MX2017013383A - Prediccion de respuesta a alvocidib mediante perfilado mitocondrial. - Google Patents

Prediccion de respuesta a alvocidib mediante perfilado mitocondrial.

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Publication number
MX2017013383A
MX2017013383A MX2017013383A MX2017013383A MX2017013383A MX 2017013383 A MX2017013383 A MX 2017013383A MX 2017013383 A MX2017013383 A MX 2017013383A MX 2017013383 A MX2017013383 A MX 2017013383A MX 2017013383 A MX2017013383 A MX 2017013383A
Authority
MX
Mexico
Prior art keywords
alvocidib
predicting response
mitochondrial profiling
mitochondrial
profiling
Prior art date
Application number
MX2017013383A
Other languages
English (en)
Inventor
L Warner Steven
J Bearss David
Original Assignee
Tolero Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tolero Pharmaceuticals Inc filed Critical Tolero Pharmaceuticals Inc
Publication of MX2017013383A publication Critical patent/MX2017013383A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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Abstract

La presente descripción proporciona métodos de diagnóstico útiles para predecir la respuesta de un paciente a alvocidib y para guiar a la decisión de un facultativo para administrar alvocidib al paciente.
MX2017013383A 2015-04-20 2016-04-20 Prediccion de respuesta a alvocidib mediante perfilado mitocondrial. MX2017013383A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562150138P 2015-04-20 2015-04-20
PCT/US2016/028443 WO2016172214A1 (en) 2015-04-20 2016-04-20 Predicting response to alvocidib by mitochondrial profiling

Publications (1)

Publication Number Publication Date
MX2017013383A true MX2017013383A (es) 2017-12-07

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MX2017013383A MX2017013383A (es) 2015-04-20 2016-04-20 Prediccion de respuesta a alvocidib mediante perfilado mitocondrial.

Country Status (13)

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US (4) US9901574B2 (es)
EP (2) EP3611506B1 (es)
JP (1) JP6851978B2 (es)
KR (1) KR20180018507A (es)
CN (1) CN107995863A (es)
AU (1) AU2016252609B2 (es)
BR (1) BR112017022666A8 (es)
CA (1) CA2982928A1 (es)
HK (1) HK1251655A1 (es)
IL (1) IL255029B (es)
MX (1) MX2017013383A (es)
RU (1) RU2717829C2 (es)
WO (1) WO2016172214A1 (es)

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