HN2000000051A - Derivados heterociclicos utiles como agentes anticancerosos - Google Patents
Derivados heterociclicos utiles como agentes anticancerososInfo
- Publication number
- HN2000000051A HN2000000051A HN2000000051A HN2000000051A HN2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A
- Authority
- HN
- Honduras
- Prior art keywords
- useful
- target agents
- derivatives
- heterociclic
- heterociclic derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
LA PRESENTE INVENCION SE REFIERE A DERIVADOS NOVEDOSOS DE ISOTIAZOL QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES HIPERPOLIFERATIVAS, TALES COMO CANCERES EN MAMIFEROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13493399P | 1999-05-19 | 1999-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2000000051A true HN2000000051A (es) | 2001-02-02 |
Family
ID=22465672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2000000051A HN2000000051A (es) | 1999-05-19 | 2000-04-12 | Derivados heterociclicos utiles como agentes anticancerosos |
Country Status (21)
Country | Link |
---|---|
US (1) | US6380214B1 (es) |
EP (1) | EP1187826B1 (es) |
JP (2) | JP3692041B2 (es) |
AR (1) | AR029634A1 (es) |
AT (1) | ATE349440T1 (es) |
AU (1) | AU4137400A (es) |
BR (1) | BR0010746A (es) |
CA (1) | CA2374247C (es) |
CO (1) | CO5170417A1 (es) |
DE (1) | DE60032601T2 (es) |
DZ (1) | DZ3042A1 (es) |
ES (1) | ES2276681T3 (es) |
GT (1) | GT200000069A (es) |
HN (1) | HN2000000051A (es) |
MA (1) | MA26733A1 (es) |
MX (1) | MXPA01011920A (es) |
PA (1) | PA8494101A1 (es) |
PE (1) | PE20010152A1 (es) |
TN (1) | TNSN00104A1 (es) |
UY (1) | UY26143A1 (es) |
WO (1) | WO2000071532A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
DK1268472T3 (da) | 2000-02-07 | 2004-12-06 | Bristol Myers Squibb Co | 3-aminopyrazolinhibitorer af cyclinafhængige kinaser |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
CN101624391A (zh) * | 2001-06-11 | 2010-01-13 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
EP2324825A1 (en) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
US6989451B2 (en) * | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
US20070060551A1 (en) * | 2002-06-13 | 2007-03-15 | Qlt, Inc. | Methods of using isothiazole derivatives to treat cancer or inflammation |
CA2491802C (en) * | 2002-07-09 | 2012-04-10 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
US20060135568A1 (en) * | 2002-07-09 | 2006-06-22 | Townsend Craig A | Methods of treating microbial infections in humans and animals |
AU2003281664A1 (en) | 2002-07-25 | 2004-02-16 | Pfizer Products Inc. | Isothiazole derivatives useful as anticancer agents |
WO2004050681A2 (en) * | 2002-11-15 | 2004-06-17 | Exelixis, Inc. | Kinase modulators |
CN100413861C (zh) * | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
TWI369353B (en) * | 2003-03-07 | 2012-08-01 | Santen Pharmaceutical Co Ltd | Novel compound having 4-pyridylalkylthio group as substituent |
PT1626714E (pt) | 2003-05-20 | 2007-08-24 | Bayer Pharmaceuticals Corp | Diarilureias para doenças mediadas por pdgfr |
SI1663978T1 (sl) | 2003-07-23 | 2008-02-29 | Bayer Pharmaceuticals Corp | Fluoro substituirana omega-karboksiaril difenil secnina za zdravljenje ali preprecevanje bolezni instanj |
WO2005085201A1 (ja) * | 2004-02-17 | 2005-09-15 | Santen Pharmaceutical Co., Ltd. | 置換又は無置換アミノ基を導入した4-ピリジルアルキルチオ基を有する新規環式化合物 |
JP4626353B2 (ja) * | 2004-02-17 | 2011-02-09 | 参天製薬株式会社 | 置換又は無置換アミノ基を導入した4−ピリジルアルキルチオ基を有する新規環式化合物 |
ES2368153T3 (es) * | 2004-02-17 | 2011-11-14 | Santen Pharmaceutical Co., Ltd. | Nuevo compuesto cíclico que presenta un grupo 4-piridilalquiltio que presenta amino (no) sustituido introducido en el mismo. |
AU2005223483B2 (en) | 2004-03-18 | 2009-04-23 | Zoetis Llc | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
ATE517885T1 (de) | 2004-04-30 | 2011-08-15 | Bayer Healthcare Llc | Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs |
PT1784183E (pt) | 2004-08-26 | 2012-03-09 | Pfizer | Processos para a preparação de derivados de isotiazole |
JP4585978B2 (ja) * | 2005-03-03 | 2010-11-24 | 参天製薬株式会社 | キノリルアルキルチオ基を有する新規環式化合物 |
JP5030947B2 (ja) | 2005-05-13 | 2012-09-19 | ヴァイロケム・ファーマ・インコーポレーテッド | フラビウイルス感染の治療及び予防のための化合物及び方法 |
US7932390B2 (en) | 2006-06-29 | 2011-04-26 | Hoffman-La Roche Inc. | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives |
SG176488A1 (en) | 2006-11-15 | 2011-12-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
CN101622229B (zh) * | 2007-02-26 | 2013-02-27 | 参天制药株式会社 | 具有脲基和氨基羰基作为取代基的吡咯衍生物 |
WO2008153042A1 (ja) * | 2007-06-11 | 2008-12-18 | Kyowa Hakko Kirin Co., Ltd. | 抗腫瘍剤 |
MX2010001636A (es) | 2007-08-14 | 2010-03-15 | Hoffmann La Roche | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
WO2010151710A2 (en) * | 2009-06-25 | 2010-12-29 | Medolution Limited | Substituted heterocyclic compounds as kinases inhibitors and method of use thereof |
US8916555B2 (en) | 2012-03-16 | 2014-12-23 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
EA032473B1 (ru) | 2014-12-23 | 2019-05-31 | Аксикин Фармасьютикалз, Инк. | 3,5-диаминопиразоловые ингибиторы киназы |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1950990A1 (de) * | 1968-10-17 | 1970-05-14 | Ciba Geigy | Verfahren zur Herstellung von neuen triazacyclischen Verbindungen |
GB1355513A (en) * | 1971-04-07 | 1974-06-05 | May & Baker Ltd | Isothiazole derivatives |
DE2408234A1 (de) * | 1974-02-21 | 1975-09-04 | Celamerck Gmbh & Co Kg | Isothiazolylharnstoffe |
US4057416A (en) * | 1976-06-18 | 1977-11-08 | Fmc Corporation | 3-Alkylthio-, 3-alkylsulfinyl-, and 3-alkylsulfonylisothiazole derivatives as herbicides |
US4075001A (en) * | 1976-06-18 | 1978-02-21 | Fmc Corporation | 3-Aminoisothiazole derivatives as herbicides |
US4059433A (en) * | 1976-06-18 | 1977-11-22 | Fmc Corporation | 3-Alkoxyisothiazole derivatives as herbicides |
DE3529247A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
DE3540377A1 (de) * | 1985-11-14 | 1987-05-21 | Bayer Ag | Thienooxazinone, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer |
DE3541631A1 (de) * | 1985-11-26 | 1987-05-27 | Bayer Ag | Selektiv-fungizide verwendung von thienylharnstoff-derivaten |
US4859699A (en) * | 1987-07-20 | 1989-08-22 | Sandoz Ltd. | Substituted N-benzoyl-N'-thienylureas |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
DE4328425A1 (de) * | 1993-08-24 | 1995-03-02 | Basf Ag | Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung |
TW276256B (es) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
WO1996014843A2 (en) * | 1994-11-10 | 1996-05-23 | Cor Therapeutics, Inc. | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases |
US5792767A (en) * | 1995-01-27 | 1998-08-11 | Abbott Laboratories | Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists |
US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
CA2291065C (en) * | 1997-05-23 | 2010-02-09 | Bayer Corporation | Raf kinase inhibitors |
US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
-
2000
- 2000-04-12 HN HN2000000051A patent/HN2000000051A/es unknown
- 2000-04-17 CO CO00028307A patent/CO5170417A1/es not_active Application Discontinuation
- 2000-04-17 US US09/549,893 patent/US6380214B1/en not_active Expired - Fee Related
- 2000-04-18 PA PA20008494101A patent/PA8494101A1/es unknown
- 2000-05-03 ES ES00920969T patent/ES2276681T3/es not_active Expired - Lifetime
- 2000-05-03 DE DE60032601T patent/DE60032601T2/de not_active Expired - Fee Related
- 2000-05-03 JP JP2000619789A patent/JP3692041B2/ja not_active Expired - Lifetime
- 2000-05-03 AU AU41374/00A patent/AU4137400A/en not_active Abandoned
- 2000-05-03 CA CA002374247A patent/CA2374247C/en not_active Expired - Fee Related
- 2000-05-03 EP EP00920969A patent/EP1187826B1/en not_active Expired - Lifetime
- 2000-05-03 BR BR0010746-8A patent/BR0010746A/pt not_active Application Discontinuation
- 2000-05-03 AT AT00920969T patent/ATE349440T1/de not_active IP Right Cessation
- 2000-05-03 WO PCT/IB2000/000570 patent/WO2000071532A1/en active IP Right Grant
- 2000-05-03 MX MXPA01011920A patent/MXPA01011920A/es active IP Right Grant
- 2000-05-15 UY UY26143A patent/UY26143A1/es not_active Application Discontinuation
- 2000-05-16 PE PE2000000458A patent/PE20010152A1/es not_active Application Discontinuation
- 2000-05-17 MA MA25977A patent/MA26733A1/fr unknown
- 2000-05-17 DZ DZ000085A patent/DZ3042A1/xx active
- 2000-05-17 AR ARP000102369A patent/AR029634A1/es not_active Application Discontinuation
- 2000-05-17 GT GT200000069A patent/GT200000069A/es unknown
- 2000-05-17 TN TNTNSN00104A patent/TNSN00104A1/fr unknown
-
2004
- 2004-07-20 JP JP2004211640A patent/JP2005008641A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU4137400A (en) | 2000-12-12 |
PE20010152A1 (es) | 2001-02-08 |
JP3692041B2 (ja) | 2005-09-07 |
DE60032601D1 (de) | 2007-02-08 |
DZ3042A1 (fr) | 2004-03-27 |
JP2005008641A (ja) | 2005-01-13 |
CA2374247A1 (en) | 2000-11-30 |
WO2000071532A1 (en) | 2000-11-30 |
ES2276681T3 (es) | 2007-07-01 |
AR029634A1 (es) | 2003-07-10 |
GT200000069A (es) | 2001-11-08 |
EP1187826B1 (en) | 2006-12-27 |
PA8494101A1 (es) | 2003-09-05 |
EP1187826A1 (en) | 2002-03-20 |
MA26733A1 (fr) | 2004-12-20 |
BR0010746A (pt) | 2002-02-13 |
TNSN00104A1 (fr) | 2005-11-10 |
US6380214B1 (en) | 2002-04-30 |
ATE349440T1 (de) | 2007-01-15 |
CO5170417A1 (es) | 2002-06-27 |
MXPA01011920A (es) | 2002-05-06 |
UY26143A1 (es) | 2000-12-29 |
JP2003500401A (ja) | 2003-01-07 |
DE60032601T2 (de) | 2007-11-15 |
CA2374247C (en) | 2008-01-22 |
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