CU23558A1 - Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento - Google Patents

Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Info

Publication number
CU23558A1
CU23558A1 CU20060050A CU20060050A CU23558A1 CU 23558 A1 CU23558 A1 CU 23558A1 CU 20060050 A CU20060050 A CU 20060050A CU 20060050 A CU20060050 A CU 20060050A CU 23558 A1 CU23558 A1 CU 23558A1
Authority
CU
Cuba
Prior art keywords
growth hormone
secretagogs
peptidic
compounds
compounds analog
Prior art date
Application number
CU20060050A
Other languages
English (en)
Inventor
Masso Julio Raul Fernandez
Lasa Alexis Musacchio
La Nuez Veulens Ania De
Fernandez Rolando Eduardo Rodriguez
Acosta Jorge Amador Berlanga
Garcia Mario Pablo Estrada
Santiago Glay Chinea
Acosta Osvaldo Reyes
Del Barco Herrera Diana Garcia
Rodriguez Rebeca Martinez
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40130780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23558(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20060050A priority Critical patent/CU23558A1/es
Priority to CL2007000528A priority patent/CL2007000528A1/es
Priority to ARP070100806A priority patent/AR059646A1/es
Priority to CA2637593A priority patent/CA2637593C/en
Priority to MYPI20083178A priority patent/MY184130A/en
Priority to EP07711101.1A priority patent/EP1997827B1/en
Priority to RU2008138569/10A priority patent/RU2416618C2/ru
Priority to ES07711101.1T priority patent/ES2441441T3/es
Priority to MX2008011142A priority patent/MX2008011142A/es
Priority to AU2007219569A priority patent/AU2007219569B2/en
Priority to KR1020087023543A priority patent/KR101409277B1/ko
Priority to BRPI0708366-1A priority patent/BRPI0708366A2/pt
Priority to JP2008556643A priority patent/JP5183496B2/ja
Priority to US12/281,085 priority patent/US8367620B2/en
Priority to PCT/CU2007/000007 priority patent/WO2007098716A1/es
Priority to CN2007800153594A priority patent/CN101432294B/zh
Priority to ZA200807162A priority patent/ZA200807162B/xx
Priority to NO20084118A priority patent/NO20084118L/no
Publication of CU23558A1 publication Critical patent/CU23558A1/es
Priority to CL2016001648A priority patent/CL2016001648A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuestos químicos peptídicos obtenidos por modelación molecular in silico, y cuya estructura les permite efectuar las mismas funciones que los secretagogos peptídicos de la hormona de crecimiento. La invención comprende además las compocisiones que contienen dichos compuestos y su uso en la preparación de medicamentos, suplementos nutricionales, u otras formulaciones de uso humano o animal.
CU20060050A 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento CU23558A1 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CL2007000528A CL2007000528A1 (es) 2006-02-28 2007-02-27 Compuestos analogos a los secretagogos peptidicos de la hormona del crecimiento; composicion farmaceutica y veterinaria que los comprende; metodo para inducir cardioproteccion, neuroproteccion, control del apetito, y metodo para estimular el crecimiento y resistencia a enfermedades en organismos acuaticos.
ARP070100806A AR059646A1 (es) 2006-02-28 2007-02-27 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen
CN2007800153594A CN101432294B (zh) 2006-02-28 2007-02-28 类似于生长激素的肽性促分泌素的化合物以及包含其的制剂及用途
MX2008011142A MX2008011142A (es) 2006-02-28 2007-02-28 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen.
JP2008556643A JP5183496B2 (ja) 2006-02-28 2007-02-28 成長ホルモンのペプチド性分泌促進物質に類似した化合物及びそれを含有する製剤
EP07711101.1A EP1997827B1 (en) 2006-02-28 2007-02-28 Compounds analogous to growth hormone peptide secretagogues and preparations containing them
RU2008138569/10A RU2416618C2 (ru) 2006-02-28 2007-02-28 Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты
ES07711101.1T ES2441441T3 (es) 2006-02-28 2007-02-28 Compuestos análogos a secretagogos peptídicos de la hormona del crecimiento y preparaciones que los contienen
CA2637593A CA2637593C (en) 2006-02-28 2007-02-28 Compounds analogous to growth hormone peptide secretagogues and preparations containing them
AU2007219569A AU2007219569B2 (en) 2006-02-28 2007-02-28 Compounds analogous to growth hormone peptide secretagogues and preparations containing them
KR1020087023543A KR101409277B1 (ko) 2006-02-28 2007-02-28 펩티드 성장 호르몬 분비촉진제와 유사한 화합물 및 이를 포함하는 제형
BRPI0708366-1A BRPI0708366A2 (pt) 2006-02-28 2007-02-28 compostos quìmicos de natureza peptìdica, composição farmacêutica, composição veterinária e uso de compostos quìmicos
MYPI20083178A MY184130A (en) 2006-02-28 2007-02-28 Peptidic growth hormone secretagogues analog compounds and preparations thereof
US12/281,085 US8367620B2 (en) 2006-02-28 2007-02-28 Peptidic growth hormone secretagogues analog compounds and preparations thereof
PCT/CU2007/000007 WO2007098716A1 (es) 2006-02-28 2007-02-28 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen
ZA200807162A ZA200807162B (en) 2006-02-28 2008-08-19 Compounds analogous to growth hormone peptide secret-agogues and preparations containing them
NO20084118A NO20084118L (no) 2006-02-28 2008-09-29 Peptidisk veksthormonsekretutskillbare analoge forbindelser og fremstillinger derav
CL2016001648A CL2016001648A1 (es) 2006-02-28 2016-06-24 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento; composición farmacéutica y veterinaria que los comprende; método para inducir cardioprotección, neuroprotección, control del apetito, y método para estimular el crecimiento y resistencia a enfermedades en organismos acuáticos. (divisional de solicitud 2007-00528).

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Publications (1)

Publication Number Publication Date
CU23558A1 true CU23558A1 (es) 2010-07-20

Family

ID=40130780

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Country Status (18)

Country Link
US (1) US8367620B2 (es)
EP (1) EP1997827B1 (es)
JP (1) JP5183496B2 (es)
KR (1) KR101409277B1 (es)
CN (1) CN101432294B (es)
AR (1) AR059646A1 (es)
AU (1) AU2007219569B2 (es)
BR (1) BRPI0708366A2 (es)
CA (1) CA2637593C (es)
CL (2) CL2007000528A1 (es)
CU (1) CU23558A1 (es)
ES (1) ES2441441T3 (es)
MX (1) MX2008011142A (es)
MY (1) MY184130A (es)
NO (1) NO20084118L (es)
RU (1) RU2416618C2 (es)
WO (1) WO2007098716A1 (es)
ZA (1) ZA200807162B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052828A1 (ja) * 2008-11-06 2010-05-14 国立大学法人名古屋大学 非虚血性心筋障害に対する医薬
CU24473B1 (es) * 2016-11-01 2020-02-04 Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma Composición vacunal que comprende un péptido secretagogo de la hormona de crecimiento como adyuvante vacunal
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239345A (en) 1965-02-15 1966-03-08 Estrogenic compounds and animal growth promoters
US4411890A (en) 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4036979A (en) 1974-01-25 1977-07-19 American Cyanamid Company Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate
AU637316B2 (en) 1988-01-28 1993-05-27 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
DE68919213T2 (de) 1988-01-28 1995-05-11 Polygen Holding Corp Polypeptidverbindungen mit wachstumshormonfreisetzender aktivität.
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
WO1992007578A1 (en) 1990-10-25 1992-05-14 Genentech, Inc. Use of protective agents against reactive oxygen species
US5663146A (en) 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
CA2147503A1 (en) 1992-11-06 1994-05-26 Judith M. Pisano Substituted dipeptide analogs promote release of growth hormone
US5726319A (en) 1992-11-06 1998-03-10 Merck & Co., Inc. Biphenyl substituted dipeptide analogs promote release of growth hormone
US5578593A (en) 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
RO115804B1 (ro) 1992-12-11 2000-06-30 Merck & Co Inc Derivati de spiropiperidine, procedee de preparare si compozitii farmaceutice ale acestora
AU8083694A (en) 1993-10-19 1995-05-08 Merck & Co., Inc. Combination of bisphosphonates and growth hormone secretagogues
US5492916A (en) 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
CZ134296A3 (en) 1993-11-09 1996-12-11 Merck & Co Inc Piperidine, pyrrolidine and hexahydro-1h-azepine derivatives, process of their preparation and pharmaceutical compositions containing thereof
US5494919A (en) 1993-11-09 1996-02-27 Merck & Co., Inc. 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
EP0730578A4 (en) 1993-11-24 1997-10-08 Merck & Co Inc COMPOUNDS CONTAINING AN INDOLYL GROUP AND THEIR USE FOR PROMOTING THE RELEASE OF GROWTH HORMONES
US5721251A (en) 1993-12-10 1998-02-24 Merck & Co., Inc. Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
BR9408377A (pt) 1993-12-23 1997-08-19 Novo Nordisk As Composto composição farmacêutica processo para estimular a liberação de hormônio de crescimento da pituitária e uso do composto
US5721250A (en) 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
CN1052730C (zh) 1993-12-23 2000-05-24 诺沃挪第克公司 具有生长激素释放特性的化合物
US5777112A (en) 1994-06-13 1998-07-07 Merck & Co., Inc Piperazine compounds promote release of growth hormone
AU3128195A (en) 1994-07-20 1996-02-16 Merck & Co., Inc. Piperidines and hexahydro-1h-azepines spiro substituted at the 4-position promote release of growth hormone
US5798337A (en) 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
WO1996022996A1 (fr) 1995-01-25 1996-08-01 Nippon Chemiphar Co., Ltd. Derives de dihydrophenazine
DE69633003T2 (de) 1995-01-27 2005-08-18 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
WO1996024580A1 (en) 1995-02-09 1996-08-15 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4534696A (en) 1995-02-09 1996-08-27 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5559128A (en) 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
WO1996033189A1 (en) 1995-04-19 1996-10-24 Merck & Co., Inc. Process for the preparation of spiroindolines
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
DE69533991T2 (de) 1995-05-29 2006-04-13 Pfizer Inc. Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
KR19990028303A (ko) 1995-06-22 1999-04-15 한센 핀 베네드, 안네 제헤르 성장호르몬 방출 특성을 가지는 화합물
EP0761219A1 (en) 1995-08-21 1997-03-12 Eli Lilly And Company 2-Acylaminopropanamines as growth hormone secretagogues
AU6772996A (en) 1995-08-21 1997-03-12 Eli Lilly And Company 2-acylaminopropanamides as growth hormone secretagogues
EP0766966A3 (en) 1995-09-08 2001-02-28 Eli Lilly And Company Method of treating insulin resistance
WO1997011697A1 (en) 1995-09-26 1997-04-03 Merck & Co., Inc. 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
CZ128298A3 (cs) 1995-10-27 1998-07-15 Merck And Co., Inc. Způsob výroby N-/1(R)-/(1,2-dihydro-1-methansulfonylspiro/3H-indol-3,4´-piperdin/-1´-yl)karbonyl/-2-(fenylmethyloxy)-ethyl/-2-amino-2-methylpropanamidu
US5723616A (en) 1995-10-27 1998-03-03 Merck & Co., Inc. Process for the preparation of a growth hormone secretagogue
US5767124A (en) 1995-10-27 1998-06-16 Merck & Co., Inc. Polymorphic forms of a growth hormone secretagogue
JPH11513989A (ja) 1995-10-27 1999-11-30 メルク エンド カンパニー インコーポレーテッド 成長ホルモン分泌促進薬の湿式造粒製剤
WO1997022004A1 (en) 1995-12-13 1997-06-19 Merck & Co., Inc. Assays for growth hormone secretagogue receptors
CA2240427C (en) 1995-12-13 2007-08-14 Merck & Co., Inc. Growth hormone secretagogue receptor family
WO1997022367A1 (en) 1995-12-20 1997-06-26 Merck & Co., Inc. Radiolabeled growth hormone secretagogue
IT1277113B1 (it) 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
ATE424412T1 (de) 1995-12-22 2009-03-15 Novo Nordisk As Verbindungen mit wachstumshormon-freisetzenden eigenschaften
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
AU2334097A (en) 1996-03-21 1997-10-10 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
WO1997036873A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
SE9601397D0 (sv) 1996-04-12 1996-04-12 Pharmacia Ab Use of growth hormone
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
CN1127488C (zh) 1996-04-24 2003-11-12 诺沃挪第克公司 具有生长激素释放特性的化合物
US5919777A (en) 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1997041878A1 (en) 1996-05-07 1997-11-13 Merck & Co., Inc. Treatment of mood disorders with a growth hormone secretagogue
EP0900086A4 (en) 1996-05-07 2000-01-12 Merck & Co Inc IMPROVING THE SLEEP BY MEANS OF A SUBSTANCE PROMOTING THE SECRETION OF GROWTH HORMONES
EP0912551A1 (en) 1996-05-14 1999-05-06 Novo Nordisk A/S Somatostatin agonists and antagonists
WO1997044042A1 (en) 1996-05-22 1997-11-27 Arch Development Corporation Sleep quality improvement using a growth hormone secretagogue
AU3025997A (en) 1996-05-31 1998-01-05 Novo Nordisk A/S Growth hormone component and bone anti-resorptive agent in cyclic (coherence) treatment of osteoporosis
US5922770A (en) 1996-07-22 1999-07-13 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4342097A (en) 1996-09-13 1998-04-02 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
WO1998018815A1 (en) 1996-10-25 1998-05-07 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
SE9703929D0 (sv) 1996-11-22 1997-10-28 Pharmacia & Upjohn Ab Therapeutical use and method
WO1998046569A1 (fr) 1997-04-11 1998-10-22 Sumitomo Pharmaceuticals Co., Ltd. Derives de benzene
WO1998051687A1 (en) 1997-05-14 1998-11-19 Fujisawa Pharmaceutical Co., Ltd. Piperidino derivatives which promote growth hormone release
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
WO1998058950A1 (en) 1997-06-20 1998-12-30 Novo Nordisk A/S Compounds with growth hormone releasing properties
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
AU7445498A (en) 1997-06-25 1999-01-04 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
ZA987383B (en) 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
US6864250B1 (en) 1997-08-22 2005-03-08 Kaken Pharmaceutical Co., Ltd. N-acylated lipophilic amino acid derivatives
DE69921611T2 (de) 1998-01-16 2005-11-03 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
WO1999039730A1 (fr) 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Preparation a administration orale contenant des peptides favorisant la secretion d'hormone de croissance
CN1291994A (zh) 1998-03-03 2001-04-18 诺沃挪第克公司 新的(2e)-5-氨基-5-甲基已-2-烯酸n-甲基-n-((1r)-1-(n-甲基-n-(1r)-1-(甲基氨基甲酰基)-2-苯2基氨基甲酰基-2-(2-萘基)2基酰胺的盐
DK1077941T3 (da) 1998-05-11 2009-12-07 Novo Nordisk As Forbindelser med væksthormonfrigörende egenskaber
AU4256799A (en) 1998-06-09 1999-12-30 Novo Nordisk A/S A method for preparing a compound with growth hormone releasing properties
PA8475901A1 (es) 1998-06-16 2000-05-24 Pfizer Prod Inc Terapia de combinacion para la fragilidad musculoesqueletica
IL139587A0 (en) 1998-06-16 2002-02-10 Pfizer Prod Inc Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty
EP1100824B1 (en) 1998-06-30 2011-03-02 Novo Nordisk A/S Compounds with growth hormone releasing properties
DE69923692T2 (de) 1998-08-20 2006-03-23 Sumitomo Pharmaceuticals Co., Ltd. Wachstumshormon-freisetzende oxindolderivate
US6358951B1 (en) 1998-08-21 2002-03-19 Pfizer Inc. Growth hormone secretagogues
DE60022683D1 (de) 1999-12-28 2005-10-20 Kaken Pharma Co Ltd Nervenschutzmittel
US6967237B2 (en) 2000-05-30 2005-11-22 Merck & Co., Inc. Ghrelin analogs
EP1159964B1 (en) 2000-05-31 2009-10-28 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating gastrointestinal motility
DE60128494T2 (de) 2000-06-13 2008-01-17 Zentaris Gmbh Verbindungen zur Stimulation der Sekretion von Wachstumshormonen
WO2001097831A1 (fr) 2000-06-23 2001-12-27 Kaken Pharmaceutical Co., Ltd. Agents therapeutiques et prophylactiques destines a l'insuffisance cardiaque
ITMI20011445A1 (it) 2001-07-06 2003-01-06 Europ Geie Analoghi della cortistantina capaci di legarsi selettivamente ai recettori dei secretagoghi dell'ormone della crescita
HK1077740A1 (en) 2001-12-20 2006-02-24 Ct Ingenieria Genetica Biotech Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005039625A1 (en) 2003-10-28 2005-05-06 Rheoscience A/S Growth hormone secretagogue receptor agonists
MXPA06005038A (es) 2003-11-04 2007-12-12 Elixir Pharmaceuticals Inc Compuestos terapeuticos y usos de los mismos.
WO2005048916A2 (en) 2003-11-20 2005-06-02 Biovitrum Ab Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders

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NO20084118L (no) 2008-09-29
ZA200807162B (en) 2009-06-24
EP1997827A1 (en) 2008-12-03
CA2637593A1 (en) 2007-09-07
AU2007219569B2 (en) 2012-03-15
CL2016001648A1 (es) 2017-02-24
AR059646A1 (es) 2008-04-16
EP1997827B1 (en) 2013-10-09
MY184130A (en) 2021-03-19
WO2007098716A1 (es) 2007-09-07
KR20080110763A (ko) 2008-12-19
AU2007219569A1 (en) 2007-09-07
CN101432294B (zh) 2013-09-11
JP2009528303A (ja) 2009-08-06
CA2637593C (en) 2015-04-14
RU2416618C2 (ru) 2011-04-20
ES2441441T3 (es) 2014-02-04
KR101409277B1 (ko) 2014-06-24
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MX2008011142A (es) 2008-09-08
WO2007098716A8 (es) 2008-12-18
JP5183496B2 (ja) 2013-04-17
BRPI0708366A2 (pt) 2011-05-24
RU2008138569A (ru) 2010-04-10

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