DE69923692D1 - Wachstumshormon-freisetzende oxindolderivate - Google Patents
Wachstumshormon-freisetzende oxindolderivateInfo
- Publication number
- DE69923692D1 DE69923692D1 DE69923692T DE69923692T DE69923692D1 DE 69923692 D1 DE69923692 D1 DE 69923692D1 DE 69923692 T DE69923692 T DE 69923692T DE 69923692 T DE69923692 T DE 69923692T DE 69923692 D1 DE69923692 D1 DE 69923692D1
- Authority
- DE
- Germany
- Prior art keywords
- optionally substituted
- growth hormone
- independently hydrogen
- hormone releasing
- alkyl etc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23464398 | 1998-08-20 | ||
| JP23464398 | 1998-08-20 | ||
| PCT/JP1999/004443 WO2000010975A1 (en) | 1998-08-20 | 1999-08-18 | Oxindole derivatives as growth hormone releasers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69923692D1 true DE69923692D1 (de) | 2005-03-17 |
| DE69923692T2 DE69923692T2 (de) | 2006-03-23 |
Family
ID=16974248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69923692T Expired - Lifetime DE69923692T2 (de) | 1998-08-20 | 1999-08-18 | Wachstumshormon-freisetzende oxindolderivate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6576656B1 (de) |
| EP (1) | EP1105376B1 (de) |
| JP (1) | JP4445133B2 (de) |
| KR (1) | KR100680085B1 (de) |
| CN (1) | CN1161333C (de) |
| AT (1) | ATE288895T1 (de) |
| AU (1) | AU5301199A (de) |
| CA (1) | CA2340701C (de) |
| DE (1) | DE69923692T2 (de) |
| ES (1) | ES2237135T3 (de) |
| WO (1) | WO2000010975A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2252230T3 (es) | 2000-05-11 | 2006-05-16 | Bristol-Myers Squibb Company | Analogos de tetrahidroisoquinolina utiles como secretores de la hormona del crecimiento. |
| WO2002060878A1 (en) * | 2001-01-30 | 2002-08-08 | Sumitomo Pharmaceuticals Co., Ltd. | Benzimidazolidinone derivatives |
| AU2002357692A1 (en) | 2001-11-09 | 2003-05-26 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
| SE0104340D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| SE0104341D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
| TW200301123A (en) * | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
| ES2289171T3 (es) | 2001-12-21 | 2008-02-01 | Astrazeneca Ab | Uso de derivados de oxindol en el tratamiento de trastornos relacionados con la demencia, de la enfermedad de alzheimer y afecciones asociadas con glucogeno sintasa quinasa-3. |
| SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| CN100340557C (zh) * | 2002-10-24 | 2007-10-03 | 辉瑞产品公司 | 具有神经镇静活性的齐拉西酮的酰基衍生物 |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| US6912165B2 (en) * | 2003-08-22 | 2005-06-28 | International Business Machines Corporation | Method for transparent updates of output driver impedance |
| WO2005035498A1 (ja) * | 2003-10-08 | 2005-04-21 | Dainippon Sumitomo Pharma Co., Ltd. | 含窒素二環性化合物の摂食調節剤としての用途 |
| AU2005277389A1 (en) | 2004-08-18 | 2006-03-02 | Elixir Pharmaceuticals, Inc. | Growth-hormone secretagogues |
| EP1935883A4 (de) | 2005-09-14 | 2010-07-21 | Dainippon Sumitomo Pharma Co | Oxindolderivate als mittel zur steuerung der nahrungsaufnahme |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| EP2118080B1 (de) | 2007-02-09 | 2016-08-31 | Ocera Therapeutics, Inc. | Makrocyclische ghrelin-rezeptormodulatoren und verwendungsverfahren dafür |
| FR2920023B1 (fr) | 2007-08-16 | 2013-02-08 | Sanofi Aventis | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique |
| US20110086834A1 (en) * | 2008-06-26 | 2011-04-14 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| FR2941947B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
| FR2941946B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
| EP2246326A1 (de) * | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| CA2853826C (en) | 2011-10-28 | 2021-03-23 | Vanderbilt University | Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| WO2013071201A1 (en) | 2011-11-11 | 2013-05-16 | Vanderbilt University | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| US9029563B2 (en) | 2012-01-06 | 2015-05-12 | Vanderbilt University | Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors |
| US8697888B2 (en) * | 2012-01-06 | 2014-04-15 | Vanderbilt University | Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors |
| US9012445B2 (en) | 2012-01-12 | 2015-04-21 | Vanderbilt University | Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors |
| WO2014065341A1 (ja) | 2012-10-24 | 2014-05-01 | 第一三共株式会社 | 筋萎縮性側索硬化症治療剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB125671A (en) | 1917-07-03 | 1919-05-01 | James Rossiter Hoyle | Improvements in or relating to Armour Piercing Projectiles. |
| US3441570A (en) * | 1966-01-20 | 1969-04-29 | Parke Davis & Co | 3-tertiary aminoalkylamino-3-phenyl oxindole compounds |
| US3891644A (en) * | 1971-01-11 | 1975-06-24 | Wyeth John & Brother Ltd | 10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives |
| GB1450137A (en) | 1973-12-20 | 1976-09-22 | Wyeth John & Brother Ltd | Indole derivatives |
| US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
-
1999
- 1999-08-18 US US09/763,241 patent/US6576656B1/en not_active Expired - Fee Related
- 1999-08-18 CN CNB998098574A patent/CN1161333C/zh not_active Expired - Fee Related
- 1999-08-18 ES ES99938515T patent/ES2237135T3/es not_active Expired - Lifetime
- 1999-08-18 DE DE69923692T patent/DE69923692T2/de not_active Expired - Lifetime
- 1999-08-18 JP JP2000566249A patent/JP4445133B2/ja not_active Expired - Fee Related
- 1999-08-18 CA CA002340701A patent/CA2340701C/en not_active Expired - Fee Related
- 1999-08-18 WO PCT/JP1999/004443 patent/WO2000010975A1/en active IP Right Grant
- 1999-08-18 AU AU53011/99A patent/AU5301199A/en not_active Abandoned
- 1999-08-18 KR KR1020017002123A patent/KR100680085B1/ko not_active IP Right Cessation
- 1999-08-18 EP EP99938515A patent/EP1105376B1/de not_active Expired - Lifetime
- 1999-08-18 AT AT99938515T patent/ATE288895T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69923692T2 (de) | 2006-03-23 |
| JP2002523400A (ja) | 2002-07-30 |
| KR20010085413A (ko) | 2001-09-07 |
| AU5301199A (en) | 2000-03-14 |
| CN1313853A (zh) | 2001-09-19 |
| CA2340701C (en) | 2009-05-26 |
| ATE288895T1 (de) | 2005-02-15 |
| EP1105376B1 (de) | 2005-02-09 |
| JP4445133B2 (ja) | 2010-04-07 |
| CA2340701A1 (en) | 2000-03-02 |
| CN1161333C (zh) | 2004-08-11 |
| EP1105376A1 (de) | 2001-06-13 |
| WO2000010975A1 (en) | 2000-03-02 |
| US6576656B1 (en) | 2003-06-10 |
| KR100680085B1 (ko) | 2007-02-28 |
| ES2237135T3 (es) | 2005-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP |