YU165791A - PROCEDURE FOR PREPARATION OF 8-CHLOROCHINOLONE DERIVATIVES - Google Patents
PROCEDURE FOR PREPARATION OF 8-CHLOROCHINOLONE DERIVATIVESInfo
- Publication number
- YU165791A YU165791A YU165791A YU165791A YU165791A YU 165791 A YU165791 A YU 165791A YU 165791 A YU165791 A YU 165791A YU 165791 A YU165791 A YU 165791A YU 165791 A YU165791 A YU 165791A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- carbon atoms
- atom
- preparation
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
POSTOPEK ZA PRIPRAVO DERIVATOV 8-KLOROKINOLONA, postopek za pripravo derivata 8-klorokinolona, ki ga predstavlja formula (II) v kateri X pomeni atom halogena R1 pomeni atom vodika, alkilno skupino z 1 do 6 atomi ogljika ali fenilalkilno skupino, ki lahko vsebuje na fenilnem delu nitro skupino, atom klora ali alkoksilno skupino, in R2 pomeni 4- do 8-člensko nasičeno heterociklično skupino, ki vsebuje kot obročni člen en ali dva atoma dušika, pri čemer lahko ta heterociklična skupina nadalje vsebuje kot obročni člen atom kisika ali atom žvepla in ima lahko enega ali več substituentov, izbranih iz skupine, ki sestoji iz amino skupine, mono- ali dialkilamino skupine z 1 do 6 atomi ogljika v njenem alkilnem delu, alkilkarbonilamino skupine z 2 do 7 atomi ogljika, alkiloksikar-bonilamino skupine z 2 do 7 atomi ogljika, halogenoalkilkarbonilne skupine z 2 do 7 atomi ogljika, halogenoalkiloksikarbonilamino skupine z 2 do 7 atomi ogljika, fenilalkiloksikarbonilamino skupine, ki ima lahko na fenilnem delu nitro skupino ali atom klora, alkilno skupino z 1 do 6 atomi ogljika, alkilensko skupino z 2 do 6 atomi ogljika, ki lahko skupaj z atomom ogljika, ki sestavlja heterociklično skupino, tvori spiro obroč, atom halogena in alkoksi skupino z 1 do 6 atomi ogljika, pri katerem presnovimo kinolonsko spojino, ki jo predstavlja formula (I) v kateri so X, R1 in R2 definirani kot zgoraj, s klorirnim sredstvom.A process for the preparation of 8-chloroquinolone derivatives, a process for the preparation of an 8-chloroquinolone derivative represented by formula (II) in which X represents a halogen atom; R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a phenylalkyl group which may contain the phenyl moiety is a nitro group, a chlorine atom or an alkoxyl group, and R 2 represents a 4- to 8-membered saturated heterocyclic group containing one or two nitrogen atoms as a ring member, this heterocyclic group may further contain an oxygen atom or an atom as a ring member sulfur and may have one or more substituents selected from the group consisting of an amino group, a mono- or dialkylamino group having 1 to 6 carbon atoms in its alkyl moiety, an alkylcarbonylamino group having 2 to 7 carbon atoms, an alkyloxycarbonylamino group having 2 up to 7 carbon atoms, haloalkylcarbonyl groups with 2 to 7 carbon atoms, haloalkyloxycarbonylamino groups with 2 to 7 carbon atoms, phenylalkyloxycarbonylamino groups which may have a nitro group or a chlorine atom, an alkyl group having 1 to 6 carbon atoms, an alkylene group having 2 to 6 carbon atoms which, together with the carbon atom making up the heterocyclic group, may form a spiro ring, a halogen atom and an alkoxy group having 1 to 6 carbon atoms. 6 carbon atoms in which a quinolone compound represented by formula (I) in which X, R 1 and R 2 are as defined above is reacted with a chlorinating agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR930084A HRP930084B1 (en) | 1990-10-18 | 1993-02-01 | Production of 8-chloroquinoline derivative |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27977890 | 1990-10-18 | ||
| JP22815391 | 1991-05-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU165791A true YU165791A (en) | 1994-05-10 |
| YU48819B YU48819B (en) | 2001-12-26 |
Family
ID=26528079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU165791A YU48819B (en) | 1990-10-18 | 1991-10-14 | Process for preparing 8-chloroquinolone derivatives |
Country Status (16)
| Country | Link |
|---|---|
| KR (1) | KR100253047B1 (en) |
| CN (1) | CN1038509C (en) |
| AR (1) | AR247884A1 (en) |
| AT (1) | AT402501B (en) |
| EE (1) | EE03027B1 (en) |
| ES (1) | ES2039300B1 (en) |
| FI (1) | FI100531B (en) |
| GR (1) | GR1000997B (en) |
| HU (1) | HU221195B1 (en) |
| MX (1) | MX9101668A (en) |
| MY (1) | MY109714A (en) |
| NO (1) | NO179517C (en) |
| PL (1) | PL168831B1 (en) |
| PT (1) | PT99268B (en) |
| RU (1) | RU2049778C1 (en) |
| YU (1) | YU48819B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992021659A1 (en) * | 1991-05-28 | 1992-12-10 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative |
| ZA946853B (en) * | 1993-09-10 | 1995-04-24 | Daiichi Seiyaku Co | Crystals of antimicrobial compound. |
| CN1184221C (en) * | 2001-08-08 | 2005-01-12 | 中国医学科学院医药生物技术研究所 | New quinaldinic acid derivative with 7-(7-aminomethyl-5-azaspiro [2,4] heplane) substituent and its preparation method |
| CN103483315B (en) * | 2013-09-18 | 2015-07-01 | 浙江司太立制药股份有限公司 | 7-(3-aminomethyl-4-alkoxyimino-1-piperidyl)-1-[(1R,2S)-2-fluorocyclopropyl] quinolone carboxylic acid compounds and preparation method thereof |
| CN103709100A (en) * | 2013-12-31 | 2014-04-09 | 南京工业大学 | Preparation method of 8-chloroquinolone derivative |
| CN104892600B (en) * | 2015-06-04 | 2017-02-01 | 浙江司太立制药股份有限公司 | 7-(3-aminomethyl-4-substituted-benzyloxyimino-1-pyrrolidinyl)naphthyridinone carboxylic acid compounds |
| CN107513053A (en) * | 2015-08-10 | 2017-12-26 | 江苏吴中医药集团有限公司 | A kind of preparation method of sitafloxacin hydrate |
| CN105669646B (en) * | 2016-02-26 | 2018-03-09 | 济川药业集团有限公司 | A kind of synthetic method of sitafloxacin |
| CN113527200B (en) * | 2021-05-27 | 2022-12-02 | 北京斯利安药业有限公司 | Preparation method of cloquinadol |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2840437A1 (en) * | 1978-09-16 | 1980-04-03 | Hoechst Ag | 8-CHLORINE-5,6,7,8-TETRAHYDRO-2-CHINOLONE AND 8-CHROME-5,6,7,8-TETRAHYDRO-2-CHINOLONE, THEIR HYDROCHLORIDE OR. HYDROBROMIDE AND METHOD FOR THE PRODUCTION THEREOF |
| DE3576335D1 (en) * | 1984-12-14 | 1990-04-12 | Daiichi Seiyaku Co | CHINOLINE CARBONIC ACID DERIVATIVES. |
| JPH0635457B2 (en) * | 1985-06-28 | 1994-05-11 | 杏林製薬株式会社 | Pyridonecarboxylic acid derivative and method for producing the same |
| DE3635218A1 (en) * | 1986-10-16 | 1988-04-21 | Bayer Ag | 7-AMINO-1-CYCLOPROPYL-8-CHLORINE-6-FLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR ANTIBACTERIAL AGENTS CONTAINING THEM |
| JPS6490183A (en) * | 1987-09-30 | 1989-04-06 | Kyorin Seiyaku Kk | Production of quinolonecarboxylic acid derivative |
| JPH0196786A (en) * | 1987-10-09 | 1989-04-14 | Toshiba Corp | Data totalization processing system for ticket checker |
| MY105136A (en) * | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
| CA1336090C (en) * | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
-
1991
- 1991-10-12 MY MYPI91001865A patent/MY109714A/en unknown
- 1991-10-14 YU YU165791A patent/YU48819B/en unknown
- 1991-10-16 FI FI914875A patent/FI100531B/en active
- 1991-10-16 NO NO914053A patent/NO179517C/en unknown
- 1991-10-17 HU HU280/91A patent/HU221195B1/en not_active IP Right Cessation
- 1991-10-17 PT PT99268A patent/PT99268B/en not_active IP Right Cessation
- 1991-10-17 PL PL91292087A patent/PL168831B1/en not_active IP Right Cessation
- 1991-10-17 AT AT0206691A patent/AT402501B/en not_active IP Right Cessation
- 1991-10-17 RU SU915010041A patent/RU2049778C1/en not_active IP Right Cessation
- 1991-10-17 ES ES09102304A patent/ES2039300B1/en not_active Expired - Fee Related
- 1991-10-17 GR GR910100427A patent/GR1000997B/en not_active IP Right Cessation
- 1991-10-17 AR AR91320942A patent/AR247884A1/en active
- 1991-10-18 KR KR1019910018376A patent/KR100253047B1/en not_active IP Right Cessation
- 1991-10-18 CN CN91110833A patent/CN1038509C/en not_active Expired - Lifetime
- 1991-10-18 MX MX9101668A patent/MX9101668A/en unknown
-
1994
- 1994-11-22 EE EE9400253A patent/EE03027B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU913280D0 (en) | 1992-01-28 |
| MX9101668A (en) | 1992-06-05 |
| NO914053D0 (en) | 1991-10-16 |
| KR920008007A (en) | 1992-05-27 |
| FI100531B (en) | 1997-12-31 |
| GR910100427A (en) | 1992-09-25 |
| ES2039300A1 (en) | 1993-09-16 |
| FI914875A0 (en) | 1991-10-16 |
| ES2039300B1 (en) | 1994-05-16 |
| PT99268B (en) | 1999-04-30 |
| PL168831B1 (en) | 1996-04-30 |
| PT99268A (en) | 1992-08-31 |
| NO914053L (en) | 1992-04-21 |
| AR247884A1 (en) | 1995-04-28 |
| HUT59388A (en) | 1992-05-28 |
| GR1000997B (en) | 1993-03-31 |
| YU48819B (en) | 2001-12-26 |
| MY109714A (en) | 1997-04-30 |
| CN1038509C (en) | 1998-05-27 |
| KR100253047B1 (en) | 2000-05-01 |
| RU2049778C1 (en) | 1995-12-10 |
| EE03027B1 (en) | 1997-08-15 |
| FI914875A (en) | 1992-04-19 |
| HU221195B1 (en) | 2002-08-28 |
| PL292087A1 (en) | 1992-11-16 |
| ATA206691A (en) | 1996-10-15 |
| AT402501B (en) | 1997-06-25 |
| NO179517B (en) | 1996-07-15 |
| CN1062906A (en) | 1992-07-22 |
| NO179517C (en) | 1996-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY131297A (en) | Herbicides | |
| NO307255B1 (en) | New compounds and antitumor agents | |
| ES8600288A1 (en) | Benzo-heterocyclic compounds. | |
| ES8700228A1 (en) | Substituted propargyloxyacetonitrile derivatives, process for production thereof, and herbicide and agricultural-horticultural fungicide comprising said derivatives as active ingredients. | |
| DE69511260D1 (en) | Bicyclische amidinderivate als no-synthetase inhibitoren | |
| MY100115A (en) | Nitrogen containing heterocyclic compounds, and their production and use. | |
| YU165791A (en) | PROCEDURE FOR PREPARATION OF 8-CHLOROCHINOLONE DERIVATIVES | |
| ES469008A1 (en) | Aniline derivatives | |
| ES2019163A6 (en) | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | |
| NZ221699A (en) | Pyridazinone derivatives; pharmaceutical compositions and intermediates | |
| IE811580L (en) | Herbicidal compounds | |
| DE2965377D1 (en) | 6-amino substituted n-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them | |
| DE3852008D1 (en) | Links. | |
| YU27091A (en) | HERBICIDAL COMPOSITIONS | |
| DE3174132D1 (en) | New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof | |
| EP0132914A3 (en) | Imidazolinone derivatives as histamine h2-antagonists | |
| TW330147B (en) | Halogenobenzimidazoles, their preparation processes and their use | |
| ES478206A1 (en) | Pyrrolidin-2-one derivatives | |
| MY104164A (en) | Heterocyclic compounds. | |
| TH11554EX (en) | Procedures for the preparation of various derivatives of 8-chloroquine winolone. | |
| IL101032A0 (en) | 1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them | |
| ES8302712A1 (en) | Imidazobenzodiazepines |