DE69624371T2 - D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern - Google Patents

D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern

Info

Publication number
DE69624371T2
DE69624371T2 DE69624371T DE69624371T DE69624371T2 DE 69624371 T2 DE69624371 T2 DE 69624371T2 DE 69624371 T DE69624371 T DE 69624371T DE 69624371 T DE69624371 T DE 69624371T DE 69624371 T2 DE69624371 T2 DE 69624371T2
Authority
DE
Germany
Prior art keywords
mrp
release
growth hormone
hydrogen
alkyltryptophane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624371T
Other languages
English (en)
Other versions
DE69624371D1 (de
Inventor
Dr Deghenghi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ardana Bioscience Ltd
Original Assignee
Ardana Bioscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardana Bioscience Ltd filed Critical Ardana Bioscience Ltd
Publication of DE69624371D1 publication Critical patent/DE69624371D1/de
Application granted granted Critical
Publication of DE69624371T2 publication Critical patent/DE69624371T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69624371T 1995-12-20 1996-12-04 D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern Expired - Fee Related DE69624371T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002681A IT1277113B1 (it) 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
PCT/EP1996/005393 WO1997022620A1 (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Publications (2)

Publication Number Publication Date
DE69624371D1 DE69624371D1 (de) 2002-11-21
DE69624371T2 true DE69624371T2 (de) 2003-06-18

Family

ID=11372755

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624371T Expired - Fee Related DE69624371T2 (de) 1995-12-20 1996-12-04 D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern

Country Status (19)

Country Link
EP (1) EP0868429B1 (de)
JP (1) JP2000502089A (de)
KR (1) KR100369104B1 (de)
CN (1) CN1126759C (de)
AT (1) ATE226214T1 (de)
AU (1) AU1175997A (de)
BR (1) BR9612146A (de)
CA (1) CA2239702C (de)
DE (1) DE69624371T2 (de)
DK (1) DK0868429T3 (de)
ES (1) ES2186810T3 (de)
HK (1) HK1016193A1 (de)
IL (1) IL124507A (de)
IT (1) IT1277113B1 (de)
MX (1) MX9804868A (de)
PT (1) PT868429E (de)
RU (1) RU2182156C2 (de)
WO (1) WO1997022620A1 (de)
ZA (1) ZA9610591B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69921611T2 (de) 1998-01-16 2005-11-03 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
KR100699404B1 (ko) 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 성장 호르몬 분비촉진제로서의 신규 아미드 유도체
US6417397B1 (en) * 1999-10-04 2002-07-09 The Regents Of The University Of California, San Diego N-substituted alkylamino acids for use as amino-protecting groups
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
EP1159964B1 (de) 2000-05-31 2009-10-28 Pfizer Products Inc. Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005105828A1 (en) * 2004-04-28 2005-11-10 Romano Deghenghi Pseudopeptides growth hormone secretagogues
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
BRPI0807046A2 (pt) 2007-02-09 2015-05-26 Tranzyme Pharma Inc Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit.
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
RU2157378C2 (ru) * 1994-09-27 2000-10-10 Дегенги Романо Полипептидные соединения, содержащие d-2-алкилтриптофан, стимулирующий высвобождение гормона роста

Also Published As

Publication number Publication date
DK0868429T3 (da) 2003-02-10
ITMI952681A0 (de) 1995-12-20
MX9804868A (es) 1998-10-31
DE69624371D1 (de) 2002-11-21
CN1204341A (zh) 1999-01-06
ATE226214T1 (de) 2002-11-15
IT1277113B1 (it) 1997-11-04
CA2239702A1 (en) 1997-06-26
ZA9610591B (en) 1997-06-24
EP0868429A1 (de) 1998-10-07
HK1016193A1 (en) 1999-10-29
AU1175997A (en) 1997-07-14
PT868429E (pt) 2003-02-28
JP2000502089A (ja) 2000-02-22
KR100369104B1 (ko) 2003-06-12
RU2182156C2 (ru) 2002-05-10
WO1997022620A1 (en) 1997-06-26
ITMI952681A1 (it) 1997-06-20
IL124507A0 (en) 1998-12-06
ES2186810T3 (es) 2003-05-16
CN1126759C (zh) 2003-11-05
EP0868429B1 (de) 2002-10-16
CA2239702C (en) 2007-08-07
BR9612146A (pt) 1999-07-13
IL124507A (en) 2001-03-19
KR20000064444A (ko) 2000-11-06

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee