ES2147499A1 - Derivados de acidos carboxilicos, metodo para su elaboracion y agentes terapeuticos que contienen estos compuestos. - Google Patents

Derivados de acidos carboxilicos, metodo para su elaboracion y agentes terapeuticos que contienen estos compuestos.

Info

Publication number
ES2147499A1
ES2147499A1 ES009702245A ES9702245A ES2147499A1 ES 2147499 A1 ES2147499 A1 ES 2147499A1 ES 009702245 A ES009702245 A ES 009702245A ES 9702245 A ES9702245 A ES 9702245A ES 2147499 A1 ES2147499 A1 ES 2147499A1
Authority
ES
Spain
Prior art keywords
compounds
carboxylic acid
therapeutic agents
acid derivatives
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009702245A
Other languages
English (en)
Other versions
ES2147499B1 (es
Inventor
Tsuyoshi Tomiyama
Akira Tomiyama
Takashi Yanagisawa
Atsushi Noda
Yoshinori Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kotobuki Seiyaku Co Ltd
Original Assignee
Kotobuki Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kotobuki Seiyaku Co Ltd filed Critical Kotobuki Seiyaku Co Ltd
Publication of ES2147499A1 publication Critical patent/ES2147499A1/es
Application granted granted Critical
Publication of ES2147499B1 publication Critical patent/ES2147499B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/30—Azulenes; Hydrogenated azulenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Derivados de ácidos carboxílicos método para su elaboración y agentes terapéuticos que contienen estos compuestos. Los derivados están representados por sus siguientes sales: en donde R{sub,1 , R{sub,2 , R{sub,3 y A tienen los significados indicados en la memoria. El método se caracteriza porque se hace reaccionar un ácido- éster carboxílico (II) con una amina (III), seguido de la hidrólisis de la esteramida (IV) para dar la amida de ácido carboxílico (V); o bien la amida (V) se hace reaccionar con hidroxilamina, para dar amida de ácido hidroxámico (VI).
ES009702245A 1996-11-01 1997-10-29 Derivados de acidos carboxilicos, metodo para su elaboracion y agentes terapeuticos que contienen estos compuestos. Expired - Fee Related ES2147499B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8291737A JPH10130217A (ja) 1996-11-01 1996-11-01 カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物

Publications (2)

Publication Number Publication Date
ES2147499A1 true ES2147499A1 (es) 2000-09-01
ES2147499B1 ES2147499B1 (es) 2001-04-16

Family

ID=17772754

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009702245A Expired - Fee Related ES2147499B1 (es) 1996-11-01 1997-10-29 Derivados de acidos carboxilicos, metodo para su elaboracion y agentes terapeuticos que contienen estos compuestos.

Country Status (9)

Country Link
US (1) US5990158A (es)
JP (1) JPH10130217A (es)
KR (1) KR19980041978A (es)
BE (1) BE1014887A5 (es)
DE (1) DE19748040B4 (es)
ES (1) ES2147499B1 (es)
FR (1) FR2755438B1 (es)
GB (1) GB2318789B (es)
IT (1) IT1295936B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0887339A1 (de) * 1997-06-27 1998-12-30 Roche Diagnostics GmbH Neue Azulenderivate und diese enthaltende Arzneimittel
EP0922702A1 (de) * 1997-12-13 1999-06-16 Roche Diagnostics GmbH Neue Azulenderivate und diese enthaltende Arzneimittel
JP2001055327A (ja) * 1999-06-11 2001-02-27 Fuji Chemical Industries Ltd 新規なヒドロキサム酸誘導体を含む医薬
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
CN101353320A (zh) * 2007-07-24 2009-01-28 中国人民解放军军事医学科学院毒物药物研究所 基质金属蛋白酶抑制剂、含有它们的药物组合物及其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022966A1 (en) * 1994-02-25 1995-08-31 Sanofi Winthrop, Inc. Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR927003521A (ko) * 1990-12-03 1992-12-18 죤 에드워드 베리만 펩티딜(peptidyl) 유도체
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022966A1 (en) * 1994-02-25 1995-08-31 Sanofi Winthrop, Inc. Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
US5618844A (en) * 1994-02-25 1997-04-08 Sanofi S.A. Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRUCE E. TOMCZUK y col. HYDROXAMATE INHIBITORS OF THE MATRIX METALLO-PROTEINASES (MMPs) CONTAINING NOVEL P1' HETEROATOM BASED MODIFACATIONS. Bioorganic & Medicinal Chemistry Letters, 1995, Vol. 5, No 4, paginas 343-348. Tabla 1. *
MADHUSUDHAN R. GROWRAVARAM y col. Inhibition of Matrix Metalloproteinases by Hydroxamates Containing Heteroatom-Based Modifications of the P1' Group. J. Med. Chem. 1995. Vol. 38, No 14, 2570-2581. Pagina 2575, tabla 2, compuesto 14l. *

Also Published As

Publication number Publication date
JPH10130217A (ja) 1998-05-19
IT1295936B1 (it) 1999-05-28
FR2755438A1 (fr) 1998-05-07
FR2755438B1 (fr) 2004-08-20
BE1014887A5 (fr) 2004-06-01
DE19748040A1 (de) 1998-05-07
GB2318789B (en) 2001-03-21
ITMI972440A1 (it) 1999-04-30
GB2318789A (en) 1998-05-06
KR19980041978A (ko) 1998-08-17
GB9723192D0 (en) 1998-01-07
US5990158A (en) 1999-11-23
DE19748040B4 (de) 2005-12-29
ES2147499B1 (es) 2001-04-16

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