ES8302623A1 - "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxipropionico". - Google Patents

"procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxipropionico".

Info

Publication number
ES8302623A1
ES8302623A1 ES512387A ES512387A ES8302623A1 ES 8302623 A1 ES8302623 A1 ES 8302623A1 ES 512387 A ES512387 A ES 512387A ES 512387 A ES512387 A ES 512387A ES 8302623 A1 ES8302623 A1 ES 8302623A1
Authority
ES
Spain
Prior art keywords
antiinflammatory
analgesic activity
preparation
pharmaceutical compositions
novel compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512387A
Other languages
English (en)
Other versions
ES512387A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ausonia Farmaceutici SRL
Original Assignee
Ausonia Farmaceutici SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ausonia Farmaceutici SRL filed Critical Ausonia Farmaceutici SRL
Publication of ES512387A0 publication Critical patent/ES512387A0/es
Publication of ES8302623A1 publication Critical patent/ES8302623A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO (2'',4''-DIFLUORO-4-BIFENIL)-OXIPROPIONICO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES CON METALES O BASES ORGANICAS; COMPUESTO QUE TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA Y ANALGESICA. CONSISTE EN LA REACCION DE LA SAL SODICA DEL 4-(2'',4''-DIFLUOROFENIL)-FENOL CON BROMO-PROPIONATO DE ETILO, EN UN ALCOHOL INFERIOR, TAL COMO ETANOL, A LA TEMPERATURA DE REFLUJO; SEGUIDA DE LA HIDROLISIS DEL ESTER FORMADO CON UNA DISOLUCION ACUOSA DE UN HIDROXIDO ALCALINO; Y, FINALMENTE ACIDIFICACION DEL COMPUESTO OBTENIDO CON UN ACIDO MINERAL, TAL COMO ACIDO CLORHIDRICO.
ES512387A 1981-11-24 1982-05-20 "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxipropionico". Expired ES8302623A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8125243A IT1211135B (it) 1981-11-24 1981-11-24 Composti ad attivita'analgesica e antiinfiammatoria, processo per la loro preparazione e relative composizioni farmaceutiche.

Publications (2)

Publication Number Publication Date
ES512387A0 ES512387A0 (es) 1983-02-01
ES8302623A1 true ES8302623A1 (es) 1983-02-01

Family

ID=11216107

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512387A Expired ES8302623A1 (es) 1981-11-24 1982-05-20 "procedimiento para la preparacion del acido (2',4'-difluoro-4-bifenil)-oxipropionico".

Country Status (13)

Country Link
US (1) US4440787A (es)
EP (1) EP0080010B1 (es)
JP (1) JPS5892636A (es)
KR (1) KR830010038A (es)
AR (1) AR230422A1 (es)
AT (1) ATE14720T1 (es)
CA (1) CA1185617A (es)
DE (1) DE3265210D1 (es)
ES (1) ES8302623A1 (es)
GR (1) GR75481B (es)
IT (1) IT1211135B (es)
PT (1) PT74937A (es)
ZA (1) ZA823487B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2079997A1 (es) * 1993-06-15 1996-01-16 Lilly Co Eli Compuestos de fenil fenol sustituidos antagonistas de leucotrieno, procedimiento para su obtencion y formulaciones farmaceuticas de los mismos.

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83109A (en) * 1986-07-11 1992-06-21 Ciba Geigy Ag Guanidinium aspartates,their preparation and pharmaceutical compositions containing them
US4883818A (en) * 1987-11-17 1989-11-28 Analgesic Associates Onset-hastened/enhanced analgesia
US5286751A (en) * 1987-12-24 1994-02-15 Analgesic Associates Sustained/enhanced antipyretic response
US4927854A (en) * 1987-12-24 1990-05-22 Analgesic Associates Sustained/enhanced analgesia
CA2912747C (en) * 2013-06-27 2021-05-04 Lg Life Sciences Ltd. Biaryl derivatives as gpr120 agonists
AU2015367977B9 (en) * 2014-12-24 2020-02-06 Lg Chem, Ltd Biaryl derivative as GPR120 agonist

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
US3755603A (en) * 1970-07-01 1973-08-28 Syntex Corp Biphenylyloxyacetic acids in pharmaceutical compositions
US4021479A (en) * 1971-03-17 1977-05-03 Boehringer Ingelheim Gmbh Derivatives of 4-(4-biphenylyl)-butyric acid
US3948973A (en) * 1972-08-29 1976-04-06 Sterling Drug Inc. Halocyclopropyl substituted phenoxyalkanoic acids
GB1459084A (en) * 1973-05-24 1976-12-22 Boots Co Ltd Preparation of arylalkanoic acid
US4188491A (en) * 1975-04-04 1980-02-12 The Boots Company Limited Preparation of therapeutic compounds
US4151302A (en) * 1975-06-28 1979-04-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Araliphatic dihalogen compounds composition and method of use
US4189499A (en) * 1977-03-16 1980-02-19 Biochefarm S.A. Lysine 4-allyloxy-3-chlorophenylacetate and method of its preparation
US4225730A (en) * 1978-05-11 1980-09-30 Merck & Co., Inc. Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid
JPS5576840A (en) * 1978-12-01 1980-06-10 Kaken Pharmaceut Co Ltd New oxyacetic acid derivative, its preparation and blood- lipid depressor containing it as active principle
IT1141655B (it) * 1980-02-12 1986-10-08 Schiapparelli Spa Nuovi derivati dell'acido propanoico ad attivita' ipolipidemica e ipocolesterolemica

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2079997A1 (es) * 1993-06-15 1996-01-16 Lilly Co Eli Compuestos de fenil fenol sustituidos antagonistas de leucotrieno, procedimiento para su obtencion y formulaciones farmaceuticas de los mismos.

Also Published As

Publication number Publication date
CA1185617A (en) 1985-04-16
JPS5892636A (ja) 1983-06-02
GR75481B (es) 1984-07-23
IT8125243A0 (it) 1981-11-24
US4440787A (en) 1984-04-03
ES512387A0 (es) 1983-02-01
ZA823487B (en) 1983-04-27
AR230422A1 (es) 1984-04-30
JPS6124374B2 (es) 1986-06-10
PT74937A (en) 1982-06-01
EP0080010B1 (en) 1985-08-07
EP0080010A1 (en) 1983-06-01
IT1211135B (it) 1989-09-29
ATE14720T1 (de) 1985-08-15
DE3265210D1 (en) 1985-09-12
KR830010038A (ko) 1983-12-24

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