UA75880C2

UA75880C2 - Indazole compounds as antiproliferative agents, a pharmaceutical composition (variants) and a method for treatment of diseases and disorders (variants) associated wiyh unwanted angiogenesis and/or cellular proliferation

Indazole compounds as antiproliferative agents, a pharmaceutical composition (variants) and a method for treatment of diseases and disorders (variants) associated wiyh unwanted angiogenesis and/or cellular proliferation Download PDF

Info

Publication number: UA75880C2
Authority: UA; Ukraine
Prior art keywords: ring atoms; compound; nitrogen heteroatoms; substituted; carbocycle
Prior art date: 2000-01-18

Application number

UA2002086633A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Agouron Pharma

Priority date

2000-01-18

Filing date

2001-01-18

Publication date

2006-06-15

2001-01-18 Application filed by Agouron Pharma filed Critical Agouron Pharma

2006-06-15 Publication of UA75880C2 publication Critical patent/UA75880C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 181
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239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 23
230000033115 angiogenesis Effects 0.000 title claims abstract description 18
125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title abstract description 3
230000001028 anti-proliverative effect Effects 0.000 title description 6
208000037765 diseases and disorders Diseases 0.000 title 1
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 73
150000003839 salts Chemical class 0.000 claims description 68
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239000000651 prodrug Substances 0.000 claims description 50
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239000001257 hydrogen Substances 0.000 claims description 37
229910052757 nitrogen Inorganic materials 0.000 claims description 35
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 31
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230000001105 regulatory effect Effects 0.000 claims description 21
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
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125000002837 carbocyclic group Chemical group 0.000 claims description 14
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