DK1563069T3 - Sammensætninger og systemer til genregulering - Google Patents
Sammensætninger og systemer til genreguleringInfo
- Publication number
- DK1563069T3 DK1563069T3 DK03780534.8T DK03780534T DK1563069T3 DK 1563069 T3 DK1563069 T3 DK 1563069T3 DK 03780534 T DK03780534 T DK 03780534T DK 1563069 T3 DK1563069 T3 DK 1563069T3
- Authority
- DK
- Denmark
- Prior art keywords
- regulation
- compositions
- systems
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42834702P | 2002-11-22 | 2002-11-22 | |
US47571503P | 2003-06-04 | 2003-06-04 | |
PCT/IB2003/006328 WO2004048583A2 (en) | 2002-11-22 | 2003-11-24 | Compositions and systems for the regulation of genes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1563069T3 true DK1563069T3 (da) | 2012-07-23 |
Family
ID=32397114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03780534.8T DK1563069T3 (da) | 2002-11-22 | 2003-11-24 | Sammensætninger og systemer til genregulering |
Country Status (7)
Country | Link |
---|---|
US (3) | US20050014166A1 (da) |
EP (1) | EP1563069B1 (da) |
CN (1) | CN1759182A (da) |
AU (1) | AU2003288686A1 (da) |
CA (1) | CA2506798C (da) |
DK (1) | DK1563069T3 (da) |
WO (1) | WO2004048583A2 (da) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005059120A1 (en) * | 2003-12-19 | 2005-06-30 | Stem Cell Australia Pty Lyd | Methods of preventing transplantation rejection by creating immunologically neutral stem cells using gene silencing technology |
US8236771B2 (en) * | 2004-05-18 | 2012-08-07 | National Institute Of Transplantation Foundation | Vectors and methods for long-term immune evasion to prolong transplant viability |
US8361976B2 (en) * | 2004-07-09 | 2013-01-29 | University Of Massachusetts | Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules |
KR100637925B1 (ko) | 2005-03-19 | 2006-10-24 | 한양대학교 산학협력단 | 테트라사이클린 유도성 siRNA 발현 레트로바이러스벡터 |
EP1891219A2 (en) * | 2005-05-31 | 2008-02-27 | The Centre National de la Recherche Scientifique | Tetracycline-dependent regulation of rna interference |
EP1888750A1 (en) * | 2005-06-09 | 2008-02-20 | ARTEMIS Pharmaceuticals GmbH | Shrna and sirna expression in a living organism under control op a codon-optimized tetracycline repressor gene |
EP1731607A1 (en) * | 2005-06-09 | 2006-12-13 | ARTEMIS Pharmaceuticals GmbH | shRNA and siRNA expression in a living organism under control of a codon-optimized tetracycline repressor gene |
US20070065862A1 (en) * | 2005-09-19 | 2007-03-22 | Ihor Lemischka | Methods for analysis of genetic interactions |
WO2008013918A2 (en) * | 2006-07-26 | 2008-01-31 | Myelin Repair Foundation, Inc. | Cell cycle regulation and differentiation |
WO2008106087A1 (en) * | 2007-02-28 | 2008-09-04 | The Brigham And Women's Hospital, Inc. | Compositions and methods for identifying factors affecting protein stability |
CN101126098B (zh) * | 2007-07-05 | 2012-07-11 | 深圳市第二人民医院 | 特异性抑制gfap蛋白表达的小干扰rna分子表达载体及其构建方法与用途 |
EP2217721A4 (en) * | 2007-10-29 | 2013-01-09 | Univ California | GENE THERAPY FOR OSTEOARTHRITIS |
EP2166107A1 (en) * | 2008-09-12 | 2010-03-24 | TaconicArtemis GmbH | Lentiviral vectors for the expression of shRNA |
US20100204299A1 (en) * | 2009-02-11 | 2010-08-12 | Daniel Regnier | C-cbl and antagonists thereof for the treatment and diagnosis of cancer |
WO2010101994A2 (en) * | 2009-03-03 | 2010-09-10 | The Regents Of The University Of Michigan | Gene fusion targeted therapy |
US20110294114A1 (en) * | 2009-12-04 | 2011-12-01 | Cincinnati Children's Hospital Medical Center | Optimization of determinants for successful genetic correction of diseases, mediated by hematopoietic stem cells |
CA2793633A1 (en) * | 2010-03-29 | 2011-10-13 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
CN102206645B (zh) * | 2011-04-29 | 2013-11-27 | 中国科学院武汉病毒研究所 | 利用慢病毒载体介导RNAi的方法 |
US10704060B2 (en) * | 2013-06-05 | 2020-07-07 | Duke University | RNA-guided gene editing and gene regulation |
AP2016009207A0 (en) | 2013-10-25 | 2016-05-31 | Livestock Improvement Corp Ltd | Genetic markers and uses therefor |
CA2924013A1 (en) | 2013-11-05 | 2015-05-14 | Clontech Laboratories, Inc. | Dry transfection compositions and methods for making and using the same |
JP6509884B2 (ja) | 2014-01-30 | 2019-05-08 | チルドレンズ ホスピタル メディカル センター | 鎌状赤血球病の遺伝子的是正のための改善された胎児ヘモグロビン |
WO2015171723A1 (en) | 2014-05-06 | 2015-11-12 | Research Development Foundation | Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy |
CA2959737A1 (en) | 2014-09-23 | 2016-03-31 | Aggenetics, Inc. | Materials and methods for producing animals with short hair |
CN106148408A (zh) * | 2015-03-26 | 2016-11-23 | 复旦大学 | 一种基于gfap启动子和慢病毒载体的载体系统及其应用 |
KR20180030965A (ko) | 2015-05-18 | 2018-03-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 노화 관련 장애를 치료하기 위한 방법 및 조성물 |
CA3028786A1 (en) * | 2016-07-26 | 2018-02-01 | The University Of North Carolina At Chapel Hill | Vector-mediated immune tolerance in the eye |
CN109207518B (zh) * | 2017-07-07 | 2020-12-01 | 中国科学院动物研究所 | 用于基因转录激活的药物诱导型CRISPR/Cas9系统 |
KR102051393B1 (ko) * | 2018-05-04 | 2019-12-04 | (주)지뉴인텍 | 아데노부속바이러스 기반 유전자 전달용 재조합 벡터 및 이를 이용한 암질환 예방 또는 치료용 조성물 |
CN110556158B (zh) * | 2019-08-30 | 2022-02-15 | 山西农业大学 | 抗心肌纤维化药物的筛选方法 |
JP2023510916A (ja) * | 2020-01-17 | 2023-03-15 | サナ バイオテクノロジー,インコーポレイテッド | 遺伝子発現の制御のための安全スイッチ |
CN115074336B (zh) * | 2022-06-29 | 2024-03-22 | 电子科技大学 | 一种具有磷脂翻转酶活性的蛋白及其纯化方法 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308236D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Dna vectors |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4682195A (en) * | 1985-09-30 | 1987-07-21 | General Electric Company | Insulated gate device with configured emitter contact pad |
US5019384A (en) * | 1986-06-30 | 1991-05-28 | Massachusetts Institute Of Technology | Immunonodulating compositions and their use |
US5466468A (en) * | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
US5885570A (en) * | 1991-01-23 | 1999-03-23 | The General Hospital Corporation | Induction of tolerance with modified immunogens |
DE4204650C1 (da) * | 1992-02-15 | 1993-07-08 | Hoffmeister, Helmut, Dr., 4400 Muenster, De | |
DE4228457A1 (de) * | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
US5834256A (en) * | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
US5912411A (en) * | 1993-06-14 | 1999-06-15 | University Of Heidelberg | Mice transgenic for a tetracycline-inducible transcriptional activator |
FR2722208B1 (fr) * | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
US5599302A (en) * | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
GB9510272D0 (en) * | 1995-05-22 | 1995-07-19 | Isis Innovation | Retroviral vectors |
US6013516A (en) * | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
US5705629A (en) * | 1995-10-20 | 1998-01-06 | Hybridon, Inc. | Methods for H-phosphonate synthesis of mono- and oligonucleotides |
GB9525639D0 (en) * | 1995-12-15 | 1996-02-14 | Isis Innovation | Improved retroviral vectors |
US5928906A (en) * | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
EP1793421A3 (en) * | 1996-10-08 | 2007-08-01 | Hitachi Chemical Co., Ltd. | Semiconductor device, substrate for mounting a semiconductor chip, process for their production, adhesive, and double-sided adhesive film |
GB9621680D0 (en) * | 1996-10-17 | 1996-12-11 | Oxford Biomedica Ltd | Lentiviral vectors |
DE69703974T2 (de) * | 1996-10-17 | 2001-07-19 | Oxford Biomedica Ltd | Retrovirale vektoren |
US5846225A (en) * | 1997-02-19 | 1998-12-08 | Cornell Research Foundation, Inc. | Gene transfer therapy delivery device and method |
US6017758A (en) * | 1997-02-20 | 2000-01-25 | Vanderbilt University | DMNPE caged nucleic acid and vector |
JP2001513643A (ja) * | 1997-03-06 | 2001-09-04 | ウーベルラ、クラウス | レンチウイルスをベースとするベクター及びベクター系 |
US6531123B1 (en) * | 1997-05-01 | 2003-03-11 | Lung-Ji Chang | Lentiviral vectors |
US6207455B1 (en) * | 1997-05-01 | 2001-03-27 | Lung-Ji Chang | Lentiviral vectors |
JP4390860B2 (ja) * | 1997-05-13 | 2009-12-24 | ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | レンチウイルスをベースにした遺伝子転移ベクター |
US5981830A (en) * | 1997-05-30 | 1999-11-09 | Schering Aktiengesellschaft | Knockout mice and their progeny with a disrupted hepsin gene |
US5972650A (en) * | 1997-06-26 | 1999-10-26 | Brigham And Women's Hospital | Tetracycline repressor regulated mammalian cell transcription and viral replication switch |
US6136597A (en) * | 1997-09-18 | 2000-10-24 | The Salk Institute For Biological Studies | RNA export element |
US5994136A (en) * | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
DK1895010T3 (da) * | 1997-12-22 | 2011-11-21 | Oxford Biomedica Ltd | Vektorer baseret på virus for infektiøs hesteanæmi (eiav) |
US6084063A (en) * | 1998-02-06 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitors of allergic reactions |
US6218181B1 (en) * | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
US5989910A (en) * | 1998-08-03 | 1999-11-23 | University Of Lausanne | Potent genetic switch allowing regulated gene expression in eukaryotic cells |
CA2336207C (en) * | 1998-09-10 | 2004-03-23 | Pioneer Hi-Bred International, Inc. | Ecdysone receptors and methods for their use |
GB9825524D0 (en) * | 1998-11-20 | 1999-01-13 | Oxford Biomedica Ltd | Vector |
DE19856463B4 (de) * | 1998-11-26 | 2006-02-02 | Heinrich-Pette-Institut | Retrovirale, mit LCMV pseudotypisierte Hybrid-Vektoren |
US6271359B1 (en) * | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
US6218186B1 (en) * | 1999-11-12 | 2001-04-17 | Trustees Of The University Of Pennsylvania | HIV-MSCV hybrid viral vector for gene transfer |
US20020160393A1 (en) * | 2000-12-28 | 2002-10-31 | Symonds Geoffrey P. | Double-stranded RNA-mediated gene suppression |
EP1229134A3 (en) * | 2001-01-31 | 2004-01-28 | Nucleonics, Inc | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
JP3765574B2 (ja) * | 2001-02-22 | 2006-04-12 | 三菱化学株式会社 | 逆向き反復配列を含む組み換え遺伝子及びその利用 |
US7732193B2 (en) * | 2001-09-13 | 2010-06-08 | California Institute Of Technology | Method for expression of small RNA molecules within a cell |
GB0130955D0 (en) * | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
-
2003
- 2003-11-24 DK DK03780534.8T patent/DK1563069T3/da active
- 2003-11-24 CA CA2506798A patent/CA2506798C/en not_active Expired - Fee Related
- 2003-11-24 US US10/720,987 patent/US20050014166A1/en not_active Abandoned
- 2003-11-24 CN CN200380109095.0A patent/CN1759182A/zh active Pending
- 2003-11-24 EP EP03780534A patent/EP1563069B1/en not_active Expired - Lifetime
- 2003-11-24 AU AU2003288686A patent/AU2003288686A1/en not_active Abandoned
- 2003-11-24 WO PCT/IB2003/006328 patent/WO2004048583A2/en not_active Application Discontinuation
-
2007
- 2007-07-06 US US11/774,177 patent/US20110172120A1/en not_active Abandoned
-
2012
- 2012-04-17 US US13/448,580 patent/US20130096370A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003288686A8 (en) | 2004-06-18 |
CA2506798A1 (en) | 2004-06-10 |
AU2003288686A1 (en) | 2004-06-18 |
US20130096370A1 (en) | 2013-04-18 |
EP1563069A2 (en) | 2005-08-17 |
US20110172120A1 (en) | 2011-07-14 |
WO2004048583A2 (en) | 2004-06-10 |
CN1759182A (zh) | 2006-04-12 |
EP1563069B1 (en) | 2012-06-06 |
CA2506798C (en) | 2013-01-22 |
US20050014166A1 (en) | 2005-01-20 |
WO2004048583A3 (en) | 2004-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1563069T3 (da) | Sammensætninger og systemer til genregulering | |
IS7520A (is) | Pyrimidínonefnasambönd, samsetningar og aðferðir | |
DK1504126T3 (da) | Fremgangsmåde til regulering af genekspression | |
NO2015010I1 (no) | Everolimus - se vedlegg til søknad | |
DE60331027D1 (de) | tsprechendes System | |
DK1490463T3 (da) | Lav-transfedtsyrer til konfekture og fedtsammensætninger til bagning | |
DK1583542T3 (da) | Sammensætninger og fremgangsmåder til antiviral kombinationsterapi | |
DE60319881D1 (de) | Lösbare befestigungssysteme und -verfahren | |
DK1575379T3 (da) | Ernæringssammensætninger | |
DK1569712T3 (da) | Forbindelsesindretning | |
DE60318511D1 (de) | Gleitelement | |
DK1361490T3 (da) | Strömningsregulator | |
DE60325447D1 (de) | Gleitelement | |
DK1540907T3 (da) | Konferencesystem | |
IS7799A (is) | Hleðslubrík og kerfi til að búa til hleðslueiningar | |
DE50308694D1 (de) | Bestrahlungsger t | |
DE10393374D2 (de) | Zusammensetzung | |
SE0500163L (sv) | Sammansättning | |
DK1561472T3 (da) | Faststofsammensætning | |
DE60207518D1 (de) | Dämpfungseinrichtung | |
NO20043718L (no) | Tradkoplet telefonisystem | |
DE50312149D1 (de) | Ventilsystem | |
ATA12182002A (de) | Schaltwandler | |
DE60216645D1 (de) | Antiulcus pflanzenzusammensetzung(en) | |
DE50303404D1 (de) | Rückflussverhinderer |