EP0644769A4 - Biologisch aktive peptide mit n-terminalen substitutionen. - Google Patents

Biologisch aktive peptide mit n-terminalen substitutionen.

Info

Publication number
EP0644769A4
EP0644769A4 EP93915173A EP93915173A EP0644769A4 EP 0644769 A4 EP0644769 A4 EP 0644769A4 EP 93915173 A EP93915173 A EP 93915173A EP 93915173 A EP93915173 A EP 93915173A EP 0644769 A4 EP0644769 A4 EP 0644769A4
Authority
EP
European Patent Office
Prior art keywords
biologically active
active peptides
terminal substitutions
substitutions
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP93915173A
Other languages
English (en)
French (fr)
Other versions
EP0644769A1 (de
Inventor
U Prasad Kari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Magainin Pharmaceuticals Inc
Original Assignee
Magainin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magainin Pharmaceuticals Inc filed Critical Magainin Pharmaceuticals Inc
Publication of EP0644769A1 publication Critical patent/EP0644769A1/de
Publication of EP0644769A4 publication Critical patent/EP0644769A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP93915173A 1992-06-01 1993-05-27 Biologisch aktive peptide mit n-terminalen substitutionen. Ceased EP0644769A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89120192A 1992-06-01 1992-06-01
US891201 1992-06-01
PCT/US1993/005192 WO1993024138A1 (en) 1992-06-01 1993-05-27 Biologically active peptides having n-terminal substitutions

Publications (2)

Publication Number Publication Date
EP0644769A1 EP0644769A1 (de) 1995-03-29
EP0644769A4 true EP0644769A4 (de) 1995-08-09

Family

ID=25397782

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93915173A Ceased EP0644769A4 (de) 1992-06-01 1993-05-27 Biologisch aktive peptide mit n-terminalen substitutionen.

Country Status (5)

Country Link
EP (1) EP0644769A4 (de)
JP (1) JPH08500818A (de)
AU (1) AU674525B2 (de)
CA (1) CA2137087A1 (de)
WO (1) WO1993024138A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348445B1 (en) 1992-06-01 2002-02-19 Magainin Pharmaceuticals, Inc. Biologically active peptides with reduced toxicity in animals and a method for preparing same
US5654274A (en) * 1992-06-01 1997-08-05 Magainin Pharmaceuticals, Inc. Biologically active peptides having N-terminal substitutions
US5593866A (en) * 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
AU693518B2 (en) * 1994-01-18 1998-07-02 Magainin Pharmaceuticals, Inc. Ion-channel forming amphiphilic peptides having n-terminal modifications
US5589364A (en) * 1994-07-29 1996-12-31 Magainin Pharmaceuticals Inc. Recombinant production of biologically active peptides and proteins
WO1996008270A2 (en) * 1994-09-13 1996-03-21 Magainin Pharmaceuticals Inc. Method for inhibiting sexually transmitted diseases using magaining antimicrobials or squalamine compounds
US6057291A (en) 1995-06-02 2000-05-02 University Of British Columbia Antimicrobial cationic peptides
ES2316154T3 (es) 1995-08-23 2009-04-01 University Of British Columbia Peptidos cationicos antimicrobianos y procedimientos de seleccion de los mismos.
JP2001510164A (ja) * 1997-07-15 2001-07-31 マガイニン ファーマシューティカルズ インコーポレイテッド 動物に対する毒性を減じた生物活性ペプチドおよび同ペプチドを調製する方法。
NL1008139C2 (nl) * 1998-01-27 1999-07-28 Stichting Tech Wetenschapp Antimicrobiële peptiden.
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
NL1010692C2 (nl) * 1998-12-01 2000-06-06 Stichting Tech Wetenschapp Antivirale peptiden.
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
EP2263684A1 (de) * 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 Derivate
US8475784B2 (en) 2006-10-26 2013-07-02 Novo Nordisk A/S IL-21 variants
DK2252627T3 (en) 2008-01-24 2017-08-14 Esperance Pharmaceuticals MERGER CONSTRUCTION WITH LYTIC DOMAIN AND METHOD FOR PRODUCING AND USING SAME.
BR112015009752A2 (pt) 2012-10-30 2017-07-11 Esperance Pharmaceuticals Inc conjugados de anticorpo/fármaco e métodos de uso

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001462A1 (en) * 1990-07-19 1992-02-06 The Scripps Research Institute Amphiphilic peptide compositions and analogues thereof
WO1992022317A1 (en) * 1991-06-12 1992-12-23 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides having c-terminal substitutions
WO1993005802A1 (en) * 1991-09-13 1993-04-01 Magainin Pharmaceuticals Inc. Biologically active amphiphilic peptide compositions and uses therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514464A4 (en) * 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
JPH06507402A (ja) * 1991-03-20 1994-08-25 ワーナー−ランバート・コンパニー 治療活性を有するα−置換ポリペプチド
WO1993000359A1 (en) * 1991-06-27 1993-01-07 The Du Pont Merck Pharmaceutical Company Modified peptides transportable into the central nervous system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001462A1 (en) * 1990-07-19 1992-02-06 The Scripps Research Institute Amphiphilic peptide compositions and analogues thereof
WO1992022317A1 (en) * 1991-06-12 1992-12-23 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides having c-terminal substitutions
WO1993005802A1 (en) * 1991-09-13 1993-04-01 Magainin Pharmaceuticals Inc. Biologically active amphiphilic peptide compositions and uses therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9324138A1 *

Also Published As

Publication number Publication date
AU4525893A (en) 1993-12-30
CA2137087A1 (en) 1993-12-09
AU674525B2 (en) 1997-01-02
JPH08500818A (ja) 1996-01-30
EP0644769A1 (de) 1995-03-29
WO1993024138A1 (en) 1993-12-09

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Legal Events

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