ES2193362T3 - Derivados de 2-pirimidinamina y su procedimiento de preparacion de los mismos. - Google Patents
Derivados de 2-pirimidinamina y su procedimiento de preparacion de los mismos.Info
- Publication number
- ES2193362T3 ES2193362T3 ES97912296T ES97912296T ES2193362T3 ES 2193362 T3 ES2193362 T3 ES 2193362T3 ES 97912296 T ES97912296 T ES 97912296T ES 97912296 T ES97912296 T ES 97912296T ES 2193362 T3 ES2193362 T3 ES 2193362T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- optionally substituted
- compounds
- pyrimidinamine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL (1), DONDE AR ES UN GRUPO AROMATICO OPCIONALMENTE SUSTITUIDO; R2 ES HIDROGENO O UN ATOMO DE HALOGENO O UN GRUPO X 1 - R 2A , DONDE X 1 ES UN ENLACE DIRECTO O UN ATOMO O GRUPO DE UNION; Y R 2A ES UN GRUPO ALQUILO, ALQUENILO O ALQUINILO DE CADENA LINEAL O RAMIFICADA, OPCIONALMENTE SUSTITUIDO; R 3 ES UN GRUPO HETEROCICLOALQUILO OPCIONALMENTE SUST ITUIDO; Y LAS SALES, SOLVATOS, HIDRATOS Y N - OXIDOS DE LOS MISMOS. DICHOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE LA PROTEINA TIROSINA QUINASA, ESPECIALMENTE DE LAS QUINASAS ZAP-70 Y SYK, Y SON UTILES EN LA PROFILAXIS Y TRATAMIENTO DE ENFERMEDADES INMUNITARIAS O ALERGICAS, Y EN ENFERMEDADES QUE IMPLICAN UNA ACTIVACION PLAQUETARIA INADECUADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9622363.1A GB9622363D0 (en) | 1996-10-28 | 1996-10-28 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2193362T3 true ES2193362T3 (es) | 2003-11-01 |
Family
ID=10802032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97912296T Expired - Lifetime ES2193362T3 (es) | 1996-10-28 | 1997-10-27 | Derivados de 2-pirimidinamina y su procedimiento de preparacion de los mismos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US6114333A (es) |
EP (1) | EP0934304B1 (es) |
JP (1) | JP2001503047A (es) |
AT (1) | ATE233256T1 (es) |
AU (1) | AU732155B2 (es) |
CA (1) | CA2269095A1 (es) |
DE (1) | DE69719350T2 (es) |
ES (1) | ES2193362T3 (es) |
GB (1) | GB9622363D0 (es) |
WO (1) | WO1998018782A1 (es) |
Families Citing this family (116)
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DE69933680T2 (de) | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
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GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
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ATE288420T1 (de) * | 1999-06-09 | 2005-02-15 | Yamanouchi Pharma Co Ltd | Neuartige heterocyclische carboxamid-derivate |
AU6605200A (en) | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
US6498165B1 (en) | 1999-06-30 | 2002-12-24 | Merck & Co., Inc. | Src kinase inhibitor compounds |
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US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
JP2003511378A (ja) | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | トリアジン系キナーゼ阻害薬 |
US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
US20020002169A1 (en) | 1999-12-08 | 2002-01-03 | Griffin John H. | Protein kinase inhibitors |
WO2001060816A1 (en) * | 2000-02-17 | 2001-08-23 | Amgen Inc. | Kinase inhibitors |
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GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
GB0021726D0 (en) | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
DE10206505A1 (de) * | 2002-02-16 | 2003-08-28 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern |
US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
US7429599B2 (en) * | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
ATE430742T1 (de) | 2000-12-21 | 2009-05-15 | Smithkline Beecham Corp | Pyrimidinamine als angiogenesemodulatoren |
GB0100102D0 (en) * | 2001-01-03 | 2001-02-14 | Syngenta Participations Ag | Organic compounds |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
DE60214701T2 (de) | 2001-04-13 | 2007-09-13 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von c-jun-n-terminalen-kinasen (jnk) und anderen proteinkinasen |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
JP2005500294A (ja) * | 2001-06-19 | 2005-01-06 | ブリストル−マイヤーズ スクイブ カンパニー | ホスホジエステラーゼ7に対するピリミジン阻害剤 |
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JP2004537542A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患(ibd)を治療するための、チロシンキナーゼ阻害剤の使用 |
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-
1996
- 1996-10-28 GB GBGB9622363.1A patent/GB9622363D0/en active Pending
-
1997
- 1997-10-27 CA CA002269095A patent/CA2269095A1/en not_active Abandoned
- 1997-10-27 AU AU49540/97A patent/AU732155B2/en not_active Ceased
- 1997-10-27 EP EP97912296A patent/EP0934304B1/en not_active Expired - Lifetime
- 1997-10-27 WO PCT/GB1997/002949 patent/WO1998018782A1/en active IP Right Grant
- 1997-10-27 AT AT97912296T patent/ATE233256T1/de not_active IP Right Cessation
- 1997-10-27 US US08/958,419 patent/US6114333A/en not_active Expired - Fee Related
- 1997-10-27 DE DE69719350T patent/DE69719350T2/de not_active Expired - Fee Related
- 1997-10-27 ES ES97912296T patent/ES2193362T3/es not_active Expired - Lifetime
- 1997-10-27 JP JP10520184A patent/JP2001503047A/ja not_active Ceased
-
1999
- 1999-10-20 US US09/420,755 patent/US6552029B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69719350D1 (de) | 2003-04-03 |
ATE233256T1 (de) | 2003-03-15 |
CA2269095A1 (en) | 1998-05-07 |
US6552029B1 (en) | 2003-04-22 |
EP0934304A1 (en) | 1999-08-11 |
AU4954097A (en) | 1998-05-22 |
US6114333A (en) | 2000-09-05 |
WO1998018782A1 (en) | 1998-05-07 |
AU732155B2 (en) | 2001-04-12 |
JP2001503047A (ja) | 2001-03-06 |
EP0934304B1 (en) | 2003-02-26 |
DE69719350T2 (de) | 2003-12-04 |
GB9622363D0 (en) | 1997-01-08 |
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