IT1277113B1 - Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita - Google Patents

Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Info

Publication number
IT1277113B1
IT1277113B1 IT95MI002681A ITMI952681A IT1277113B1 IT 1277113 B1 IT1277113 B1 IT 1277113B1 IT 95MI002681 A IT95MI002681 A IT 95MI002681A IT MI952681 A ITMI952681 A IT MI952681A IT 1277113 B1 IT1277113 B1 IT 1277113B1
Authority
IT
Italy
Prior art keywords
mrp
release
growth hormone
hydrogen
alkyltryptophane
Prior art date
Application number
IT95MI002681A
Other languages
English (en)
Inventor
Romano Deghenghi
Original Assignee
Romano Deghenghi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romano Deghenghi filed Critical Romano Deghenghi
Publication of ITMI952681A0 publication Critical patent/ITMI952681A0/it
Priority to IT95MI002681A priority Critical patent/IT1277113B1/it
Priority to IL12450796A priority patent/IL124507A/xx
Priority to JP9522460A priority patent/JP2000502089A/ja
Priority to PT96942326T priority patent/PT868429E/pt
Priority to DE69624371T priority patent/DE69624371T2/de
Priority to EP96942326A priority patent/EP0868429B1/en
Priority to KR10-1998-0704587A priority patent/KR100369104B1/ko
Priority to BR9612146A priority patent/BR9612146A/pt
Priority to ES96942326T priority patent/ES2186810T3/es
Priority to RU98113920/04A priority patent/RU2182156C2/ru
Priority to AU11759/97A priority patent/AU1175997A/en
Priority to CA002239702A priority patent/CA2239702C/en
Priority to CN96199086A priority patent/CN1126759C/zh
Priority to PCT/EP1996/005393 priority patent/WO1997022620A1/en
Priority to DK96942326T priority patent/DK0868429T3/da
Priority to AT96942326T priority patent/ATE226214T1/de
Priority to ZA9610591A priority patent/ZA9610591B/xx
Publication of ITMI952681A1 publication Critical patent/ITMI952681A1/it
Application granted granted Critical
Publication of IT1277113B1 publication Critical patent/IT1277113B1/it
Priority to MX9804868A priority patent/MX9804868A/es
Priority to HK99101182A priority patent/HK1016193A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IT95MI002681A 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita IT1277113B1 (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT95MI002681A IT1277113B1 (it) 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
AU11759/97A AU1175997A (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CN96199086A CN1126759C (zh) 1995-12-20 1996-12-04 含d－2－烷基色氨酸、能促进生长激素释放的寡肽化合物
PT96942326T PT868429E (pt) 1995-12-20 1996-12-04 Compostos oligopeptidicos que contem d-2-alquiltriptofano susceptiveis de promover a libertacao da hormona do crescimento
DE69624371T DE69624371T2 (de) 1995-12-20 1996-12-04 D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern
EP96942326A EP0868429B1 (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
KR10-1998-0704587A KR100369104B1 (ko) 1995-12-20 1996-12-04 성장호르몬의유리를촉진하는2-알킬트립토판함유-올리고펩티드화합물
BR9612146A BR9612146A (pt) 1995-12-20 1996-12-04 Compsostos de oligopeptídeo contendo d-2alquiltriptofano capazes de promover a liberação de hormônio de crescimento
ES96942326T ES2186810T3 (es) 1995-12-20 1996-12-04 Compuestos oligopeptidicos que contienen aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona del crecimiento.
RU98113920/04A RU2182156C2 (ru) 1995-12-20 1996-12-04 Производные олигопептидов, содержащие d-алкилтриптофан и способные активировать высвобождение гормона роста
IL12450796A IL124507A (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CA002239702A CA2239702C (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
JP9522460A JP2000502089A (ja) 1995-12-20 1996-12-04 成長ホルモンの放出を促進できるｄ―２―アルキルトリプトファンを含有するオリゴペプチド化合物
PCT/EP1996/005393 WO1997022620A1 (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
DK96942326T DK0868429T3 (da) 1995-12-20 1996-12-04 Oligopeptidforbindelser indeholdende D-2-alkyltryptophan hvilke er i stand til at fremme frigivelsen af væksthormon
AT96942326T ATE226214T1 (de) 1995-12-20 1996-12-04 D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern
ZA9610591A ZA9610591B (en) 1995-12-20 1996-12-17 Oligopeptide compounds conaining d-2-alkyltryptophOligopeptide compounds containing D-2-alkyltryptopphan capable of promoting the release of growth hoan capable of promoting the release of growth hormone rmone
MX9804868A MX9804868A (es) 1995-12-20 1998-06-17 Compuestos oligopeptidicos que contienen d-2-alquiltriptofano capaz de promover la liberacion de hormona del crecimiento.
HK99101182A HK1016193A1 (en) 1995-12-20 1999-03-23 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002681A IT1277113B1 (it) 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Publications (3)

Publication Number Publication Date
ITMI952681A0 ITMI952681A0 (it) 1995-12-20
ITMI952681A1 ITMI952681A1 (it) 1997-06-20
IT1277113B1 true IT1277113B1 (it) 1997-11-04

Family

ID=11372755

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002681A IT1277113B1 (it) 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Country Status (19)

Country Link
EP (1) EP0868429B1 (it)
JP (1) JP2000502089A (it)
KR (1) KR100369104B1 (it)
CN (1) CN1126759C (it)
AT (1) ATE226214T1 (it)
AU (1) AU1175997A (it)
BR (1) BR9612146A (it)
CA (1) CA2239702C (it)
DE (1) DE69624371T2 (it)
DK (1) DK0868429T3 (it)
ES (1) ES2186810T3 (it)
HK (1) HK1016193A1 (it)
IL (1) IL124507A (it)
IT (1) IT1277113B1 (it)
MX (1) MX9804868A (it)
PT (1) PT868429E (it)
RU (1) RU2182156C2 (it)
WO (1) WO1997022620A1 (it)
ZA (1) ZA9610591B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL341707A1 (en) 1998-01-16 2001-04-23 Novo Nordisk As Compounds exibiting growth hormone releasing properties
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
CA2362290A1 (en) 1999-02-18 2000-08-24 Kaken Pharmaceutical Co., Ltd. Novel amide derivatives as growth hormone secretagogues
US6417397B1 (en) 1999-10-04 2002-07-09 The Regents Of The University Of California, San Diego N-substituted alkylamino acids for use as amino-protecting groups
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
ES2333097T3 (es) 2000-05-31 2010-02-17 Raqualia Pharma Inc Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
PL1756142T3 (pl) * 2004-04-28 2008-12-31 Mediolanum Farm S P A Pseudopeptydy pobudzające wydzielanie hormonu wzrostu
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CN101657436A (zh) 2007-02-09 2010-02-24 特兰齐姆制药公司 大环生长素释放肽受体调节剂及其使用方法
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
CN1121413C (zh) * 1994-09-27 2003-09-17 R·德根格希 含d－2－烷基色氨酸的能促进生长激素释放的多肽化合物

Also Published As

Publication number Publication date
ZA9610591B (en) 1997-06-24
PT868429E (pt) 2003-02-28
CA2239702C (en) 2007-08-07
BR9612146A (pt) 1999-07-13
KR100369104B1 (ko) 2003-06-12
CA2239702A1 (en) 1997-06-26
DE69624371D1 (de) 2002-11-21
ITMI952681A0 (it) 1995-12-20
JP2000502089A (ja) 2000-02-22
DK0868429T3 (da) 2003-02-10
IL124507A (en) 2001-03-19
AU1175997A (en) 1997-07-14
CN1204341A (zh) 1999-01-06
DE69624371T2 (de) 2003-06-18
EP0868429A1 (en) 1998-10-07
MX9804868A (es) 1998-10-31
WO1997022620A1 (en) 1997-06-26
ATE226214T1 (de) 2002-11-15
RU2182156C2 (ru) 2002-05-10
HK1016193A1 (en) 1999-10-29
IL124507A0 (en) 1998-12-06
CN1126759C (zh) 2003-11-05
EP0868429B1 (en) 2002-10-16
KR20000064444A (ko) 2000-11-06
ITMI952681A1 (it) 1997-06-20
ES2186810T3 (es) 2003-05-16

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