YU43902A - Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže - Google Patents

Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Info

Publication number
YU43902A
YU43902A YU43902A YUP43902A YU43902A YU 43902 A YU43902 A YU 43902A YU 43902 A YU43902 A YU 43902A YU P43902 A YUP43902 A YU P43902A YU 43902 A YU43902 A YU 43902A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
phenyl
amino
triazol
producing
Prior art date
Application number
YU43902A
Other languages
English (en)
Inventor
Michel Geslin
Danielle Gully
Jean-Pierre Maffrand
Pierre Roger
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of YU43902A publication Critical patent/YU43902A/sh
Publication of RS50289B publication Critical patent/RS50289B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pronalazak se odnosi na jedinjenje opste formule (I) gde R1, R2, i R3 predstavljaju, svaki nezavisno jedan od drugog, atom vodonika; atom halogena (C1-C5)alkil; (C1-C5)alkoksi; trifluormetil grupu ili S-R grupu, gde R predstavlja (C1-C5)alkil; R4, R5 su (C1-C5)alkil; alkinil sa 3 do 5 atoma ugljenika; (C3-C5)cikloalkil ili Ra-X-(C1-C2)alkil grupu gde Ra predstavlja (C1-C3)alkil i X je O; R6 predstavlja -CHR7R8 gde R7 predstavlja, fenil grupu koja moze biti supstituisana sa jednim ili vise radikala Z' u polozaju 3, 4 ili 5, gde Z' predstavlja halogen; (C1-C5)alkil; (C1-C5)alkil-X- ili (C1-C3)alkil-X-(C1-C2)alkil ili X predstavlja O; ili metilendioksi grupu; i R8 predstavlja (C1-C6)alkil; (C3-C5)acikloalkil(C1-C3)alkil; (C1-C3)alkil-X-(C1-C3)alkil gde X predstavlja O. Ova jedinjenja su pogodna za CRF receptore.
YUP-439/02A 1999-12-17 2000-12-14 Novi razgranati supstituisani amino derivati od 3-amino-1- fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže RS50289B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9915935A FR2802530B1 (fr) 1999-12-17 1999-12-17 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
YU43902A true YU43902A (sh) 2005-03-15
RS50289B RS50289B (sr) 2009-09-08

Family

ID=9553380

Country Status (33)

Country Link
US (1) US6806282B2 (sh)
EP (1) EP1242389B1 (sh)
JP (1) JP4146641B2 (sh)
KR (1) KR100705525B1 (sh)
CN (1) CN1293061C (sh)
AR (1) AR031837A1 (sh)
AT (1) ATE264847T1 (sh)
AU (1) AU780711B2 (sh)
BR (1) BR0017023A (sh)
CA (1) CA2398772C (sh)
CO (1) CO5251379A1 (sh)
CZ (1) CZ302460B6 (sh)
DE (1) DE60010126T2 (sh)
DK (1) DK1242389T3 (sh)
EA (1) EA004957B1 (sh)
EE (1) EE04778B1 (sh)
ES (1) ES2219436T3 (sh)
FR (1) FR2802530B1 (sh)
HU (1) HUP0204080A3 (sh)
IL (2) IL150037A0 (sh)
IS (1) IS2315B (sh)
ME (1) MEP12108A (sh)
MX (1) MXPA02006033A (sh)
NO (1) NO20022828L (sh)
PL (1) PL203819B1 (sh)
PT (1) PT1242389E (sh)
RS (1) RS50289B (sh)
SK (1) SK285994B6 (sh)
TR (2) TR200401775T4 (sh)
TW (1) TWI289554B (sh)
UA (1) UA73333C2 (sh)
WO (1) WO2001044207A2 (sh)
ZA (1) ZA200204422B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1663211B1 (en) * 2003-08-06 2010-01-20 Vertex Pharmaceuticals Incorporated Aminotriazole compounds useful as inhibitors of protein kinases
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
ES2424023T3 (es) 2007-10-18 2013-09-26 Janssen Pharmaceutica N.V. 1,2,4-triazoles trisustituidos
CA2714662C (en) * 2008-03-19 2016-05-10 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles as nicotinic acetylcholine receptor modulators
CL2009001125A1 (es) 2008-05-09 2011-02-11 Janssen Pharmaceutica Nv Compuestos derivados de pirazol trisustituido, moduladores alostericos positivos de los receptores ach nicotinicos; composicion farmaceutica que los comprende; proceso de preparacion de la composicion; y su uso en el tratamiento de enfermedades de snc o inflamatorias.
US20130225583A1 (en) * 2010-10-21 2013-08-29 Gerald W. Shipps, Jr. Substituted amino-triazolyl pde10 inhibitors
RU2718918C2 (ru) 2014-01-21 2020-04-15 Ньюрокрайн Байосайенсиз, Инк. Антагонисты рецептора cfr1 для лечения врожденной гиперплазии коры надпочечников
CN104059027B (zh) * 2014-07-01 2015-10-28 河北大学 一类含1,2,4-三唑的(e)-甲氧基亚氨基苯乙酸甲酯类化合物及其制备方法和用途
BR112021010847A2 (pt) 2018-12-07 2021-09-08 Neurocrine Biosciences Inc. Antagonista de receptor de crf1, formulações farmacêuticas e formas sólidas das mesmas para o tratamento de hiperplasia adrenal congênita
TWI849432B (zh) * 2019-09-25 2024-07-21 波蘭商摩爾治療股份公司 製造5-(4-((2s,5s)-5-(4-氯芐基)-2-甲基嗎啉基)哌啶-1-基)-1h-1,2,4-三唑-3-胺的方法
US12383536B2 (en) 2019-09-27 2025-08-12 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3869167D1 (de) * 1987-03-27 1992-04-23 Kumiai Chemical Industry Co Phenyltriazol-derivate und insectizid.
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
DK1242389T3 (da) 2004-08-09
CA2398772A1 (fr) 2001-06-21
SK8502002A3 (en) 2003-02-04
HK1055947A1 (en) 2004-01-30
EE04778B1 (et) 2007-02-15
EA004957B1 (ru) 2004-10-28
KR20020061002A (ko) 2002-07-19
IL150037A0 (en) 2002-12-01
TR200201600T2 (tr) 2002-10-21
UA73333C2 (en) 2005-07-15
PT1242389E (pt) 2004-08-31
ES2219436T3 (es) 2004-12-01
CO5251379A1 (es) 2003-02-28
SK285994B6 (sk) 2008-01-07
EP1242389A2 (fr) 2002-09-25
IL150037A (en) 2007-02-11
EP1242389B1 (fr) 2004-04-21
DE60010126T2 (de) 2005-04-28
TR200401775T4 (tr) 2004-09-21
ATE264847T1 (de) 2004-05-15
CZ302460B6 (cs) 2011-06-01
IS6402A (is) 2002-05-28
EA200200523A1 (ru) 2002-12-26
FR2802530B1 (fr) 2002-02-22
PL355811A1 (en) 2004-05-17
WO2001044207A8 (fr) 2001-07-12
NO20022828D0 (no) 2002-06-13
NO20022828L (no) 2002-08-19
JP4146641B2 (ja) 2008-09-10
WO2001044207B1 (fr) 2002-06-06
JP2003516975A (ja) 2003-05-20
TWI289554B (en) 2007-11-11
HUP0204080A2 (hu) 2003-04-28
FR2802530A1 (fr) 2001-06-22
EE200200331A (et) 2003-06-16
WO2001044207A2 (fr) 2001-06-21
HUP0204080A3 (en) 2005-01-28
WO2001044207A3 (fr) 2001-12-20
CN1293061C (zh) 2007-01-03
AU780711B2 (en) 2005-04-14
BR0017023A (pt) 2002-12-03
US20030162771A1 (en) 2003-08-28
MXPA02006033A (es) 2003-01-28
US6806282B2 (en) 2004-10-19
PL203819B1 (pl) 2009-11-30
AR031837A1 (es) 2003-10-08
DE60010126D1 (de) 2004-05-27
CA2398772C (fr) 2011-07-05
MEP12108A (en) 2010-06-10
IS2315B (is) 2007-11-15
ZA200204422B (en) 2003-11-26
KR100705525B1 (ko) 2007-04-10
RS50289B (sr) 2009-09-08
CN1434808A (zh) 2003-08-06
AU2525901A (en) 2001-06-25
CZ20022099A3 (cs) 2002-09-11

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