GR1000997B - Process for preparing 8-chloroquinolone derivatives - Google Patents

Process for preparing 8-chloroquinolone derivatives

Info

Publication number
GR1000997B
GR1000997B GR910100427A GR910100427A GR1000997B GR 1000997 B GR1000997 B GR 1000997B GR 910100427 A GR910100427 A GR 910100427A GR 910100427 A GR910100427 A GR 910100427A GR 1000997 B GR1000997 B GR 1000997B
Authority
GR
Greece
Prior art keywords
group
derivative
formula
finger member
chloroquinolone
Prior art date
Application number
GR910100427A
Other languages
Greek (el)
Other versions
GR910100427A (en
Inventor
Hayakawa Isao
Kaneuchi Tohru
Kimura Yoichi
Yukimoto Yusuke
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of GR910100427A publication Critical patent/GR910100427A/en
Publication of GR1000997B publication Critical patent/GR1000997B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Παράγωγον 8-χλωροκινολόνης του χημικού τύπου (ΙΙ):εις τον οποίον το Χ παριστά αλογόνον το R1 παριστά υδρογόνον, αλκύλιον C1-6 ή ομάδα φαινυλαλκυλίου έχουσα νιτρο, χλώριον ή αλκοξυ ομάδα επί του τμήματος φαινυλίου και το R2 παριστά 4- μελή έως 8-μελή κεκορεσμένην ετεροκυκλικήν ομάδα περιέχουσα 1-2 άζωτα ως δακτυλικόν μέλος, η ρηθείσα ετεροκυκλική ομάς δύναται να περιέχη περαιτέρω Ο ή S ως δακτυλικόν μέλος και έναν ή περισσοτέρους υποκαταστάτας εκλεγομένους εξ αμινο,μονο- ή δι-αλκυλαμινο ομάδος εχούσης C1-6 εις το τμήμα αλκυλίου της αλκυλοκαρβονυλαμινο ομάδος C2-7, αλκυλοξυκαρβονυλαμινο ομάδος C2-7, ομάδας αλογονοκαρβονυλίου C2-7,αλογονοαλκυλοξυκαρβονυλαμινο ομάδος C2-7, φαινυλαλκυλοξυκαρβονυλαμινο ομάδος εχούσης νίτρο ομάδα ή άτομον χλωρίου επί του τμήματος φαινυλίου, ομάδος αλκυλίου C1-6, ομάδος αλκυλενίου C2-C6 η οποία λαμβάνεται με άτομον άνθρακος συνιστώντος την ετεροκυκλικήν ομάδα σχηματιζομένου σπιρο δακτύλιου, ατόμου αλογόνου και αλκοξυ ομάδος C1-6, παρασκευαζόμενον (το παράγωγον) δι'αντιδράσεως ενώσεως κινολόνης του χημικού τύπου (Ι) εις τον οποιον τα X,R1 και R2 είναι ως ανωτέρω, μετά παράγοντος χλωριώσεως. ωAn 8-chloroquinolone derivative of formula (II): wherein X represents halogen R1 represents hydrogen, C 1-6 alkyl or a phenylalkyl group having a nitro, chlorine or alkoxy group on the phenyl moiety and R 2 to 8 represents 4- a saturated heterocyclic group containing 1-2 nitrogen as a finger member, said heterocyclic group may further contain O or S as a finger member and one or more substituents selected from the amino, mono- or di-alkylamino group having the C1 group. alkyl moiety of alkylcarbonylamino group C2-7, alkyloxycarbonylamino group C2-7, halocarbonyl group C2-7, haloalkyloxycarbonylamino group C2-7, phenylalkyloxycarbonylamino group C6 obtained from a carbon atom constituting the heterocyclic group forming a spiro ring, a halogen atom and an alkoxy group C1-6, prepared (the derivative ) by reacting a quinolone compound of formula (I) in which X, R1 and R2 are as above, after chlorination. ω

GR910100427A 1990-10-18 1991-10-17 Process for preparing 8-chloroquinolone derivatives GR1000997B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27977890 1990-10-18
JP22815391 1991-05-30

Publications (2)

Publication Number Publication Date
GR910100427A GR910100427A (en) 1992-09-25
GR1000997B true GR1000997B (en) 1993-03-31

Family

ID=26528079

Family Applications (1)

Application Number Title Priority Date Filing Date
GR910100427A GR1000997B (en) 1990-10-18 1991-10-17 Process for preparing 8-chloroquinolone derivatives

Country Status (16)

Country Link
KR (1) KR100253047B1 (en)
CN (1) CN1038509C (en)
AR (1) AR247884A1 (en)
AT (1) AT402501B (en)
EE (1) EE03027B1 (en)
ES (1) ES2039300B1 (en)
FI (1) FI100531B (en)
GR (1) GR1000997B (en)
HU (1) HU221195B1 (en)
MX (1) MX9101668A (en)
MY (1) MY109714A (en)
NO (1) NO179517C (en)
PL (1) PL168831B1 (en)
PT (1) PT99268B (en)
RU (1) RU2049778C1 (en)
YU (1) YU48819B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2110260C (en) * 1991-05-28 2001-12-04 Isao Hayakawa Pyridonecarboxylic acid derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
CN1184221C (en) * 2001-08-08 2005-01-12 中国医学科学院医药生物技术研究所 New quinaldinic acid derivative with 7-(7-aminomethyl-5-azaspiro [2,4] heplane) substituent and its preparation method
CN103483315B (en) * 2013-09-18 2015-07-01 浙江司太立制药股份有限公司 7-(3-aminomethyl-4-alkoxyimino-1-piperidyl)-1-[(1R,2S)-2-fluorocyclopropyl] quinolone carboxylic acid compounds and preparation method thereof
CN103709100A (en) * 2013-12-31 2014-04-09 南京工业大学 Preparation method of 8-chloroquinolone derivatives
CN104892600B (en) * 2015-06-04 2017-02-01 浙江司太立制药股份有限公司 7-(3-aminomethyl-4-substituted-benzyloxyimino-1-pyrrolidinyl)naphthyridinone carboxylic acid compounds
CN107513053A (en) * 2015-08-10 2017-12-26 江苏吴中医药集团有限公司 A kind of preparation method of sitafloxacin hydrate
CN105669646B (en) * 2016-02-26 2018-03-09 济川药业集团有限公司 A kind of synthetic method of sitafloxacin
CN113527200B (en) * 2021-05-27 2022-12-02 北京斯利安药业有限公司 Preparation method of cloquinadol

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2840437A1 (en) * 1978-09-16 1980-04-03 Hoechst Ag 8-CHLORINE-5,6,7,8-TETRAHYDRO-2-CHINOLONE AND 8-CHROME-5,6,7,8-TETRAHYDRO-2-CHINOLONE, THEIR HYDROCHLORIDE OR. HYDROBROMIDE AND METHOD FOR THE PRODUCTION THEREOF
DE3576335D1 (en) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co CHINOLINE CARBONIC ACID DERIVATIVES.
JPH0635457B2 (en) * 1985-06-28 1994-05-11 杏林製薬株式会社 Pyridonecarboxylic acid derivative and method for producing the same
DE3635218A1 (en) * 1986-10-16 1988-04-21 Bayer Ag 7-AMINO-1-CYCLOPROPYL-8-CHLORINE-6-FLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR ANTIBACTERIAL AGENTS CONTAINING THEM
JPS6490183A (en) * 1987-09-30 1989-04-06 Kyorin Seiyaku Kk Production of quinolonecarboxylic acid derivative
JPH0196786A (en) * 1987-10-09 1989-04-14 Toshiba Corp Data totalization processing system for ticket checker
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives

Also Published As

Publication number Publication date
CN1038509C (en) 1998-05-27
MX9101668A (en) 1992-06-05
HUT59388A (en) 1992-05-28
KR100253047B1 (en) 2000-05-01
NO179517C (en) 1996-10-23
PL168831B1 (en) 1996-04-30
PT99268A (en) 1992-08-31
YU165791A (en) 1994-05-10
HU221195B1 (en) 2002-08-28
MY109714A (en) 1997-04-30
CN1062906A (en) 1992-07-22
NO179517B (en) 1996-07-15
FI914875A0 (en) 1991-10-16
AR247884A1 (en) 1995-04-28
KR920008007A (en) 1992-05-27
YU48819B (en) 2001-12-26
NO914053L (en) 1992-04-21
ES2039300A1 (en) 1993-09-16
ES2039300B1 (en) 1994-05-16
FI100531B (en) 1997-12-31
RU2049778C1 (en) 1995-12-10
PT99268B (en) 1999-04-30
EE03027B1 (en) 1997-08-15
NO914053D0 (en) 1991-10-16
HU913280D0 (en) 1992-01-28
FI914875A (en) 1992-04-19
ATA206691A (en) 1996-10-15
AT402501B (en) 1997-06-25
GR910100427A (en) 1992-09-25
PL292087A1 (en) 1992-11-16

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