CN107995863A - 通过线粒体分析预测对阿伏西地的应答 - Google Patents
通过线粒体分析预测对阿伏西地的应答 Download PDFInfo
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- CN107995863A CN107995863A CN201680023137.6A CN201680023137A CN107995863A CN 107995863 A CN107995863 A CN 107995863A CN 201680023137 A CN201680023137 A CN 201680023137A CN 107995863 A CN107995863 A CN 107995863A
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Abstract
Description
阳性数量/总数量 | |
患者数 | 63 |
中位数年龄 | 58 |
中位数BM母细胞% | 38 |
诊断时的中位数WBC计数 | 6020 |
不良细胞遗传学 | 26/63 |
中等细胞遗传学 | 34/63 |
有利细胞遗传学 | 3/63 |
FLT3突变 | 11/62 |
NPM1突变 | 10/37 |
MDS/骨髓病史 | 25/63 |
先前化疗史 | 7/63 |
FLAM治疗 | 54/63 |
完全缓解 | 29/63 |
Claims (31)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562150138P | 2015-04-20 | 2015-04-20 | |
US62/150,138 | 2015-04-20 | ||
PCT/US2016/028443 WO2016172214A1 (en) | 2015-04-20 | 2016-04-20 | Predicting response to alvocidib by mitochondrial profiling |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107995863A true CN107995863A (zh) | 2018-05-04 |
Family
ID=55863240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680023137.6A Pending CN107995863A (zh) | 2015-04-20 | 2016-04-20 | 通过线粒体分析预测对阿伏西地的应答 |
Country Status (13)
Country | Link |
---|---|
US (4) | US9901574B2 (zh) |
EP (2) | EP3286564A1 (zh) |
JP (1) | JP6851978B2 (zh) |
KR (1) | KR20180018507A (zh) |
CN (1) | CN107995863A (zh) |
AU (1) | AU2016252609B2 (zh) |
BR (1) | BR112017022666A8 (zh) |
CA (1) | CA2982928A1 (zh) |
HK (1) | HK1251655A1 (zh) |
IL (1) | IL255029B (zh) |
MX (1) | MX2017013383A (zh) |
RU (1) | RU2717829C2 (zh) |
WO (1) | WO2016172214A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112997078A (zh) * | 2018-11-14 | 2021-06-18 | 阿斯利康(瑞典)有限公司 | 治疗癌症的方法 |
CN114096256A (zh) * | 2019-05-13 | 2022-02-25 | 苏州亚盛药业有限公司 | 用于预测bcl-2/bcl-xl抑制剂对癌症的功效的方法和组合物 |
Families Citing this family (15)
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RU2717829C2 (ru) | 2015-04-20 | 2020-03-26 | Толеро Фармасьютикалз, Инк. | Прогнозирование ответа на альвоцидиб с помощью анализа профиля митохондрий |
DK3298021T3 (da) | 2015-05-18 | 2019-08-05 | Tolero Pharmaceuticals Inc | Alvocidib-prodrugs, der har øget biotilgængelighed |
KR20180034538A (ko) * | 2015-08-03 | 2018-04-04 | 톨레로 파마수티컬스, 인크. | 암의 치료를 위한 병행 요법 |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
US10132797B2 (en) | 2016-12-19 | 2018-11-20 | Tolero Pharmaceuticals, Inc. | Profiling peptides and methods for sensitivity profiling |
US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
EP3737757A4 (en) * | 2018-01-12 | 2021-09-22 | Children's Hospital Medical Center | METHOD OF TREATMENT BY INHIBITION OF BFL 1 |
US20190314357A1 (en) * | 2018-04-13 | 2019-10-17 | Tolero Pharmaceuticals, Inc. | Cyclin-dependent kinase inhibitors in combination with anthracyclines for treatment of cancer |
US20210277037A1 (en) * | 2018-06-21 | 2021-09-09 | Sumitomo Dainippon Pharma Oncology, Inc. | Deuterated alvocidib and alvocidib prodrugs |
CA3119807A1 (en) | 2018-12-04 | 2020-06-11 | Sumitomo Dainippon Pharma Oncology, Inc. | Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病(aml)の処置 |
WO2021007314A2 (en) * | 2019-07-08 | 2021-01-14 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of cancer |
US20220305037A1 (en) | 2019-07-08 | 2022-09-29 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of Cancer |
CN112852959A (zh) * | 2019-11-27 | 2021-05-28 | 苏州亚盛药业有限公司 | 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物 |
JP2023504515A (ja) | 2019-12-05 | 2023-02-03 | スミトモ ファーマ オンコロジー, インコーポレイテッド | 骨髄異形成症候群の処置のための併用療法 |
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WO2013170176A2 (en) * | 2012-05-10 | 2013-11-14 | Eutropics Pharmaceuticals, Inc. | Surrogate functional diagnostics test for cancer |
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Cited By (3)
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CN112997078A (zh) * | 2018-11-14 | 2021-06-18 | 阿斯利康(瑞典)有限公司 | 治疗癌症的方法 |
CN114096256A (zh) * | 2019-05-13 | 2022-02-25 | 苏州亚盛药业有限公司 | 用于预测bcl-2/bcl-xl抑制剂对癌症的功效的方法和组合物 |
TWI770503B (zh) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物 |
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US9901574B2 (en) | 2018-02-27 |
JP6851978B2 (ja) | 2021-03-31 |
EP3286564A1 (en) | 2018-02-28 |
AU2016252609A1 (en) | 2017-11-02 |
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HK1251655A1 (zh) | 2019-02-01 |
BR112017022666A8 (pt) | 2022-10-18 |
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RU2717829C2 (ru) | 2020-03-26 |
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AU2016252609B2 (en) | 2022-06-30 |
RU2017140030A3 (zh) | 2019-09-27 |
US20160303101A1 (en) | 2016-10-20 |
WO2016172214A1 (en) | 2016-10-27 |
CA2982928A1 (en) | 2016-10-27 |
JP2018516245A (ja) | 2018-06-21 |
EP3611506A1 (en) | 2020-02-19 |
US20190282557A1 (en) | 2019-09-19 |
IL255029A0 (en) | 2017-12-31 |
BR112017022666A2 (pt) | 2018-07-17 |
US10624880B2 (en) | 2020-04-21 |
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