DK185287A - 4h-1-benzopyran-4-on-derivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler - Google Patents

4h-1-benzopyran-4-on-derivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler

Info

Publication number
DK185287A
DK185287A DK185287A DK185287A DK185287A DK 185287 A DK185287 A DK 185287A DK 185287 A DK185287 A DK 185287A DK 185287 A DK185287 A DK 185287A DK 185287 A DK185287 A DK 185287A
Authority
DK
Denmark
Prior art keywords
alkyl
aryl
cycloalkyl
represents hydrogen
integer
Prior art date
Application number
DK185287A
Other languages
English (en)
Other versions
DK185287D0 (da
DK169760B1 (da
Inventor
Samba Laxminarayan Kattige
Ramchandra Ganapati Naik
Aftab Dawoodbhai Lakdawalla
Alihussein Nomanbha Dohadwalla
Richard Helmut Rupp
Noel John De Souza
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK185287D0 publication Critical patent/DK185287D0/da
Publication of DK185287A publication Critical patent/DK185287A/da
Application granted granted Critical
Publication of DK169760B1 publication Critical patent/DK169760B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK185287A 1986-04-11 1987-04-10 4H-1-Benzopyran-4-on-derivater, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidler DK169760B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863612337 DE3612337A1 (de) 1986-04-11 1986-04-11 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3612337 1986-04-11

Publications (3)

Publication Number Publication Date
DK185287D0 DK185287D0 (da) 1987-04-10
DK185287A true DK185287A (da) 1987-10-12
DK169760B1 DK169760B1 (da) 1995-02-20

Family

ID=6298535

Family Applications (1)

Application Number Title Priority Date Filing Date
DK185287A DK169760B1 (da) 1986-04-11 1987-04-10 4H-1-Benzopyran-4-on-derivater, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidler

Country Status (16)

Country Link
US (1) US4900727A (da)
EP (1) EP0241003B1 (da)
JP (1) JPH0686446B2 (da)
KR (1) KR950009861B1 (da)
AT (2) ATE95519T1 (da)
AU (1) AU602891B2 (da)
CA (1) CA1332238C (da)
DE (2) DE3612337A1 (da)
DK (1) DK169760B1 (da)
ES (1) ES2060582T3 (da)
HK (1) HK1006021A1 (da)
IE (1) IE62244B1 (da)
IL (1) IL82149A (da)
IN (1) IN164232B (da)
PT (1) PT84654B (da)
ZA (1) ZA872555B (da)

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US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
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US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
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US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
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US6087366A (en) * 1996-03-07 2000-07-11 The Trustees Of Columbia University In The City Of New York Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death
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US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
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DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
AU2001230869A1 (en) * 2000-01-18 2001-07-31 Aventis Pharmaceuticals Inc. Ethanol solvate of
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PL200696B1 (pl) * 2000-01-18 2009-01-30 Aventis Pharma Inc Pseudopolimorficzna Forma I chlorowodorku (-)-cis-2-(2-chlorofenylo)-5,7-dihydroksy-8[4R-(3S-hydroksy-1-metylo)-piperydynylo]-4H-1-benzopiran-4-onu wolna od Formy II i sposób wytwarzania Formy I
US6821990B2 (en) * 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
CA2482041C (en) 2002-04-17 2012-06-05 Cytokinetics, Inc. 4-chromanone derivatives for treating cellular proliferative diseases and disorders
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
US7884127B2 (en) * 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US7915301B2 (en) * 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
AU2003252025A1 (en) * 2002-07-17 2004-02-02 Cytokinetics, Inc. Compounds, compositions, and methods
JP2005539062A (ja) * 2002-09-13 2005-12-22 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods
TR200808208T1 (tr) * 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi
US20050171182A1 (en) * 2003-12-11 2005-08-04 Roger Briesewitz Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
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CA2655789C (en) 2006-06-21 2014-04-01 Piramal Life Sciences Limited Enantiomerically pure flavone derivatives for the treatment of poliferative disorders and processes for their preparation
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TWI461194B (zh) 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
KR20130027476A (ko) 2010-02-26 2013-03-15 피라말 엔터프라이지즈 리미티드 염증 질환을 치료하기 위한 피롤리딘으로 치환된 플라본
ES2685171T3 (es) 2010-06-14 2018-10-05 The Scripps Research Institute Reprogramación de células a un nuevo destino
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
WO2014167580A1 (en) 2013-04-10 2014-10-16 Council Of Scientific & Industrial Research Novel chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders
EP2986605B1 (en) 2013-04-17 2017-11-15 Council of Scientific and Industrial Research Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
CN117731786A (zh) 2013-07-12 2024-03-22 皮拉马尔企业有限公司 用于治疗黑素瘤的药物组合
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CA2982928A1 (en) 2015-04-20 2016-10-27 Tolero Pharmaceuticals, Inc. Predicting response to alvocidib by mitochondrial profiling
EP3298021B1 (en) 2015-05-18 2019-05-01 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs having increased bioavailability
US10568887B2 (en) 2015-08-03 2020-02-25 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
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DE3445852A1 (de) * 1984-12-15 1986-06-19 Bayer Ag, 5090 Leverkusen Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
DK185287D0 (da) 1987-04-10
AU602891B2 (en) 1990-11-01
DE3787661D1 (de) 1993-11-11
ATE95519T1 (de) 1993-10-15
IL82149A0 (en) 1987-10-30
KR870010045A (ko) 1987-11-30
HK1006021A1 (en) 1999-02-05
CA1332238C (en) 1994-10-04
JPS62242680A (ja) 1987-10-23
US4900727A (en) 1990-02-13
EP0241003A2 (de) 1987-10-14
KR950009861B1 (en) 1995-08-29
PT84654B (pt) 1989-12-29
IE870941L (en) 1987-10-11
EP0241003B1 (de) 1993-10-06
DK169760B1 (da) 1995-02-20
PT84654A (de) 1987-05-01
IE62244B1 (en) 1995-01-11
IN164232B (da) 1989-02-04
DE3612337A1 (de) 1987-10-15
IL82149A (en) 1994-01-25
EP0241003A3 (en) 1988-10-12
ZA872555B (en) 1987-11-25
JPH0686446B2 (ja) 1994-11-02
ATA260587A (de) 1989-07-15
ES2060582T3 (es) 1994-12-01
AU7139787A (en) 1987-10-15
AT389875B (de) 1990-02-12

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired