ATE375342T1 - 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren - Google Patents

2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren

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Publication number
ATE375342T1
ATE375342T1 AT03784419T AT03784419T ATE375342T1 AT E375342 T1 ATE375342 T1 AT E375342T1 AT 03784419 T AT03784419 T AT 03784419T AT 03784419 T AT03784419 T AT 03784419T AT E375342 T1 ATE375342 T1 AT E375342T1
Authority
AT
Austria
Prior art keywords
aminoaryl
thiazoles
aryl
amino
kit inhibitors
Prior art date
Application number
AT03784419T
Other languages
English (en)
Inventor
Marco Ciufolini
Camille Wermuth
Bruno Giethlen
Alain Moussy
Original Assignee
Ab Science
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Filing date
Publication date
Application filed by Ab Science filed Critical Ab Science
Application granted granted Critical
Publication of ATE375342T1 publication Critical patent/ATE375342T1/de

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
AT03784419T 2002-08-02 2003-07-31 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren ATE375342T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40006402P 2002-08-02 2002-08-02

Publications (1)

Publication Number Publication Date
ATE375342T1 true ATE375342T1 (de) 2007-10-15

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AT03784419T ATE375342T1 (de) 2002-08-02 2003-07-31 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren

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Country Link
US (5) US20050239852A1 (de)
EP (1) EP1525200B1 (de)
JP (1) JP4726486B2 (de)
KR (1) KR101036866B1 (de)
CN (1) CN100491374C (de)
AT (1) ATE375342T1 (de)
BR (1) BRPI0313165B8 (de)
CA (1) CA2494695C (de)
CY (1) CY1107036T1 (de)
DE (1) DE60316810T2 (de)
DK (1) DK1525200T3 (de)
ES (1) ES2294344T3 (de)
IL (1) IL166528A0 (de)
MX (1) MXPA05001277A (de)
NO (1) NO330608B1 (de)
NZ (1) NZ538490A (de)
PT (1) PT1525200E (de)
WO (1) WO2004014903A1 (de)
ZA (1) ZA200501331B (de)

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US7741335B2 (en) 2001-06-29 2010-06-22 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory diseases
WO2003003006A2 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
JP3836019B2 (ja) * 2001-11-21 2006-10-18 松下電器産業株式会社 受信装置、送信装置及び送信方法
ATE375342T1 (de) * 2002-08-02 2007-10-15 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
US20050282814A1 (en) * 2002-10-03 2005-12-22 Targegen, Inc. Vasculostatic agents and methods of use thereof
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EP2471524A3 (de) 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Fazial-amphiphile Polymere und Oligomere sowie Verwendungen davon
CA2523852A1 (en) * 2003-04-28 2004-11-11 Ab Science Use of tyrosine kinase inhibitors for treating cerebral ischemia
EP1653934B1 (de) * 2003-08-15 2008-05-14 AB Science Verwendung von c-kit-inhibitoren für die behandlung von typ-2-diabetes
HUE034712T2 (hu) * 2003-12-25 2018-02-28 Nippon Shinyaku Co Ltd Amidszármazék és gyógyszer
KR20120107142A (ko) 2004-01-23 2012-09-28 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 표면적으로 친양쪽성인 폴리아릴 및 폴리아릴알키닐 중합체와 올리고머, 그리고 이들의 용도
AU2005209485A1 (en) * 2004-01-30 2005-08-11 Ab Science 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors
EP1809614B1 (de) * 2004-04-08 2014-05-07 TargeGen, Inc. Benzotriazin-kinasehemmer
CA2564568A1 (en) * 2004-04-20 2005-11-03 Ab Science Use of c-kit inhibitors for treating inflammatory muscle disorders including myositis and muscular dystrophy
WO2005102318A1 (en) * 2004-04-20 2005-11-03 Ab Science Use of c-kit inhibitors for treating hiv related diseases
US20070225293A1 (en) * 2004-04-23 2007-09-27 Ab Science Use of C-Kit Inhibitors for Treating Fibrosis
WO2005102326A2 (en) * 2004-04-23 2005-11-03 Ab Science Use of c-kit inhibitors for treating renal diseases
EP1748044A4 (de) 2004-05-17 2007-12-12 Otsuka Pharma Co Ltd Thiazolverbindung und deren verwendung
WO2005112920A1 (en) * 2004-05-18 2005-12-01 Ab Science Use of mast cells inhibitors for treating patients exposed to chemical or biological weapons
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