AU2722297A - Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone - Google Patents

Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone

Info

Publication number
AU2722297A
AU2722297A AU27222/97A AU2722297A AU2722297A AU 2722297 A AU2722297 A AU 2722297A AU 27222/97 A AU27222/97 A AU 27222/97A AU 2722297 A AU2722297 A AU 2722297A AU 2722297 A AU2722297 A AU 2722297A
Authority
AU
Australia
Prior art keywords
azepines
pyrrolidines
piperidines
hexahydro
growth hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU27222/97A
Inventor
Prasun K. Chakravarty
Meng H Chen
Ravi Nargund
Arthur A. Patchett
James R. Tata
Mu Tsu Wu
Lihu Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609664.9A external-priority patent/GB9609664D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2722297A publication Critical patent/AU2722297A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU27222/97A 1996-04-03 1997-03-31 Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone Abandoned AU2722297A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1479796P 1996-04-03 1996-04-03
US60014797 1996-04-03
GB9609664 1996-05-09
GBGB9609664.9A GB9609664D0 (en) 1996-05-09 1996-05-09 Piperidines pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
PCT/US1997/005378 WO1997036873A1 (en) 1996-04-03 1997-03-31 Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone

Publications (1)

Publication Number Publication Date
AU2722297A true AU2722297A (en) 1997-10-22

Family

ID=26309288

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27222/97A Abandoned AU2722297A (en) 1996-04-03 1997-03-31 Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone

Country Status (2)

Country Link
AU (1) AU2722297A (en)
WO (1) WO1997036873A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US6303620B1 (en) 1998-05-11 2001-10-16 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU757217B2 (en) * 1998-05-11 2003-02-06 Helsinn Healthcare Sa Compounds with growth hormone releasing properties
KR100699404B1 (en) 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 Novel Amide Derivatives as Growth Hormone Secretagogues
US6541634B2 (en) 1999-02-26 2003-04-01 Pfizer Inc. Process for preparing growth hormone secretagogues
ES2219368T3 (en) * 1999-07-13 2004-12-01 MERCK & CO., INC. AMIDOESPIROPIPERIDINAS THAT PROMOTE THE RELEASE OF THE HORMONE OF GROWTH.
EP1159964B1 (en) 2000-05-31 2009-10-28 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating gastrointestinal motility
EP1181933A3 (en) * 2000-06-29 2002-04-10 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating or increasing appetite
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005021502A1 (en) * 2003-08-29 2005-03-10 Takeda Pharmaceutical Company Limited METHOD FOR PRODUCING OPTICALLY ACTIVE THREO-β-ALKYLTRYPTOPHAN DERIVATIVE AND INTERMEDIATE THEREOF
EP1966130B1 (en) 2005-12-23 2013-12-11 Zealand Pharma A/S Modified lysine-mimetic compounds
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
US20080188545A1 (en) 2006-12-21 2008-08-07 Alimardanov Asaf R Synthesis of pyrrolidine compounds
BRPI0807046A2 (en) 2007-02-09 2015-05-26 Tranzyme Pharma Inc Compound, pharmaceutical composition, methods of treating a disorder, cardiovascular disease and a patient suffering from reduced or dysfunctional gastrointestinal motility and, kit.
WO2009068214A2 (en) * 2007-11-30 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituted piperidines
DE102009014484A1 (en) 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituted piperidines
DE102009022896A1 (en) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituted piperidines
DE102009022894A1 (en) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituted piperidines
JP6989864B2 (en) 2017-05-05 2022-02-03 ジーランド ファーマ，アー／エス Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease
CN114805305A (en) * 2022-04-20 2022-07-29 成都诺和晟泰生物科技有限公司 Compound and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5438136A (en) * 1993-11-02 1995-08-01 Merck & Co., Inc. Benzo-fused macrocycles promote release of growth hormone
US5494919A (en) * 1993-11-09 1996-02-27 Merck & Co., Inc. 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone

Also Published As

Publication number Publication date
WO1997036873A1 (en) 1997-10-09

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