AR108325A1 - Isoquinolin-3-il carboxamidas y preparación y uso de las mismas - Google Patents

Isoquinolin-3-il carboxamidas y preparación y uso de las mismas

Info

Publication number
AR108325A1
AR108325A1 ARP170101055A ARP170101055A AR108325A1 AR 108325 A1 AR108325 A1 AR 108325A1 AR P170101055 A ARP170101055 A AR P170101055A AR P170101055 A ARP170101055 A AR P170101055A AR 108325 A1 AR108325 A1 AR 108325A1
Authority
AR
Argentina
Prior art keywords
unsubstituted
alkylene
optionally substituted
group
haloalkyl
Prior art date
Application number
ARP170101055A
Other languages
English (en)
Inventor
Chandramouli Chiruta
Vankataiah Bollu
Jianguo Cao
Brian Walter Eastman
Gopi Kumar Mittapalli
Chi Ching Mak
Sunil Kumar Kc
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of AR108325A1 publication Critical patent/AR108325A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Abstract

Se divulgan compuestos isoquinolina para tratar diversas enfermedades y patologías. Más específicamente, se refiere al uso de un compuesto isoquinolina o a análogos del mismo, en el tratamiento de trastornos caracterizados por la activación de la señalización de la vía de Wnt (por ejemplo, cáncer, proliferación celular anormal, angiogénesis, trastornos fibróticos, enfermedades óseas y de los cartílagos y osteoartritis), la modulación de eventos celulares mediados por la señalización de la vía de Wnt, así como enfermedades genéticas y condiciones / trastornos / enfermedades neurológicas debido a mutaciones o la desregulación de la vía de Wnt y/o de uno o más componentes de la señalización de Wnt. También se proveen métodos para tratar estados de enfermedad relacionados con Wnt. Reivindicación 1: Un compuesto o una sal farmacéuticamente aceptable del mismo, de la fórmula (1), en donde: R¹, R², R⁴ y R⁵ se seleccionan independientemente del grupo que consiste en H, haluro, amino, -(haloalquilo C₁₋₃) no sustituido y -(alquilo C₁₋₃) no sustituido; R³ es un heteroarilo de 5 miembros opcionalmente sustituido con 1 - 4 R⁴⁵; R⁶ se selecciona del grupo que consiste en -fenilo sustituido con 1 - 5 R³⁶, -(alquileno C₁₋₃)ₚ-piridinilo opcionalmente sustituido con 1 - 6 R³⁷ y un heteroarilo de 6 - 10 miembros opcionalmente sustituido con 1 - 6 R³⁷; en donde el carbonilo de la fórmula (1) está unido a un anillo aromático del heteroarilo; en donde el -(alquileno C₁₋₃) se sustituye opcionalmente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁶ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₉) no sustituido, -(alquenilo C₂₋₉) no sustituido, -(alquinilo C₂₋₉) no sustituido, -(haloalquilo C₁₋₉) no sustituido, -XR⁴², -C(=O)N(R⁴⁷)₂, -(alquileno C₁₋₄)ₚ-N(R⁵⁰)₂, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 10 R⁴³ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁷ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₉) no sustituido, -(alquenilo C₂₋₉) no sustituido, -(alquinilo C₂₋₉) no sustituido, -(haloalquilo C₁₋₉) no sustituido, -XR⁴², -C(=O)N(R⁴⁷)₂, -(alquileno C₁₋₄)ₚ-N(R⁵⁰)₂, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 10 R⁴³ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁸ se selecciona independientemente del grupo que consisto en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁹ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴⁰ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴¹ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -CN; cada R⁴² se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -(alquileno C₁₋₄)N(R⁴⁸)₂, -(alquileno C₁₋₄)ₚ-arilo opcionalmente sustituido con 1 - 10 R⁴⁶, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 12 R⁴³ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴³ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN, -OH, -C(=O)R⁵¹, -N(R⁵⁰)₂ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴⁴ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -CN; cada R⁴⁵ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₉) no sustituido, -(alquenilo C₂₋₉) no sustituido, -(alquinilo C₂₋₉) no sustituido, -(haloalquilo C₁₋₉) no sustituido, -(alquileno C₁₋₄)ₚ-N(R⁴⁸)₂, -(alquileno C₁₋₄)ₚ-OR⁴⁹, -C(=O)N(R⁴⁸)₂, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 10 R³⁸, -carbociclilo opcionalmente sustituido con 1 - 12 R³⁹; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; alternativamente, dos R⁴⁵ adyacentes tomados juntos forman un anillo que se selecciona del grupo que consiste en -heterociclilo opcionalmente sustituido con 1 - 10 R⁴⁰ y -carbociclilo opcionalmente sustituido con 1 - 12 R⁴¹; cada R⁴⁶ se selecciona independientemente del grupo que consiste en -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -CN; cada R⁴⁷ se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido y -(haloalquilo C₁₋₅) no sustituido; cada R⁴⁸ se selecciona del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido; cada R⁴⁹ se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido y -(haloalquilo C₁₋₅) no sustituido; cada R⁵⁰ se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -(alquileno C₁₋₄)N(R⁴⁸)₂; en donde el -(alquileno C₁₋₄) se sustituye opcionalmente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁵¹ es un heteroarilo opcionalmente sustituido con 1 - 6 R⁵²; cada R⁵² es un -heterociclilo opcionalmente sustituido con 1 - 10 R⁴⁶; cada X se selecciona del grupo que consiste en O, S y NR⁴⁸; y cada p es independientemente 0 ó 1.
ARP170101055A 2016-04-27 2017-04-26 Isoquinolin-3-il carboxamidas y preparación y uso de las mismas AR108325A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662328255P 2016-04-27 2016-04-27

Publications (1)

Publication Number Publication Date
AR108325A1 true AR108325A1 (es) 2018-08-08

Family

ID=60157337

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101055A AR108325A1 (es) 2016-04-27 2017-04-26 Isoquinolin-3-il carboxamidas y preparación y uso de las mismas

Country Status (28)

Country Link
US (7) US10106527B2 (es)
EP (2) EP3448386B1 (es)
JP (1) JP6993985B2 (es)
KR (1) KR102374844B1 (es)
CN (1) CN109310690B (es)
AR (1) AR108325A1 (es)
AU (1) AU2017258193B2 (es)
CA (1) CA3022002A1 (es)
CL (2) CL2018003065A1 (es)
CO (1) CO2018012299A2 (es)
CY (1) CY1124302T1 (es)
DK (1) DK3448386T3 (es)
ES (1) ES2865374T3 (es)
HR (1) HRP20210607T1 (es)
HU (1) HUE054103T2 (es)
IL (1) IL262470B (es)
LT (1) LT3448386T (es)
MA (1) MA43619B1 (es)
MD (1) MD3448386T2 (es)
MX (1) MX2018013174A (es)
PE (1) PE20190326A1 (es)
PH (1) PH12018502258A1 (es)
PL (1) PL3448386T3 (es)
PT (1) PT3448386T (es)
RS (1) RS61879B1 (es)
SG (2) SG10201914054SA (es)
SI (1) SI3448386T1 (es)
WO (1) WO2017189829A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
AU2016348639B2 (en) 2015-11-06 2022-09-08 Samumed, Llc Treatment of osteoarthritis
EA201800367A1 (ru) 2015-12-10 2019-02-28 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения болезни хантингтона
AR108325A1 (es) * 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
EP3601259B1 (en) 2017-03-30 2022-02-23 F. Hoffmann-La Roche AG Isoquinolines as inhibitors of hpk1
CA3066224A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics Inc. Compounds for treating huntington's disease
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
US10604514B2 (en) 2017-10-19 2020-03-31 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
US10413537B2 (en) 2017-10-27 2019-09-17 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
US10653688B2 (en) 2017-10-27 2020-05-19 Samumed, Llc 6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
US10703748B2 (en) 2017-10-31 2020-07-07 Samumed, Llc Diazanaphthalen-3-yl carboxamides and preparation and use thereof
WO2019191092A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
JP2021528398A (ja) 2018-06-18 2021-10-21 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲγＴのモジュレーターとしての６−アミノピリジン−３−イルピラゾール
US11345666B2 (en) 2018-06-18 2022-05-31 Janssen Pharmaceutica Nv Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
CN112566901A (zh) 2018-06-18 2021-03-26 詹森药业有限公司 作为RORγt的调节剂的苯基取代的吡唑类
ES2925473T3 (es) 2018-06-18 2022-10-18 Janssen Pharmaceutica Nv Pirazoles de piridinilo como moduladores de RORyt
SG11202012674PA (en) 2018-06-27 2021-01-28 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for treating huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
WO2020150552A2 (en) 2019-01-17 2020-07-23 Samumed, Llc Methods of treating cartilage disorders through inhibition of clk and dyrk
WO2021004547A1 (en) * 2019-07-11 2021-01-14 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heterocyclic compounds as inhibitors of hpk1
WO2021007378A1 (en) * 2019-07-11 2021-01-14 Ptc Therapeutics, Inc. Compounds for use in treating huntington's disease
JPWO2021235293A1 (es) * 2020-05-20 2021-11-25
CN117088876A (zh) * 2020-10-28 2023-11-21 杭州阿诺生物医药科技有限公司 一种高活性Wnt通路抑制剂化合物
TW202321244A (zh) * 2021-07-26 2023-06-01 大陸商杭州阿諾生物醫藥科技有限公司 一種Ｗｎｔ通路抑制劑化合物
TW202334157A (zh) * 2022-01-29 2023-09-01 大陸商杭州阿諾生物醫藥科技有限公司 一種Ｗｎｔ通路抑制劑化合物
WO2024022365A1 (zh) * 2022-07-28 2024-02-01 杭州阿诺生物医药科技有限公司 一种Wnt通路抑制剂化合物

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6440102B1 (en) 1998-07-23 2002-08-27 Durect Corporation Fluid transfer and diagnostic system for treating the inner ear
DE19853299C2 (de) 1998-11-19 2003-04-03 Thomas Lenarz Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs
US6120484A (en) 1999-02-17 2000-09-19 Silverstein; Herbert Otological implant for delivery of medicament and method of using same
US6967023B1 (en) 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
US6648873B2 (en) 2001-09-21 2003-11-18 Durect Corp. Aural catheter system including anchor balloon and balloon inflation device
GB0310867D0 (en) 2003-05-12 2003-06-18 Novartis Ag Organic compounds
EP2256106B1 (en) 2003-07-22 2015-05-06 Astex Therapeutics Limited 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
US7008953B2 (en) 2003-07-30 2006-03-07 Agouron Pharmaceuticals, Inc. 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
EP1861161A4 (en) 2005-01-24 2012-05-16 Neurosystec Corp APPARATUS AND METHOD FOR DISPENSING THERAPEUTIC AND / OR OTHER AGENTS IN THE INTERNAL EAR AND OTHER FABRICS
WO2007125405A2 (en) * 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
US8088793B2 (en) 2007-08-15 2012-01-03 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
WO2009085226A2 (en) 2007-12-21 2009-07-09 Sirtris Pharmaceuticals, Inc. Inhibitors of cdc2-like kinases (clks) and methods of use thereof
UA103918C2 (en) 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
BR112012002942A2 (pt) 2009-08-10 2015-10-13 Epitherix Llc indazóis como inibidores da trilha de sinalização de wnt/b-catenina e empregos terapêuticos destes.
ES2835553T3 (es) 2009-08-10 2021-06-22 Biosplice Therapeutics Inc Inhibidores de indazol de la vía de señalización de Wnt y sus usos terapéuticos
US7998878B2 (en) 2009-11-20 2011-08-16 Eastman Kodak Company Method for selective deposition and devices
CA2986631C (en) 2009-12-21 2020-06-02 Samumed, Llc 1h-pyrazolo[3,4-.beta.]pyridines and thereapeutic uses thereof
US20130096119A1 (en) 2010-03-31 2013-04-18 Daniel Bur Isoquinolin-3-Ylurea Derivatives
TW201307292A (zh) * 2010-12-17 2013-02-16 Hoffmann La Roche 經取代之６，６－稠合含氮雜環化合物及其用途
CN102558173B (zh) * 2010-12-31 2015-05-20 广州源生医药科技有限公司 抑制wnt信号传导的化合物、组合物及其应用
MX341504B (es) * 2011-09-14 2016-08-19 Samumed Llc Indazol-3-carboxamidas y su uso como inhibidores de la trayectoria de señalización de wnt/b-catenina.
WO2013169793A2 (en) * 2012-05-09 2013-11-14 Ipierian, Inc. Methods and compositions for tdp-43 proteinopathies
US9557993B2 (en) 2012-10-23 2017-01-31 Analog Devices Global Processor architecture and method for simplifying programming single instruction, multiple data within a register
BR112016021626A2 (pt) 2014-03-20 2018-05-15 Samumed, Llc indazol-3-carboxamidas 5-substituídas e preparação e uso das mesmas
GB201416754D0 (en) 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) * 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
CN109937039A (zh) 2016-09-30 2019-06-25 斯坦福国际研究院 用于癌症治疗的双重clk/cdk1抑制剂
US20220062240A1 (en) 2018-06-26 2022-03-03 Biosplice Therapeutics, Inc. Methods of treating cancer using a clk inhibitor
WO2020150545A1 (en) 2019-01-17 2020-07-23 Samumed, Llc Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway

Also Published As

Publication number Publication date
HRP20210607T1 (hr) 2021-06-25
CA3022002A1 (en) 2017-11-02
SG11201809301YA (en) 2018-11-29
US10544128B2 (en) 2020-01-28
AU2017258193B2 (en) 2021-06-03
US20190233396A1 (en) 2019-08-01
BR112018072169A2 (pt) 2019-02-12
CY1124302T1 (el) 2022-07-22
KR102374844B1 (ko) 2022-03-16
CN109310690A (zh) 2019-02-05
RU2018141395A3 (es) 2020-08-13
PL3448386T3 (pl) 2021-11-02
EP3892276A1 (en) 2021-10-13
CN109310690B (zh) 2021-09-07
RU2018141395A (ru) 2020-05-28
US20180155323A1 (en) 2018-06-07
KR20190014505A (ko) 2019-02-12
PT3448386T (pt) 2021-04-22
IL262470B (en) 2021-12-01
BR112018072169A8 (pt) 2022-11-08
US20220332698A1 (en) 2022-10-20
US20180093970A1 (en) 2018-04-05
US20230286945A1 (en) 2023-09-14
US20200299263A1 (en) 2020-09-24
ES2865374T3 (es) 2021-10-15
AU2017258193A1 (en) 2018-11-15
RS61879B1 (sr) 2021-06-30
US10100038B2 (en) 2018-10-16
MX2018013174A (es) 2019-02-13
CL2018003065A1 (es) 2019-02-01
MD3448386T2 (ro) 2022-05-31
MA43619B1 (fr) 2020-10-28
EP3448386A1 (en) 2019-03-06
US20170313682A1 (en) 2017-11-02
LT3448386T (lt) 2021-06-25
CO2018012299A2 (es) 2019-04-30
JP6993985B2 (ja) 2022-01-14
JP2019514938A (ja) 2019-06-06
EP3448386A4 (en) 2019-12-18
SI3448386T1 (sl) 2021-08-31
WO2017189829A1 (en) 2017-11-02
US10106527B2 (en) 2018-10-23
PH12018502258A1 (en) 2019-09-16
MA43619A1 (fr) 2019-10-31
EP3448386B1 (en) 2021-03-03
US11548872B2 (en) 2023-01-10
CL2019001343A1 (es) 2019-10-11
DK3448386T3 (da) 2021-04-26
US9951048B1 (en) 2018-04-24
IL262470A (en) 2018-12-31
PE20190326A1 (es) 2019-03-05
HUE054103T2 (hu) 2021-08-30
US10947217B2 (en) 2021-03-16
SG10201914054SA (en) 2020-03-30

Similar Documents

Publication Publication Date Title
AR108325A1 (es) Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108326A1 (es) Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR115993A2 (es) Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
RU2019119893A (ru) Ингибиторы jak2 и alk2 и способы их использования
AR119651A1 (es) Compuestos heterocíclicos y de heteroarilo para tratar la enfermedad de huntington
AR109788A1 (es) Compuestos de benzo[b]tiofeno como agonistas de sting
CY1118739T1 (el) Ενωσεις αμφι(φθoρoαλκυλ)-1,4-βενζoδιαζεπινoνης ως αναστολεις toy notch
AR103833A1 (es) Compuestos bicíclicos de sulfonamida cetona
EA201592126A1 (ru) 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
AR095885A1 (es) Compuestos derivados de arilpirrolopiridina como inhibidores de lrrk2
EA201592199A1 (ru) Производные бипиразола в качестве ингибиторов jak
EA201691302A1 (ru) Новые гетероциклические соединения
SA515361086B1 (ar) Fasn مركبات وتركيبات جديدة لتثبيط
AR103251A1 (es) Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico
AR085004A1 (es) Inhibidores selectivos de glicosidasas y usos de los mismos
AR087915A1 (es) N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la bace1
AR089285A1 (es) Derivados de betulina
AR089781A1 (es) Fluorometil-5,6-dihidro-4h-[1,3]oxazinas
EA201592287A1 (ru) Замещенные тетрагидрокарбазольные и карбазолкарбоксамидные соединения
EA201690012A1 (ru) Карбазолкарбоксамидные соединения
AR094496A1 (es) Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas
AR097435A1 (es) 6-alquinilpiridinas
AR111494A1 (es) Compuestos de anilinoquinazolina c₅ y su uso en el tratamiento del cáncer
AR100715A1 (es) Derivados de alquilo de compuestos 1-oxa-4,9-diazaespiro undeceno que tienen actividad multimodal contra el dolor
AR093408A1 (es) Derivados de oxazolidin-2-ona-pirimidina