HK1016193A1 - Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone - Google Patents

Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Info

Publication number
HK1016193A1
HK1016193A1 HK99101182A HK99101182A HK1016193A1 HK 1016193 A1 HK1016193 A1 HK 1016193A1 HK 99101182 A HK99101182 A HK 99101182A HK 99101182 A HK99101182 A HK 99101182A HK 1016193 A1 HK1016193 A1 HK 1016193A1
Authority
HK
Hong Kong
Prior art keywords
mrp
alkyltryptophan
promoting
release
growth hormone
Prior art date
Application number
HK99101182A
Other languages
English (en)
Inventor
Romano Deghenghi
Original Assignee
Ardana Bioscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardana Bioscience Ltd filed Critical Ardana Bioscience Ltd
Publication of HK1016193A1 publication Critical patent/HK1016193A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HK99101182A 1995-12-20 1999-03-23 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone HK1016193A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002681A IT1277113B1 (it) 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
PCT/EP1996/005393 WO1997022620A1 (en) 1995-12-20 1996-12-04 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Publications (1)

Publication Number Publication Date
HK1016193A1 true HK1016193A1 (en) 1999-10-29

Family

ID=11372755

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99101182A HK1016193A1 (en) 1995-12-20 1999-03-23 Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Country Status (19)

Country Link
EP (1) EP0868429B1 (de)
JP (1) JP2000502089A (de)
KR (1) KR100369104B1 (de)
CN (1) CN1126759C (de)
AT (1) ATE226214T1 (de)
AU (1) AU1175997A (de)
BR (1) BR9612146A (de)
CA (1) CA2239702C (de)
DE (1) DE69624371T2 (de)
DK (1) DK0868429T3 (de)
ES (1) ES2186810T3 (de)
HK (1) HK1016193A1 (de)
IL (1) IL124507A (de)
IT (1) IT1277113B1 (de)
MX (1) MX9804868A (de)
PT (1) PT868429E (de)
RU (1) RU2182156C2 (de)
WO (1) WO1997022620A1 (de)
ZA (1) ZA9610591B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1506969B1 (de) 1998-01-16 2010-06-09 Helsinn Therapeutics (U.S.), Inc. Verbindungen mit Wachstumshormon-freisetzender Eigenschaft
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
EP1158996A4 (de) 1999-02-18 2005-01-12 Kaken Pharma Co Ltd Neue amidderivate als wachstumshormonsekretionsförderer
US6417397B1 (en) * 1999-10-04 2002-07-09 The Regents Of The University Of California, San Diego N-substituted alkylamino acids for use as amino-protecting groups
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
ES2333097T3 (es) 2000-05-31 2010-02-17 Raqualia Pharma Inc Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
ATE399791T1 (de) * 2004-04-28 2008-07-15 Mediolanum Farmaceutici Srl Pseudopeptide, die die sekretion von wachstumshormon anregen
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
BRPI0807046A2 (pt) 2007-02-09 2015-05-26 Tranzyme Pharma Inc Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit.
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
CZ291798B6 (cs) * 1994-09-27 2003-05-14 Romano Deghenghi Peptidy, jejich použití a farmaceutický prostředek s jejich obsahem

Also Published As

Publication number Publication date
CN1204341A (zh) 1999-01-06
AU1175997A (en) 1997-07-14
CN1126759C (zh) 2003-11-05
IL124507A0 (en) 1998-12-06
MX9804868A (es) 1998-10-31
DE69624371T2 (de) 2003-06-18
ITMI952681A1 (it) 1997-06-20
BR9612146A (pt) 1999-07-13
KR20000064444A (ko) 2000-11-06
CA2239702C (en) 2007-08-07
ATE226214T1 (de) 2002-11-15
WO1997022620A1 (en) 1997-06-26
EP0868429B1 (de) 2002-10-16
EP0868429A1 (de) 1998-10-07
PT868429E (pt) 2003-02-28
RU2182156C2 (ru) 2002-05-10
ES2186810T3 (es) 2003-05-16
IT1277113B1 (it) 1997-11-04
ITMI952681A0 (de) 1995-12-20
DK0868429T3 (da) 2003-02-10
JP2000502089A (ja) 2000-02-22
KR100369104B1 (ko) 2003-06-12
DE69624371D1 (de) 2002-11-21
IL124507A (en) 2001-03-19
CA2239702A1 (en) 1997-06-26
ZA9610591B (en) 1997-06-24

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20081204