BRPI0514409A - redobra de proteìnas da famìlia de fator de crescimento transformante beta - Google Patents

redobra de proteìnas da famìlia de fator de crescimento transformante beta

Info

Publication number
BRPI0514409A
BRPI0514409A BRPI0514409-4A BRPI0514409A BRPI0514409A BR PI0514409 A BRPI0514409 A BR PI0514409A BR PI0514409 A BRPI0514409 A BR PI0514409A BR PI0514409 A BRPI0514409 A BR PI0514409A
Authority
BR
Brazil
Prior art keywords
growth factor
transforming growth
factor beta
beta family
refolding proteins
Prior art date
Application number
BRPI0514409-4A
Other languages
English (en)
Inventor
Anthony Rossomando
Banjian Gong
R Blake Pepinsky
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of BRPI0514409A publication Critical patent/BRPI0514409A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

REDOBRA DE PROTEìNAS DA FAMìLIA DE FATOR DE CRESCIMENTO TRANSFORMANTE BETA. A presente invenção refere-se a composições e métodos para dobra de proteínas pertencentes à superfamília de fator de crescimento transformante beta que são descritas. As composições e métodos permitem a dobra de tais proteínas quando produzidas em um sistema de expressão que não produziu um produto biologicamente ativo, apropriadamente dobrado.
BRPI0514409-4A 2004-08-19 2005-08-18 redobra de proteìnas da famìlia de fator de crescimento transformante beta BRPI0514409A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60282504P 2004-08-19 2004-08-19
PCT/US2005/029638 WO2006023782A2 (en) 2004-08-19 2005-08-18 Refolding transforming growth factor beta family proteins

Publications (1)

Publication Number Publication Date
BRPI0514409A true BRPI0514409A (pt) 2008-06-10

Family

ID=35968236

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514409-4A BRPI0514409A (pt) 2004-08-19 2005-08-18 redobra de proteìnas da famìlia de fator de crescimento transformante beta

Country Status (16)

Country Link
US (2) US8722862B2 (pt)
EP (1) EP1784203B1 (pt)
JP (1) JP4959566B2 (pt)
KR (1) KR101241551B1 (pt)
CN (2) CN101043899B (pt)
AT (1) ATE472333T1 (pt)
AU (1) AU2005277227B2 (pt)
BR (1) BRPI0514409A (pt)
CA (1) CA2577690C (pt)
DE (1) DE602005022082D1 (pt)
ES (1) ES2349043T3 (pt)
HK (1) HK1103988A1 (pt)
IL (1) IL181312A (pt)
IS (1) IS8609A (pt)
NZ (1) NZ553420A (pt)
WO (1) WO2006023782A2 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2328446T5 (es) 2000-02-04 2014-02-27 Children's Hospital Research Foundation Uso de lipasa ácida lisosomal para tratar la aterosclerosis y enfermedades asociadas
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
EP1618179B1 (en) 2003-04-18 2014-05-07 Biogen Idec MA Inc. Polymer-conjugated glycosylated neublastin
CN101043899B (zh) 2004-08-19 2011-03-30 比奥根艾迪克Ma公司 重折叠转化型生长因子beta家族蛋白
MX2007002029A (es) * 2004-08-19 2007-03-28 Biogen Idec Inc Variantes de neublastina.
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
GB0604964D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
JP5274795B2 (ja) * 2006-07-27 2013-08-28 三洋化成工業株式会社 タンパク質のリフォールディング方法
JP5452022B2 (ja) * 2006-12-11 2014-03-26 独立行政法人科学技術振興機構 植物生長調整剤及びその利用
TWI445544B (zh) * 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
JP2010132649A (ja) * 2008-10-28 2010-06-17 Sanyo Chem Ind Ltd タンパク質のリフォールディング剤及びタンパク質の製造方法
EP2445924B2 (en) 2009-06-25 2023-12-13 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
CA2995446C (en) 2010-04-23 2020-05-12 Synageva Biopharma Corp Lysosomal storage disease enzyme
CA3209456A1 (en) 2010-09-09 2012-04-19 Alexion Pharmaceuticals, Inc. Use of lysosomal acid lipase for treating lysosomal acid lipase deficiency in patients
KR20140006037A (ko) 2011-02-15 2014-01-15 시나게바 바이오파르마, 코포레이션 리소좀의 산 리파제 결핍을 치료하는 방법들
US9930887B2 (en) 2011-12-12 2018-04-03 Okayama Prefecture Compound for increasing amino acid content in plant, and use thereof
US9556427B2 (en) * 2013-02-27 2017-01-31 Syngenta Participations Ag Methods and compositions for preparation of nucleic acids
WO2015042580A1 (en) 2013-09-23 2015-03-26 Biogen Idec Ma Inc. Compositions and methods for treatment of neuropathic pain
WO2016022800A1 (en) 2014-08-07 2016-02-11 Biogen Ma Inc. Characterization of cystine knot superfamily proteins
AU2017228489A1 (en) * 2016-03-04 2018-09-06 Ngm Biopharmaceuticals, Inc. Compositions and methods for modulating body weight
US20220340630A1 (en) * 2019-09-13 2022-10-27 National Science And Technology Development Agency Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof
CN116874555B (zh) * 2023-09-08 2023-11-28 成都华任康生物科技有限公司 一种置换液及其试剂盒和相关应用

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4407957A (en) * 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
US5525464A (en) * 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US4883666A (en) * 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
DE3829752A1 (de) * 1988-09-01 1990-03-22 Akzo Gmbh Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration
DE3829766A1 (de) * 1988-09-01 1990-03-22 Akzo Gmbh Verfahren zur herstellung von membranen
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
ES2107537T3 (es) * 1991-04-25 1997-12-01 Univ Brown Res Found Vehiculo inmunoaislante biocompatible implantable para suministrar productos terapeuticos seleccionados.
ATE359842T1 (de) * 1991-07-02 2007-05-15 Nektar Therapeutics Abgabevorrichtung für nebelförmige medikamente
EP0610254B1 (en) 1991-09-20 2004-09-01 Amgen Inc. Glial derived neurotrophic factor
US5939524A (en) * 1991-12-09 1999-08-17 The Scripps Research Institute Platelet GPIII P1A1 and P1A2 epitopes, their preparation and use
US5414135A (en) * 1991-12-30 1995-05-09 Sterling Winthrop Inc. Vinyl sulfone coupling of polyoxyalkylenes to proteins
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
PT679088E (pt) * 1992-09-29 2002-12-31 Inhale Therapeutic Syst Administracao pulmonar de fragmentos activos de hormona paratiroide
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors
US6472178B1 (en) 1998-02-27 2002-10-29 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
CA2092271C (en) * 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
ATE218893T1 (de) 1993-08-12 2002-06-15 Neurotech Sa Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten
DE4339605A1 (de) * 1993-11-20 1995-05-24 Beiersdorf Ag Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Fettsäurepartialglyceriden
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US5739307A (en) 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US5733729A (en) * 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
AU1121997A (en) 1995-11-29 1997-06-19 Amgen, Inc. Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US6063757A (en) * 1995-11-29 2000-05-16 Urso; Richard G. Wound treatment method with nerve growth factor
EP0943690B1 (en) * 1995-12-21 2006-11-29 Ajinomoto Co., Inc. Method for refolding human activin a
US6299895B1 (en) * 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US6878544B2 (en) 1996-04-19 2005-04-12 Neurotech Sa Retinal cell lines with extended life-span and their applications
US6677135B1 (en) * 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
US5754524A (en) * 1996-08-30 1998-05-19 Wark; Barry J. Computerized method and system for analysis of an electrophoresis gel test
US6083725A (en) * 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
JP2001501093A (ja) * 1996-09-26 2001-01-30 メディカル リサーチ カウンシル シャペロン断片
KR100195886B1 (ko) * 1996-11-01 1999-06-15 김상조 당뇨병 치료용 의약조성물
WO1998032869A1 (en) 1997-01-29 1998-07-30 Neurosearch A/S Expression vectors and methods for in vivo expression of therapeutic polypeptides
BR9812267B1 (pt) 1997-07-14 2013-11-26 Hormônio de crescimento recombinante.
GB9718908D0 (en) 1997-09-05 1997-11-12 Rowett Research Services Limit Proteins
US20020192209A1 (en) 1997-09-17 2002-12-19 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US6653098B1 (en) 1998-02-23 2003-11-25 G. D. Searle & Co. Method of producing mouse and human endostatin
ATE320489T1 (de) 1998-03-23 2006-04-15 Genentech Inc Gfr-alpha3 und seine verwendungen
US20020055467A1 (en) 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
BR9911908A (pt) * 1998-07-06 2001-03-27 Nsgene As ácido nucléico, sequência de ácido nucléico, processos de usar um ácido nucléico, de usar o vetor, de fabricar o polipeptìdeo, de administrar o polipeptìdeo, de tratar uma doença ou distúrbio neurodegenerativos em um animal, de determinar se uma doença ou distúrbio neurodegenerativos em um animal, de produzir qualquer um polipeptìdeo, processo para identificar, isolar ou amplificar uma sequência de ácido nucléico de neublastina, de diagnosticar ou avaliar quanto a presença de uma doença ou distúrbio ou uma predisposiçãopara desnvolvê-los, para avaliar um polipeptìdeo de neublastina purificado ou um derivado ou fragmento deste ou um modulador da atividade dos precedentes quanto a atividade em tratar ou prevenir uma doença, de tratar um distúbio neurológico, de usar a sequência de um ou mais ácidos nucléicos, e para identificar um composto candidato que induza um efeito biológico mediado pela neuroblastina, vetor, célula transformada com ácido nucléico, polipeptìdeo, cmposição, anticorpo, gene sintético, e, conjunto.
DE69933771T2 (de) 1998-07-14 2007-09-13 Janssen Pharmaceutica N.V. Neurotrophischer wachstumsfaktor
US7067473B1 (en) * 1998-07-14 2006-06-27 Janssen Pharmaceutica N.V. Neurotrophic growth factor
JP2002524104A (ja) * 1998-09-14 2002-08-06 ラース オースターガード ペダーセン 機能化免疫グロブリンスーパーファミリータンパク質を製造する方法
JP2003524381A (ja) * 1998-09-22 2003-08-19 ユニヴァーシティ オブ メリーランド，ボルチモア システインノット成長因子ミュータント
US6284540B1 (en) 1998-09-29 2001-09-04 Washington University Artemin, a novel neurotrophic factor
WO2000034475A2 (en) 1998-12-09 2000-06-15 Amgen Inc. Grnf4, a gdnf-related neurotrophic factor
DK1607402T3 (da) 1999-03-08 2007-04-16 Genentech Inc Sammensætninger og fremgangsmåder til tumorbehandling
US6361771B1 (en) * 1999-04-06 2002-03-26 Neurotech S.A. ARPE-19 as a platform cell line for encapsulated cell-based delivery
MXPA01010692A (es) 1999-04-22 2004-09-06 Univ Zuerich Matrices de proteina modificadas para ingenieria de tejidos o liberacion controlada.
ES2287020T3 (es) 1999-06-02 2007-12-16 Genentech, Inc. Procedimiento y composiciones para inhibir el crecimiento de celulas neoplasicas.
ATE238806T1 (de) * 1999-10-29 2003-05-15 Bioph Biotech Entw Pharm Gmbh Verwendung von gdnf für behandlung von hornhautdefekten
US6866851B1 (en) 1999-12-28 2005-03-15 Washington University GFRα1-RET specific agonists and methods therefor
AU2001289307A1 (en) 2000-04-06 2001-10-23 Pharmacia Corporation Chemically-modified myelopoietin conjugates
ATE367398T1 (de) 2000-05-16 2007-08-15 Bolder Biotechnology Inc Verfahren zur rückfaltung von proteinen mit freien cysteinresten
JP2001329126A (ja) 2000-05-22 2001-11-27 Bridgestone Corp 硬化性組成物
CA2327208A1 (en) * 2000-11-30 2002-05-30 The Government Of The United States Of America Methods of increasing distribution of therapeutic agents
IL140110A0 (en) 2000-12-05 2002-02-10 Applied Research Systems Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
MXPA03005721A (es) * 2000-12-22 2004-04-21 Genentech Inc Uso novedoso de artemina, un miembro de la familia de ligandos gdnf.
EE05537B1 (et) * 2001-02-01 2012-04-16 Biogen, Inc. Neublastiini polmeerkonjugaadid ja meetodid nende kasutamiseks
US7442370B2 (en) * 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US20040077543A1 (en) * 2001-03-28 2004-04-22 Sah Dinah W. Y. Treatment using neublastin polypeptides
ATE526982T1 (de) 2001-03-28 2011-10-15 Biogen Idec Inc Verwendung von neublastin-polypeptide zur behandlung von neuropathischen schmerzen
CA2445612C (en) * 2001-04-24 2011-10-25 Purdue Research Foundation Methods and compositions for treating mammalian nerve tissue injuries
US20030125521A1 (en) * 2001-06-20 2003-07-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US20040028613A1 (en) * 2001-06-25 2004-02-12 Nastech Pharmaceutical Company Inc Dopamine agonist formulations for enhanced central nervous system delivery
US7129085B2 (en) * 2001-10-11 2006-10-31 Bristol-Myers Squibb Company Polynucleotides encoding a human leucine-rich repeat domain containing protein, HLLRCR-1
EP1314739A1 (en) 2001-11-22 2003-05-28 Bayer Ag Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines
GB0205022D0 (en) * 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage
JP4310608B2 (ja) 2002-04-25 2009-08-12 東洋紡績株式会社 Ｈｓｐ７０ファミリータンパク質基質結合ドメインフラグメントの利用方法
DE10229175A1 (de) 2002-06-28 2004-01-15 Valeo Klimasysteme Gmbh Zylinderklappe mit strukturierter rauher Oberfläche
SI1594436T1 (sl) * 2003-01-31 2011-01-31 Biogen Idec Inc Mutirani neoblastin
EP1618179B1 (en) 2003-04-18 2014-05-07 Biogen Idec MA Inc. Polymer-conjugated glycosylated neublastin
EP1636260B1 (en) * 2003-06-10 2009-02-18 Nsgene A/S Improved secretion of neublastin
US7598059B2 (en) * 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
NZ547185A (en) 2003-10-20 2009-03-31 Nsgene As In vivo gene therapy of parkinson's disease
US20050180957A1 (en) * 2004-01-16 2005-08-18 Scharp David W. Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
KR100917403B1 (ko) * 2004-06-23 2009-09-14 티슈진, 인코포레이티드 신경 재생
US7598356B2 (en) * 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily
MX2007002029A (es) * 2004-08-19 2007-03-28 Biogen Idec Inc Variantes de neublastina.
CN101043899B (zh) 2004-08-19 2011-03-30 比奥根艾迪克Ma公司 重折叠转化型生长因子beta家族蛋白
US20060165667A1 (en) 2004-12-03 2006-07-27 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization
WO2007042040A2 (en) 2005-10-11 2007-04-19 Ns Gene A/S TREATMENT OF RETINOPATHIES USING GFRα3 AGONISTS
TWI501774B (zh) * 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
AU2007244826B2 (en) * 2006-04-25 2013-04-11 The Regents Of The University Of California Administration of growth factors for the treatment of CNS disorders
TWI445544B (zh) * 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
US20110135648A1 (en) 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof

Also Published As

Publication number Publication date
CN101123978A (zh) 2008-02-13
CA2577690A1 (en) 2006-03-02
CN101123978B (zh) 2012-12-12
US20140322752A1 (en) 2014-10-30
WO2006023782A3 (en) 2007-01-04
EP1784203B1 (en) 2010-06-30
KR101241551B1 (ko) 2013-03-11
EP1784203A2 (en) 2007-05-16
EP1784203A4 (en) 2008-08-20
IS8609A (is) 2007-02-14
CN101043899A (zh) 2007-09-26
JP2008510720A (ja) 2008-04-10
IL181312A0 (en) 2007-07-04
US8969042B2 (en) 2015-03-03
KR20070050965A (ko) 2007-05-16
US20080249287A1 (en) 2008-10-09
DE602005022082D1 (de) 2010-08-12
NZ553420A (en) 2010-02-26
CN101043899B (zh) 2011-03-30
AU2005277227A1 (en) 2006-03-02
HK1103988A1 (en) 2008-01-04
ES2349043T3 (es) 2010-12-22
WO2006023782A2 (en) 2006-03-02
ATE472333T1 (de) 2010-07-15
IL181312A (en) 2013-12-31
US8722862B2 (en) 2014-05-13
AU2005277227B2 (en) 2011-10-06
CA2577690C (en) 2013-08-06
JP4959566B2 (ja) 2012-06-27

Similar Documents

Publication Publication Date Title
BRPI0514409A (pt) redobra de proteìnas da famìlia de fator de crescimento transformante beta
CY1117735T1 (el) Σκευασμα αντισωματος
CY1116700T1 (el) Παρασκευη συνθετικου χολικου οξεος
CY1108077T1 (el) Αρυλο-υποκατεστημενες πολυκυκλικες αμινες, μεθοδος για την παρασκευη τους και η χρηση τους ως φαρμακων
IL172925A (en) Antibodies that bind to the insulin-like growth factor i receptor and their use in the preparation of pharmaceutical preparations
CY1110780T1 (el) Τοπικα σκευασματα νεπαφενακης
TNSN04199A1 (en) Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
EP3381445A3 (en) Aqueous formulation of antibody stablised by antioxidants for parenteral administration
MXPA06000921A (es) Derivados de benzamidazoles como inhibidores de mek.
GT200500363A (es) 3-amino-pirazol [3,4b] piridinas con inhibidores de proteintirosinquinasas, su preparacion y uso como medicamento.
RS115004A (en) Novel thiophenylglycoside derivatives,methods for production thereof, medicaments comprising said compounds and use thereof
EP2450360A3 (en) (S)-N-Methylnaltrexone
EA200900282A1 (ru) Применение полиолов для получения устойчивых полиморфных форм рифаксимина
WO2007021937A3 (en) Unsaturated heterocyclic derivatives
ECSP12012045A (es) Emulsiones nutricionales que comprenden beta-hidroxi-beta-metilbutirato (hmb)de calcio y proteína soluble
DE602007007322D1 (de) Neue imidazolderivate, ihre herstellung und ihre verwendung als medizin
DE602006006046D1 (de) Verwendung nativer peptide und deren optimierter derivate zur impfung
UY29036A1 (es) Derivados de oxopiperidina, su preparacion y su aplicacion en terapeutica
ATE459338T1 (de) Formulierungen für benzimidazolylpyridylether
WO2008089093A3 (en) Efficient processes for preparing steroids and vitamin d derivatives with the unnatural configuration at c20 (20 alpha-methyl) from pregnenolone
CY1115938T1 (el) Νεα συνθεση για αυξηση της bio-διαθεσιμοτητας της νεουρτουρινης (neurturin)
ATE452120T1 (de) Fettsäure-benzenediol-derivate sowie herstellungs-und verwendungsverfahren dafür
DE60327651D1 (de) Thio-analoga von paclitaxel und deren vorprodukte
ATE512968T1 (de) 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung
AR039186A1 (es) Celulas madre indiferenciadas programables de origen monocitaro, su obtencion y uso

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: REF. A RPI NO 2154 DE 17/04/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements