MX2010001636A - Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. - Google Patents
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.Info
- Publication number
- MX2010001636A MX2010001636A MX2010001636A MX2010001636A MX2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A
- Authority
- MX
- Mexico
- Prior art keywords
- diazo bicyclic
- smac mimetics
- mimetics
- bicyclic smac
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención está dirigida a derivados de pirazolo[3,4-d]pirimidina novedosos de fórmula (I), y sales y ésteres farmacéuticamente aceptables de los mismos, donde R, el Anillo A, L y el anillo B son como se describe aquí. Esos compuestos y sus sales y ésteres farmacéuticamente aceptables inhiben la Raf cinasa y tienen actividad antiproliferativa. Por lo tanto, son útiles en el tratamiento o control de trastornos proliferativos como el cáncer, en particular tumores sólidos, de manera más particular tumor de mama, tumor de colón, tumor de pulmón, tumor de próstata y melanoma. También se describe una composición y una formulación de dosis unitaria que comprende ese compuesto, o una sal o éster farmacéuticamente aceptable del mismo para producir esos compuestos, y métodos para usar esos compuestos, o sus sales o ésteres farmacéuticamente aceptables, en el tratamiento de trastornos proliferativos. (Ver fórmula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95565307P | 2007-08-14 | 2007-08-14 | |
| PCT/US2008/060215 WO2008128171A2 (en) | 2007-04-13 | 2008-04-14 | Diazo bicyclic smac mimetics and the uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001636A true MX2010001636A (es) | 2010-03-15 |
Family
ID=39760502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001636A MX2010001636A (es) | 2007-08-14 | 2008-04-14 | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7968554B2 (es) |
| EP (1) | EP2188290B1 (es) |
| JP (1) | JP5296790B2 (es) |
| KR (1) | KR20100038431A (es) |
| CN (1) | CN101965349B (es) |
| AT (1) | ATE512152T1 (es) |
| AU (1) | AU2008288538A1 (es) |
| BR (1) | BRPI0815334A2 (es) |
| CA (1) | CA2694666C (es) |
| ES (1) | ES2366268T3 (es) |
| MX (1) | MX2010001636A (es) |
| WO (1) | WO2009021869A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| JP7341060B2 (ja) | 2017-02-10 | 2023-09-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ｍａｐｋ経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物 |
| US11725185B2 (en) | 2017-12-28 | 2023-08-15 | University Of Houston System | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| SG11202110547YA (en) * | 2019-04-10 | 2021-10-28 | Cellestia Biotech Ag | Compounds for the treatment of oncovirus induced cancer and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732970B1 (fr) | 1995-04-14 | 1997-05-16 | Hoechst Schering Agrevo Sa | Nouveaux derives de l'acide beta-methoxy acrylique, leur procede de preparation et leur application comme pesticides |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| ES2206191T3 (es) | 1999-01-11 | 2004-05-16 | Princeton University | Inhibidores de alta afinidad para validacion de dianas y usos de los mismos. |
| HN2000000051A (es) | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
| AP2001002358A0 (en) | 2000-11-28 | 2001-12-31 | Pfizer Prod Inc | Salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4- pyrrolidin-1-yl-butyl)ureido]-isothiazole-4-carboxilic acid amide and method of production. |
| AU2003226211B2 (en) | 2002-03-29 | 2008-05-29 | Novartis Vaccines And Diagnostics, Inc. | Substituted benzazoles and use thereof as RAF kinase inhibitors |
| CA2502429A1 (en) * | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| JP2006528685A (ja) | 2003-05-06 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
| US20050020619A1 (en) * | 2003-07-24 | 2005-01-27 | Patrick Betschmann | Thienopyridine kinase inhibitors |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| US20050026944A1 (en) * | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
| KR20070029643A (ko) | 2003-12-05 | 2007-03-14 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | ＩＫＫ 억제제로서의 치환된3-아미노-티에노[2,3-ｂ]피리딘-2-카복실산 아미드 화합물 |
| WO2005074603A2 (en) * | 2004-02-03 | 2005-08-18 | Abbott Laboratories | Aminobenzoxazoles as therapeutic agents |
| US20050256154A1 (en) * | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| JP2008540674A (ja) | 2005-05-20 | 2008-11-20 | アレイ バイオファーマ、インコーポレイテッド | Ｒａｆ阻害化合物およびその使用方法 |
| PE20070100A1 (es) * | 2005-06-22 | 2007-03-10 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-b]PIRIDINA COMO MODULADORES DE QUINASAS |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| KR100968099B1 (ko) * | 2005-09-15 | 2010-07-06 | 에프. 호프만-라 로슈 아게 | 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산 유도체 |
| CA2631664C (en) * | 2005-12-08 | 2012-05-08 | Abbott Laboratories | 9-membered heterobicyclic compounds as inhibitors of protein kinases |
| JP2009520028A (ja) | 2005-12-19 | 2009-05-21 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | Ｉｇｆｒ抑制剤および抗癌剤の併用 |
-
2008
- 2008-04-14 MX MX2010001636A patent/MX2010001636A/es not_active Application Discontinuation
- 2008-07-18 US US12/175,562 patent/US7968554B2/en not_active Expired - Fee Related
- 2008-08-04 JP JP2010520530A patent/JP5296790B2/ja not_active Expired - Fee Related
- 2008-08-04 CN CN200880102683.4A patent/CN101965349B/zh not_active Expired - Fee Related
- 2008-08-04 WO PCT/EP2008/060215 patent/WO2009021869A1/en active Application Filing
- 2008-08-04 KR KR1020107002618A patent/KR20100038431A/ko not_active Application Discontinuation
- 2008-08-04 ES ES08786828T patent/ES2366268T3/es active Active
- 2008-08-04 BR BRPI0815334A patent/BRPI0815334A2/pt not_active IP Right Cessation
- 2008-08-04 AT AT08786828T patent/ATE512152T1/de not_active IP Right Cessation
- 2008-08-04 CA CA2694666A patent/CA2694666C/en not_active Expired - Fee Related
- 2008-08-04 AU AU2008288538A patent/AU2008288538A1/en not_active Abandoned
- 2008-08-04 EP EP08786828A patent/EP2188290B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008288538A1 (en) | 2009-02-19 |
| JP5296790B2 (ja) | 2013-09-25 |
| CA2694666A1 (en) | 2009-02-19 |
| ATE512152T1 (de) | 2011-06-15 |
| ES2366268T3 (es) | 2011-10-18 |
| CA2694666C (en) | 2015-07-14 |
| EP2188290B1 (en) | 2011-06-08 |
| CN101965349A (zh) | 2011-02-02 |
| WO2009021869A1 (en) | 2009-02-19 |
| BRPI0815334A2 (pt) | 2019-09-24 |
| EP2188290A1 (en) | 2010-05-26 |
| KR20100038431A (ko) | 2010-04-14 |
| JP2010535835A (ja) | 2010-11-25 |
| US7968554B2 (en) | 2011-06-28 |
| US20090048274A1 (en) | 2009-02-19 |
| CN101965349B (zh) | 2016-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009011069A (es) | Mimeticos de smac diazo biciclicos y usos de los mismos. | |
| WO2007130626A3 (en) | Bivalent smac mimetics and the uses thereof | |
| WO2005069888A3 (en) | Smac peptidomimetics and the uses thereof | |
| WO2005069894A3 (en) | Conformationally constrained smac mimetics and the uses thereof | |
| WO2006010118A3 (en) | Conformationally constrained smac mimetics and the uses thereof | |
| WO2009126947A3 (en) | Heteroaryl-substituted bicyclic smac mimetics and the uses thereof | |
| TN2012000485A1 (en) | Predictive markers useful in the treatment of fragile x syndrome (fxs) | |
| SMT201600003B (it) | Inibitori indazolici della via di segnalazione wnt e loro usi terapeutici | |
| HN2009000214A (es) | Peptidomimeticos de smac utiles como inhibidores de proteinas de apoptosis (iap) | |
| ECSP066893A (es) | Inhibidores de proteínas de apoptosis (iap) | |
| CL2012002904A1 (es) | Combinación o composición farmacéutica que comprende un inhibidor de la señalización de células y/o de la angiogénesis y un inhibidor de la quinasa aurora (aki); kit faramcéutico que la comprende; su uso en el tratamiento de enfermedades oncológicas y fibróticas; y compuestos derivados de indol y pirimidina sustituidos. | |
| WO2011050068A3 (en) | Bivalent diazo bicyclic smac mimetics and the uses thereof | |
| EP2378875A4 (en) | CELL-PERMITTING KINASE-HEMMER ON PEPTIDE BASE | |
| EA200601562A1 (ru) | Сокристаллы госсипола и их применение | |
| EP1967207A4 (en) | INHIBITOR OF INDUCTION OF CYTOTOXIC T CELLS | |
| CL2010001637A1 (es) | Compuestos derivados de isoindolonas; composición farmacéutica que los comprende; y su uso como inhibidores de la quinasa mek para tratar enfermedades hiperproliferativas y/o inflamatorias tales como cáncer, artritis reumatoidea entre otras. | |
| EA201270553A1 (ru) | Ингибиторы тирозинкиназы брутона | |
| BR112012000934A2 (pt) | cassetes e métodos de utilizacao destes | |
| EP2155228A4 (en) | POLYPEPTIDE INHIBITORS OF HSP27 KINASE AND USES THEREOF | |
| HK1129298A1 (en) | Dihydrodiazepines useful as inhibitors of protein kinases | |
| ECSP13012394A (es) | Nuevas formas de dosificación de liberación modificada de un inhibidor de la xantina oxidorreductasa o de inhibidores de xantina oxidasa | |
| IL194699A0 (en) | Tetrahydropteridines useful as inhibitors of protein kinases | |
| WO2006050447A3 (en) | Apogossypolone and the uses thereof | |
| BRPI0911332A2 (pt) | composições e uso de inibidores de epas1 | |
| MX2010001636A (es) | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |