ATE225806T1 - D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet - Google Patents

D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet

Info

Publication number
ATE225806T1
ATE225806T1 AT95932735T AT95932735T ATE225806T1 AT E225806 T1 ATE225806 T1 AT E225806T1 AT 95932735 T AT95932735 T AT 95932735T AT 95932735 T AT95932735 T AT 95932735T AT E225806 T1 ATE225806 T1 AT E225806T1
Authority
AT
Austria
Prior art keywords
growth hormone
alkyltryptophane
hormone releasing
containing polypeptides
releasing activity
Prior art date
Application number
AT95932735T
Other languages
English (en)
Inventor
Bioscience Limited Ardana
Original Assignee
Bioscience Limited Ardana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI941954A external-priority patent/IT1270021B/it
Priority claimed from IT95MI001293A external-priority patent/IT1276734B1/it
Application filed by Bioscience Limited Ardana filed Critical Bioscience Limited Ardana
Application granted granted Critical
Publication of ATE225806T1 publication Critical patent/ATE225806T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95932735T 1994-09-27 1995-09-13 D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet ATE225806T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI941954A IT1270021B (it) 1994-09-27 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"
IT95MI001293A IT1276734B1 (it) 1995-06-16 1995-06-16 Composti polipeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della
PCT/EP1995/003601 WO1996010040A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Publications (1)

Publication Number Publication Date
ATE225806T1 true ATE225806T1 (de) 2002-10-15

Family

ID=26331189

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95932735T ATE225806T1 (de) 1994-09-27 1995-09-13 D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet

Country Status (20)

Country Link
US (1) US5795957A (de)
EP (1) EP0783521B8 (de)
JP (1) JP3810083B2 (de)
KR (1) KR100369105B1 (de)
CN (1) CN1121413C (de)
AT (1) ATE225806T1 (de)
AU (1) AU700066B2 (de)
CA (1) CA2201122A1 (de)
CZ (1) CZ291798B6 (de)
DE (1) DE69528531T2 (de)
DK (1) DK0783521T3 (de)
ES (1) ES2186730T3 (de)
HU (1) HU221481B (de)
IL (1) IL115381A (de)
MX (1) MX9702275A (de)
PL (1) PL181588B1 (de)
PT (1) PT783521E (de)
RU (1) RU2157378C2 (de)
SK (1) SK284550B6 (de)
WO (1) WO1996010040A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en) 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
IT1277113B1 (it) * 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1999039730A1 (en) * 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
ATE496940T1 (de) * 2002-07-23 2011-02-15 Ipsen Pharma Ghrelin-analoga
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
EP1781264B1 (de) 2004-08-04 2013-07-24 Evonik Corporation Verfahren zur herstellung von abgabevorrichtungen und damit erhaltene vorrichtungen
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
EP2222281B1 (de) 2007-12-20 2018-12-05 Evonik Corporation Verfahren zur herstellung von mikropartikeln mit geringer restlösemittelmenge
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1080470A (en) * 1963-12-31 1967-08-23 Merck & Co Inc Indole derivatives
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228155A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4224316A (en) * 1979-03-30 1980-09-23 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4226857A (en) * 1979-03-30 1980-10-07 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223021A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228157A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228158A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
SU1316565A3 (ru) * 1979-09-20 1987-06-07 Фармиталия Карло Эрба С.П.А. (Фирма) Способ получени пептидов
BR8208035A (pt) * 1981-12-28 1983-11-22 Beckman Instruments Inc Peptideos sinteticos tendo atividade liberadora de hormonio do crescimento da pituitaria
US4410513A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
SU1341970A1 (ru) * 1985-10-04 1990-03-23 Институт Органического Синтеза Ан Латвсср Аналог энкефалина, обладающий анальгетической активностью
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
DE68922602T2 (de) * 1988-01-28 1995-12-07 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
DE3915361A1 (de) * 1989-05-11 1990-11-15 Merck Patent Gmbh Cyclopeptide
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
WO1994007519A1 (en) * 1992-09-25 1994-04-14 Smithkline Beecham Corporation Growth hormone releasing peptides

Also Published As

Publication number Publication date
HU221481B (en) 2002-10-28
CN1121413C (zh) 2003-09-17
WO1996010040A1 (en) 1996-04-04
AU700066B2 (en) 1998-12-17
CZ291798B6 (cs) 2003-05-14
RU2157378C2 (ru) 2000-10-10
DK0783521T3 (da) 2003-01-27
KR970706305A (ko) 1997-11-03
CZ91497A3 (en) 1997-09-17
EP0783521B1 (de) 2002-10-09
MX9702275A (es) 1997-06-28
ES2186730T3 (es) 2003-05-16
US5795957A (en) 1998-08-18
JPH10506114A (ja) 1998-06-16
CA2201122A1 (en) 1996-04-04
JP3810083B2 (ja) 2006-08-16
PT783521E (pt) 2003-02-28
HUT77525A (hu) 1998-05-28
EP0783521B8 (de) 2003-04-09
IL115381A0 (en) 1995-12-31
AU3566895A (en) 1996-04-19
SK39997A3 (en) 1997-09-10
KR100369105B1 (ko) 2003-04-07
EP0783521A1 (de) 1997-07-16
CN1158622A (zh) 1997-09-03
HK1001207A1 (en) 1998-06-05
DE69528531D1 (de) 2002-11-14
DE69528531T2 (de) 2003-06-05
PL181588B1 (pl) 2001-08-31
SK284550B6 (sk) 2005-06-02
IL115381A (en) 2000-07-16
PL319382A1 (en) 1997-08-04

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