CO5170533A1 - Derivados del acido fenil propanoico empleados en el tratami ento de padecimientos inflamatorios - Google Patents
Derivados del acido fenil propanoico empleados en el tratami ento de padecimientos inflamatoriosInfo
- Publication number
- CO5170533A1 CO5170533A1 CO99078241A CO99078241A CO5170533A1 CO 5170533 A1 CO5170533 A1 CO 5170533A1 CO 99078241 A CO99078241 A CO 99078241A CO 99078241 A CO99078241 A CO 99078241A CO 5170533 A1 CO5170533 A1 CO 5170533A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- tar1
- 6alkyl
- piperidin
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un compuesto de fórmula I:<EMI FILE="99078241_1" ID="1" IMF=JPEG >caracterizado porque R1 y R2 independientemente representan (i) alquiloC1-C6, cicloalquiloC3-8 o alquiloC1-3 cicloalquiloC3-8, o tal grupo en el cual el alquilo o cicloalquilo está substituido por uno o más grupos halógenos, -CN, nitro, hidroxi o OalquiloC1-6;(ii) -(CH2)e Ar1 o -(CH2)e OAr1; o NR1R2 juntos representan pirrolidinilo, piperidinilo, piperazinilo, tiomorfolinilo, morfolinilo o azepinilo, o tal grupo fusionado a un anillo benceno, opcionalmente substituido por uno o más grupos -(CO)n(CH2)tAr1; -(CO)nalquiloC1-6Ar1Ar2, -(CO)nalquiloC1-6, -(CH2)rOH, -(CH2)rO(CH2)pOH, -(CH2)rOalquiloC1-6, -O(CH2)tAr1, -(CH2)rSO2Ar1, piperidin-1-il, -(CH2)tCONR8R9, -NR10(CO)n(CH2)tAr1, -NR10(CO)nalquiloC1-3cicloalquilo C3-6, -NR10(CO)nalquiloC1-6dicicloalquiloC3-6, -CONR10(CH2)tAr1, halógeno, -NHSO2alquiloC1-6, -SO2NR10 R11, -SO2alquiloC1-6 o -SO2AR2;R3 representa alquilo C1-C6NHC(=NH)NH2, -alqueniloC2-6NHC(=NH)NH2, alquinilo C2-6NHC(=NH)NH2, alquilo C1-6NR14R18, -(CH2)hCONR14R18, -(CH2)hCOalquiloC1-6, (CH2)dCHNR18CONR20R21, -(CH2)mNR18CONR14R18, -(CH2)dNR18Ar3, -(CH2)dCONR18Ar3, -(CH2)hCOOR18, -(CH2)cAr3, -O(CH2)cAr3, -(CH2)dCO(CH2)sAr3 o -(CH2)dOAr3);o R3 representa -(CH2)c-2,4-imidazolidinodiona, -(CH2)c(piperidin-4-il), -(CH2)c(piperidin-3-il), -(CH2)c(piperidin-2-il), -(CH2)c(morfolin-3-il) o (CH2)c(morfolin-2-il) opcionalmente sustituido en nitrógeno por -(CO)falquiloC1-6, -(CO)f(CH2)cAr2 o -C(=NH)NH2;o R3 representa -(CH2)zdibenzofurano opcionalmente sustituido con alquiloC1-6, ó halogeno, ó R3 representa -(CH2)c-tioxanten-9-ona;R4 representa hidrógeno, alquiloC1-6, alquiloC1-3cicloalquiloC3-6, -(CH2)qAr2, -alquilo C1-4, -X-R7, -alquiloC1-4SO2alquiloC1-4, -alquiloC1-6NR12R13 o -alquiloC1-6NR12COalquilo C1-6;R5 representa hidrógeno, o R4R5 junto con el átomo de carbono al cual están unidos forman un anillo cicloalquiloC5-7;R6 representa hidrógeno ó alquilo C1-6 ó R6 y R4 junto con los átomos de nitrógeno o carbono al cual están respectivamente unidos, forman un anillo pirrolidina;R7 representa hidrógeno, -(CH2)wN12R13, -(CH2)uAr2 o -(CH2)wNR12COalquiloC1-6; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9828074.6A GB9828074D0 (en) | 1998-12-18 | 1998-12-18 | Therapeutically useful compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5170533A1 true CO5170533A1 (es) | 2002-06-27 |
Family
ID=10844608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99078241A CO5170533A1 (es) | 1998-12-18 | 1999-12-15 | Derivados del acido fenil propanoico empleados en el tratami ento de padecimientos inflamatorios |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6867192B1 (es) |
| EP (1) | EP1140837B1 (es) |
| JP (1) | JP4431282B2 (es) |
| KR (1) | KR20010101258A (es) |
| CN (1) | CN1330637A (es) |
| AR (1) | AR023727A1 (es) |
| AT (1) | ATE273954T1 (es) |
| AU (1) | AU760169B2 (es) |
| BR (1) | BR9916282A (es) |
| CA (1) | CA2355630A1 (es) |
| CO (1) | CO5170533A1 (es) |
| CZ (1) | CZ20012209A3 (es) |
| DE (1) | DE69919580T2 (es) |
| ES (1) | ES2226488T3 (es) |
| GB (1) | GB9828074D0 (es) |
| GT (1) | GT199900217A (es) |
| HK (1) | HK1038744A1 (es) |
| HU (1) | HUP0104867A3 (es) |
| IL (1) | IL142908A0 (es) |
| NO (1) | NO20012995L (es) |
| NZ (1) | NZ511478A (es) |
| PE (1) | PE20001387A1 (es) |
| PL (1) | PL348059A1 (es) |
| TR (1) | TR200101709T2 (es) |
| WO (1) | WO2000037444A1 (es) |
| ZA (1) | ZA200103948B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL357109A1 (en) | 1999-12-28 | 2004-07-12 | Pfizer Products Inc. | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
| GB0014869D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014892D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014947D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014883D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014849D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Pharmaceutical aerosol formulation |
| GB0014851D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014881D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Pharmaceutical aerosol formulation |
| GB0127423D0 (en) * | 2001-11-15 | 2002-01-09 | Glaxo Group Ltd | Process |
| GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
| WO2004103967A2 (en) | 2003-05-20 | 2004-12-02 | Genentech, Inc. | Thiocarbamate inhibitors of alpha-4 integrins |
| AR049200A1 (es) | 2004-06-04 | 2006-07-05 | Genentech Inc | Metodo para tratar esclerosis multiple con una composicion que contiene un anticuerpo cd20 |
| US7999994B2 (en) | 2005-02-23 | 2011-08-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
| US8159428B2 (en) | 2005-02-23 | 2012-04-17 | Pixtronix, Inc. | Display methods and apparatus |
| US9082353B2 (en) | 2010-01-05 | 2015-07-14 | Pixtronix, Inc. | Circuits for controlling display apparatus |
| US9158106B2 (en) | 2005-02-23 | 2015-10-13 | Pixtronix, Inc. | Display methods and apparatus |
| US8482496B2 (en) | 2006-01-06 | 2013-07-09 | Pixtronix, Inc. | Circuits for controlling MEMS display apparatus on a transparent substrate |
| US9229222B2 (en) | 2005-02-23 | 2016-01-05 | Pixtronix, Inc. | Alignment methods in fluid-filled MEMS displays |
| US8310442B2 (en) | 2005-02-23 | 2012-11-13 | Pixtronix, Inc. | Circuits for controlling display apparatus |
| US20070205969A1 (en) | 2005-02-23 | 2007-09-06 | Pixtronix, Incorporated | Direct-view MEMS display devices and methods for generating images thereon |
| US8519945B2 (en) | 2006-01-06 | 2013-08-27 | Pixtronix, Inc. | Circuits for controlling display apparatus |
| US7742016B2 (en) | 2005-02-23 | 2010-06-22 | Pixtronix, Incorporated | Display methods and apparatus |
| US9261694B2 (en) | 2005-02-23 | 2016-02-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| US8526096B2 (en) | 2006-02-23 | 2013-09-03 | Pixtronix, Inc. | Mechanical light modulators with stressed beams |
| US9176318B2 (en) * | 2007-05-18 | 2015-11-03 | Pixtronix, Inc. | Methods for manufacturing fluid-filled MEMS displays |
| AR073295A1 (es) | 2008-09-16 | 2010-10-28 | Genentech Inc | Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. |
| US8169679B2 (en) | 2008-10-27 | 2012-05-01 | Pixtronix, Inc. | MEMS anchors |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| EP2531997A1 (en) | 2010-02-02 | 2012-12-12 | Pixtronix Inc. | Circuits for controlling display apparatus |
| CN102834763B (zh) | 2010-02-02 | 2015-07-22 | 皮克斯特罗尼克斯公司 | 用于制造填充冷密封流体的显示装置的方法 |
| WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| US20130243750A1 (en) | 2012-01-31 | 2013-09-19 | Genentech, Inc. | Anti-ige antibodies and methods using same |
| US9134552B2 (en) | 2013-03-13 | 2015-09-15 | Pixtronix, Inc. | Display apparatus with narrow gap electrostatic actuators |
| RU2016152499A (ru) * | 2014-05-30 | 2018-07-04 | Драг Дискавери Ресеч Сентэ | Новые соединения в качестве противотуберкулезных препаратов |
| UA123728C2 (uk) | 2015-07-08 | 2021-05-26 | Аксеровіжн, Інк. | Фармацевтичні композиції, що містять антагоніст інтегрину альфа4, для застосування в лікуванні запальних станів ока |
| JP2018529747A (ja) | 2015-10-06 | 2018-10-11 | ジェネンテック， インコーポレイテッド | 多発性硬化症を治療するための方法 |
| CN116731101A (zh) * | 2016-06-01 | 2023-09-12 | 雅斯娜 | 用于治疗多种疾病的n-己酸-l-酪氨酸-l-异亮氨酸-(6)-氨基己酰胺的衍生物 |
| CN109722455B (zh) * | 2017-10-31 | 2022-03-11 | 中国科学院天津工业生物技术研究所 | 微生物发酵生产谷内酯的方法、工程菌及应用 |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| CA3115830C (en) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
| US11224600B2 (en) | 2018-10-30 | 2022-01-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| AU2019373240B2 (en) | 2018-10-30 | 2023-04-20 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| CN116670116A (zh) * | 2020-10-21 | 2023-08-29 | 阿祖拉眼科有限公司 | 用于治疗眼部病症的化合物和方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593858A1 (de) | 1967-03-02 | 1970-10-29 | Hoechst Ag | Verfahren zur Herstellung tyrosinhaltiger Peptide und deren Derivaten |
| US4105602A (en) * | 1975-02-10 | 1978-08-08 | Armour Pharmaceutical Company | Synthesis of peptides with parathyroid hormone activity |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| CA2291778A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| ATE318841T1 (de) | 1997-05-29 | 2006-03-15 | Merck & Co Inc | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
| CA2291708A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
| DE69820614T2 (de) | 1997-05-30 | 2004-09-30 | Celltech Therapeutics Ltd., Slough | Entzündungshemmende tyrosin-derivate |
-
1998
- 1998-12-18 GB GBGB9828074.6A patent/GB9828074D0/en not_active Ceased
-
1999
- 1999-12-15 CO CO99078241A patent/CO5170533A1/es not_active Application Discontinuation
- 1999-12-15 AR ARP990106429A patent/AR023727A1/es not_active Application Discontinuation
- 1999-12-16 ES ES99964583T patent/ES2226488T3/es not_active Expired - Lifetime
- 1999-12-16 WO PCT/EP1999/010000 patent/WO2000037444A1/en not_active Application Discontinuation
- 1999-12-16 CA CA002355630A patent/CA2355630A1/en not_active Abandoned
- 1999-12-16 IL IL14290899A patent/IL142908A0/xx unknown
- 1999-12-16 EP EP99964583A patent/EP1140837B1/en not_active Expired - Lifetime
- 1999-12-16 TR TR2001/01709T patent/TR200101709T2/xx unknown
- 1999-12-16 PL PL99348059A patent/PL348059A1/xx not_active Application Discontinuation
- 1999-12-16 KR KR1020017007579A patent/KR20010101258A/ko not_active Application Discontinuation
- 1999-12-16 PE PE1999001274A patent/PE20001387A1/es not_active Application Discontinuation
- 1999-12-16 US US09/868,395 patent/US6867192B1/en not_active Expired - Lifetime
- 1999-12-16 BR BR9916282-2A patent/BR9916282A/pt not_active IP Right Cessation
- 1999-12-16 CZ CZ20012209A patent/CZ20012209A3/cs unknown
- 1999-12-16 AT AT99964583T patent/ATE273954T1/de not_active IP Right Cessation
- 1999-12-16 DE DE69919580T patent/DE69919580T2/de not_active Expired - Lifetime
- 1999-12-16 NZ NZ511478A patent/NZ511478A/en unknown
- 1999-12-16 HU HU0104867A patent/HUP0104867A3/hu unknown
- 1999-12-16 CN CN99814654A patent/CN1330637A/zh active Pending
- 1999-12-16 AU AU30391/00A patent/AU760169B2/en not_active Ceased
- 1999-12-16 JP JP2000589516A patent/JP4431282B2/ja not_active Expired - Lifetime
- 1999-12-17 GT GT199900217A patent/GT199900217A/es unknown
-
2001
- 2001-05-15 ZA ZA200103948A patent/ZA200103948B/en unknown
- 2001-06-15 NO NO20012995A patent/NO20012995L/no not_active Application Discontinuation
-
2002
- 2002-01-09 HK HK02100145.2A patent/HK1038744A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4431282B2 (ja) | 2010-03-10 |
| DE69919580D1 (de) | 2004-09-23 |
| ZA200103948B (en) | 2002-11-15 |
| EP1140837B1 (en) | 2004-08-18 |
| GT199900217A (es) | 2001-06-09 |
| NO20012995L (no) | 2001-08-15 |
| TR200101709T2 (tr) | 2001-12-21 |
| NO20012995D0 (no) | 2001-06-15 |
| AU760169B2 (en) | 2003-05-08 |
| CZ20012209A3 (cs) | 2001-09-12 |
| AR023727A1 (es) | 2002-09-04 |
| HK1038744A1 (zh) | 2002-03-28 |
| HUP0104867A2 (hu) | 2002-04-29 |
| WO2000037444A1 (en) | 2000-06-29 |
| AU3039100A (en) | 2000-07-12 |
| NZ511478A (en) | 2003-08-29 |
| EP1140837A1 (en) | 2001-10-10 |
| ES2226488T3 (es) | 2005-03-16 |
| CN1330637A (zh) | 2002-01-09 |
| KR20010101258A (ko) | 2001-11-14 |
| IL142908A0 (en) | 2002-04-21 |
| GB9828074D0 (en) | 1999-02-17 |
| PE20001387A1 (es) | 2000-12-22 |
| PL348059A1 (en) | 2002-05-06 |
| DE69919580T2 (de) | 2005-09-01 |
| CA2355630A1 (en) | 2000-06-29 |
| JP2002533326A (ja) | 2002-10-08 |
| HUP0104867A3 (en) | 2002-06-28 |
| US6867192B1 (en) | 2005-03-15 |
| ATE273954T1 (de) | 2004-09-15 |
| BR9916282A (pt) | 2001-10-02 |
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