BR0017023A - Derivados amino substituìdos ramificados do 3-amino-1-fenil-1h [1,2,4] triazol, processos para o respectivo preparo e composições farmacêuticas que os contêm - Google Patents

Derivados amino substituìdos ramificados do 3-amino-1-fenil-1h [1,2,4] triazol, processos para o respectivo preparo e composições farmacêuticas que os contêm

Info

Publication number
BR0017023A
BR0017023A BR0017023-2A BR0017023A BR0017023A BR 0017023 A BR0017023 A BR 0017023A BR 0017023 A BR0017023 A BR 0017023A BR 0017023 A BR0017023 A BR 0017023A
Authority
BR
Brazil
Prior art keywords
alkyl
phenyl
amino
triazole
processes
Prior art date
Application number
BR0017023-2A
Other languages
English (en)
Inventor
Michel Geslin
Danielle Gully
Jean-Pierre Maffrand
Pierre Roger
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR0017023A publication Critical patent/BR0017023A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS AMINO SUBSTITUìDOS RAMIFICADOS DO 3-AMINO-1-FENIL-1H[1,2,4]TRIAZOL, PROCESSOS PARA O RESPECTIVO PREPARO E COMPOSIçõES FARMACêUTICAS QUE OS CONTêM". A presente invenção refere-se a compostos de fórmula (I), na qual notadamente R~ 1~, R~ 2~, R~ 3~ representam, cada um, independentemente um do outro, o hidrogênio, um átomo de halogênio; UM (C~ 1~-C~ 5~)alquila; um (C~ 1~C~ 5~)alcóxi; um trifluorometila ou um grupo S-R, no qual R representa um (C~ 1~C~ 5~)alquila; R~ 4~ e R~ 5~ representam um (C~ 1~-C~ 5~) alquila; um alcinila de 3 a 5 átomos de carbono; um (C~ 3~-C~ 5~)cicloalquil ou um grupo R~ a~-X-(C~ 1~-C~ 2~)alquila, no qual R~ a~ representa um (C~ 1~-C~ 3~)alquila e X representa O; R~ 6~ representa CHR~ 7~R~ 8~, no qual R~ 7~ representa um grupo fenila que pode ser substituído em posição 3, 4 e 5 por um ou vários radicais Z', com Z' representando uma halogênio; um (C~ 1~-C~ 5~)alquila; um (C~ 1~-C~ 5~)alquil-X- ou (C~ 1~-C~ 3~)alquil-X-(C~ 1~C~ 2~)alquila no qual X representa O; ou um grupo metilenodióxi; e R~ 8~ representa um (C~ 1~-C~ 6~)alquila; (C~ 3~-C~ 5~)cicloalquil (C~ 1~-C~ 3~) alquila; (C~ 1~-C~ 3~)alquil-X(C~ 1~-C~ 3~) alquila no qual X representa O. Esses compostos são afins para os receptores da CRF.
BR0017023-2A 1999-12-17 2000-12-14 Derivados amino substituìdos ramificados do 3-amino-1-fenil-1h [1,2,4] triazol, processos para o respectivo preparo e composições farmacêuticas que os contêm BR0017023A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9915935A FR2802530B1 (fr) 1999-12-17 1999-12-17 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/003536 WO2001044207A2 (fr) 1999-12-17 2000-12-14 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2 4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
BR0017023A true BR0017023A (pt) 2002-12-03

Family

ID=9553380

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0017023-2A BR0017023A (pt) 1999-12-17 2000-12-14 Derivados amino substituìdos ramificados do 3-amino-1-fenil-1h [1,2,4] triazol, processos para o respectivo preparo e composições farmacêuticas que os contêm

Country Status (34)

Country Link
US (1) US6806282B2 (pt)
EP (1) EP1242389B1 (pt)
JP (1) JP4146641B2 (pt)
KR (1) KR100705525B1 (pt)
CN (1) CN1293061C (pt)
AR (1) AR031837A1 (pt)
AT (1) ATE264847T1 (pt)
AU (1) AU780711B2 (pt)
BR (1) BR0017023A (pt)
CA (1) CA2398772C (pt)
CO (1) CO5251379A1 (pt)
CZ (1) CZ302460B6 (pt)
DE (1) DE60010126T2 (pt)
DK (1) DK1242389T3 (pt)
EA (1) EA004957B1 (pt)
EE (1) EE04778B1 (pt)
ES (1) ES2219436T3 (pt)
FR (1) FR2802530B1 (pt)
HK (1) HK1055947A1 (pt)
HU (1) HUP0204080A3 (pt)
IL (2) IL150037A0 (pt)
IS (1) IS2315B (pt)
ME (1) MEP12108A (pt)
MX (1) MXPA02006033A (pt)
NO (1) NO20022828L (pt)
PL (1) PL203819B1 (pt)
PT (1) PT1242389E (pt)
RS (1) RS50289B (pt)
SK (1) SK285994B6 (pt)
TR (2) TR200201600T2 (pt)
TW (1) TWI289554B (pt)
UA (1) UA73333C2 (pt)
WO (1) WO2001044207A2 (pt)
ZA (1) ZA200204422B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4889489B2 (ja) * 2003-08-06 2012-03-07 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なアミノトリアゾール化合物
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
ES2424023T3 (es) 2007-10-18 2013-09-26 Janssen Pharmaceutica N.V. 1,2,4-triazoles trisustituidos
AU2009226988B2 (en) 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
BRPI0912196A2 (pt) 2008-05-09 2015-10-06 Janssen Pharmaceutica Nv pirazóis trissubstituídos como moduladores do receptor de acetilcolina.
WO2012054366A2 (en) * 2010-10-21 2012-04-26 Merck Sharp & Dohme Corp. Substituted amino-triazolyl pde10 inhibitors
CA3155599A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
CN104059027B (zh) * 2014-07-01 2015-10-28 河北大学 一类含1,2,4-三唑的(e)-甲氧基亚氨基苯乙酸甲酯类化合物及其制备方法和用途
EP4041726A1 (en) * 2019-09-25 2022-08-17 Molecure SA Process for the production of 5-(4-((2 s,5 s)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1 h-1,2,4-triazol-3-amine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3869167D1 (de) * 1987-03-27 1992-04-23 Kumiai Chemical Industry Co Phenyltriazol-derivate und insectizid.
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
PL203819B1 (pl) 2009-11-30
DE60010126T2 (de) 2005-04-28
FR2802530A1 (fr) 2001-06-22
DK1242389T3 (da) 2004-08-09
JP2003516975A (ja) 2003-05-20
HUP0204080A2 (hu) 2003-04-28
EA004957B1 (ru) 2004-10-28
MXPA02006033A (es) 2003-01-28
ATE264847T1 (de) 2004-05-15
EA200200523A1 (ru) 2002-12-26
IS6402A (is) 2002-05-28
TR200401775T4 (tr) 2004-09-21
SK285994B6 (sk) 2008-01-07
PL355811A1 (en) 2004-05-17
CA2398772C (fr) 2011-07-05
KR100705525B1 (ko) 2007-04-10
AR031837A1 (es) 2003-10-08
CA2398772A1 (fr) 2001-06-21
EE04778B1 (et) 2007-02-15
TR200201600T2 (tr) 2002-10-21
IS2315B (is) 2007-11-15
WO2001044207B1 (fr) 2002-06-06
SK8502002A3 (en) 2003-02-04
TWI289554B (en) 2007-11-11
CZ302460B6 (cs) 2011-06-01
HK1055947A1 (en) 2004-01-30
DE60010126D1 (de) 2004-05-27
WO2001044207A2 (fr) 2001-06-21
ZA200204422B (en) 2003-11-26
IL150037A (en) 2007-02-11
IL150037A0 (en) 2002-12-01
CN1293061C (zh) 2007-01-03
KR20020061002A (ko) 2002-07-19
EE200200331A (et) 2003-06-16
US20030162771A1 (en) 2003-08-28
CN1434808A (zh) 2003-08-06
JP4146641B2 (ja) 2008-09-10
ES2219436T3 (es) 2004-12-01
WO2001044207A3 (fr) 2001-12-20
FR2802530B1 (fr) 2002-02-22
WO2001044207A8 (fr) 2001-07-12
AU2525901A (en) 2001-06-25
NO20022828L (no) 2002-08-19
RS50289B (sr) 2009-09-08
PT1242389E (pt) 2004-08-31
EP1242389B1 (fr) 2004-04-21
HUP0204080A3 (en) 2005-01-28
AU780711B2 (en) 2005-04-14
CZ20022099A3 (cs) 2002-09-11
YU43902A (sh) 2005-03-15
US6806282B2 (en) 2004-10-19
UA73333C2 (en) 2005-07-15
EP1242389A2 (fr) 2002-09-25
MEP12108A (en) 2010-06-10
CO5251379A1 (es) 2003-02-28
NO20022828D0 (no) 2002-06-13

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