ATE288895T1 - Wachstumshormon-freisetzende oxindolderivate - Google Patents
Wachstumshormon-freisetzende oxindolderivateInfo
- Publication number
- ATE288895T1 ATE288895T1 AT99938515T AT99938515T ATE288895T1 AT E288895 T1 ATE288895 T1 AT E288895T1 AT 99938515 T AT99938515 T AT 99938515T AT 99938515 T AT99938515 T AT 99938515T AT E288895 T1 ATE288895 T1 AT E288895T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- growth hormone
- independently hydrogen
- hormone releasing
- alkyl etc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23464398 | 1998-08-20 | ||
| PCT/JP1999/004443 WO2000010975A1 (en) | 1998-08-20 | 1999-08-18 | Oxindole derivatives as growth hormone releasers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288895T1 true ATE288895T1 (de) | 2005-02-15 |
Family
ID=16974248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99938515T ATE288895T1 (de) | 1998-08-20 | 1999-08-18 | Wachstumshormon-freisetzende oxindolderivate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6576656B1 (de) |
| EP (1) | EP1105376B1 (de) |
| JP (1) | JP4445133B2 (de) |
| KR (1) | KR100680085B1 (de) |
| CN (1) | CN1161333C (de) |
| AT (1) | ATE288895T1 (de) |
| AU (1) | AU5301199A (de) |
| CA (1) | CA2340701C (de) |
| DE (1) | DE69923692T2 (de) |
| ES (1) | ES2237135T3 (de) |
| WO (1) | WO2000010975A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02010452A (es) * | 2000-05-11 | 2003-06-06 | Bristol Myers Squibb Co | Analogos de tetrahidroisoquinolina utiles como secretagogos de la hormona del crecimiento. |
| US6939887B2 (en) | 2001-01-30 | 2005-09-06 | Sumitomo Pharmaceuticals Co., Ltd. | Benzimidazolidinone derivatives |
| US6649606B1 (en) | 2001-11-09 | 2003-11-18 | Bristol-Myers Squibb Co. | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
| SE0104341D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| WO2003055877A1 (en) * | 2001-12-21 | 2003-07-10 | Astrazeneca Ab | Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3 |
| TW200301123A (en) * | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
| SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| NZ566615A (en) * | 2002-10-24 | 2009-08-28 | Pfizer Prod Inc | Acyl derivatives of 5-(2-(4-(1,2 benzisothiazole-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one having neuroleptic activity |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| US6912165B2 (en) * | 2003-08-22 | 2005-06-28 | International Business Machines Corporation | Method for transparent updates of output driver impedance |
| JPWO2005035498A1 (ja) * | 2003-10-08 | 2006-12-21 | 住友製薬株式会社 | 含窒素二環性化合物の摂食調節剤としての用途 |
| JP2008510706A (ja) | 2004-08-18 | 2008-04-10 | エリクシアー ファーマシューティカルズ， インコーポレイテッド | 成長ホルモン分泌促進物質 |
| US7825155B2 (en) | 2005-09-14 | 2010-11-02 | Dainippon Sumitomo Pharma Co., Ltd. | Oxindole derivative as feeding control agent |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| EP2644618B1 (de) | 2007-02-09 | 2016-08-17 | Ocera Therapeutics, Inc. | Intermediaten für die Synthese von Makrozyklische Ghrelin-Rezeptormodulatoren |
| FR2920023B1 (fr) * | 2007-08-16 | 2013-02-08 | Sanofi Aventis | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique |
| CA2728767A1 (en) * | 2008-06-26 | 2009-12-30 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| FR2941947B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
| FR2941946B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
| EP2246326A1 (de) * | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| DK2770997T3 (en) | 2011-10-28 | 2016-12-19 | Univ Vanderbilt | SUBSTITUTED 2- (4-HETEROCYCLYLBENSYL) isoindolin-1-ON-ANALOGS AS POSITIVE allosteric modulators OF THE muscarinic acetylcholine receptor M1 |
| US9073935B2 (en) | 2011-11-11 | 2015-07-07 | Vanderbilt University | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
| US9029563B2 (en) | 2012-01-06 | 2015-05-12 | Vanderbilt University | Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors |
| US8697888B2 (en) * | 2012-01-06 | 2014-04-15 | Vanderbilt University | Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors |
| WO2013106795A1 (en) | 2012-01-12 | 2013-07-18 | Vanderbilt University | Substituted 4-(1h~pyrazol-4.yl)benzyl analogues as positive allosteric modulators of machr m1 receptors |
| KR20200108494A (ko) | 2012-10-24 | 2020-09-18 | 다이이찌 산쿄 가부시키가이샤 | 근위축성 측삭 경화증 치료제 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB125671A (en) | 1917-07-03 | 1919-05-01 | James Rossiter Hoyle | Improvements in or relating to Armour Piercing Projectiles. |
| US3441570A (en) * | 1966-01-20 | 1969-04-29 | Parke Davis & Co | 3-tertiary aminoalkylamino-3-phenyl oxindole compounds |
| US3891644A (en) * | 1971-01-11 | 1975-06-24 | Wyeth John & Brother Ltd | 10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives |
| GB1450137A (en) | 1973-12-20 | 1976-09-22 | Wyeth John & Brother Ltd | Indole derivatives |
| US5283241A (en) | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
-
1999
- 1999-08-18 KR KR1020017002123A patent/KR100680085B1/ko not_active IP Right Cessation
- 1999-08-18 CN CNB998098574A patent/CN1161333C/zh not_active Expired - Fee Related
- 1999-08-18 ES ES99938515T patent/ES2237135T3/es not_active Expired - Lifetime
- 1999-08-18 EP EP99938515A patent/EP1105376B1/de not_active Expired - Lifetime
- 1999-08-18 JP JP2000566249A patent/JP4445133B2/ja not_active Expired - Fee Related
- 1999-08-18 US US09/763,241 patent/US6576656B1/en not_active Expired - Fee Related
- 1999-08-18 AU AU53011/99A patent/AU5301199A/en not_active Abandoned
- 1999-08-18 DE DE69923692T patent/DE69923692T2/de not_active Expired - Lifetime
- 1999-08-18 CA CA002340701A patent/CA2340701C/en not_active Expired - Fee Related
- 1999-08-18 AT AT99938515T patent/ATE288895T1/de not_active IP Right Cessation
- 1999-08-18 WO PCT/JP1999/004443 patent/WO2000010975A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69923692T2 (de) | 2006-03-23 |
| EP1105376B1 (de) | 2005-02-09 |
| AU5301199A (en) | 2000-03-14 |
| KR20010085413A (ko) | 2001-09-07 |
| DE69923692D1 (de) | 2005-03-17 |
| CA2340701C (en) | 2009-05-26 |
| WO2000010975A1 (en) | 2000-03-02 |
| CN1161333C (zh) | 2004-08-11 |
| EP1105376A1 (de) | 2001-06-13 |
| US6576656B1 (en) | 2003-06-10 |
| ES2237135T3 (es) | 2005-07-16 |
| JP2002523400A (ja) | 2002-07-30 |
| KR100680085B1 (ko) | 2007-02-28 |
| JP4445133B2 (ja) | 2010-04-07 |
| CN1313853A (zh) | 2001-09-19 |
| CA2340701A1 (en) | 2000-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |