NO984861L - Piperidines and pyrrolidines - Google Patents

Piperidines and pyrrolidines

Info

Publication number
NO984861L
NO984861L NO984861A NO984861A NO984861L NO 984861 L NO984861 L NO 984861L NO 984861 A NO984861 A NO 984861A NO 984861 A NO984861 A NO 984861A NO 984861 L NO984861 L NO 984861L
Authority
NO
Norway
Prior art keywords
compounds
formula
pyrrolidines
piperidines
novel
Prior art date
Application number
NO984861A
Other languages
Norwegian (no)
Other versions
NO984861D0 (en
Inventor
Joachim Morz
Ttcher Henning B
Ralf Devant
Hartmut Greiner
Gerd Bartoszyk
J Rgen Harting
Christoph Seyfried
Bengt Ronny Andersson
Lars Olov Hansson
Clas Ke Sonesson
F Nils Peter Stjernl
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO984861D0 publication Critical patent/NO984861D0/en
Publication of NO984861L publication Critical patent/NO984861L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Oppfinnelsen vedrører nye piperidin- og pyrrolidinderivater med formel (I). hvor,,, k, 1, m og n har betyd-ningene angitt i krav 1, og deres sal-ter, nye mellomprodukter og fremgangs-måter for fremstilling av forbindelsene ifølge oppfinnelsen. Forbindelsene med formel (I) virker som 5-HT-reseptor-antagonister og utviser 5-HT-gjenopp-taksinhiberende virkninger, og kan an-vendes til fremstillingen av medika-menter .The invention relates to novel piperidine and pyrrolidine derivatives of formula (I). wherein k, 1, m and n have the meanings given in claim 1, and their salts, novel intermediates and methods of preparation of the compounds of the invention. The compounds of formula (I) act as 5-HT receptor antagonists and exhibit 5-HT reuptake inhibitory effects, and can be used in the manufacture of medicaments.

NO984861A 1996-04-18 1998-10-16 Piperidines and pyrrolidines NO984861L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19615232A DE19615232A1 (en) 1996-04-18 1996-04-18 New carbamoyl derivatives and their use as 5-HT ¶1¶¶A¶ antagonists
PCT/EP1997/001853 WO1997040038A1 (en) 1996-04-18 1997-04-14 Piperidines and pyrrolidines

Publications (2)

Publication Number Publication Date
NO984861D0 NO984861D0 (en) 1998-10-16
NO984861L true NO984861L (en) 1998-10-16

Family

ID=7791576

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984861A NO984861L (en) 1996-04-18 1998-10-16 Piperidines and pyrrolidines

Country Status (15)

Country Link
EP (1) EP0898569A1 (en)
JP (1) JP2000508670A (en)
KR (1) KR20000005505A (en)
AR (1) AR006690A1 (en)
AU (1) AU2696797A (en)
BR (1) BR9708677A (en)
CA (1) CA2252385A1 (en)
CZ (1) CZ330598A3 (en)
DE (1) DE19615232A1 (en)
HU (1) HUP9901389A3 (en)
NO (1) NO984861L (en)
PL (1) PL329351A1 (en)
SK (1) SK141998A3 (en)
WO (1) WO1997040038A1 (en)
ZA (1) ZA973301B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756036A1 (en) * 1997-12-17 1999-06-24 Merck Patent Gmbh New indole amide derivatives
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
WO1999051591A2 (en) * 1998-04-08 1999-10-14 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression
WO1999055697A1 (en) * 1998-04-29 1999-11-04 American Home Products Corporation Serotonergic agents
BR9911280A (en) * 1998-06-15 2001-03-13 American Home Prod Aryl piperazines, piperidines and tetrahydro pyridines substituted with an alkyl cycle as serotonergic agents
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
AU3123500A (en) * 1998-12-17 2000-07-03 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1areceptor activity
DE69925160T2 (en) * 1998-12-17 2006-02-16 Wyeth ARYLPIPERIDINE AND ARYL 1,2,5,6-TETRAHYDROPYRIDINAMIDE DERIVATIVES WITH 5HT1A RECEPTOR ACTIVITY
US6239126B1 (en) 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
CA2360683A1 (en) * 1999-01-28 2000-08-03 Joseph P. Yevich Antidepressant heterocyclic compounds
JP4159358B2 (en) * 2000-12-27 2008-10-01 アクシオジェネシス アーゲー A system for cell-specific and growth-specific selection of differentiating embryonic stem cells, adult stem cells and embryonic germline cells
KR100459917B1 (en) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
DE10337184A1 (en) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituted 3-pyrrolidine-indole derivatives
UY36390A (en) * 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2964276A1 (en) 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents
MX2024009077A (en) 2022-01-29 2024-09-30 Suven Life Sciences Ltd Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226392A (en) * 1960-03-07 1965-12-28 Sterling Drug Inc 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
IL101722A (en) * 1991-05-02 1996-05-14 Wyeth John & Brother Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
FR2706894A1 (en) * 1993-06-22 1994-12-30 Synthelabo N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
DE19615232A1 (en) 1997-10-23
SK141998A3 (en) 1999-03-12
KR20000005505A (en) 2000-01-25
WO1997040038A1 (en) 1997-10-30
JP2000508670A (en) 2000-07-11
NO984861D0 (en) 1998-10-16
AU2696797A (en) 1997-11-12
HUP9901389A2 (en) 1999-08-30
ZA973301B (en) 1997-10-24
CZ330598A3 (en) 1999-01-13
HUP9901389A3 (en) 2000-09-28
EP0898569A1 (en) 1999-03-03
CA2252385A1 (en) 1997-10-30
PL329351A1 (en) 1999-03-29
BR9708677A (en) 1999-08-03
AR006690A1 (en) 1999-09-08

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