SV2002000293A - Compuestos indazole, composiciones farmaceuticas, y metodos para mediar o inhibir la proliferacion celular caso no. 0092-01-sv - Google Patents

Compuestos indazole, composiciones farmaceuticas, y metodos para mediar o inhibir la proliferacion celular caso no. 0092-01-sv

Info

Publication number
SV2002000293A
SV2002000293A SV2001000293A SV2001000293A SV2002000293A SV 2002000293 A SV2002000293 A SV 2002000293A SV 2001000293 A SV2001000293 A SV 2001000293A SV 2001000293 A SV2001000293 A SV 2001000293A SV 2002000293 A SV2002000293 A SV 2002000293A
Authority
SV
El Salvador
Prior art keywords
inhibit
pharmaceutical compositions
cell proliferation
compounds
methods
Prior art date
Application number
SV2001000293A
Other languages
English (en)
Inventor
Siegfried Heinz Reich
Ted M Bleckman
Susan Elizabeth Kephart
Iii William Henry Romines
Michael Brennan Wallace
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of SV2002000293A publication Critical patent/SV2002000293A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
    • B22D41/00—Casting melt-holding vessels, e.g. ladles, tundishes, cups or the like
    • B22D41/50—Pouring-nozzles
    • B22D41/56—Means for supporting, manipulating or changing a pouring-nozzle
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN LOS COMPUESTOS DE INDAZOL QUE MODULAN Y/O INHIBEN LA PROLIFERACION CELULAR, TALES COMO LA ACTIVIDAD DE LAS PROTEINQUINASAS. ESTOS COMPUESTOS Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN SON CAPACES DE MEDIAR, POR EJEMPLO, EN ENFERMEDADES QUINASA-DEPENDIENTES PARA MODULAR Y/O INHIBIR LA PROLIFERACION INDESEADA DE CELULAS. EL INVENTO ESTA TAMBIEN DIRIGIDO AL USO TERAPEUTICO O PROFILACTICO DE COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS, Y A METODOS DE TRATAR EL CANCER ASI COMO OTROS ESTADOS DE ENFERMEDAD ASOCIADOS CON ANGIOGENESIS INDESEADA Y/O PROLIFERACION CELULAR, TALES COMO RETINOPATIA DIABETICA, GLAUCOMA NEOVASCULAR, ARTRITIS REUMATOIDE, Y PSORIASIS, POR MEDIO DE LA ADMINISTRACION DE CANTIDADES EFECTIVAS DE TALES COMPUESTOS.
SV2001000293A 2000-01-18 2001-01-22 Compuestos indazole, composiciones farmaceuticas, y metodos para mediar o inhibir la proliferacion celular caso no. 0092-01-sv SV2002000293A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17648400P 2000-01-18 2000-01-18

Publications (1)

Publication Number Publication Date
SV2002000293A true SV2002000293A (es) 2002-12-02

Family

ID=22644536

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000293A SV2002000293A (es) 2000-01-18 2001-01-22 Compuestos indazole, composiciones farmaceuticas, y metodos para mediar o inhibir la proliferacion celular caso no. 0092-01-sv

Country Status (39)

Country Link
US (4) US6555539B2 (es)
EP (1) EP1250326A2 (es)
JP (1) JP2003520273A (es)
KR (1) KR20020073505A (es)
CN (1) CN1394205A (es)
AP (1) AP1609A (es)
AR (1) AR032438A1 (es)
AU (1) AU785013B2 (es)
BG (1) BG107011A (es)
BR (1) BR0107783A (es)
CA (1) CA2388885A1 (es)
CO (1) CO5280070A1 (es)
CR (1) CR6630A (es)
DO (1) DOP2001000120A (es)
DZ (1) DZ3301A1 (es)
EA (1) EA200200768A1 (es)
EE (1) EE200200398A (es)
GE (1) GEP20043363B (es)
GT (1) GT200100009A (es)
HN (1) HN2001000007A (es)
HR (1) HRP20020675A2 (es)
HU (1) HUP0203965A3 (es)
IL (1) IL150730A0 (es)
IS (1) IS6474A (es)
MA (1) MA27589A1 (es)
MX (1) MXPA02007058A (es)
MY (1) MY136604A (es)
NO (1) NO20022117L (es)
NZ (1) NZ518531A (es)
OA (1) OA12160A (es)
PA (1) PA8509901A1 (es)
PE (1) PE20011334A1 (es)
PL (1) PL357590A1 (es)
SK (1) SK10052002A3 (es)
SV (1) SV2002000293A (es)
UA (1) UA75880C2 (es)
WO (1) WO2001053268A2 (es)
YU (1) YU54202A (es)
ZA (1) ZA200203040B (es)

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