MX9702275A - Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento. - Google Patents

Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento.

Info

Publication number
MX9702275A
MX9702275A MX9702275A MX9702275A MX9702275A MX 9702275 A MX9702275 A MX 9702275A MX 9702275 A MX9702275 A MX 9702275A MX 9702275 A MX9702275 A MX 9702275A MX 9702275 A MX9702275 A MX 9702275A
Authority
MX
Mexico
Prior art keywords
phe
lys
alkyltryptophan
promoting
release
Prior art date
Application number
MX9702275A
Other languages
English (en)
Other versions
MXPA97002275A (es
Inventor
Romano Deghenghi
Original Assignee
Romano Deghenghi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI941954A external-priority patent/IT1270021B/it
Priority claimed from IT95MI001293A external-priority patent/IT1276734B1/it
Application filed by Romano Deghenghi filed Critical Romano Deghenghi
Publication of MXPA97002275A publication Critical patent/MXPA97002275A/es
Publication of MX9702275A publication Critical patent/MX9702275A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invencion se refiere a un péptido de la formula: A-D-Mrp(Ala)n-B-C, en donde A es cualquier L-aminoácido natural o su D-isomero, siempre y cuando A no sea His si B es Trp y C es D-Phe-Lys-NH2; o A es imidazolacetilo, isonipecotilo, 4-aminobutirilo, 4-(aminometil) ciclohexilcarbonilo, Glu-Try-Ala-His, Try-Ala-His, Try-His, D-Trys-His; D se refiere al isomero dextrogiro, Mrp es 2-alquiltriptofano; n es 0 o 1; B es L- o D-Trp, Php o D-Beta-naftilalanina, C es NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-LysNH2, Phe-LysNH2, D-Phe-Lys-ThrNH2, D-Phe-Lys-D-ThrNH2, OR, en donde R es un grupo alquilo de 1 a 3 átomos de carbono; y las sales de adiccion con ácidos orgánicos o inorgánicos farmacéuticamente aceptables de cualquiera de dichos polipéptidos, en donde estos compuestos son capaces de promover la liberacion de hormona del crecimiento y son activos por la vía oral.
MX9702275A 1994-09-27 1995-09-13 Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento. MX9702275A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
MIMI94A001954 1994-09-27
ITMI941954A IT1270021B (it) 1994-09-27 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"
IT95MI001293A IT1276734B1 (it) 1995-06-16 1995-06-16 Composti polipeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della
MIMI95A001293 1995-06-16
PCT/EP1995/003601 WO1996010040A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Publications (2)

Publication Number Publication Date
MXPA97002275A MXPA97002275A (es) 1997-06-01
MX9702275A true MX9702275A (es) 1997-06-28

Family

ID=26331189

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702275A MX9702275A (es) 1994-09-27 1995-09-13 Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento.

Country Status (21)

Country Link
US (1) US5795957A (es)
EP (1) EP0783521B8 (es)
JP (1) JP3810083B2 (es)
KR (1) KR100369105B1 (es)
CN (1) CN1121413C (es)
AT (1) ATE225806T1 (es)
AU (1) AU700066B2 (es)
CA (1) CA2201122A1 (es)
CZ (1) CZ291798B6 (es)
DE (1) DE69528531T2 (es)
DK (1) DK0783521T3 (es)
ES (1) ES2186730T3 (es)
HK (1) HK1001207A1 (es)
HU (1) HU221481B (es)
IL (1) IL115381A (es)
MX (1) MX9702275A (es)
PL (1) PL181588B1 (es)
PT (1) PT783521E (es)
RU (1) RU2157378C2 (es)
SK (1) SK284550B6 (es)
WO (1) WO1996010040A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en) 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
IT1277113B1 (it) * 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1999039730A1 (fr) * 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Preparation a administration orale contenant des peptides favorisant la secretion d'hormone de croissance
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
EP1781264B1 (en) 2004-08-04 2013-07-24 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1080470A (en) * 1963-12-31 1967-08-23 Merck & Co Inc Indole derivatives
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223021A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228158A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228155A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4224316A (en) * 1979-03-30 1980-09-23 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4226857A (en) * 1979-03-30 1980-10-07 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228157A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
US4410513A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
WO1983002272A1 (en) * 1981-12-28 1983-07-07 Beckman Instruments Inc Synthetic peptides having pituitary growth hormone releasing activity
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
DE68922602T2 (de) * 1988-01-28 1995-12-07 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
DE3915361A1 (de) * 1989-05-11 1990-11-15 Merck Patent Gmbh Cyclopeptide
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
EP0663834A4 (en) * 1992-09-25 1996-01-24 Smithkline Beecham Corp GROWTH HORMONE RELEASING PEPTIDES.

Also Published As

Publication number Publication date
AU700066B2 (en) 1998-12-17
WO1996010040A1 (en) 1996-04-04
KR970706305A (ko) 1997-11-03
DE69528531D1 (de) 2002-11-14
DE69528531T2 (de) 2003-06-05
EP0783521B1 (en) 2002-10-09
JPH10506114A (ja) 1998-06-16
AU3566895A (en) 1996-04-19
SK39997A3 (en) 1997-09-10
CZ291798B6 (cs) 2003-05-14
PL319382A1 (en) 1997-08-04
CN1121413C (zh) 2003-09-17
DK0783521T3 (da) 2003-01-27
EP0783521A1 (en) 1997-07-16
PL181588B1 (pl) 2001-08-31
HK1001207A1 (en) 1998-06-05
PT783521E (pt) 2003-02-28
CZ91497A3 (en) 1997-09-17
RU2157378C2 (ru) 2000-10-10
ATE225806T1 (de) 2002-10-15
EP0783521B8 (en) 2003-04-09
KR100369105B1 (ko) 2003-04-07
CN1158622A (zh) 1997-09-03
IL115381A0 (en) 1995-12-31
CA2201122A1 (en) 1996-04-04
IL115381A (en) 2000-07-16
HU221481B (en) 2002-10-28
JP3810083B2 (ja) 2006-08-16
ES2186730T3 (es) 2003-05-16
SK284550B6 (sk) 2005-06-02
US5795957A (en) 1998-08-18
HUT77525A (hu) 1998-05-28

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Legal Events

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