IN164232B - - Google Patents
Info
- Publication number
- IN164232B IN164232B IN300/BOM/85A IN300BO1985A IN164232B IN 164232 B IN164232 B IN 164232B IN 300BO1985 A IN300BO1985 A IN 300BO1985A IN 164232 B IN164232 B IN 164232B
- Authority
- IN
- India
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- represents hydrogen
- integer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863612337 DE3612337A1 (de) | 1986-04-11 | 1986-04-11 | 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
IN164232B true IN164232B (es) | 1989-02-04 |
Family
ID=6298535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN300/BOM/85A IN164232B (es) | 1986-04-11 | 1985-10-31 |
Country Status (16)
Country | Link |
---|---|
US (1) | US4900727A (es) |
EP (1) | EP0241003B1 (es) |
JP (1) | JPH0686446B2 (es) |
KR (1) | KR950009861B1 (es) |
AT (2) | ATE95519T1 (es) |
AU (1) | AU602891B2 (es) |
CA (1) | CA1332238C (es) |
DE (2) | DE3612337A1 (es) |
DK (1) | DK169760B1 (es) |
ES (1) | ES2060582T3 (es) |
HK (1) | HK1006021A1 (es) |
IE (1) | IE62244B1 (es) |
IL (1) | IL82149A (es) |
IN (1) | IN164232B (es) |
PT (1) | PT84654B (es) |
ZA (1) | ZA872555B (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
US5278174A (en) * | 1990-06-04 | 1994-01-11 | Scios Nova, Inc. | Sigma binding site agents |
EP0508347A1 (en) * | 1991-04-10 | 1992-10-14 | Hoechst Aktiengesellschaft | 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use |
US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
GB9604709D0 (en) * | 1996-03-05 | 1996-05-01 | Imperial College | A compound |
US6903084B2 (en) | 1991-08-29 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
CZ285937B6 (cs) * | 1992-01-16 | 1999-12-15 | Hoechst Aktiengesellschaft | Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití |
US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
US20060241173A1 (en) * | 1996-02-16 | 2006-10-26 | Sterix Ltd. | Compound |
US6506792B1 (en) | 1997-03-04 | 2003-01-14 | Sterix Limited | Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using |
US6087366A (en) * | 1996-03-07 | 2000-07-11 | The Trustees Of Columbia University In The City Of New York | Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death |
US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
US5908934A (en) * | 1996-09-26 | 1999-06-01 | Bristol-Myers Squibb Company | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs |
DE19802449A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
GB9807779D0 (en) * | 1998-04-09 | 1998-06-10 | Ciba Geigy Ag | Organic compounds |
US6399633B1 (en) * | 1999-02-01 | 2002-06-04 | Aventis Pharmaceuticals Inc. | Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation |
DE19959546A1 (de) * | 1999-12-09 | 2001-06-21 | Rhone Poulenc Rorer Gmbh | Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen |
US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
NZ520280A (en) * | 2000-01-18 | 2004-04-30 | Aventis Pharma Inc | Pseudopolymorph of (-)-CIS-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-methyl)piperidinyl]-4H-1-benzopyran-4-one |
PL201690B1 (pl) * | 2000-01-18 | 2009-04-30 | Aventis Pharma Inc | Forma II etanolowego solwatu chlorowodorku (-)-cis-2-(2-chlorofenylo)-5,7-dihydroksy-8[4R-(3S-hydroksy-1-metylo)-piperydynylo]-4H-1-benzopiran-4-onu, sposób jej wytwarzania, kompozycja farmaceutyczna i zastosowanie Formy II |
US6576647B2 (en) | 2000-01-18 | 2003-06-10 | Aventis Pharmaceuticals Inc. | Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one |
US6821990B2 (en) | 2000-01-18 | 2004-11-23 | Aventis Pharma Deutschland Gmbh | Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one |
FR2805538B1 (fr) * | 2000-02-29 | 2006-08-04 | Hoechst Marion Roussel Inc | Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
CN100381437C (zh) | 2002-04-17 | 2008-04-16 | 赛特凯恩蒂克公司 | 化合物、组合物和方法 |
US7915301B2 (en) | 2002-07-08 | 2011-03-29 | Piramal Life Science Limited | Inhibitors of cyclin dependent kinases and their use |
US7271193B2 (en) * | 2002-07-08 | 2007-09-18 | Nicholas Piramal India, Ltd. | Inhibitors of cyclin-dependent kinases and their use |
US7884127B2 (en) * | 2002-07-08 | 2011-02-08 | Pirimal Life Sciences Ltd. | Inhibitors of cyclin dependent kinases and their use |
US6949538B2 (en) * | 2002-07-17 | 2005-09-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
WO2004024086A2 (en) * | 2002-09-13 | 2004-03-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
EP1670456A2 (en) * | 2003-10-06 | 2006-06-21 | Cytokinetics, Inc. | Compounds, compositions and methods |
RU2006124421A (ru) * | 2003-12-09 | 2008-01-20 | ПРАВИТЕЛЬСТВО СОЕДИНЕННЫХ ШТАТОВ АМЕРИКИ, ПРЕДСТАВЛЕННОЕ СЕКРЕТАРЕМ ДЕПАРТАМЕНТА ЗДРАВООХРАНЕНИЯ И СЛУЖБЫ ДЛЯ ЛЮДЕЙ, УС Национальный Институт здравоохранени , Ведомство по передаче технологий (US) | Способ подавления ответной иммунной реакции или лечения пролиферативного нарушения |
JP2007513967A (ja) * | 2003-12-11 | 2007-05-31 | セラヴァンス, インコーポレーテッド | 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物 |
CA2594477C (en) | 2005-01-21 | 2016-07-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
JP5498782B2 (ja) | 2006-06-21 | 2014-05-21 | ピラマル エンタープライジーズ リミテッド | 増殖性疾患治療用のエナンチオマー的に純粋なフラボン誘導体の調製方法 |
EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
TWI461194B (zh) | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
MX2012009830A (es) | 2010-02-26 | 2013-02-11 | Piramal Entpr Ltd | Flavonas sustituidas de pirrolidina para el tratamiento de desordenes inflamatorios. |
US9376664B2 (en) | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
TW201300105A (zh) | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
US9776989B2 (en) | 2013-04-10 | 2017-10-03 | Council Of Scientific & Industrial Research | Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders |
WO2014170914A1 (en) | 2013-04-17 | 2014-10-23 | Council Of Scientific And Industrial Research | Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof |
CN117731786A (zh) | 2013-07-12 | 2024-03-22 | 皮拉马尔企业有限公司 | 用于治疗黑素瘤的药物组合 |
PT3218005T (pt) | 2014-11-12 | 2023-04-11 | Seagen Inc | Compostos que interagem com glicano e métodos de uso |
AU2016252609B2 (en) | 2015-04-20 | 2022-06-30 | Sumitomo Pharma Oncology, Inc. | Predicting response to alvocidib by mitochondrial profiling |
PT3298021T (pt) * | 2015-05-18 | 2019-08-05 | Tolero Pharmaceuticals Inc | Pró-fármacos de alvocidib possuindo biodisponibilidade aumentada |
JP7083497B2 (ja) | 2015-08-03 | 2022-06-13 | スミトモ ファーマ オンコロジー, インコーポレイテッド | がんの処置のための併用療法 |
IL302822A (en) | 2015-11-12 | 2023-07-01 | Seagen Inc | Compounds interacting with glycans and methods of use |
WO2018094143A1 (en) | 2016-11-17 | 2018-05-24 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
AU2017379847B2 (en) | 2016-12-19 | 2022-05-26 | Sumitomo Pharma Oncology, Inc. | Profiling peptides and methods for sensitivity profiling |
JP2020510671A (ja) | 2017-03-03 | 2020-04-09 | シアトル ジェネティックス, インコーポレイテッド | グリカン相互作用化合物および使用の方法 |
US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
KR20210099066A (ko) | 2018-12-04 | 2021-08-11 | 스미토모 다이니폰 파마 온콜로지, 인크. | 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체 |
JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病(aml)の処置 |
JPWO2020213714A1 (es) * | 2019-04-18 | 2020-10-22 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1223690A (en) * | 1967-10-17 | 1971-03-03 | Fisons Pharmaceuticals Ltd | Substituted chromon-2-carboxylic acids |
DE2731566A1 (de) * | 1977-07-13 | 1979-02-01 | Bayer Ag | Verfahren zur herstellung von neuen chromon-derivaten, sowie ihre verwendung als pflanzenschutzmittel |
GB2101115A (en) * | 1980-10-23 | 1983-01-12 | Pfizer Ltd | Thromboxane synthetase inhibitors |
DE3311005A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3329186A1 (de) * | 1983-08-12 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Chromonalkaloid, verfahren zu seiner isolierung aus dysoxylum binectariferum, und seine verwendung als arzneimittel |
DE3445852A1 (de) * | 1984-12-15 | 1986-06-19 | Bayer Ag, 5090 Leverkusen | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1985
- 1985-10-31 IN IN300/BOM/85A patent/IN164232B/en unknown
-
1986
- 1986-04-11 DE DE19863612337 patent/DE3612337A1/de not_active Withdrawn
-
1987
- 1987-04-08 DE DE87105180T patent/DE3787661D1/de not_active Expired - Lifetime
- 1987-04-08 EP EP87105180A patent/EP0241003B1/de not_active Expired - Lifetime
- 1987-04-08 AT AT87105180T patent/ATE95519T1/de not_active IP Right Cessation
- 1987-04-08 ES ES87105180T patent/ES2060582T3/es not_active Expired - Lifetime
- 1987-04-09 IL IL8214987A patent/IL82149A/en not_active IP Right Cessation
- 1987-04-09 ZA ZA872555A patent/ZA872555B/xx unknown
- 1987-04-10 PT PT84654A patent/PT84654B/pt unknown
- 1987-04-10 AU AU71397/87A patent/AU602891B2/en not_active Expired
- 1987-04-10 IE IE94187A patent/IE62244B1/en not_active IP Right Cessation
- 1987-04-10 KR KR87003427A patent/KR950009861B1/ko not_active IP Right Cessation
- 1987-04-10 DK DK185287A patent/DK169760B1/da not_active IP Right Cessation
- 1987-04-10 CA CA000534430A patent/CA1332238C/en not_active Expired - Lifetime
- 1987-04-10 JP JP62087252A patent/JPH0686446B2/ja not_active Expired - Lifetime
- 1987-10-08 AT AT0260587A patent/AT389875B/de active
-
1989
- 1989-01-26 US US07/302,084 patent/US4900727A/en not_active Expired - Lifetime
-
1998
- 1998-06-11 HK HK98105203A patent/HK1006021A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR950009861B1 (en) | 1995-08-29 |
DK169760B1 (da) | 1995-02-20 |
JPS62242680A (ja) | 1987-10-23 |
PT84654A (de) | 1987-05-01 |
AU7139787A (en) | 1987-10-15 |
ES2060582T3 (es) | 1994-12-01 |
AT389875B (de) | 1990-02-12 |
ATA260587A (de) | 1989-07-15 |
JPH0686446B2 (ja) | 1994-11-02 |
DE3787661D1 (de) | 1993-11-11 |
KR870010045A (ko) | 1987-11-30 |
IL82149A (en) | 1994-01-25 |
IE870941L (en) | 1987-10-11 |
CA1332238C (en) | 1994-10-04 |
AU602891B2 (en) | 1990-11-01 |
EP0241003A2 (de) | 1987-10-14 |
IL82149A0 (en) | 1987-10-30 |
DK185287D0 (da) | 1987-04-10 |
IE62244B1 (en) | 1995-01-11 |
PT84654B (pt) | 1989-12-29 |
ZA872555B (en) | 1987-11-25 |
DE3612337A1 (de) | 1987-10-15 |
EP0241003B1 (de) | 1993-10-06 |
HK1006021A1 (en) | 1999-02-05 |
DK185287A (da) | 1987-10-12 |
US4900727A (en) | 1990-02-13 |
EP0241003A3 (en) | 1988-10-12 |
ATE95519T1 (de) | 1993-10-15 |
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