque et son utilisation comme medicament |
-
1996
- 1996-05-15 ES ES96916121T patent/ES2167563T3/es not_active Expired - Lifetime
- 1996-05-15 NZ NZ309065A patent/NZ309065A/xx unknown
- 1996-05-15 AT AT96916121T patent/ATE208766T1/de not_active IP Right Cessation
- 1996-05-15 EP EP96916121A patent/EP0827500B1/en not_active Expired - Lifetime
- 1996-05-15 PT PT96916121T patent/PT827500E/pt unknown
- 1996-05-15 KR KR1019970707669A patent/KR100446099B1/ko not_active IP Right Cessation
- 1996-05-15 DE DE69617001T patent/DE69617001T2/de not_active Expired - Lifetime
- 1996-05-15 DK DK96916121T patent/DK0827500T3/da active
- 1996-05-15 WO PCT/EP1996/002141 patent/WO1996037486A1/en active IP Right Grant
- 1996-05-15 CA CA002220140A patent/CA2220140C/en not_active Expired - Lifetime
- 1996-05-15 AU AU58992/96A patent/AU710037B2/en not_active Ceased
- 1996-05-15 JP JP8535361A patent/JPH11505815A/ja active Pending
- 1996-05-21 MY MYPI96001904A patent/MY117938A/en unknown
- 1996-05-22 IL IL11837996A patent/IL118379A/xx not_active IP Right Cessation
- 1996-05-22 ZA ZA9604100A patent/ZA964100B/xx unknown
- 1996-06-04 TW TW085106627A patent/TW505639B/zh active
-
1997
- 1997-11-21 NO NO975342A patent/NO309900B1/no unknown
-
1999
- 1999-09-22 US US09/401,729 patent/US6100262A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2220140A1 (en) | 1996-11-28 |
DK0827500T3 (da) | 2002-02-25 |
NO309900B1 (no) | 2001-04-17 |
NZ309065A (en) | 1999-06-29 |
PT827500E (pt) | 2002-04-29 |
KR100446099B1 (ko) | 2004-11-10 |
ATE208766T1 (de) | 2001-11-15 |
KR19990008144A (ko) | 1999-01-25 |
ZA964100B (en) | 1997-11-24 |
WO1996037486A1 (en) | 1996-11-28 |
DE69617001T2 (de) | 2002-07-11 |
TW505639B (en) | 2002-10-11 |
AU710037B2 (en) | 1999-09-09 |
AU5899296A (en) | 1996-12-11 |
NO975342D0 (no) | 1997-11-21 |
MY117938A (en) | 2004-08-30 |
EP0827500A1 (en) | 1998-03-11 |
JPH11505815A (ja) | 1999-05-25 |
IL118379A (en) | 1999-12-31 |
CA2220140C (en) | 2008-02-12 |
IL118379A0 (en) | 1996-09-12 |
NO975342L (no) | 1997-11-21 |
US6100262A (en) | 2000-08-08 |
DE69617001D1 (de) | 2001-12-20 |
EP0827500B1 (en) | 2001-11-14 |
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