US5849769A
(en)
*
|
1994-08-24 |
1998-12-15 |
Medivir Ab |
N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
|
US6294532B1
(en)
|
1997-08-22 |
2001-09-25 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
UA60365C2
(uk)
*
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
EP1158985B1
(en)
|
1999-01-13 |
2011-12-28 |
Bayer HealthCare LLC |
OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
US7125875B2
(en)
|
1999-04-15 |
2006-10-24 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
RU2260592C9
(ru)
|
1999-04-15 |
2017-04-07 |
Бристол-Маерс Сквибб Ко. |
Циклические ингибиторы протеинтирозинкиназ
|
HN2000000051A
(es)
*
|
1999-05-19 |
2001-02-02 |
Pfizer Prod Inc |
Derivados heterociclicos utiles como agentes anticancerosos
|
JP2003529609A
(ja)
*
|
2000-03-16 |
2003-10-07 |
ジーンソフト インコーポレイティッド |
核酸結合部分を含む荷電した化合物およびその利用法
|
US7078536B2
(en)
|
2001-03-14 |
2006-07-18 |
Genesoft Pharmaceuticals, Inc. |
Charged compounds comprising a nucleic acid binding moiety and uses therefor
|
MXPA03001189A
(es)
|
2000-08-09 |
2004-05-14 |
Agouron Pharma |
Compuestos de pirazol-tiazol, composiciones farmaceuticas que los contienen y su uso para inhibir las cinasas dependientes de ciclinas.
|
CN1466583A
(zh)
|
2000-08-17 |
2004-01-07 |
�¬ |
用于电光应用场合的高级nlo物质的设计和合成
|
BR0113258A
(pt)
|
2000-08-18 |
2003-07-15 |
Agouron Pharma |
Compostos, pró-drogas, metabólitos ou sais, métodos de tratamento de condição doentia em mamìferos, mediada pela atividade de proteìna cinase e métodos de modulação ou inibição da atividade de um receptor de proteìna cinase
|
DE60134679D1
(de)
|
2000-10-20 |
2008-08-14 |
Eisai R&D Man Co Ltd |
Stickstoff enthaltende aromatische Heterozyklen
|
EE200300247A
(et)
*
|
2000-11-28 |
2003-10-15 |
Pfizer Products Inc. |
Isotiasool-4-karboksamiidi soolad ja nende kasutamine hüperproliferatsioonivastaste vahenditena
|
MXPA03005696A
(es)
|
2000-12-21 |
2003-10-06 |
Glaxo Group Ltd |
Pirimidinaminas como moduladores de angiogenesis.
|
PE20020801A1
(es)
|
2001-01-05 |
2002-09-06 |
Pfizer |
Anticuerpos contra el receptor del factor de crecimiento similar a insulina
|
AU2002314744A1
(en)
|
2001-04-17 |
2002-10-28 |
Sepracor, Inc. |
Thiazole and other heterocyclic ligands and use thereof
|
AU2002345792A1
(en)
|
2001-06-21 |
2003-01-08 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
HN2002000156A
(es)
|
2001-07-06 |
2003-11-27 |
Inc Agouron Pharmaceuticals |
Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
|
WO2003015778A1
(en)
|
2001-08-17 |
2003-02-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
US20030143165A1
(en)
*
|
2002-01-25 |
2003-07-31 |
Allan Evans |
NSAID-containing topical formulations that demonstrate chemopreventive activity
|
EP1478358B1
(en)
|
2002-02-11 |
2013-07-03 |
Bayer HealthCare LLC |
Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
|
WO2003068223A1
(en)
*
|
2002-02-11 |
2003-08-21 |
Bayer Corporation |
Aryl ureas with raf kinase and angiogenesis inhibiting activity
|
WO2003068229A1
(en)
|
2002-02-11 |
2003-08-21 |
Bayer Pharmaceuticals Corporation |
Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
|
DE60318198T2
(de)
|
2002-05-02 |
2008-12-04 |
Merck & Co., Inc. |
Tyrosinkinase-hemmer
|
US6989451B2
(en)
*
|
2002-06-04 |
2006-01-24 |
Valeant Research & Development |
Heterocyclic compounds and uses thereof
|
CA2489355A1
(en)
*
|
2002-06-13 |
2003-12-24 |
Qlt Inc. |
Methods of using isothiazole derivatives to treat cancer or inflammation
|
MXPA05000130A
(es)
|
2002-06-27 |
2005-02-17 |
Novo Nordisk As |
Derivados de aril-carbonilo como agentes terapeuticos.
|
JP4511352B2
(ja)
*
|
2002-07-25 |
2010-07-28 |
ファイザー・インク |
抗癌薬として有用なイソチアゾール誘導体
|
WO2004012736A1
(en)
|
2002-08-02 |
2004-02-12 |
Genesoft Pharmaceuticals, Inc. |
Biaryl compounds having anti-infective activity
|
GEP20074134B
(en)
*
|
2002-08-19 |
2007-06-25 |
Pfizer Prod Inc |
Combination therapy for hyperproliferative diseases
|
EP1562931A2
(en)
|
2002-10-25 |
2005-08-17 |
Genesoft Pharmaceuticals, Inc. |
Anti-infective biaryl compounds
|
AU2003297822A1
(en)
|
2002-12-10 |
2004-06-30 |
Oscient Pharmaceuticals Corporation |
Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
|
JP3814285B2
(ja)
|
2002-12-19 |
2006-08-23 |
ファイザー・インク |
眼疾患の治療に有用なプロテインキナーゼ阻害剤としての2−(1h−インダゾール−6−イルアミノ)−ベンズアミド化合物
|
JP2006516603A
(ja)
*
|
2003-01-27 |
2006-07-06 |
ファイザー・プロダクツ・インク |
イソチアゾール誘導体
|
UY28213A1
(es)
|
2003-02-28 |
2004-09-30 |
Bayer Pharmaceuticals Corp |
Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
|
PT1622569E
(pt)
|
2003-04-24 |
2016-03-03 |
Incyte Corp |
Derivados de aza espiro alcanos como inibidores de metaloproteases
|
CA2526636C
(en)
|
2003-05-20 |
2012-10-02 |
Bayer Pharmaceuticals Corporation |
Diaryl ureas for diseases mediated by pdgfr
|
NZ544797A
(en)
|
2003-07-18 |
2011-04-29 |
Amgen Fremont Inc |
Specific antibodies that bind HGF and neutralise binding of HGF to met
|
CL2004001834A1
(es)
|
2003-07-23 |
2005-06-03 |
Bayer Pharmaceuticals Corp |
Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
|
AR045563A1
(es)
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
Anticuerpos dirigidos a m-csf
|
EP1683785B1
(en)
|
2003-11-11 |
2013-10-16 |
Eisai R&D Management Co., Ltd. |
Urea derivative and process for producing the same
|
CA2551324C
(en)
|
2004-01-06 |
2012-11-27 |
Novo Nordisk A/S |
Heteroaryl-ureas and their use as glucokinase activators
|
ES2246687B2
(es)
*
|
2004-02-11 |
2006-11-16 |
Miguel Muñoz Saez |
Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
|
WO2005081997A2
(en)
*
|
2004-02-20 |
2005-09-09 |
The Scripps Research Institute |
Isothiazole based protein kinase inhibitors
|
WO2005102327A1
(en)
*
|
2004-04-20 |
2005-11-03 |
Pfizer Products Inc. |
Dosage forms and methods of treatment using vegfr inhibitors
|
MXPA06012394A
(es)
|
2004-04-30 |
2007-01-31 |
Bayer Pharmaceuticals Corp |
Derivados de pirazolilurea sustituidos utiles en el tratamiento de cancer.
|
TW200538104A
(en)
*
|
2004-05-17 |
2005-12-01 |
Pfizer Prod Inc |
Phenyl derivatives for the treatment of abnormal cell growth
|
PL1786785T3
(pl)
|
2004-08-26 |
2010-08-31 |
Pfizer |
Enancjomerycznie czyste związki aminoheteroarylowe jako kinazy białkowe
|
KR100893977B1
(ko)
|
2004-08-26 |
2009-04-20 |
화이자 프로덕츠 인코포레이티드 |
이소티아졸 유도체의 제조 방법
|
US8772269B2
(en)
|
2004-09-13 |
2014-07-08 |
Eisai R&D Management Co., Ltd. |
Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
|
WO2006030941A1
(ja)
|
2004-09-13 |
2006-03-23 |
Eisai R & D Management Co., Ltd. |
スルホンアミド含有化合物の血管新生阻害物質との併用
|
ES2322175T3
(es)
|
2004-09-17 |
2009-06-17 |
EISAI R&D MANAGEMENT CO., LTD. |
Composicion medicinal con estabilidad mejorada y gelificacion reducida.
|
US7652009B2
(en)
|
2004-11-30 |
2010-01-26 |
Amgem Inc. |
Substituted heterocycles and methods of use
|
US7429667B2
(en)
|
2005-01-20 |
2008-09-30 |
Ardea Biosciences, Inc. |
Phenylamino isothiazole carboxamidines as MEK inhibitors
|
US8093011B2
(en)
|
2005-03-16 |
2012-01-10 |
Haley John D |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
US20060216288A1
(en)
*
|
2005-03-22 |
2006-09-28 |
Amgen Inc |
Combinations for the treatment of cancer
|
EP1863848A4
(en)
|
2005-03-31 |
2009-09-23 |
Agensys Inc |
CORRESPONDING ANTIBODIES AND MOLECULES THAT ATTACH PROTEINS 161P2F10B
|
MX2007013304A
(es)
|
2005-04-26 |
2007-12-13 |
Pfizer |
Anticuerpos de p-caderina.
|
EP1904466A1
(en)
|
2005-07-08 |
2008-04-02 |
Novo Nordisk A/S |
Dicycloalkyl urea glucokinase activators
|
JP4989476B2
(ja)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を検定する方法
|
PL2447283T3
(pl)
|
2005-09-07 |
2015-12-31 |
Amgen Fremont Inc |
Ludzkie przeciwciała monoklonalne przeciwko kinazie podobnej do receptora aktywiny-1 (ALK-1)
|
ES2374450T3
(es)
|
2005-09-20 |
2012-02-16 |
OSI Pharmaceuticals, LLC |
Marcadores biológicos predictivos de respuesta anticancerígena para inhibidores de cinasa del receptor del factor de crecimiento 1 similar a insulina.
|
US20080108664A1
(en)
*
|
2005-12-23 |
2008-05-08 |
Liu Belle B |
Solid-state form of AMG 706 and pharmaceutical compositions thereof
|
AR059066A1
(es)
*
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
|
US7989631B2
(en)
*
|
2006-02-10 |
2011-08-02 |
Amgen Inc. |
Hydrate forms of AMG706
|
WO2007121269A2
(en)
|
2006-04-11 |
2007-10-25 |
Ardea Biosciences, Inc. |
N-aryl-n'alkyl sulfamides as mek inhibitors
|
CA2649122C
(en)
*
|
2006-04-18 |
2015-06-30 |
Ardea Biosciences, Inc. |
Pyridone sulfonamides and pyridone sulfamides as mek inhibitors
|
MEP43308A
(en)
|
2006-05-09 |
2011-02-10 |
Pfizer Prod Inc |
Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
|
WO2007136103A1
(ja)
|
2006-05-18 |
2007-11-29 |
Eisai R & D Management Co., Ltd. |
甲状腺癌に対する抗腫瘍剤
|
US7910108B2
(en)
*
|
2006-06-05 |
2011-03-22 |
Incyte Corporation |
Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
|
PT2076502E
(pt)
*
|
2006-06-08 |
2011-06-07 |
Lilly Co Eli |
Carboxamidas substituídas
|
US7932390B2
(en)
|
2006-06-29 |
2011-04-26 |
Hoffman-La Roche Inc. |
Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
WO2008026748A1
(fr)
|
2006-08-28 |
2008-03-06 |
Eisai R & D Management Co., Ltd. |
Agent antitumoral pour cancer gastrique non différencié
|
EP2125781A2
(en)
|
2006-12-20 |
2009-12-02 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
ES2449482T3
(es)
|
2007-01-09 |
2014-03-19 |
Amgen Inc. |
Derivados de bis-aril-amida útiles para el tratamiento de cáncer
|
KR101445892B1
(ko)
|
2007-01-29 |
2014-09-29 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
미분화형 위암 치료용 조성물
|
JP2010519204A
(ja)
|
2007-02-16 |
2010-06-03 |
アムジエン・インコーポレーテツド |
窒素含有複素環ケトン類およびそれらのc−Met阻害薬としての使用
|
US7977371B2
(en)
*
|
2007-02-26 |
2011-07-12 |
Santen Pharmaceutical Co., Ltd. |
Pyrrole derivative having ureido group and aminocarbonyl group as substituents
|
EP2137535B1
(en)
*
|
2007-04-13 |
2015-06-03 |
Dana-Farber Cancer Institute, Inc. |
Receptor tyrosine kinase profiling
|
EP2076289B1
(en)
|
2007-04-13 |
2014-11-12 |
Dana-Farber Cancer Institute, Inc. |
Methods for treating cancer resistant to erbb therapeutics
|
US8509487B2
(en)
*
|
2007-04-19 |
2013-08-13 |
Avago Technologies General Ip (Singapore) Pte. Ltd. |
System and method for optically measuring a parameter of an object
|
MX2010001636A
(es)
|
2007-08-14 |
2010-03-15 |
Hoffmann La Roche |
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
|
SI2188313T1
(en)
|
2007-08-21 |
2018-04-30 |
Amgen, Inc. |
HUMAN C-FMS ANTIGEN TRANSFER PROTEIN
|
US8952035B2
(en)
|
2007-11-09 |
2015-02-10 |
Eisai R&D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
US20100029491A1
(en)
*
|
2008-07-11 |
2010-02-04 |
Maike Schmidt |
Methods and compositions for diagnostic use for tumor treatment
|
EP2382472B1
(en)
|
2008-12-23 |
2015-05-06 |
F.Hoffmann-La Roche Ag |
Methods and compositions for diagnostic use in cancer patients
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
EP2400990A2
(en)
|
2009-02-26 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
In situ methods for monitoring the emt status of tumor cells in vivo
|
JP2012519281A
(ja)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012519282A
(ja)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
|
PE20120770A1
(es)
|
2009-03-25 |
2012-07-10 |
Genentech Inc |
ANTICUERPOS ANTI alfa5ß1 CON ACTIVIDAD SOBRE GLIOBLASTOMAS
|
BR112012000735A2
(pt)
|
2009-07-13 |
2016-11-16 |
Genentech Inc |
"métodos, kits e conjuntos de compostos"
|
US20120128670A1
(en)
|
2009-07-31 |
2012-05-24 |
OSI Pharmaceuticals, LLC |
mTOR INHIBITOR AND ANGIOGENESIS INHIBITOR COMBINATION THERAPY
|
CA2772670A1
(en)
|
2009-09-17 |
2011-03-24 |
F. Hoffmann-La Roche Ag |
Methods and compositions for diagnostics use in cancer patients
|
WO2011073521A1
(en)
|
2009-12-15 |
2011-06-23 |
Petri Salven |
Methods for enriching adult-derived endothelial progenitor cells and uses thereof
|
CA2783846C
(en)
|
2009-12-21 |
2021-01-19 |
Genentech, Inc. |
Antibody formulation
|
CN104876937B
(zh)
|
2010-02-12 |
2017-07-28 |
辉瑞公司 |
8‑氟‑2‑{4‑[(甲氨基)甲基]苯基}‑1,3,4,5‑四氢‑6H‑氮杂*并[5,4,3‑cd]吲哚‑6‑酮的马来酸盐、其药物组合物及其用途
|
US20110275644A1
(en)
|
2010-03-03 |
2011-11-10 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
EP2542893A2
(en)
|
2010-03-03 |
2013-01-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
JP2013538042A
(ja)
|
2010-06-16 |
2013-10-10 |
ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション |
エンドプラスミンに対する抗体およびその使用
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
BR112012032462A2
(pt)
|
2010-06-25 |
2016-11-08 |
Eisai R&D Man Co Ltd |
agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.
|
EP2596026B1
(en)
|
2010-07-23 |
2020-04-08 |
Trustees of Boston University |
Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
GB201103578D0
(en)
|
2011-03-02 |
2011-04-13 |
Sabrepharm Ltd |
Dipyridinium derivatives
|
UA112539C2
(uk)
|
2011-03-03 |
2016-09-26 |
Новартіс Аг |
Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
|
WO2012129344A1
(en)
|
2011-03-23 |
2012-09-27 |
Amgen Inc. |
Fused tricyclic dual inhibitors of cdk 4/6 and flt3
|
US8962650B2
(en)
|
2011-04-18 |
2015-02-24 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
EP3444363B1
(en)
|
2011-06-03 |
2020-11-25 |
Eisai R&D Management Co., Ltd. |
Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
EP3409278B8
(en)
|
2011-07-21 |
2020-11-04 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
WO2013025939A2
(en)
|
2011-08-16 |
2013-02-21 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
WO2013101954A1
(en)
*
|
2011-12-28 |
2013-07-04 |
Allergan, Inc. |
3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
CN103508961B
(zh)
|
2012-06-26 |
2015-07-22 |
中美冠科生物技术(太仓)有限公司 |
抗肿瘤药物
|
US9505749B2
(en)
|
2012-08-29 |
2016-11-29 |
Amgen Inc. |
Quinazolinone compounds and derivatives thereof
|
ES2644758T3
(es)
|
2012-10-16 |
2017-11-30 |
Tolero Pharmaceuticals, Inc. |
Moduladores de PKM2 y métodos para su uso
|
MX2015004979A
(es)
|
2012-12-21 |
2015-07-17 |
Eisai R&D Man Co Ltd |
Forma amorfa de derivado de quinolina y metodo para su produccion.
|
SG10201913932VA
(en)
|
2013-03-13 |
2020-03-30 |
Genentech Inc |
Antibody formulations
|
WO2014152661A1
(en)
|
2013-03-14 |
2014-09-25 |
Panoptica, Inc. |
Ocular formulations for drug-delivery to the posterior segment of the eye
|
CN105308033B
(zh)
|
2013-03-14 |
2018-08-24 |
特雷罗药物股份有限公司 |
Jak2和alk2抑制剂及其使用方法
|
ES2687968T3
(es)
|
2013-05-14 |
2018-10-30 |
Eisai R&D Management Co., Ltd. |
Biomarcadores para pronosticar y evaluar la reactividad de sujetos con cáncer de endometrio a compuestos con lenvatinib
|
CN111808957A
(zh)
|
2014-04-04 |
2020-10-23 |
中美冠科生物技术(太仓)有限公司 |
用于确定对mek/erk抑制剂的应答性的方法
|
BR112017002827B1
(pt)
|
2014-08-28 |
2023-04-18 |
Eisai R&D Management Co., Ltd |
Derivado de quinolina altamente puro e método para produção do mesmo
|
US20160137727A1
(en)
|
2014-09-15 |
2016-05-19 |
Genentech, Inc. |
Antibody formulations
|
RU2704810C2
(ru)
|
2014-09-17 |
2019-10-31 |
Паноптика, Инк. |
Офтальмологические составы для доставки лекарств и защиты переднего отдела глаза
|
US9353093B2
(en)
|
2014-10-07 |
2016-05-31 |
Allergan, Inc. |
Indole-1-carboxamides as kinase inhibitors
|
US9403803B2
(en)
|
2014-10-08 |
2016-08-02 |
Allergan, Inc. |
Indole-3-carboxamides as kinase inhibitors
|
US9371314B2
(en)
|
2014-10-09 |
2016-06-21 |
Allergan, Inc. |
Pyridyl benzothiophenes as kinase inhibitors
|
US9359336B2
(en)
|
2014-10-09 |
2016-06-07 |
Allergan, Inc. |
Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
|
WO2016097918A1
(en)
|
2014-12-18 |
2016-06-23 |
Pfizer Inc. |
Pyrimidine and triazine derivatives and their use as axl inhibitors
|
AU2016205311B2
(en)
|
2015-01-08 |
2022-02-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Factors and cells that provide for induction of bone, bone marrow, and cartilage
|
MX2017010474A
(es)
|
2015-02-25 |
2017-11-28 |
Eisai R&D Man Co Ltd |
Metodo para suprimir el amargor de un derivado de quinoleina.
|
KR20240064733A
(ko)
|
2015-03-04 |
2024-05-13 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
MX2017013383A
(es)
|
2015-04-20 |
2017-12-07 |
Tolero Pharmaceuticals Inc |
Prediccion de respuesta a alvocidib mediante perfilado mitocondrial.
|
TR201911032T4
(tr)
|
2015-05-18 |
2019-08-21 |
Tolero Pharmaceuticals Inc |
Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları.
|
SG11201710198YA
(en)
|
2015-06-16 |
2018-01-30 |
Eisai R&D Man Co Ltd |
Anticancer agent
|
AU2016301315C1
(en)
|
2015-08-03 |
2022-07-07 |
Sumitomo Pharma Oncology, Inc. |
Combination therapies for treatment of cancer
|
GB2543550A
(en)
|
2015-10-21 |
2017-04-26 |
Hox Therapeutics Ltd |
Peptides
|
EP3383375A1
(en)
|
2015-12-03 |
2018-10-10 |
Agios Pharmaceuticals, Inc. |
Mat2a inhibitors for treating mtap null cancer
|
WO2018094275A1
(en)
|
2016-11-18 |
2018-05-24 |
Tolero Pharmaceuticals, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
KR20190099260A
(ko)
|
2016-12-19 |
2019-08-26 |
톨레로 파마수티컬스, 인크. |
프로파일링 펩티드 및 감도 프로파일링을 위한 방법
|
RS62456B1
(sr)
|
2016-12-22 |
2021-11-30 |
Amgen Inc |
Derivati benzizotiazola, izotiazolo[3,4-b]piridina, hinazolina, ftalazina, pirido[2,3-d]piridazina i pirido[2,3-d]pirimidina kao kras g12c inhibitori za tretman raka pluća, pankreasa ili debelog creva
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
CA3075046A1
(en)
|
2017-09-08 |
2019-03-14 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
WO2019055579A1
(en)
|
2017-09-12 |
2019-03-21 |
Tolero Pharmaceuticals, Inc. |
TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR
|
MA52496A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
MA52501A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
JP7360396B2
(ja)
|
2018-06-01 |
2023-10-12 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及び同一物の使用方法
|
JP7357644B2
(ja)
|
2018-06-11 |
2023-10-06 |
アムジエン・インコーポレーテツド |
がんを処置するためのkras g12c阻害剤
|
EP3806852A1
(en)
|
2018-06-12 |
2021-04-21 |
vTv Therapeutics LLC |
Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
|
WO2020050890A2
(en)
|
2018-06-12 |
2020-03-12 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
CN112512597A
(zh)
|
2018-07-26 |
2021-03-16 |
大日本住友制药肿瘤公司 |
用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
WO2020106640A1
(en)
|
2018-11-19 |
2020-05-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
WO2020117988A1
(en)
|
2018-12-04 |
2020-06-11 |
Tolero Pharmaceuticals, Inc. |
Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
|
EP3897670A4
(en)
|
2018-12-19 |
2022-09-07 |
Disarm Therapeutics, Inc. |
MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS
|
WO2020132649A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
TWI844602B
(zh)
|
2018-12-20 |
2024-06-11 |
美商安進公司 |
Kif18a抑制劑
|
CA3123042A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Kif18a inhibitors
|
EP3898592A1
(en)
|
2018-12-20 |
2021-10-27 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
CA3127502A1
(en)
|
2019-02-12 |
2020-08-20 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
WO2020180768A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
AU2020232616A1
(en)
|
2019-03-01 |
2021-09-09 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
US11793802B2
(en)
|
2019-03-20 |
2023-10-24 |
Sumitomo Pharma Oncology, Inc. |
Treatment of acute myeloid leukemia (AML) with venetoclax failure
|
EP3941463A1
(en)
|
2019-03-22 |
2022-01-26 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Compositions comprising pkm2 modulators and methods of treatment using the same
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
MX2021014126A
(es)
|
2019-05-21 |
2022-01-04 |
Amgen Inc |
Formas en estado solido.
|
AU2020325115A1
(en)
|
2019-08-02 |
2022-03-17 |
Amgen Inc. |
Pyridine derivatives as KIF18A inhibitors
|
JP2022542967A
(ja)
|
2019-08-02 |
2022-10-07 |
アムジエン・インコーポレーテツド |
Kif18a阻害剤
|
JP2022542394A
(ja)
|
2019-08-02 |
2022-10-03 |
アムジエン・インコーポレーテツド |
Kif18a阻害剤として有用なヘテロアリールアミド
|
MX2022001296A
(es)
|
2019-08-02 |
2022-02-22 |
Amgen Inc |
Inhibidores de kif18a.
|
MX2022004656A
(es)
|
2019-10-24 |
2022-05-25 |
Amgen Inc |
Derivados de piridopirimidina utiles como inhibidores de kras g12c y kras g12d en el tratamiento del cancer.
|
TW202132314A
(zh)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
TW202132316A
(zh)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
CR20220240A
(es)
|
2019-11-04 |
2022-08-03 |
Revolution Medicines Inc |
Inhibidores de ras
|
CN114901662A
(zh)
|
2019-11-08 |
2022-08-12 |
锐新医药公司 |
双环杂芳基化合物及其用途
|
US20230192682A1
(en)
|
2019-11-14 |
2023-06-22 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
BR112022009390A2
(pt)
|
2019-11-14 |
2022-08-09 |
Amgen Inc |
Síntese melhorada de composto inibidor de kras g12c
|
WO2021108683A1
(en)
|
2019-11-27 |
2021-06-03 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
IL294484A
(en)
|
2020-01-07 |
2022-09-01 |
Revolution Medicines Inc |
Dosage for shp2 inhibitor and methods for treating cancer
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|
CA3187757A1
(en)
|
2020-09-03 |
2022-03-24 |
Ethan AHLER |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
TW202227460A
(zh)
|
2020-09-15 |
2022-07-16 |
美商銳新醫藥公司 |
Ras抑制劑
|
JP2024501280A
(ja)
|
2020-12-22 |
2024-01-11 |
キル・レガー・セラピューティクス・インコーポレーテッド |
Sos1阻害剤およびその使用
|
TW202309053A
(zh)
|
2021-05-05 |
2023-03-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
CR20230570A
(es)
|
2021-05-05 |
2024-01-22 |
Revolution Medicines Inc |
Inhibidores de ras
|
JP2024516450A
(ja)
|
2021-05-05 |
2024-04-15 |
レボリューション メディシンズ インコーポレイテッド |
共有結合性ras阻害剤及びその使用
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
WO2024081916A1
(en)
|
2022-10-14 |
2024-04-18 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|
WO2024140850A1
(zh)
*
|
2022-12-28 |
2024-07-04 |
苏州必扬医药科技有限公司 |
一种蛋白酪氨酸激酶抑制剂及其医药用途
|