US20020150921A1
(en)
*
|
1996-02-09 |
2002-10-17 |
Francis Barany |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
CN100379734C
(zh)
|
1999-12-24 |
2008-04-09 |
阿文蒂斯药物有限公司 |
氮杂吲哚类化合物
|
YU54202A
(sh)
*
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
|
US20050009876A1
(en)
*
|
2000-07-31 |
2005-01-13 |
Bhagwat Shripad S. |
Indazole compounds, compositions thereof and methods of treatment therewith
|
US7211594B2
(en)
|
2000-07-31 |
2007-05-01 |
Signal Pharmaceuticals, Llc |
Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
|
US6897231B2
(en)
|
2000-07-31 |
2005-05-24 |
Signal Pharmaceuticals, Inc. |
Indazole derivatives as JNK inhibitors and compositions and methods related thereto
|
AU2001277621A1
(en)
*
|
2000-08-09 |
2002-03-04 |
Astrazeneca Ab |
Antiangiogenic bicyclic derivatives
|
ATE309996T1
(de)
|
2000-09-11 |
2005-12-15 |
Chiron Corp |
Chinolinonderivate als tyrosin-kinase inhibitoren
|
DE10046029A1
(de)
*
|
2000-09-18 |
2002-03-28 |
Bayer Ag |
Indazole
|
CA2440842A1
(en)
|
2001-04-16 |
2002-10-24 |
Eisai Co., Ltd. |
Novel 1h-indazole compounds
|
GB0115109D0
(en)
|
2001-06-21 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
US7642278B2
(en)
|
2001-07-03 |
2010-01-05 |
Novartis Vaccines And Diagnostics, Inc. |
Indazole benzimidazole compounds
|
EP1401831A1
(en)
*
|
2001-07-03 |
2004-03-31 |
Chiron Corporation |
Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
|
FR2827861B1
(fr)
|
2001-07-27 |
2004-04-02 |
Aventis Pharma Sa |
Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie
|
US20040077702A1
(en)
*
|
2001-09-14 |
2004-04-22 |
Wen-Mei Fu |
Treatment of nuerodegenerative diseases
|
CZ2004359A3
(cs)
*
|
2001-09-26 |
2004-09-15 |
Pharmacia Italia S.P.A. |
Aminoindazolové deriváty aktivní jako inhibitory kinázy, způsob jejich přípravy a farmaceutické prostředky obsahující tyto deriváty
|
BR0206161A
(pt)
*
|
2001-10-19 |
2005-02-01 |
Ortho Mcneil Pharm Inc |
2-fenil benzimidazóis e imidazo-[4,5]-piridinas como inibidores de cds1/chk2 e adjuvantes para quimioterapia ou terapia por radiação no tratamento de câncer
|
US6897208B2
(en)
|
2001-10-26 |
2005-05-24 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles
|
IL161576A0
(en)
*
|
2001-10-26 |
2004-09-27 |
Aventis Pharma Inc |
Benzimidazoles and analogues and their use as protein kinases inhibitors
|
FR2831537B1
(fr)
*
|
2001-10-26 |
2008-02-29 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
|
FR2831536A1
(fr)
*
|
2001-10-26 |
2003-05-02 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
|
US7074805B2
(en)
*
|
2002-02-20 |
2006-07-11 |
Abbott Laboratories |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
|
US6867320B2
(en)
*
|
2002-02-21 |
2005-03-15 |
Asahi Kasei Pharma Corporation |
Substituted phenylalkanoic acid derivatives and use thereof
|
EP1487436A4
(en)
*
|
2002-03-08 |
2009-06-03 |
Signal Pharm Inc |
POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS
|
FR2836914B1
(fr)
|
2002-03-11 |
2008-03-14 |
Aventis Pharma Sa |
Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
|
US7166293B2
(en)
|
2002-03-29 |
2007-01-23 |
Carlsbad Technology, Inc. |
Angiogenesis inhibitors
|
US20050119278A1
(en)
*
|
2002-05-16 |
2005-06-02 |
Che-Ming Teng |
Anti-angiogenesis methods
|
WO2003102151A2
(en)
*
|
2002-05-30 |
2003-12-11 |
Celgene Corporation |
Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors
|
WO2003101968A1
(fr)
*
|
2002-05-31 |
2003-12-11 |
Eisai Co., Ltd. |
Compose de pyrazole et composition medicinale le contenant
|
JP2004075673A
(ja)
*
|
2002-06-19 |
2004-03-11 |
Mitsubishi Chemicals Corp |
化合物およびこれを用いた有機電界発光素子
|
GB0218625D0
(en)
*
|
2002-08-10 |
2002-09-18 |
Astex Technology Ltd |
Pharmaceutical compounds
|
AU2003259749A1
(en)
*
|
2002-08-12 |
2004-02-25 |
Sugen, Inc. |
3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
|
US20040087642A1
(en)
*
|
2002-10-24 |
2004-05-06 |
Zeldis Jerome B. |
Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
|
WO2004050088A1
(ja)
*
|
2002-12-03 |
2004-06-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Jnk阻害剤
|
MXPA05006676A
(es)
|
2002-12-19 |
2005-08-16 |
Pfizer |
Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas, y procedimientos para su uso.
|
US20050019366A1
(en)
*
|
2002-12-31 |
2005-01-27 |
Zeldis Jerome B. |
Drug-coated stents and methods of use therefor
|
US6933311B2
(en)
*
|
2003-02-11 |
2005-08-23 |
Abbott Laboratories |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
|
EP1597256A1
(en)
*
|
2003-02-21 |
2005-11-23 |
Pfizer Inc. |
N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
|
WO2004076450A1
(en)
|
2003-02-27 |
2004-09-10 |
J. Uriach Y Compañia S.A. |
Pyrazolopyridine derivates
|
ES2214150B1
(es)
*
|
2003-02-27 |
2005-12-01 |
J. URIACH & CIA S.A. |
"nuevos derivados de pirazolopiridinas".
|
JP4726235B2
(ja)
|
2003-04-17 |
2011-07-20 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
癌の処置のためのチェックポイントキナーゼcds1(chk2)インヒビターとしての2−フェニル−ベンズイミダゾールおよび2−フェニル−イミダゾ−‘4,5!−ピリジン誘導体
|
FR2854159B1
(fr)
*
|
2003-04-25 |
2008-01-11 |
Aventis Pharma Sa |
Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr
|
US7015233B2
(en)
*
|
2003-06-12 |
2006-03-21 |
Abbott Laboratories |
Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
|
TWI372050B
(en)
|
2003-07-03 |
2012-09-11 |
Astex Therapeutics Ltd |
(morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
|
ITRM20030355A1
(it)
*
|
2003-07-18 |
2005-01-19 |
Sigma Tau Ind Farmaceuti |
Composti ad attivita' citotossica derivati della combretastatina.
|
WO2005012256A1
(en)
|
2003-07-22 |
2005-02-10 |
Astex Therapeutics Limited |
3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
|
US7008953B2
(en)
*
|
2003-07-30 |
2006-03-07 |
Agouron Pharmaceuticals, Inc. |
3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
|
EP1650194A4
(en)
*
|
2003-07-30 |
2008-10-01 |
Kyowa Hakko Kogyo Kk |
INHIBITOR OF PROTEIN KINASE
|
ATE553092T1
(de)
*
|
2003-07-30 |
2012-04-15 |
Kyowa Hakko Kirin Co Ltd |
Indazolderivate
|
US20050090529A1
(en)
*
|
2003-07-31 |
2005-04-28 |
Pfizer Inc |
3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
|
TW200517381A
(en)
*
|
2003-08-01 |
2005-06-01 |
Genelabs Tech Inc |
Bicyclic heteroaryl derivatives
|
US20050113576A1
(en)
*
|
2003-08-05 |
2005-05-26 |
Chih-Hung Lee |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
|
WO2005014554A1
(en)
*
|
2003-08-08 |
2005-02-17 |
Astex Therapeutics Limited |
1h-indazole-3-carboxamide compounds as mapkap kinase modulators
|
WO2005016862A1
(en)
|
2003-08-14 |
2005-02-24 |
Asahi Kasei Pharma Corporation |
Substituted arylalkanoic acid derivative and use thereof
|
JP2005089457A
(ja)
*
|
2003-09-03 |
2005-04-07 |
Yung Shin Pharmaceutical Industry Co Ltd |
骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
|
US6984652B2
(en)
*
|
2003-09-05 |
2006-01-10 |
Warner-Lambert Company Llc |
Gyrase inhibitors
|
DK1682553T3
(da)
*
|
2003-09-08 |
2010-08-23 |
Aventis Pharma Inc |
Thienopyrazoler
|
CN1863779B
(zh)
*
|
2003-10-15 |
2010-05-05 |
宇部兴产株式会社 |
吲唑衍生物
|
CN1901903A
(zh)
*
|
2003-11-06 |
2007-01-24 |
细胞基因公司 |
用于治疗和控制石棉相关性疾病和病症的包含jnk抑制剂的组合物以及其使用方法
|
EP1692085A4
(en)
|
2003-11-07 |
2010-10-13 |
Novartis Vaccines & Diagnostic |
INHIBITION OF FGFR3 AND TREATMENT OF MULTIPLE MYELOMA
|
US20060179711A1
(en)
*
|
2003-11-17 |
2006-08-17 |
Aerogrow International, Inc. |
Devices and methods for growing plants
|
JP2007511618A
(ja)
|
2003-11-19 |
2007-05-10 |
シグナル ファーマシューティカルズ,エルエルシー |
インダゾール化合物およびタンパク質キナーゼ阻害剤としてのその使用方法
|
US7488817B2
(en)
*
|
2004-02-02 |
2009-02-10 |
The Trustees Of The University Of Pennsylvania |
Metal complex protein kinase inhibitors
|
JPWO2005094823A1
(ja)
*
|
2004-03-30 |
2007-08-16 |
協和醗酵工業株式会社 |
Flt−3阻害剤
|
EP1740184A1
(en)
*
|
2004-03-30 |
2007-01-10 |
Pfizer Products Incorporated |
Combinations of signal transduction inhibitors
|
GB0409080D0
(en)
*
|
2004-04-23 |
2004-05-26 |
Biofocus Discovery Ltd |
Compounds which interact with protein kinases
|
CN101027053A
(zh)
*
|
2004-07-27 |
2007-08-29 |
诺瓦提斯公司 |
Hsp90抑制剂
|
US20070054916A1
(en)
*
|
2004-10-01 |
2007-03-08 |
Amgen Inc. |
Aryl nitrogen-containing bicyclic compounds and methods of use
|
FR2876584B1
(fr)
*
|
2004-10-15 |
2007-04-13 |
Centre Nat Rech Scient Cnrse |
Utilisation de la kenpaullone pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules
|
WO2006054143A1
(en)
*
|
2004-11-17 |
2006-05-26 |
Pfizer Inc. |
Polymorphs of {5-[3-(4,6-difluoro-1h-benzoimidazol-2-yl)-1h-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-amine
|
US20060116519A1
(en)
*
|
2004-11-17 |
2006-06-01 |
Agouron Pharmaceuticals, Inc. |
Synthesis of 5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
|
MX2007006066A
(es)
*
|
2004-11-23 |
2007-07-11 |
Celgene Corp |
Inhibidores de jnk para el tratamiento de lesiones del snc.
|
MX2007008008A
(es)
|
2004-12-30 |
2007-11-12 |
Astex Therapeutics Ltd |
Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora.
|
MX2007008781A
(es)
|
2005-01-21 |
2007-09-11 |
Astex Therapeutics Ltd |
Compuestos farmaceuticos.
|
AU2006207321B2
(en)
|
2005-01-21 |
2012-09-06 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
AU2006209712B2
(en)
|
2005-01-27 |
2011-06-09 |
Kyowa Hakko Kirin Co., Ltd. |
IGF-1R inhibitor
|
GT200600042A
(es)
*
|
2005-02-10 |
2006-09-27 |
Aventis Pharma Inc |
Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
|
US20070004777A1
(en)
*
|
2005-03-23 |
2007-01-04 |
Bhagwat Shripad S |
Methods for treating or preventing acute myelogenous leukemia
|
RS51616B
(en)
|
2005-03-29 |
2011-08-31 |
Icos Corporation |
HETEROARYL UREE DERIVATIVES USEFUL TO INHIBIT CHK1
|
JP2008540345A
(ja)
*
|
2005-04-29 |
2008-11-20 |
セルジーン・コーポレーション |
1−(5−(1h−1,2,4−トリアゾール−5−イル)(1h−インダゾール−3−イル))−3−(2−ピペリジルエトキシ)ベンゼンの固体形態
|
BRPI0610355A2
(pt)
|
2005-05-17 |
2010-06-15 |
Novartis Ag |
métodos par sintetizar compostos heterocìclicos
|
US7541367B2
(en)
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
US7470787B2
(en)
|
2005-07-11 |
2008-12-30 |
Aerie Pharmaceuticals, Inc. |
Isoquinoline compounds
|
WO2007058626A1
(en)
*
|
2005-11-16 |
2007-05-24 |
S*Bio Pte Ltd |
Indazole compounds
|
KR20080074143A
(ko)
|
2005-11-29 |
2008-08-12 |
노파르티스 아게 |
퀴놀리논 제제
|
US20090170847A1
(en)
*
|
2006-01-23 |
2009-07-02 |
Seung Chul Lee |
Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same
|
US20100048660A1
(en)
*
|
2006-02-10 |
2010-02-25 |
Graham Michael Wynne |
Treatment of duchenne muscular dystrophy
|
CA2645892A1
(en)
*
|
2006-03-23 |
2007-09-27 |
F. Hoffmann-La Roche Ag |
Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
|
CN101484426A
(zh)
*
|
2006-06-30 |
2009-07-15 |
协和发酵麒麟株式会社 |
Aurora抑制剂
|
CN101484427A
(zh)
|
2006-06-30 |
2009-07-15 |
协和发酵麒麟株式会社 |
Abl激酶抑制剂
|
WO2008020606A1
(fr)
*
|
2006-08-16 |
2008-02-21 |
Kyowa Hakko Kirin Co., Ltd. |
Agent anti-angiogénique
|
US7767705B2
(en)
*
|
2006-08-25 |
2010-08-03 |
Abbott Laboratories |
Compounds that inhibit TRPV1 and uses thereof
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
EP2068878B1
(en)
|
2006-09-20 |
2019-04-10 |
Aerie Pharmaceuticals, Inc. |
Rho kinase inhibitors
|
JP5528807B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
JP5528806B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
US8071779B2
(en)
|
2006-12-18 |
2011-12-06 |
Inspire Pharmaceuticals, Inc. |
Cytoskeletal active rho kinase inhibitor compounds, composition and use
|
US20100022517A1
(en)
*
|
2006-12-18 |
2010-01-28 |
Richards Lori A |
Ophthalmic formulation of rho kinase inhibitor compound
|
EP2450346A1
(en)
|
2006-12-20 |
2012-05-09 |
Abbott Laboratories |
Antagonists of the TRPV1 receptor and uses thereof
|
US8455513B2
(en)
|
2007-01-10 |
2013-06-04 |
Aerie Pharmaceuticals, Inc. |
6-aminoisoquinoline compounds
|
US8063089B2
(en)
*
|
2007-02-28 |
2011-11-22 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Inhibitors of nucleophosmin (NPM) and methods for inducing apoptosis
|
EP2133095A4
(en)
|
2007-03-05 |
2012-09-26 |
Kyowa Hakko Kirin Co Ltd |
PHARMACEUTICAL COMPOSITION
|
US8648069B2
(en)
|
2007-06-08 |
2014-02-11 |
Abbvie Inc. |
5-substituted indazoles as kinase inhibitors
|
CN101790526A
(zh)
*
|
2007-06-08 |
2010-07-28 |
雅培制药有限公司 |
用作激酶抑制剂的5-杂芳基取代的吲唑化合物
|
CN101909631B
(zh)
*
|
2007-10-25 |
2012-09-12 |
健泰科生物技术公司 |
制备噻吩并嘧啶化合物的方法
|
US8455514B2
(en)
|
2008-01-17 |
2013-06-04 |
Aerie Pharmaceuticals, Inc. |
6-and 7-amino isoquinoline compounds and methods for making and using the same
|
JP2011515414A
(ja)
*
|
2008-03-20 |
2011-05-19 |
アボット・ラボラトリーズ |
Trpv1アンタゴニストである中枢神経系薬剤を作製する方法
|
CA2722102C
(en)
|
2008-04-28 |
2013-06-11 |
Asahi Kasei Pharma Corporation |
Phenylpropionic acid derivative and use thereof
|
US8106039B2
(en)
*
|
2008-04-30 |
2012-01-31 |
The Trustees Of The University Of Pennsylvania |
Metal complex phosphatidyl-inositol-3-kinase inhibitors
|
US8450344B2
(en)
|
2008-07-25 |
2013-05-28 |
Aerie Pharmaceuticals, Inc. |
Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
|
CA2756568C
(en)
|
2009-04-06 |
2018-02-13 |
University Health Network |
Kinase inhibitors and method of treating cancer with same
|
CA2929545C
(en)
|
2009-05-01 |
2019-04-09 |
Aerie Pharmaceuticals, Inc. |
Dual mechanism inhibitors for the treatment of disease
|
SI2464232T1
(sl)
|
2009-08-10 |
2016-03-31 |
Samumed, Llc. |
Indazolovi inhibitorji signalne poti WNT in njihova terapevtska uporaba
|
CA2770320A1
(en)
*
|
2009-08-10 |
2011-02-17 |
Epitherix, Llc |
Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof
|
AR078887A1
(es)
|
2009-11-06 |
2011-12-07 |
Boehringer Ingelheim Int |
Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
|
WO2011084486A1
(en)
|
2009-12-21 |
2011-07-14 |
Epitherix, Llc |
1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
CN102892766B
(zh)
|
2010-04-06 |
2015-05-20 |
大学健康网络 |
激酶抑制剂和用其治疗癌症的方法
|
WO2012020725A1
(ja)
*
|
2010-08-10 |
2012-02-16 |
塩野義製薬株式会社 |
Npy y5受容体拮抗作用を有するヘテロ環誘導体
|
PL2605652T3
(pl)
|
2010-08-18 |
2018-04-30 |
Samumed, Llc |
Diketony i hydroksyketony jako aktywatory szlaku sygnalizacji kateninowej
|
TWI537258B
(zh)
|
2010-11-05 |
2016-06-11 |
百靈佳殷格翰國際股份有限公司 |
六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物
|
EP2649065A1
(en)
*
|
2010-12-09 |
2013-10-16 |
Amgen Inc. |
Bicyclic compounds as pim inhibitors
|
JP2014510105A
(ja)
|
2011-03-22 |
2014-04-24 |
アムジエン・インコーポレーテツド |
Pim阻害剤としてのアゾール化合物
|
BR112013025142A2
(pt)
*
|
2011-04-01 |
2019-09-24 |
Univ Utah Res Found |
análogos de 3-(1h-benzo{d}imidazol-2-il)-1h-indazol substituído como inibidores da cinase pdk1
|
CN103929963A
(zh)
|
2011-09-14 |
2014-07-16 |
萨穆梅德有限公司 |
吲唑-3-羧酰胺及其作为WNT/β-CATENIN信号传导通路抑制剂的用途
|
US9469606B2
(en)
|
2011-10-25 |
2016-10-18 |
The General Hospital Corporation |
Wnt/b-catenin inhibitors and methods of use
|
PH12017500997A1
(en)
|
2012-04-04 |
2018-02-19 |
Samumed Llc |
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
|
RS59668B1
(sr)
|
2012-05-04 |
2020-01-31 |
Samumed Llc |
1h-pirazolo[3,4-b]piridini i njihova terapeutska upotreba
|
WO2014041518A1
(en)
*
|
2012-09-14 |
2014-03-20 |
Glenmark Pharmaceuticals S.A. |
Thienopyrrole derivatives as itk inhibitors
|
CN105120862A
(zh)
*
|
2013-01-08 |
2015-12-02 |
萨穆梅德有限公司 |
Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用
|
CN104370889A
(zh)
*
|
2013-01-24 |
2015-02-25 |
韩冰 |
一类降低眼压的化合物及其制备方法和用途
|
CA2901671C
(en)
|
2013-02-22 |
2021-07-13 |
Samumed, Llc |
.gamma.-diketones as wnt/.beta. -catenin signaling pathway activators
|
WO2014134776A1
(en)
|
2013-03-04 |
2014-09-12 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
WO2014134772A1
(en)
|
2013-03-04 |
2014-09-12 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
EP2964221B1
(en)
|
2013-03-04 |
2017-12-06 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
WO2014134774A1
(en)
|
2013-03-04 |
2014-09-12 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
CN109528721B
(zh)
|
2013-03-15 |
2021-10-01 |
爱瑞制药公司 |
联合治疗
|
MX2016001331A
(es)
|
2013-07-31 |
2017-02-06 |
Council Scient Ind Res |
Compuestos novedosos de indazol y un proceso para preparar los mismos.
|
US9642856B2
(en)
|
2013-10-18 |
2017-05-09 |
University Health Network |
Treatment for pancreatic cancer
|
WO2016014904A1
(en)
|
2014-07-24 |
2016-01-28 |
Beta Pharma, Inc. |
2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof
|
RU2727039C2
(ru)
|
2014-08-20 |
2020-07-17 |
СЭМЬЮМЕД, ЭлЭлСи |
Гамма-дикетоны для лечения и профилактики старения кожи и морщин
|
WO2016040184A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040182A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
|
WO2016040185A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
|
WO2016040181A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040190A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040193A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040180A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040188A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
GB201506660D0
(en)
|
2015-04-20 |
2015-06-03 |
Cellcentric Ltd |
Pharmaceutical compounds
|
GB201506658D0
(en)
|
2015-04-20 |
2015-06-03 |
Cellcentric Ltd |
Pharmaceutical compounds
|
GB201511382D0
(en)
|
2015-06-29 |
2015-08-12 |
Imp Innovations Ltd |
Novel compounds and their use in therapy
|
US10226453B2
(en)
|
2015-08-03 |
2019-03-12 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
US10206908B2
(en)
|
2015-08-03 |
2019-02-19 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
US10285982B2
(en)
|
2015-08-03 |
2019-05-14 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
US10329309B2
(en)
|
2015-08-03 |
2019-06-25 |
Samumed, Llc |
3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
US10206909B2
(en)
|
2015-08-03 |
2019-02-19 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017024010A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10166218B2
(en)
|
2015-08-03 |
2019-01-01 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
WO2017023988A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023972A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US10231956B2
(en)
|
2015-08-03 |
2019-03-19 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017023987A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
WO2017023975A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
WO2017024021A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10285983B2
(en)
|
2015-08-03 |
2019-05-14 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof
|
WO2017024025A1
(en)
|
2015-08-03 |
2017-02-09 |
Sunil Kumar Kc |
3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US10392383B2
(en)
|
2015-08-03 |
2019-08-27 |
Samumed, Llc |
3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US10604512B2
(en)
|
2015-08-03 |
2020-03-31 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof
|
WO2017024968A1
(zh)
*
|
2015-08-07 |
2017-02-16 |
南京明德新药研发股份有限公司 |
作为fgfr和vegfr抑制剂的乙烯基化合物
|
EP3370721A4
(en)
|
2015-11-06 |
2019-05-22 |
Samumed, LLC |
TREATMENT OF OSTEOARTHRITIS
|
US9643927B1
(en)
|
2015-11-17 |
2017-05-09 |
Aerie Pharmaceuticals, Inc. |
Process for the preparation of kinase inhibitors and intermediates thereof
|
JP6832946B2
(ja)
|
2015-11-17 |
2021-02-24 |
アエリエ ファーマシューティカルズ インコーポレイテッド |
キナーゼ阻害剤およびその中間体の調製方法
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
AR108326A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
HUE060797T2
(hu)
|
2016-06-01 |
2023-04-28 |
Biosplice Therapeutics Inc |
Eljárás N-(5-(3-(7-(3-fluorfenil)-3H-imidazo[4,5-c]piridin-2-il)-1H-indazol-5-il)- piridin-3-il)-3-metilbutánamid elõállítására
|
EP3483142A1
(en)
*
|
2016-07-05 |
2019-05-15 |
Guangzhou Maxinovel Pharmaceuticals Co., Ltd. |
Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
|
US11352328B2
(en)
|
2016-07-12 |
2022-06-07 |
Arisan Therapeutics Inc. |
Heterocyclic compounds for the treatment of arenavirus
|
JP6907319B2
(ja)
|
2016-08-31 |
2021-07-21 |
アエリエ ファーマシューティカルズ インコーポレイテッド |
眼科用組成物
|
EP3528808B1
(en)
*
|
2016-10-21 |
2021-10-06 |
BioSplice Therapeutics, Inc. |
Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
|
WO2018085865A1
(en)
|
2016-11-07 |
2018-05-11 |
Samumed, Llc |
Single-dose, ready-to-use injectable formulations
|
AU2018243687C1
(en)
|
2017-03-31 |
2020-12-24 |
Alcon Inc. |
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
|
WO2019079626A1
(en)
|
2017-10-19 |
2019-04-25 |
Samumed, Llc |
6- (HETEROARYL 5-CHAIN) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE
|
US10653688B2
(en)
|
2017-10-27 |
2020-05-19 |
Samumed, Llc |
6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
|
WO2019084496A1
(en)
|
2017-10-27 |
2019-05-02 |
Samumed, Llc |
6- (HETEROARYL 5-CHAIN) ISOQUINOLIN-3-YL- (HETEROARYL 5-CHAIN) CARBOXAMIDES, PREPARATION AND USE
|
US10703748B2
(en)
|
2017-10-31 |
2020-07-07 |
Samumed, Llc |
Diazanaphthalen-3-yl carboxamides and preparation and use thereof
|
WO2019128918A1
(zh)
|
2017-12-29 |
2019-07-04 |
广州再极医药科技有限公司 |
芳香乙烯或芳香乙基类衍生物、其制备方法、中间体、药物组合物及应用
|
MX2020008852A
(es)
|
2018-02-23 |
2020-10-14 |
Samumed Llc |
Indazol-3-carboxamidas sustituidas con 5-heteroarilo y preparacion y uso de las mismas.
|
WO2019241540A1
(en)
|
2018-06-15 |
2019-12-19 |
Samumed, Llc |
Indazole containing macrocycles and therapeutic uses thereof
|
WO2020056345A1
(en)
|
2018-09-14 |
2020-03-19 |
Aerie Pharmaceuticals, Inc. |
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
|
WO2020150545A1
(en)
|
2019-01-17 |
2020-07-23 |
Samumed, Llc |
Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway
|
EP4056558A4
(en)
*
|
2019-11-06 |
2023-12-27 |
Jinan University |
INDAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND ITS APPLICATIONS
|
WO2021125229A1
(ja)
*
|
2019-12-17 |
2021-06-24 |
富士フイルム株式会社 |
インダゾール化合物またはその塩および医薬組成物
|
WO2021121420A1
(zh)
*
|
2019-12-20 |
2021-06-24 |
江苏凯迪恩医药科技有限公司 |
苯并吡唑类化合物及其中间体、制备方法和应用
|
WO2021168341A1
(en)
|
2020-02-21 |
2021-08-26 |
Samumed, Llc |
Solid forms of 1-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-n,n-dimethylmethanamine
|
CN112724134B
(zh)
*
|
2021-01-14 |
2022-04-01 |
复旦大学 |
氮杂吲唑联吡啶衍生物髓细胞增殖抑制剂及其制备方法与在制药中的应用
|
WO2023240138A1
(en)
*
|
2022-06-08 |
2023-12-14 |
Blossomhill Therapeutics, Inc. |
Indazole containing macrocycles and their use
|