GB9222253D0
(en)
*
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
GB9304919D0
(en)
*
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
GB9304920D0
(en)
*
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
GB9326600D0
(en)
*
|
1993-12-22 |
1994-03-02 |
Celltech Ltd |
Chemical compounds
|
EP0738268B1
(de)
*
|
1993-12-22 |
2004-03-03 |
Celltech R&D Limited |
Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
|
US6245774B1
(en)
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
GB9523675D0
(en)
*
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9526245D0
(en)
*
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9526246D0
(en)
*
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9608435D0
(en)
*
|
1996-04-24 |
1996-06-26 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9619284D0
(en)
*
|
1996-09-16 |
1996-10-30 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9622363D0
(en)
*
|
1996-10-28 |
1997-01-08 |
Celltech Therapeutics Ltd |
Chemical compounds
|
CA2273102A1
(en)
*
|
1996-12-03 |
1998-06-11 |
Banyu Pharmaceutical Co., Ltd. |
Urea derivatives
|
GB9625184D0
(en)
*
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
CA2274592C
(en)
*
|
1996-12-12 |
2007-03-13 |
Banyu Pharmaceutical Co., Ltd. |
Pyrazole derivatives
|
CA2274593A1
(en)
*
|
1996-12-13 |
1998-06-18 |
Banyu Pharmaceutical Co., Ltd. |
Novel aminopyrazole derivatives
|
CA2274594C
(en)
|
1996-12-16 |
2006-10-10 |
Banyu Pharmaceutical Co., Ltd. |
Aminopyrazole derivatives
|
WO1998028281A1
(en)
*
|
1996-12-23 |
1998-07-02 |
Celltech Therapeutics Limited |
Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
|
GB9705361D0
(en)
*
|
1997-03-14 |
1997-04-30 |
Celltech Therapeutics Ltd |
Chemical compounds
|
DK1023063T3
(da)
|
1997-10-06 |
2004-01-26 |
Abbott Gmbh & Co Kg |
Indeno[1,2-c]-,naphtho[1,2-c]- og benzo[6,7]cyclohepta[1,2-c]pyrazolderivater
|
CN1278724A
(zh)
|
1997-10-06 |
2001-01-03 |
巴斯福股份公司 |
抑制酪氨酸激酶活性的茚并[1,2-c]吡唑衍生物
|
US6376527B1
(en)
|
1998-05-05 |
2002-04-23 |
Syntex (U.S.A.) Llc |
Pyrazole derivatives-p38 map kinase inhibitors
|
US6316466B1
(en)
|
1998-05-05 |
2001-11-13 |
Syntex (U.S.A.) Llc |
Pyrazole derivatives P-38 MAP kinase inhibitors
|
HN2000000051A
(es)
*
|
1999-05-19 |
2001-02-02 |
Pfizer Prod Inc |
Derivados heterociclicos utiles como agentes anticancerosos
|
UA71971C2
(en)
|
1999-06-04 |
2005-01-17 |
Agoron Pharmaceuticals Inc |
Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
|
PE20010306A1
(es)
*
|
1999-07-02 |
2001-03-29 |
Agouron Pharma |
Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
|
US7141581B2
(en)
|
1999-07-02 |
2006-11-28 |
Agouron Pharmaceuticals, Inc. |
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
|
TWI262914B
(en)
|
1999-07-02 |
2006-10-01 |
Agouron Pharma |
Compounds and pharmaceutical compositions for inhibiting protein kinases
|
HUP0203542A3
(en)
|
1999-08-12 |
2003-07-28 |
Upjohn Co |
3(5)-amino-pyrazole derivatives, process for their preparation, their use and pharmaceutical compositions containing the same
|
US6387900B1
(en)
|
1999-08-12 |
2002-05-14 |
Pharmacia & Upjohn S.P.A. |
3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
|
YU54202A
(sh)
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
|
HN2001000008A
(es)
|
2000-01-21 |
2003-12-11 |
Inc Agouron Pharmaceuticals |
Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
|
DK1268472T3
(da)
|
2000-02-07 |
2004-12-06 |
Bristol Myers Squibb Co |
3-aminopyrazolinhibitorer af cyclinafhængige kinaser
|
JP2004501083A
(ja)
*
|
2000-04-18 |
2004-01-15 |
アゴーロン・ファーマシューティカルズ・インコーポレイテッド |
プロテインキナーゼを阻害するためのピラゾール
|
CA2411928A1
(en)
|
2000-08-09 |
2002-02-14 |
Agouron Pharmaceuticals, Inc. |
Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclindependent kinases
|
JP2004506720A
(ja)
|
2000-08-18 |
2004-03-04 |
アグーロン ファーマシューティカルズ,インコーポレイテッド |
複素環式ヒドロキシイミノフルオレン、およびプロテインキナーゼ阻害のためのこれらの使用
|
US7473691B2
(en)
*
|
2000-09-15 |
2009-01-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
CA2422354C
(en)
|
2000-09-15 |
2009-12-08 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
NZ526469A
(en)
*
|
2000-12-21 |
2005-10-28 |
Vertex Pharma |
Pyrazole compounds useful as protein kinase inhibitors
|
CN100480242C
(zh)
|
2001-05-29 |
2009-04-22 |
舍林股份公司 |
Cdk抑制性嘧啶化合物、其制备方法以及作为药物的应用
|
HN2002000156A
(es)
|
2001-07-06 |
2003-11-27 |
Inc Agouron Pharmaceuticals |
Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
|
CA2465247C
(en)
*
|
2001-10-26 |
2010-05-18 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles and analogues and their use as protein kinases inhibitors
|
RU2004126671A
(ru)
*
|
2002-02-06 |
2005-04-10 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Гетероарилсоединения, полезные в качестве ингибиторов gsk-3
|
ATE468336T1
(de)
*
|
2002-03-15 |
2010-06-15 |
Vertex Pharma |
Azolylaminoazine als proteinkinasehemmer
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
CN1319968C
(zh)
|
2002-08-02 |
2007-06-06 |
沃泰克斯药物股份有限公司 |
用作gsk-3的抑制剂的吡唑组合物
|
AR042067A1
(es)
*
|
2002-11-27 |
2005-06-08 |
Bayer Pharmaceuticals Corp |
Derivados de anilinopirazol utiles en el tratamiento de la diabetes
|
CN1747950A
(zh)
|
2002-12-19 |
2006-03-15 |
美国辉瑞有限公司 |
用于治疗眼病的作为蛋白激酶抑制剂的2-(1h-吲唑-6-基氨基)-苯甲酰胺化合物
|
WO2004072029A2
(en)
*
|
2003-02-06 |
2004-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridazines useful as inhibitors of protein kinases
|
WO2004098498A2
(en)
*
|
2003-04-28 |
2004-11-18 |
Bayer Pharmaceuticals Corporation |
Indole acetic acid derivatives and their use as pharmaceutical agents
|
US20050038099A1
(en)
*
|
2003-05-02 |
2005-02-17 |
Tung Jay S. |
Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
|
ATE435649T1
(de)
*
|
2003-05-02 |
2009-07-15 |
Elan Pharm Inc |
4-brom-5-(2-chlor-benzoylamino)-1h-pyrazol-3- carbonsäure(phenyl)amid-derivate und verwandte verbindungen als bradykinin b1 receptor antagonisten zur behandlung von entzündlichen erkrankungen
|
US7432379B2
(en)
|
2003-05-02 |
2008-10-07 |
Elan Pharmaceuticals, Inc. |
Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
|
KR101204247B1
(ko)
|
2003-07-22 |
2012-11-22 |
아스텍스 테라퓨틱스 리미티드 |
3,4-이치환된 1h-피라졸 화합물 및 그의 시클린 의존성키나제 (cdk) 및 글리코겐 합성효소 키나제-3(gsk-3) 조정제로서 용도
|
CA2532231A1
(en)
*
|
2003-07-25 |
2005-02-03 |
Pfizer Inc. |
Aminopyrazole compounds and use as chk1 inhibitors
|
DE602004017479D1
(de)
|
2003-08-29 |
2008-12-11 |
Pfizer |
Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
|
WO2005030128A2
(en)
*
|
2003-09-23 |
2005-04-07 |
Merck & Co., Inc. |
Pyrazole modulators of metabotropic glutamate receptors
|
WO2005056547A2
(en)
*
|
2003-12-04 |
2005-06-23 |
Vertex Pharmaceuticals Incorporated |
Quinoxalines useful as inhibitors of protein kinases
|
KR100875870B1
(ko)
|
2004-10-14 |
2008-12-26 |
에프. 호프만-라 로슈 아게 |
항암제로서의 신규 아자인돌 티아졸리논
|
US8153630B2
(en)
*
|
2004-11-17 |
2012-04-10 |
Miikana Therapeutics, Inc. |
Kinase inhibitors
|
US8404718B2
(en)
|
2005-01-21 |
2013-03-26 |
Astex Therapeutics Limited |
Combinations of pyrazole kinase inhibitors
|
AR054425A1
(es)
|
2005-01-21 |
2007-06-27 |
Astex Therapeutics Ltd |
Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
|
US7304074B2
(en)
|
2005-04-05 |
2007-12-04 |
Hoffmann-La Roche Inc. |
Substituted 1,5-naphthyridine azolinones
|
US7737151B2
(en)
*
|
2005-08-18 |
2010-06-15 |
Vertex Pharmaceuticals Incorporated |
Pyrazine kinase inhibitors
|
ES2535854T3
(es)
*
|
2005-09-30 |
2015-05-18 |
Miikana Therapeutics, Inc. |
Compuestos de pirazol sustituidos
|
BRPI0619708A2
(pt)
*
|
2005-11-03 |
2011-10-11 |
Vertex Pharma |
composto, composição, método para inibir a atividade da proteìna aurora quinase numa amostra biológica, método para tratar distúrbio proliferativo e método para tratar cáncer
|
CA2668429A1
(en)
*
|
2006-11-02 |
2008-05-15 |
Vertex Pharmaceuticals Incorporated |
Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
|
KR101450356B1
(ko)
*
|
2006-11-24 |
2014-10-15 |
에이씨 이뮨 에스.에이. |
알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 n-(메틸)-1h-피라졸-3-아민, n-(메틸)-피리딘-2-아민 및 n-(메틸)-티아졸-2-아민 유도체
|
EP2099787B1
(de)
*
|
2006-12-19 |
2010-07-21 |
Vertex Pharmaceuticals, Inc. |
Als inhibitoren von proteinkinasen geeignete aminopyrimidine
|
US7737149B2
(en)
|
2006-12-21 |
2010-06-15 |
Astrazeneca Ab |
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
|
WO2008112651A2
(en)
*
|
2007-03-09 |
2008-09-18 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as inhibitors of protein kinases
|
EP2134709A1
(de)
|
2007-03-09 |
2009-12-23 |
Vertex Pharmaceuticals, Inc. |
Aminopyridine als proteinkinasehemmer
|
MX2009009590A
(es)
*
|
2007-03-09 |
2009-11-10 |
Vertex Pharma |
Aminopirimidinas utiles como inhibidores de proteinas cinasas.
|
NZ580343A
(en)
|
2007-04-13 |
2012-03-30 |
Vertex Pharma |
Aminopyrimidines useful as kinase inhibitors
|
AU2008247592A1
(en)
|
2007-05-02 |
2008-11-13 |
Vertex Pharmaceuticals Incorporated |
Thiazoles and pyrazoles useful as kinase inhibitors
|
MX2009011812A
(es)
*
|
2007-05-02 |
2010-01-14 |
Vertex Pharma |
Aminopirimidinas utiles como inhibidores de cinasa.
|
AU2008247595A1
(en)
*
|
2007-05-02 |
2008-11-13 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as kinase inhibitors
|
JP2010528021A
(ja)
*
|
2007-05-24 |
2010-08-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
キナーゼのインヒビターとして有用なチアゾールおよびピラゾール
|
US20090029992A1
(en)
*
|
2007-06-11 |
2009-01-29 |
Agoston Gregory E |
Substituted pyrazole compounds
|
AR067762A1
(es)
*
|
2007-07-31 |
2009-10-21 |
Vertex Pharma |
Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma
|
EP2323622A1
(de)
|
2008-09-03 |
2011-05-25 |
Vertex Pharmaceuticals Incorporated |
Co-kristalle und diese enthaltende pharmazeutische formulierungen
|
US20120045459A1
(en)
*
|
2009-05-05 |
2012-02-23 |
Van Andel Research Institute |
Methods for Treating Autophagy-Related Disorders
|
EP2311823A1
(de)
|
2009-10-15 |
2011-04-20 |
AC Immune S.A. |
2,6-Diaminopyridinverbindungen zur Behandlung von Krankheiten im Zusammenhang mit Amyloidproteinen oder zur Behandlung von Augenkrankheiten
|
KR20130053404A
(ko)
*
|
2010-03-30 |
2013-05-23 |
베르선 코포레이션 |
트롬빈 억제제로서의 다중치환된 방향족 화합물
|
EP2755652B1
(de)
|
2011-09-16 |
2021-06-02 |
Novartis AG |
N-substituierte heterocyclische carboxamide
|
US20140179712A1
(en)
|
2012-12-21 |
2014-06-26 |
Astrazeneca Ab |
Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
|
US9951025B2
(en)
|
2013-03-15 |
2018-04-24 |
Verseon Corporation |
Halogenopyrazoles as inhibitors of thrombin
|
BR112015022340A2
(pt)
|
2013-03-15 |
2017-07-18 |
Verseon Corp |
método para tratamento ou prevenção de uma doença ou distúrbio relacionado à calicreína em um sujeito, composto, e, composição farmacêutica
|
CN103232394B
(zh)
*
|
2013-05-14 |
2014-09-24 |
浙江医药高等专科学校 |
含吡唑类化合物、其制备方法和用途
|
US10189810B2
(en)
|
2014-09-17 |
2019-01-29 |
Verseon Corporation |
Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
|
ES2931460T3
(es)
|
2015-02-27 |
2022-12-29 |
Verseon Int Corporation |
Compuestos de pirazol sustituido como inhibidores de serina proteasa
|
CN112694474B
(zh)
*
|
2019-10-23 |
2022-03-18 |
四川大学 |
吲唑类衍生物及其制备方法和用途
|