AR023727A1 - Compuestos empleados en el tratamiento de padecimientos inflamatorios - Google Patents
Compuestos empleados en el tratamiento de padecimientos inflamatoriosInfo
- Publication number
- AR023727A1 AR023727A1 ARP990106429A ARP990106429A AR023727A1 AR 023727 A1 AR023727 A1 AR 023727A1 AR P990106429 A ARP990106429 A AR P990106429A AR P990106429 A ARP990106429 A AR P990106429A AR 023727 A1 AR023727 A1 AR 023727A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- inflammatory
- matters
- compounds used
- therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Se proporciona de conformidad con la invencion, nuevos compuestos de formula (1) en los cuales, R1, R2, R3, R4, R5 y R6 son como se definen en laespecificacion, procedimientos para prepararlos, formulaciones que los contiene y su uso en terapia parael tratamiento de padecimientos inflamatorios.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9828074.6A GB9828074D0 (en) | 1998-12-18 | 1998-12-18 | Therapeutically useful compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023727A1 true AR023727A1 (es) | 2002-09-04 |
Family
ID=10844608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990106429A AR023727A1 (es) | 1998-12-18 | 1999-12-15 | Compuestos empleados en el tratamiento de padecimientos inflamatorios |
Country Status (26)
Country | Link |
---|---|
US (1) | US6867192B1 (es) |
EP (1) | EP1140837B1 (es) |
JP (1) | JP4431282B2 (es) |
KR (1) | KR20010101258A (es) |
CN (1) | CN1330637A (es) |
AR (1) | AR023727A1 (es) |
AT (1) | ATE273954T1 (es) |
AU (1) | AU760169B2 (es) |
BR (1) | BR9916282A (es) |
CA (1) | CA2355630A1 (es) |
CO (1) | CO5170533A1 (es) |
CZ (1) | CZ20012209A3 (es) |
DE (1) | DE69919580T2 (es) |
ES (1) | ES2226488T3 (es) |
GB (1) | GB9828074D0 (es) |
GT (1) | GT199900217A (es) |
HK (1) | HK1038744A1 (es) |
HU (1) | HUP0104867A3 (es) |
IL (1) | IL142908A0 (es) |
NO (1) | NO20012995L (es) |
NZ (1) | NZ511478A (es) |
PE (1) | PE20001387A1 (es) |
PL (1) | PL348059A1 (es) |
TR (1) | TR200101709T2 (es) |
WO (1) | WO2000037444A1 (es) |
ZA (1) | ZA200103948B (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP2002002565A0 (en) | 1999-12-28 | 2002-06-30 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases. |
GB0014883D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
GB0014892D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
GB0014851D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
GB0014869D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
GB0014849D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Pharmaceutical aerosol formulation |
GB0014881D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Pharmaceutical aerosol formulation |
GB0014947D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
GB0127423D0 (en) * | 2001-11-15 | 2002-01-09 | Glaxo Group Ltd | Process |
GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
EP1633731A2 (en) | 2003-05-20 | 2006-03-15 | Genentech, Inc. | Thiocarbamate inhibitors of alpha-4 integrins |
US20060051345A1 (en) | 2004-06-04 | 2006-03-09 | Genentech, Inc. | Method for treating multiple sclerosis |
US9082353B2 (en) | 2010-01-05 | 2015-07-14 | Pixtronix, Inc. | Circuits for controlling display apparatus |
US8159428B2 (en) | 2005-02-23 | 2012-04-17 | Pixtronix, Inc. | Display methods and apparatus |
US9158106B2 (en) | 2005-02-23 | 2015-10-13 | Pixtronix, Inc. | Display methods and apparatus |
US20070205969A1 (en) | 2005-02-23 | 2007-09-06 | Pixtronix, Incorporated | Direct-view MEMS display devices and methods for generating images thereon |
US7742016B2 (en) | 2005-02-23 | 2010-06-22 | Pixtronix, Incorporated | Display methods and apparatus |
US7999994B2 (en) | 2005-02-23 | 2011-08-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
US8482496B2 (en) | 2006-01-06 | 2013-07-09 | Pixtronix, Inc. | Circuits for controlling MEMS display apparatus on a transparent substrate |
US8519945B2 (en) | 2006-01-06 | 2013-08-27 | Pixtronix, Inc. | Circuits for controlling display apparatus |
US9229222B2 (en) | 2005-02-23 | 2016-01-05 | Pixtronix, Inc. | Alignment methods in fluid-filled MEMS displays |
US9261694B2 (en) | 2005-02-23 | 2016-02-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
US8310442B2 (en) | 2005-02-23 | 2012-11-13 | Pixtronix, Inc. | Circuits for controlling display apparatus |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
US8526096B2 (en) | 2006-02-23 | 2013-09-03 | Pixtronix, Inc. | Mechanical light modulators with stressed beams |
US9176318B2 (en) * | 2007-05-18 | 2015-11-03 | Pixtronix, Inc. | Methods for manufacturing fluid-filled MEMS displays |
TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
US8169679B2 (en) | 2008-10-27 | 2012-05-01 | Pixtronix, Inc. | MEMS anchors |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
KR20120132680A (ko) | 2010-02-02 | 2012-12-07 | 픽스트로닉스 인코포레이티드 | 저온 실 유체 충전된 디스플레이 장치의 제조 방법 |
JP2013519122A (ja) | 2010-02-02 | 2013-05-23 | ピクストロニックス・インコーポレーテッド | ディスプレイ装置を制御するための回路 |
WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
WO2013116287A1 (en) | 2012-01-31 | 2013-08-08 | Genentech, Inc. | Anti-ig-e m1' antibodies and methods using same |
US9134552B2 (en) | 2013-03-13 | 2015-09-15 | Pixtronix, Inc. | Display apparatus with narrow gap electrostatic actuators |
JP6836502B2 (ja) * | 2014-05-30 | 2021-03-03 | スプハエラ ファーマ ピーヴィーティー リミテッド | 抗結核薬としての新規な化合物 |
BR112018000112A2 (pt) | 2015-07-08 | 2018-09-04 | Axerovision, Inc. | composições farmacêuticas que compreendem um antagonista de alfa 4 integrina para uso no tratamento de condições inflamatórias oculares |
IL293708A (en) | 2015-10-06 | 2022-08-01 | Genentech Inc | A method for treating multiple sclerosis |
CA3026074A1 (en) * | 2016-06-01 | 2017-12-07 | M3 Biotechnology, Inc. | N-hexanoic-l-tyrosine-l-isoleucine-(6)-aminohexanoic amide compounds and their use to treat neurodegenerative diseases |
CN109722455B (zh) * | 2017-10-31 | 2022-03-11 | 中国科学院天津工业生物技术研究所 | 微生物发酵生产谷内酯的方法、工程菌及应用 |
EP3810085A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
KR102652797B1 (ko) | 2018-10-30 | 2024-04-02 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린의 억제를 위한 화합물 |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
EP3873605A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
AU2019373244B2 (en) | 2018-10-30 | 2022-05-26 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
WO2022084747A1 (en) * | 2020-10-21 | 2022-04-28 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1593858A1 (de) | 1967-03-02 | 1970-10-29 | Hoechst Ag | Verfahren zur Herstellung tyrosinhaltiger Peptide und deren Derivaten |
US4105602A (en) * | 1975-02-10 | 1978-08-08 | Armour Pharmaceutical Company | Synthesis of peptides with parathyroid hormone activity |
US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
CA2291708A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
ATE318841T1 (de) | 1997-05-29 | 2006-03-15 | Merck & Co Inc | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
JP2002512625A (ja) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
WO1998054207A1 (en) | 1997-05-30 | 1998-12-03 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
-
1998
- 1998-12-18 GB GBGB9828074.6A patent/GB9828074D0/en not_active Ceased
-
1999
- 1999-12-15 CO CO99078241A patent/CO5170533A1/es not_active Application Discontinuation
- 1999-12-15 AR ARP990106429A patent/AR023727A1/es not_active Application Discontinuation
- 1999-12-16 JP JP2000589516A patent/JP4431282B2/ja not_active Expired - Lifetime
- 1999-12-16 WO PCT/EP1999/010000 patent/WO2000037444A1/en not_active Application Discontinuation
- 1999-12-16 IL IL14290899A patent/IL142908A0/xx unknown
- 1999-12-16 CN CN99814654A patent/CN1330637A/zh active Pending
- 1999-12-16 PE PE1999001274A patent/PE20001387A1/es not_active Application Discontinuation
- 1999-12-16 PL PL99348059A patent/PL348059A1/xx not_active Application Discontinuation
- 1999-12-16 TR TR2001/01709T patent/TR200101709T2/xx unknown
- 1999-12-16 NZ NZ511478A patent/NZ511478A/en unknown
- 1999-12-16 US US09/868,395 patent/US6867192B1/en not_active Expired - Lifetime
- 1999-12-16 HU HU0104867A patent/HUP0104867A3/hu unknown
- 1999-12-16 CZ CZ20012209A patent/CZ20012209A3/cs unknown
- 1999-12-16 KR KR1020017007579A patent/KR20010101258A/ko not_active Application Discontinuation
- 1999-12-16 EP EP99964583A patent/EP1140837B1/en not_active Expired - Lifetime
- 1999-12-16 ES ES99964583T patent/ES2226488T3/es not_active Expired - Lifetime
- 1999-12-16 DE DE69919580T patent/DE69919580T2/de not_active Expired - Lifetime
- 1999-12-16 CA CA002355630A patent/CA2355630A1/en not_active Abandoned
- 1999-12-16 AU AU30391/00A patent/AU760169B2/en not_active Ceased
- 1999-12-16 BR BR9916282-2A patent/BR9916282A/pt not_active IP Right Cessation
- 1999-12-16 AT AT99964583T patent/ATE273954T1/de not_active IP Right Cessation
- 1999-12-17 GT GT199900217A patent/GT199900217A/es unknown
-
2001
- 2001-05-15 ZA ZA200103948A patent/ZA200103948B/en unknown
- 2001-06-15 NO NO20012995A patent/NO20012995L/no not_active Application Discontinuation
-
2002
- 2002-01-09 HK HK02100145.2A patent/HK1038744A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US6867192B1 (en) | 2005-03-15 |
GT199900217A (es) | 2001-06-09 |
PL348059A1 (en) | 2002-05-06 |
HUP0104867A2 (hu) | 2002-04-29 |
CO5170533A1 (es) | 2002-06-27 |
AU3039100A (en) | 2000-07-12 |
IL142908A0 (en) | 2002-04-21 |
ATE273954T1 (de) | 2004-09-15 |
HUP0104867A3 (en) | 2002-06-28 |
EP1140837A1 (en) | 2001-10-10 |
GB9828074D0 (en) | 1999-02-17 |
CZ20012209A3 (cs) | 2001-09-12 |
NO20012995L (no) | 2001-08-15 |
ZA200103948B (en) | 2002-11-15 |
HK1038744A1 (zh) | 2002-03-28 |
DE69919580D1 (de) | 2004-09-23 |
NO20012995D0 (no) | 2001-06-15 |
WO2000037444A1 (en) | 2000-06-29 |
BR9916282A (pt) | 2001-10-02 |
EP1140837B1 (en) | 2004-08-18 |
CA2355630A1 (en) | 2000-06-29 |
TR200101709T2 (tr) | 2001-12-21 |
KR20010101258A (ko) | 2001-11-14 |
DE69919580T2 (de) | 2005-09-01 |
AU760169B2 (en) | 2003-05-08 |
CN1330637A (zh) | 2002-01-09 |
JP2002533326A (ja) | 2002-10-08 |
JP4431282B2 (ja) | 2010-03-10 |
PE20001387A1 (es) | 2000-12-22 |
ES2226488T3 (es) | 2005-03-16 |
NZ511478A (en) | 2003-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |