MY109714A - Process for preparing 8-chloroquinolone derivatives - Google Patents

Process for preparing 8-chloroquinolone derivatives

Info

Publication number
MY109714A
MY109714A MYPI91001865A MYPI19911865A MY109714A MY 109714 A MY109714 A MY 109714A MY PI91001865 A MYPI91001865 A MY PI91001865A MY PI19911865 A MYPI19911865 A MY PI19911865A MY 109714 A MY109714 A MY 109714A
Authority
MY
Malaysia
Prior art keywords
group
carbon atoms
atom
formula
alkyl
Prior art date
Application number
MYPI91001865A
Inventor
Hayakawa Isao
Kimura Yoichi
Kawakami Katsuhiro
Kaneuchi Tohru
Yukimoto Yusuke
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of MY109714A publication Critical patent/MY109714A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A PROCESS FOR PREPARING A 8-CHLOROQUINOLONE DERIVATIVE REPRESENTED BY FORMULA (II):(FORMULA 1)WHEREIN X REPRESENTS A HALOGEN ATOM; R1 REPRESENTS A HYDROGEN ATOM, AN ALKYL GROUP HAVING FROM 1 TO 6 CARBON ATOMS OR A PHENYLALKYL GROUP WHICH MAY HAVE A NITRO GROUP, A CHLORINE ATOM OR AN ALKOXYL GROUP ON THE PHENYL MOIETY THEREOF; AND R2 REPRESENTS A 4- TO 8-MEMBERED SATURATED HETEROCYCLIC GROUP CONTAINING ONE OR TWO NITROGEN ATOMS AS A RING MEMBER, SAID HETEROCYCLIC GROUP MAY FURTHER CONTAIN AN OXYGEN ATOM OR A SULFUR ATOM AS A RING MEMBER AND MAY HAVE ONE OR MORE SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF AN AMINO GROUP, A MONO- OR DIALKYLAMINO GROUP HAVING FROM 1 TO 6 CARBON ATOMS IN ITS ALKYL MOIETY, AN ALKYLCARBONYLAMINO GROUP HAVING FROM 2 TO 7 CARBON ATOMS, AN ALKYLOXYCARBONYLAMINO GROUP HAVING FROM 2 TO 7 CARBON ATOMS, A HALOGENOALKYLCARBONYL GROUP HAVING FROM 2 TO 7 CARBON ATOMS, A HALOGENOALKYLOXYCARBONYLAMINO GROUP HAVING FROM 2 TO 7 CARBON ATOMS, A PHENYLALKYLAXYCARBONYLAMINO GROUP WHICH MAY HAVE A NITRO GROUP OR A CHLORINE ATOM ON THE PHENYL MOIETY THEREOF, AN ALKYL GROUP HAVING FROM 1 TO 6 CARBON ATOMS, AN ALKYLENE GROUP HAVING FROM 2 TO 6 CARBON ATOMS WHICH IS TAKEN TOGETHER WITH A CARBON ATOM CONSTITUTING THE HETEROCYCLIC GROUP TO FORM A SPIRO RING, A HALOGEN ATOM, AND AN ALKOXY GROUP HAVING FROM 1 TO 6 CARBON ATOMS, COMPRISING REACTING A QUINOLONE COMPOUND REPRESENTED BY FORMULA (I):(FORMULA 2)WHEREIN X, R1, AND R2 ARE AS DEFINED ABOVE, WITH A CHLORINATING AGENT.
MYPI91001865A 1990-10-18 1991-10-12 Process for preparing 8-chloroquinolone derivatives MY109714A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27977890 1990-10-18
JP22815391 1991-05-30

Publications (1)

Publication Number Publication Date
MY109714A true MY109714A (en) 1997-04-30

Family

ID=26528079

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI91001865A MY109714A (en) 1990-10-18 1991-10-12 Process for preparing 8-chloroquinolone derivatives

Country Status (16)

Country Link
KR (1) KR100253047B1 (en)
CN (1) CN1038509C (en)
AR (1) AR247884A1 (en)
AT (1) AT402501B (en)
EE (1) EE03027B1 (en)
ES (1) ES2039300B1 (en)
FI (1) FI100531B (en)
GR (1) GR1000997B (en)
HU (1) HU221195B1 (en)
MX (1) MX9101668A (en)
MY (1) MY109714A (en)
NO (1) NO179517C (en)
PL (1) PL168831B1 (en)
PT (1) PT99268B (en)
RU (1) RU2049778C1 (en)
YU (1) YU48819B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0593766T3 (en) * 1991-05-28 2000-10-09 Daiichi Seiyaku Co pyridonecarboxylic
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
CN1184221C (en) * 2001-08-08 2005-01-12 中国医学科学院医药生物技术研究所 New quinaldinic acid derivative with 7-(7-aminomethyl-5-azaspiro [2,4] heplane) substituent and its preparation method
CN103483315B (en) * 2013-09-18 2015-07-01 浙江司太立制药股份有限公司 7-(3-aminomethyl-4-alkoxyimino-1-piperidyl)-1-[(1R,2S)-2-fluorocyclopropyl] quinolone carboxylic acid compounds and preparation method thereof
CN103709100A (en) * 2013-12-31 2014-04-09 南京工业大学 Preparation method of 8-chloroquinolone derivatives
CN104892600B (en) * 2015-06-04 2017-02-01 浙江司太立制药股份有限公司 7-(3-aminomethyl-4-substituted-benzyloxyimino-1-pyrrolidinyl)naphthyridinone carboxylic acid compounds
CN107513053A (en) * 2015-08-10 2017-12-26 江苏吴中医药集团有限公司 A kind of preparation method of sitafloxacin hydrate
CN105669646B (en) * 2016-02-26 2018-03-09 济川药业集团有限公司 A kind of synthetic method of sitafloxacin
CN113527200B (en) * 2021-05-27 2022-12-02 北京斯利安药业有限公司 Preparation method of cloquinadol

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2840437A1 (en) * 1978-09-16 1980-04-03 Hoechst Ag 8-CHLORINE-5,6,7,8-TETRAHYDRO-2-CHINOLONE AND 8-CHROME-5,6,7,8-TETRAHYDRO-2-CHINOLONE, THEIR HYDROCHLORIDE OR. HYDROBROMIDE AND METHOD FOR THE PRODUCTION THEREOF
DE3576335D1 (en) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co CHINOLINE CARBONIC ACID DERIVATIVES.
JPH0635457B2 (en) * 1985-06-28 1994-05-11 杏林製薬株式会社 Pyridonecarboxylic acid derivative and method for producing the same
DE3635218A1 (en) * 1986-10-16 1988-04-21 Bayer Ag 7-AMINO-1-CYCLOPROPYL-8-CHLORINE-6-FLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR ANTIBACTERIAL AGENTS CONTAINING THEM
JPS6490183A (en) * 1987-09-30 1989-04-06 Kyorin Seiyaku Kk Production of quinolonecarboxylic acid derivative
JPH0196786A (en) * 1987-10-09 1989-04-14 Toshiba Corp Data totalization processing system for ticket checker
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives

Also Published As

Publication number Publication date
YU165791A (en) 1994-05-10
KR920008007A (en) 1992-05-27
PL168831B1 (en) 1996-04-30
FI914875A0 (en) 1991-10-16
NO914053D0 (en) 1991-10-16
NO179517C (en) 1996-10-23
ES2039300B1 (en) 1994-05-16
HU221195B1 (en) 2002-08-28
PT99268B (en) 1999-04-30
PL292087A1 (en) 1992-11-16
RU2049778C1 (en) 1995-12-10
HU913280D0 (en) 1992-01-28
YU48819B (en) 2001-12-26
GR910100427A (en) 1992-09-25
CN1062906A (en) 1992-07-22
GR1000997B (en) 1993-03-31
AT402501B (en) 1997-06-25
MX9101668A (en) 1992-06-05
ATA206691A (en) 1996-10-15
NO179517B (en) 1996-07-15
FI914875A (en) 1992-04-19
HUT59388A (en) 1992-05-28
CN1038509C (en) 1998-05-27
NO914053L (en) 1992-04-21
ES2039300A1 (en) 1993-09-16
EE03027B1 (en) 1997-08-15
KR100253047B1 (en) 2000-05-01
AR247884A1 (en) 1995-04-28
PT99268A (en) 1992-08-31
FI100531B (en) 1997-12-31

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