ZA973301B - Piperidines and pyrrolidines. - Google Patents

Piperidines and pyrrolidines.

Info

Publication number
ZA973301B
ZA973301B ZA9703301A ZA973301A ZA973301B ZA 973301 B ZA973301 B ZA 973301B ZA 9703301 A ZA9703301 A ZA 9703301A ZA 973301 A ZA973301 A ZA 973301A ZA 973301 B ZA973301 B ZA 973301B
Authority
ZA
South Africa
Prior art keywords
pyrrolidines
piperidines
Prior art date
Application number
ZA9703301A
Inventor
Joachim Maerz
Ralf Devant
Gerd Bartoszyk
Christoph Seyfried
Lars Olov Hansson
Nils Peter Stjernloef
Henning Boettcher
Hartmut Greiner
Juergen Harting
Bengt Ronny Andersson
Clas Ake Sonesson
Original Assignee
Merck Pateng Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Pateng Gmbh filed Critical Merck Pateng Gmbh
Publication of ZA973301B publication Critical patent/ZA973301B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
ZA9703301A 1996-04-18 1997-04-17 Piperidines and pyrrolidines. ZA973301B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19615232A DE19615232A1 (en) 1996-04-18 1996-04-18 New carbamoyl derivatives and their use as 5-HT ¶1¶¶A¶ antagonists

Publications (1)

Publication Number Publication Date
ZA973301B true ZA973301B (en) 1997-10-24

Family

ID=7791576

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9703301A ZA973301B (en) 1996-04-18 1997-04-17 Piperidines and pyrrolidines.

Country Status (15)

Country Link
EP (1) EP0898569A1 (en)
JP (1) JP2000508670A (en)
KR (1) KR20000005505A (en)
AR (1) AR006690A1 (en)
AU (1) AU2696797A (en)
BR (1) BR9708677A (en)
CA (1) CA2252385A1 (en)
CZ (1) CZ330598A3 (en)
DE (1) DE19615232A1 (en)
HU (1) HUP9901389A3 (en)
NO (1) NO984861D0 (en)
PL (1) PL329351A1 (en)
SK (1) SK141998A3 (en)
WO (1) WO1997040038A1 (en)
ZA (1) ZA973301B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756036A1 (en) 1997-12-17 1999-06-24 Merck Patent Gmbh New indole amide derivatives
EP1068199B1 (en) * 1998-04-08 2002-11-13 Wyeth N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
CN1307576A (en) * 1998-04-29 2001-08-08 美国家用产品公司 Serotongergic agents
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
BR9911280A (en) * 1998-06-15 2001-03-13 American Home Prod Aryl piperazines, piperidines and tetrahydro pyridines substituted with an alkyl cycle as serotonergic agents
US6239126B1 (en) 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
EP1140831A1 (en) * 1998-12-17 2001-10-10 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1a receptor activity
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
JP2002532471A (en) * 1998-12-17 2002-10-02 アメリカン・ホーム・プロダクツ・コーポレイション Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives having 5-HT1A receptor activity
AU771234B2 (en) * 1999-01-28 2004-03-18 Bristol-Myers Squibb Company Antidepressant heterocyclic compounds
WO2002051987A1 (en) * 2000-12-27 2002-07-04 Axiogenesis Ag System for the cell-specific and development-specific selection of differentiating embryonic stem cells, adult stem cells and embryonic germline cells
KR100459917B1 (en) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
DE10337184A1 (en) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituted 3-pyrrolidine-indole derivatives
UY36390A (en) 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN107205970A (en) 2014-11-05 2017-09-26 弗莱塞斯生物科学公司 Immunomodulator
AU2023211068A1 (en) 2022-01-29 2024-08-15 Suven Life Sciences Limited Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226392A (en) * 1960-03-07 1965-12-28 Sterling Drug Inc 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts
US3635982A (en) * 1969-04-08 1972-01-18 American Home Prod Amino-substituted-quinoxalinyloxazolidines and -oxazines
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
FR2706894A1 (en) * 1993-06-22 1994-12-30 Synthelabo N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
KR20000005505A (en) 2000-01-25
JP2000508670A (en) 2000-07-11
HUP9901389A2 (en) 1999-08-30
NO984861L (en) 1998-10-16
AU2696797A (en) 1997-11-12
WO1997040038A1 (en) 1997-10-30
DE19615232A1 (en) 1997-10-23
SK141998A3 (en) 1999-03-12
NO984861D0 (en) 1998-10-16
HUP9901389A3 (en) 2000-09-28
EP0898569A1 (en) 1999-03-03
PL329351A1 (en) 1999-03-29
CZ330598A3 (en) 1999-01-13
CA2252385A1 (en) 1997-10-30
AR006690A1 (en) 1999-09-08
BR9708677A (en) 1999-08-03

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