ES2108120T3 - Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf. - Google Patents

Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf.

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Publication number
ES2108120T3
ES2108120T3 ES92912051T ES92912051T ES2108120T3 ES 2108120 T3 ES2108120 T3 ES 2108120T3 ES 92912051 T ES92912051 T ES 92912051T ES 92912051 T ES92912051 T ES 92912051T ES 2108120 T3 ES2108120 T3 ES 2108120T3
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Spain
Prior art keywords
pct
mono
bis
pdgf
typhosine
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ES92912051T
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English (en)
Inventor
Alfred P Spada
Martin P Maguire
Paul E Persons
Michael R Myers
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Rhone Poulenc Rorer International Holdings Inc
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Rhone Poulenc Rorer International Holdings Inc
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS HETEROARILO Y/O ARILO BIS MONO ICION DE QUINASA TIROSINA DE PROTEINA. MAS ESPECIFICAMENTE, SE REFIERE AL METODO PARA INHIBIR LA PROLIFERACION CELULAR ANORMAL EN UN PACIENTE QUE SUFRE DE UN TRASTORNO CARACTERIZADO POR UNA PROLIFERACION QUE COMPRENDE LA ADMINISTRACION A ESTE DE UNA CANTIDAD EFECTIVA DE INHIBICION DE RECEPTORES EGF Y/O PDGF DE DICHO COMPUESTO HETEROARILO Y/O ARILO BIS MONO A LA PREPARACION DE DICHOS COMPUESTOS Y SU USO EN COMPOSICIONES FARMACEUTICAS USADAS EN ESTE METODO.
ES92912051T 1991-05-10 1992-05-06 Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf. Expired - Lifetime ES2108120T3 (es)

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US69842091A 1991-05-10 1991-05-10

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ES2108120T3 true ES2108120T3 (es) 1997-12-16

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ES92912051T Expired - Lifetime ES2108120T3 (es) 1991-05-10 1992-05-06 Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf.

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US (1) US5409930A (es)
EP (1) EP0584222B1 (es)
AT (1) ATE159009T1 (es)
AU (1) AU658646B2 (es)
CA (1) CA2102780C (es)
DE (1) DE69222637T2 (es)
DK (1) DK0584222T3 (es)
ES (1) ES2108120T3 (es)
GR (1) GR3024955T3 (es)
MX (1) MX9202181A (es)
SG (1) SG64322A1 (es)
WO (1) WO1992020642A1 (es)

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MX9202181A (es) 1993-05-01
DE69222637D1 (de) 1997-11-13
AU1993492A (en) 1992-12-30
CA2102780A1 (en) 1992-11-11
US5409930A (en) 1995-04-25
EP0584222B1 (en) 1997-10-08
DE69222637T2 (de) 1998-02-26
EP0584222A4 (en) 1994-07-06
GR3024955T3 (en) 1998-01-30
AU658646B2 (en) 1995-04-27
WO1992020642A1 (en) 1992-11-26
SG64322A1 (en) 1999-04-27
DK0584222T3 (da) 1998-02-23
JPH06507643A (ja) 1994-09-01
ATE159009T1 (de) 1997-10-15
JP3507071B2 (ja) 2004-03-15
EP0584222A1 (en) 1994-03-02
CA2102780C (en) 2007-01-09

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