DE69925472D1 - Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel - Google Patents
Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittelInfo
- Publication number
- DE69925472D1 DE69925472D1 DE69925472T DE69925472T DE69925472D1 DE 69925472 D1 DE69925472 D1 DE 69925472D1 DE 69925472 T DE69925472 T DE 69925472T DE 69925472 T DE69925472 T DE 69925472T DE 69925472 D1 DE69925472 D1 DE 69925472D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- benzoheterocyclic
- hydrogen
- derivatives
- distamycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9806692.1A GB9806692D0 (en) | 1998-03-27 | 1998-03-27 | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
GB9806692 | 1998-03-27 | ||
PCT/EP1999/001823 WO1999050266A1 (en) | 1998-03-27 | 1999-03-17 | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69925472D1 true DE69925472D1 (de) | 2005-06-30 |
DE69925472T2 DE69925472T2 (de) | 2006-02-02 |
Family
ID=10829461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69925472T Expired - Fee Related DE69925472T2 (de) | 1998-03-27 | 1999-03-17 | Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel |
Country Status (10)
Country | Link |
---|---|
US (1) | US6458768B1 (de) |
EP (1) | EP1064281B1 (de) |
JP (1) | JP2002509930A (de) |
AT (1) | ATE296300T1 (de) |
AU (1) | AU3415599A (de) |
DE (1) | DE69925472T2 (de) |
ES (1) | ES2244188T3 (de) |
GB (1) | GB9806692D0 (de) |
PT (1) | PT1064281E (de) |
WO (1) | WO1999050266A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
ATE265716T1 (de) * | 2000-02-16 | 2004-05-15 | Ericsson Telefon Ab L M | Stiftdrucker |
GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
GB0016447D0 (en) * | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
GB0029004D0 (en) | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
AU2002312371A1 (en) | 2001-06-13 | 2002-12-23 | Roland W. Burli | Aryl-benzimidazole compounds having antiinfective activity |
CA2450628A1 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Benzothiophene compounds having antiinfective activity |
WO2002101007A2 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc | Antipathogenic benzamide compounds |
US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
WO2004012736A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
US7141680B2 (en) | 2002-09-20 | 2006-11-28 | Genelabs Technologies, Inc. | Aromatic compounds possessing antifungal or antibacterial activity |
US7265129B2 (en) * | 2002-10-25 | 2007-09-04 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
US7129214B2 (en) | 2002-12-10 | 2006-10-31 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
EP2049518B1 (de) * | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazol- und isoindolderivate als glucokinaseaktivierende stoffe |
CL2009001203A1 (es) | 2008-05-16 | 2009-10-23 | Takeda San Diego Inc | Compuestos derivados de indazol y pirazol sustituidos; composicion farmaceutica de dichos compuestos; kit farmaceutico; y su uso como activadores de la glucoquinasa para tratar enfermedades metabolicas tales como hiperglicemia, diabetes, dislipidemias, obesidad, sindrome metabolico x y enfermedades cardiovasculares. |
WO2023209651A1 (en) * | 2022-04-29 | 2023-11-02 | Dong-A St Co., Ltd. | Bicycle compounds as tead inhibitor |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
IT1271456B (it) | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
AU1596097A (en) | 1996-02-02 | 1997-08-22 | Pharmacia & Upjohn S.P.A. | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
GB9610079D0 (en) * | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
GB9623522D0 (en) | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
-
1998
- 1998-03-27 GB GBGB9806692.1A patent/GB9806692D0/en not_active Ceased
-
1999
- 1999-03-17 AU AU34155/99A patent/AU3415599A/en not_active Abandoned
- 1999-03-17 US US09/623,505 patent/US6458768B1/en not_active Expired - Fee Related
- 1999-03-17 ES ES99915665T patent/ES2244188T3/es not_active Expired - Lifetime
- 1999-03-17 EP EP99915665A patent/EP1064281B1/de not_active Expired - Lifetime
- 1999-03-17 PT PT99915665T patent/PT1064281E/pt unknown
- 1999-03-17 DE DE69925472T patent/DE69925472T2/de not_active Expired - Fee Related
- 1999-03-17 JP JP2000541170A patent/JP2002509930A/ja not_active Withdrawn
- 1999-03-17 WO PCT/EP1999/001823 patent/WO1999050266A1/en active IP Right Grant
- 1999-03-17 AT AT99915665T patent/ATE296300T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2244188T3 (es) | 2005-12-01 |
EP1064281B1 (de) | 2005-05-25 |
DE69925472T2 (de) | 2006-02-02 |
ATE296300T1 (de) | 2005-06-15 |
WO1999050266A1 (en) | 1999-10-07 |
JP2002509930A (ja) | 2002-04-02 |
GB9806692D0 (en) | 1998-05-27 |
US6458768B1 (en) | 2002-10-01 |
PT1064281E (pt) | 2005-10-31 |
EP1064281A1 (de) | 2001-01-03 |
AU3415599A (en) | 1999-10-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69925472D1 (de) | Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel | |
DE69613860D1 (de) | Pyrazol-derivate, verfahren für ihre herstellung und sie enthaltende zusammensetzungen | |
YU48390B (sh) | Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate | |
DE69923300D1 (de) | Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung | |
AR009413A1 (es) | Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende | |
ATE288895T1 (de) | Wachstumshormon-freisetzende oxindolderivate | |
ES2176311T3 (es) | Nuevos derivados imidazol y procedimiento para su preparacion. | |
NZ332923A (en) | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | |
DK0868182T3 (da) | Fremgangsmåde til fremstilling af piperidinderivater | |
CA2244139A1 (en) | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | |
HUP0004020A2 (hu) | Triciklusos triazolo-benzazepin-származékok, eljárás a vegyületek előállítására és alkalmazásuk antiallergiás szerként | |
ATE261441T1 (de) | Analoga von distamycin-zimtsäurederivaten, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel | |
YU43902A (sh) | Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže | |
DE69311500D1 (de) | 2,3-Diphenyl-5-pyrrolyl-furan Derivate, Verfahren und Zwischenprodukte für ihre Herstellung und ihre Verwendung als entzündungshemmende, antiallergische und blutplättchenaggregationshemmende Mittel | |
RS50085B (sr) | Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže | |
DK1163258T3 (da) | Derivater af 22R-hydroxycholesta-8, 14-dien til inhiberingen af meiosis | |
ATE250597T1 (de) | N-benzolsulfonyl-l-prolin derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung | |
DK0782574T3 (da) | Bicycliske carboxiamider som 5-HT1A-receptorligander | |
HUP0300842A2 (hu) | Eljárás rovarirtó hatású vegyületek előállítására és az eljárás új köztitermékei | |
ATE179701T1 (de) | Phenyl imidazolinon-derivate, verfahren zu ihrer herstellung und ihre verwendung als 5-ht3- rezeptor-antagonisten | |
DE69532187D1 (de) | Abeo-ergolinderivate als 5ht1a liganden | |
DE69217148T2 (de) | Isoxazole derivate als lichtschutzmittel | |
TR200402333T4 (tr) | Artropodisidal karboksanilidler | |
ES2120885A1 (es) | Nuevas tienopirimidonas con actividad antifungica. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |