US4232027A
(en)
|
1979-01-29 |
1980-11-04 |
E. R. Squibb & Sons, Inc. |
1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives
|
GB2116183B
(en)
|
1982-03-03 |
1985-06-05 |
Genentech Inc |
Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
JP2762522B2
(ja)
|
1989-03-06 |
1998-06-04 |
藤沢薬品工業株式会社 |
血管新生阻害剤
|
GB8912336D0
(en)
|
1989-05-30 |
1989-07-12 |
Smithkline Beckman Intercredit |
Compounds
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
US5892112A
(en)
|
1990-11-21 |
1999-04-06 |
Glycomed Incorporated |
Process for preparing synthetic matrix metalloprotease inhibitors
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
CA2066898A1
(fr)
|
1991-04-29 |
1992-10-30 |
Chuan Shih |
Composes pharmaceutiques
|
CA2102780C
(fr)
|
1991-05-10 |
2007-01-09 |
Alfred P. Spada |
Composes de type bis-monoaryle, aryle bicyclique et (ou) heteroaryle inhibant l'activite de tyrosine kinase des recepteurs de l'egf et (ou) du pdgf
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
GB9125660D0
(en)
|
1991-12-03 |
1992-01-29 |
Smithkline Beecham Plc |
Novel compound
|
GB9300059D0
(en)
|
1992-01-20 |
1993-03-03 |
Zeneca Ltd |
Quinazoline derivatives
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
DE4221054A1
(de)
|
1992-06-30 |
1994-01-05 |
Herbst Bremer Goldschlaegerei |
Präparat zur prophylaktischen und therapeutischen Behandlung von Karies sowie Verfahren zum Herstellen desselben
|
ZA935111B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
ZA935112B
(en)
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
US5256790A
(en)
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
WO1994011384A1
(fr)
|
1992-11-13 |
1994-05-26 |
Immunex Corporation |
Nouvelle cytokine appelee ligand d'elk
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
US5629327A
(en)
|
1993-03-01 |
1997-05-13 |
Childrens Hospital Medical Center Corp. |
Methods and compositions for inhibition of angiogenesis
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
US5612340A
(en)
|
1993-10-01 |
1997-03-18 |
Ciba-Geigy Corporation |
Pyrimidineamine derivatives and processes for the preparation thereof
|
US5656643A
(en)
|
1993-11-08 |
1997-08-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
CA2175215C
(fr)
|
1993-11-19 |
2008-06-03 |
Yat Sun Or |
Analogues semi-synthetiques de rapamycine (macrolides) utilises comme immunomodulateurs
|
SG64372A1
(en)
|
1993-12-17 |
1999-04-27 |
Novartis Ag |
Rapamycin derivatives
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
WO1995024190A2
(fr)
|
1994-03-07 |
1995-09-14 |
Sugen, Inc. |
Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant
|
JPH09512167A
(ja)
|
1994-04-15 |
1997-12-09 |
アムジエン・インコーポレーテツド |
Hek5、hek7、hek8、hek11、新規なeph様受容体タンパク質チロシンキナーゼ
|
DE59500788D1
(de)
|
1994-05-03 |
1997-11-20 |
Ciba Geigy Ag |
Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
|
US6303769B1
(en)
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
US5919905A
(en)
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
CA2216796C
(fr)
|
1995-03-30 |
2003-09-02 |
Pfizer Inc. |
Derives de quinazoline
|
NZ304859A
(en)
|
1995-04-03 |
2000-01-28 |
Novartis Ag |
4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives, medicaments and processes for the preparation thereof
|
WO1996033172A1
(fr)
|
1995-04-20 |
1996-10-24 |
Pfizer Inc. |
Derives d'acide hydroxamique arylsufonyle en tant qu'inhibiteurs de mmp et de tnf
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
US5650415A
(en)
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
BR9609260A
(pt)
|
1995-06-09 |
1999-05-18 |
Novartis Ag |
Derivados de rapamicina
|
CA2224435C
(fr)
|
1995-07-06 |
2008-08-05 |
Novartis Ag |
Pyrrolopyrimidines et leurs procedes de preparation
|
DE19534177A1
(de)
|
1995-09-15 |
1997-03-20 |
Merck Patent Gmbh |
Cyclische Adhäsionsinhibitoren
|
AR004010A1
(es)
|
1995-10-11 |
1998-09-30 |
Glaxo Group Ltd |
Compuestos heterociclicos
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
EP0780386B1
(fr)
|
1995-12-20 |
2002-10-02 |
F. Hoffmann-La Roche Ag |
Inhibiteurs de métalloprotéases matricielles
|
DE69712745T2
(de)
|
1996-01-23 |
2002-10-31 |
Novartis Ag |
Pyrrolopyrimidinen und verfahren zu deren herstellung
|
JP3406763B2
(ja)
|
1996-01-30 |
2003-05-12 |
東レ・ダウコーニング・シリコーン株式会社 |
シリコーンゴム組成物
|
GB9603097D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
DE19629652A1
(de)
|
1996-03-06 |
1998-01-29 |
Thomae Gmbh Dr K |
4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
DE19608588A1
(de)
|
1996-03-06 |
1997-09-11 |
Thomae Gmbh Dr K |
Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
ES2203793T3
(es)
|
1996-03-15 |
2004-04-16 |
Novartis Ag |
N-7-heterociclil-pirrolo(2,3-d)pirimidinas y su empleo.
|
CA2249446C
(fr)
|
1996-04-12 |
2008-06-17 |
Warner-Lambert Company |
Inhibiteurs irreversibles de tyrosine kinases
|
GB9607729D0
(en)
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
DE69734513T2
(de)
|
1996-06-24 |
2006-07-27 |
Pfizer Inc. |
Phenylamino-substituierte tricyclische derivate zur behandlung hyperproliferativer krankheiten
|
EP0818442A3
(fr)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Dérivés cycliques de sulfones comme inhibiteurs de métalloprotéinase et de la production du facteur de nécrose des tumeurs
|
EP0937082A2
(fr)
|
1996-07-12 |
1999-08-25 |
Ariad Pharmaceuticals, Inc. |
Elements et procedes pour traiter ou prevenir les mycoses pathog nes
|
PE91098A1
(es)
|
1996-07-13 |
1999-01-15 |
Glaxo Group Ltd |
DERIVADOS DE PIRIDO[3,4-d]PIRIMIDINA
|
ID19609A
(id)
|
1996-07-13 |
1998-07-23 |
Glaxo Group Ltd |
Senyawa-senyawa heterosiklik
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
EA199900036A1
(ru)
|
1996-07-18 |
1999-06-24 |
Пфайзер Инк |
Ингибиторы металлопротеаз матрикса на основе фосфинатов, фармацевтическая композиция, способ лечения
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
ES2308787T3
(es)
|
1996-08-16 |
2008-12-01 |
Schering Corporation |
Antigenos de superficie de celular de mamiferos; reactivos relacionados.
|
JP2000501423A
(ja)
|
1996-08-23 |
2000-02-08 |
ファイザー インク. |
アリールスルホニルアミノヒドロキサム酸誘導体
|
AU720429B2
(en)
|
1996-08-23 |
2000-06-01 |
Novartis Ag |
Substituted pyrrolopyrimidines and processes for their preparation
|
DE69732780T2
(de)
|
1996-10-02 |
2006-04-06 |
Novartis Ag |
Pyrimiderivate und verfahren zu ihrer herstellung
|
AU4779897A
(en)
|
1996-10-02 |
1998-04-24 |
Novartis Ag |
Fused pyrazole derivatives and processes for their preparation
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
EP0837063A1
(fr)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
Dérivés de 4-aminoquinazoline
|
GB9621757D0
(en)
|
1996-10-18 |
1996-12-11 |
Ciba Geigy Ag |
Phenyl-substituted bicyclic heterocyclyl derivatives and their use
|
EP0950059B1
(fr)
|
1997-01-06 |
2004-08-04 |
Pfizer Inc. |
Derives de sulfone cyclique
|
PL335027A1
(en)
|
1997-02-03 |
2000-03-27 |
Pfizer Prod Inc |
Derivatives of arylsulphonylamino hydroxamic acid
|
CA2271157A1
(fr)
|
1997-02-05 |
1998-08-06 |
Warner-Lambert Company |
Pyrido[2,3d]pyrimidines et 4-aminopyrimidines en tant qu'inhibiteurs de la proliferation cellulaire
|
EP0966438A1
(fr)
|
1997-02-07 |
1999-12-29 |
Pfizer Inc. |
Derives du n-hxdroxy-beta-sulfonyl-propionamide et leur utilisation comme inhibiteurs des metalloproteases matrices
|
JP3710489B2
(ja)
|
1997-02-11 |
2005-10-26 |
ファイザー・インク |
アリールスルホニルヒドロキサム酸誘導体
|
CO4950519A1
(es)
|
1997-02-13 |
2000-09-01 |
Novartis Ag |
Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
|
US6150395A
(en)
|
1997-05-30 |
2000-11-21 |
The Regents Of The University Of California |
Indole-3-carbinol (I3C) derivatives and methods
|
US6329375B1
(en)
|
1997-08-05 |
2001-12-11 |
Sugen, Inc. |
Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
|
WO1999007675A1
(fr)
|
1997-08-08 |
1999-02-18 |
Pfizer Products Inc. |
Derives de l'acide aryloxyarylsulfonylamino hydroxamique
|
WO2000012089A1
(fr)
|
1998-08-31 |
2000-03-09 |
Merck & Co., Inc. |
Nouveaux inhibiteurs d'angiogenese
|
WO1999020758A1
(fr)
|
1997-10-21 |
1999-04-29 |
Human Genome Sciences, Inc. |
Proteines tr11, tr11sv1 et tr11sv2 de type recepteur du facteur de necrose tumorale humain
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
WO1999040196A1
(fr)
|
1998-02-09 |
1999-08-12 |
Genentech, Inc. |
Nouveaux homologues recepteurs du facteur necrosant des tumeurs et acides nucleiques codant ceux-ci
|
WO1999045009A1
(fr)
|
1998-03-04 |
1999-09-10 |
Bristol-Myers Squibb Company |
Inhibiteurs de la proteine tyrosine kinase, a base d'imidazopyrazine a substitution heterocyclo
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
CA2314156C
(fr)
|
1998-05-29 |
2010-05-25 |
Sugen, Inc. |
Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
AU747427B2
(en)
|
1998-07-10 |
2002-05-16 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
ATE260255T1
(de)
|
1998-11-05 |
2004-03-15 |
Pfizer Prod Inc |
5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate
|
ATE556713T1
(de)
|
1999-01-13 |
2012-05-15 |
Bayer Healthcare Llc |
Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
|
PT1165085E
(pt)
|
1999-03-30 |
2006-10-31 |
Novartis Ag |
Derivados de ftalazina para tratar doencas inflamatorias
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
US6521424B2
(en)
|
1999-06-07 |
2003-02-18 |
Immunex Corporation |
Recombinant expression of Tek antagonists
|
US6413932B1
(en)
|
1999-06-07 |
2002-07-02 |
Immunex Corporation |
Tek antagonists comprising soluble tek extracellular binding domain
|
ATE376837T1
(de)
|
1999-07-12 |
2007-11-15 |
Genentech Inc |
Stimulierung oder hemmung von angiogenese und herzvaskularisierung mit tumor nekrose faktor ligand/rezeptor homologen
|
WO2001014387A1
(fr)
|
1999-08-24 |
2001-03-01 |
Ariad Gene Therapeutics, Inc. |
Analogues d'epirapamycine-28
|
PL203782B1
(pl)
|
1999-11-05 |
2009-11-30 |
Astrazeneca Ab |
Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
|
PT1233943E
(pt)
|
1999-11-24 |
2011-09-01 |
Sugen Inc |
Formulações para agentes farmacêuticos ionizáveis como ácidos livres ou bases livres
|
US6515004B1
(en)
|
1999-12-15 |
2003-02-04 |
Bristol-Myers Squibb Company |
N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
|
US6727225B2
(en)
|
1999-12-20 |
2004-04-27 |
Immunex Corporation |
TWEAK receptor
|
DE60127656T2
(de)
|
2000-02-25 |
2007-12-20 |
Immunex Corp., Seattle |
Integrin antagonisten
|
JP3811775B2
(ja)
|
2000-07-19 |
2006-08-23 |
ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー |
4−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
|
US6630500B2
(en)
|
2000-08-25 |
2003-10-07 |
Cephalon, Inc. |
Selected fused pyrrolocarbazoles
|
ATE430742T1
(de)
|
2000-12-21 |
2009-05-15 |
Smithkline Beecham Corp |
Pyrimidinamine als angiogenesemodulatoren
|
US7105682B2
(en)
|
2001-01-12 |
2006-09-12 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
US20020147198A1
(en)
|
2001-01-12 |
2002-10-10 |
Guoqing Chen |
Substituted arylamine derivatives and methods of use
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
US7102009B2
(en)
|
2001-01-12 |
2006-09-05 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
US20050026868A1
(en)
|
2003-07-11 |
2005-02-03 |
Metcalf Chester A. |
Phosphorus-containing macrocycles
|
US7307088B2
(en)
|
2002-07-09 |
2007-12-11 |
Amgen Inc. |
Substituted anthranilic amide derivatives and methods of use
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
US20050009849A1
(en)
|
2003-01-03 |
2005-01-13 |
Veach Darren R. |
Pyridopyrimidine kinase inhibitors
|
US7618632B2
(en)
|
2003-05-23 |
2009-11-17 |
Wyeth |
Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies
|
US20060173033A1
(en)
|
2003-07-08 |
2006-08-03 |
Michaela Kneissel |
Use of rapamycin and rapamycin derivatives for the treatment of bone loss
|
WO2005007190A1
(fr)
|
2003-07-11 |
2005-01-27 |
Schering Corporation |
Agonistes ou antagonistes du recepteur du facteur de necrose tumorale induit par les glucocorticoides (gitr) ou de son ligand utilises dans le traitement des troubles immuns, des infections et du cancer
|
AR045134A1
(es)
|
2003-07-29 |
2005-10-19 |
Smithkline Beecham Plc |
Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic
|
JP2007503388A
(ja)
|
2003-08-22 |
2007-02-22 |
アバニール・ファーマシューティカルズ |
マクロファージ遊走阻止因子の阻害剤としての置換ナフチリジン誘導体、およびヒト疾患の治療におけるそれらの使用
|
WO2005055808A2
(fr)
|
2003-12-02 |
2005-06-23 |
Genzyme Corporation |
Compositions et methodes pour le diagnostic et le traitement du cancer du poumon
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
EP1765402A2
(fr)
|
2004-06-04 |
2007-03-28 |
Duke University |
Methodes et compositions ameliorant l'immunite par depletion in vivo de l'activite cellulaire immunosuppressive
|
GEP20104906B
(en)
|
2004-08-26 |
2010-02-25 |
Pfizer |
Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
|
CA2582163A1
(fr)
|
2004-10-13 |
2006-04-27 |
Wyeth |
Analogues de la 17-hydroxywortmannine employes en tant qu'inhibiteurs de pi3k
|
KR20070073791A
(ko)
|
2004-10-18 |
2007-07-10 |
암젠 인코포레이티드 |
티아디아졸 화합물 및 이의 사용방법
|
JP5238936B2
(ja)
|
2005-03-25 |
2013-07-17 |
ジーアイティーアール,インク. |
Gitr結合分子およびその使用
|
EP1896582A4
(fr)
|
2005-05-09 |
2009-04-08 |
Ono Pharmaceutical Co |
Anticorps monoclonaux humains pour mort programmée 1 (mp-1) et procédés pour traiter le cancer en utilisant des anticorps anti-mp-1 seuls ou associés à d'autres immunothérapies
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
CN101267824A
(zh)
|
2005-09-20 |
2008-09-17 |
辉瑞产品公司 |
使用酪氨酸激酶抑制剂的治疗剂型和方法
|
AU2007207743B2
(en)
|
2006-01-18 |
2010-07-08 |
Amgen Inc. |
Thiazole compounds as protein kinase B (PKB) inhibitors
|
WO2007133822A1
(fr)
|
2006-01-19 |
2007-11-22 |
Genzyme Corporation |
Anticorps anti-gitr destinés au traitement du cancer
|
AU2007329352B2
(en)
|
2006-12-07 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
UA98955C2
(ru)
|
2007-03-23 |
2012-07-10 |
Амген Инк. |
Гетероциклические соединения и их применение
|
EP2139882B1
(fr)
|
2007-03-23 |
2013-12-25 |
Amgen Inc. |
Dérivés de quinoléine ou quinoxaline 3-substituée et leur utilisation en tant qu'inhibiteurs de phosphatidylinositol 3-kinase (pi3k)
|
WO2008118454A2
(fr)
|
2007-03-23 |
2008-10-02 |
Amgen Inc. |
Composés hétérocycliques et leurs utilisations
|
WO2008153947A2
(fr)
|
2007-06-07 |
2008-12-18 |
Amgen Inc. |
Modulateurs de la raf kinase et leurs méthodes d'utilisation
|
CA2693677C
(fr)
|
2007-07-12 |
2018-02-13 |
Tolerx, Inc. |
Therapies combinees utilisant des molecules de liaison au gitr
|
WO2009011880A2
(fr)
|
2007-07-17 |
2009-01-22 |
Amgen Inc. |
Modulateurs hétérocycliques de pkb
|
US7919504B2
(en)
|
2007-07-17 |
2011-04-05 |
Amgen Inc. |
Thiadiazole modulators of PKB
|
JP5561702B2
(ja)
|
2007-08-02 |
2014-07-30 |
アムジエン・インコーポレーテツド |
Pi3キナーゼ調節剤および使用方法
|
TWI471134B
(zh)
|
2007-09-12 |
2015-02-01 |
Genentech Inc |
肌醇磷脂3-激酶抑制劑化合物及化療劑之組合及使用方法
|
WO2009055730A1
(fr)
|
2007-10-25 |
2009-04-30 |
Genentech, Inc. |
Procédé de préparation de composés de thiénopyrimidine
|
EP2231661A1
(fr)
|
2007-12-19 |
2010-09-29 |
Amgen, Inc. |
Inhibiteurs de la pi3 kinase
|
EP2231656A1
(fr)
|
2007-12-19 |
2010-09-29 |
Amgen Inc. |
Composés condensés de pyridine, de pyrimidine et de triazine en tant qu'inhibiteurs du cycle cellulaire
|
US8389533B2
(en)
|
2008-04-07 |
2013-03-05 |
Amgen Inc. |
Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
|
MX315904B
(es)
|
2008-05-30 |
2013-11-29 |
Amgen Inc |
Inhibidores de fosfoinosituro-3 cinasa.
|
JP2011526794A
(ja)
|
2008-07-02 |
2011-10-20 |
エマージェント プロダクト デベロップメント シアトル, エルエルシー |
TGF−βアンタゴニスト多重標的結合性分子
|
WO2010030002A1
(fr)
|
2008-09-12 |
2010-03-18 |
国立大学法人三重大学 |
Cellule capable d'exprimer un ligand gitr exogène
|
EP2387570A1
(fr)
|
2009-01-15 |
2011-11-23 |
Amgen, Inc |
Thiazoles substitués par fluoroisoquinoléine et leurs méthodes d'application
|
MX2011008674A
(es)
|
2009-02-18 |
2011-11-04 |
Amgen Inc |
Compuestos de indol/bencimidazol como inhibidores de quinasa mtor.
|
WO2010108074A2
(fr)
|
2009-03-20 |
2010-09-23 |
Amgen Inc. |
Inhibiteurs de pi3 kinase
|
UY32582A
(es)
|
2009-04-28 |
2010-11-30 |
Amgen Inc |
Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
|
JP2012526836A
(ja)
|
2009-05-13 |
2012-11-01 |
アムジエン・インコーポレーテツド |
Pikk阻害薬としてのヘテロアリール化合物
|
US20100331306A1
(en)
|
2009-06-25 |
2010-12-30 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
CN102625799A
(zh)
|
2009-06-25 |
2012-08-01 |
安姆根有限公司 |
杂环化合物及其用途
|
AU2010266064A1
(en)
|
2009-06-25 |
2012-01-19 |
Amgen Inc. |
4H - pyrido [1, 2 - a] pyrimidin - 4 - one derivatives as PI3 K inhibitors
|
WO2010151737A2
(fr)
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
Composés hétérocycliques et leurs utilisations
|
KR20170119746A
(ko)
|
2009-09-03 |
2017-10-27 |
머크 샤프 앤드 돔 코포레이션 |
항-gitr 항체
|
MX2012003041A
(es)
|
2009-09-11 |
2012-06-27 |
Amgen Inc |
Uso de n-(4-((3-(2-amino-4-pirimidinil)-2-piridinil)oxi)fenil)-4-( 4-metil-2-tienil)-1-ftalazinamina en el tratamiento de cancer resistente al agente antimitotico.
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
PL2519543T3
(pl)
|
2009-12-29 |
2016-12-30 |
|
Białka wiążące heterodimery i ich zastosowania
|
US9133164B2
(en)
|
2011-04-13 |
2015-09-15 |
Innov88 Llc |
MIF inhibitors and their uses
|
WO2013039954A1
(fr)
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anticorps anti-gitr
|
EP2836482B1
(fr)
|
2012-04-10 |
2019-12-25 |
The Regents of The University of California |
Compositions et méthodes pour le traitement du cancer
|
ES2618004T3
(es)
|
2012-08-07 |
2017-06-20 |
Merck Patent Gmbh |
Derivados de piridopirimidina como inhibidores de proteínas quinasas
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
CN105189456B
(zh)
|
2013-03-15 |
2017-12-19 |
亚瑞克西斯制药公司 |
Kras g12c的共价抑制剂
|
WO2014143659A1
(fr)
|
2013-03-15 |
2014-09-18 |
Araxes Pharma Llc |
Inhibiteurs covalents irréversibles de la gtpase k-ras g12c
|
GB201312059D0
(en)
|
2013-07-05 |
2013-08-21 |
Univ Leuven Kath |
Novel GAK modulators
|
EP3055290B1
(fr)
|
2013-10-10 |
2019-10-02 |
Araxes Pharma LLC |
Inhibiteurs de kras g12c
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
GB201320729D0
(en)
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
WO2016035008A1
(fr)
|
2014-09-04 |
2016-03-10 |
Lupin Limited |
Dérivés de pyridopyrimidine utilisés comme inhibiteurs de mek
|
JO3556B1
(ar)
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
علاجات مدمجة لمعالجة السرطان
|
WO2016049565A1
(fr)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions et procédés pour inhiber la ras
|
US9862701B2
(en)
|
2014-09-25 |
2018-01-09 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
WO2016049568A1
(fr)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Méthodes et compositions permettant l'inhibition de la ras
|
US10246424B2
(en)
|
2015-04-10 |
2019-04-02 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
EP3283462B1
(fr)
|
2015-04-15 |
2020-12-02 |
Araxes Pharma LLC |
Inhibiteurs tricycliques condensés de kras et procédés pour les utiliser
|
MX2018000777A
(es)
|
2015-07-22 |
2018-03-23 |
Araxes Pharma Llc |
Compuestos de quinazolina sustituido y su uso como inhibidores de proteinas kras, hras y/o nras mutantes g12c.
|
EP3356351A1
(fr)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibiteurs de protéines kras portant la mutation g12c
|
US10730867B2
(en)
|
2015-09-28 |
2020-08-04 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
WO2017058728A1
(fr)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibiteurs de protéines kras portant la mutation g12c
|
EP3356339A1
(fr)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibiteurs de protéines mutantes kras g12c
|
EP3356349A1
(fr)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibiteurs de protéines mutantes kras g12c
|
EP3356347A1
(fr)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibiteurs de protéines kras portant la mutation g12c
|
EP3356359B1
(fr)
|
2015-09-28 |
2021-10-20 |
Araxes Pharma LLC |
Inhibiteurs de protéines kras portant la mutation g12c
|
CA3005089A1
(fr)
|
2015-11-16 |
2017-05-26 |
Araxes Pharma Llc |
Composes quinazoline substitues en position 2 comprenant un groupe heterocyclique substitue et leur methode d'utilisation
|
US9988357B2
(en)
|
2015-12-09 |
2018-06-05 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
HUE056019T2
(hu)
|
2015-12-23 |
2022-01-28 |
eleva GmbH |
Polipeptidek komplement aktiváció gátlására
|
WO2017172979A1
(fr)
|
2016-03-30 |
2017-10-05 |
Araxes Pharma Llc |
Composés quinazoline substitués et procédés d'utilisation
|
AU2017266911B2
(en)
|
2016-05-18 |
2021-09-02 |
Array Biopharma, Inc. |
KRas G12C inhibitors
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
US10280172B2
(en)
|
2016-09-29 |
2019-05-07 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
CN110312711A
(zh)
|
2016-10-07 |
2019-10-08 |
亚瑞克西斯制药公司 |
作为ras抑制剂的杂环化合物及其使用方法
|
MA47107B1
(fr)
|
2016-12-22 |
2021-11-30 |
Amgen Inc |
Dérivés de benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine et pyrido[2,3-d]pyrimidine en tant qu'inhibiteurs de kras g12c pour le traitement de cancer du poumon, du pancréas ou de l'intestin
|
EP3573966A1
(fr)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Composés n-hétérocycliques fusionnés et leurs procédés d'utilisation
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
US11639346B2
(en)
|
2017-05-25 |
2023-05-02 |
Araxes Pharma Llc |
Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
|
US10640504B2
(en)
|
2017-09-08 |
2020-05-05 |
Amgen Inc. |
Inhibitors of KRAS G12C and methods of using the same
|
JP7361722B2
(ja)
|
2018-05-04 |
2023-10-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及び同一物の使用方法
|
MA52501A
(fr)
*
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
US10988485B2
(en)
|
2018-05-10 |
2021-04-27 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
US11096939B2
(en)
|
2018-06-01 |
2021-08-24 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
AU2019284472B2
(en)
|
2018-06-11 |
2024-05-30 |
Amgen Inc. |
KRAS G12C inhibitors for treating cancer
|
EP3807276A2
(fr)
|
2018-06-12 |
2021-04-21 |
Amgen Inc. |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
CA3103049A1
(fr)
|
2018-06-21 |
2019-12-26 |
Janssen Pharmaceutica Nv |
Composes inhibiteurs d'oga
|
AU2019291099A1
(en)
|
2018-06-21 |
2021-01-07 |
Janssen Pharmaceutica Nv |
Oga inhibitor compounds
|
US11528607B2
(en)
|
2018-08-13 |
2022-12-13 |
Apple Inc. |
Techniques in evolved packet core for restricted local operator services access
|
JP2020090482A
(ja)
|
2018-11-16 |
2020-06-11 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
JP7454572B2
(ja)
|
2018-11-19 |
2024-03-22 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及びその使用方法
|
EP3919483A4
(fr)
|
2019-01-29 |
2022-02-09 |
Brightgene Bio-medical Technology Co., Ltd. |
Composé de benzopyridone hétérocyclique et son utilisation
|
EP3738593A1
(fr)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosage d'inhibiteur de kras pour le traitement de cancers
|
EP3972973A1
(fr)
|
2019-05-21 |
2022-03-30 |
Amgen Inc. |
Formes à l'état solide
|
AU2020277398A1
(en)
|
2019-05-21 |
2021-12-09 |
Amgen Inc. |
Solid state forms
|
MX2022004656A
(es)
|
2019-10-24 |
2022-05-25 |
Amgen Inc |
Derivados de piridopirimidina utiles como inhibidores de kras g12c y kras g12d en el tratamiento del cancer.
|
WO2021126816A1
(fr)
|
2019-12-16 |
2021-06-24 |
Amgen Inc. |
Schéma posologique d'un inhibiteur du kras g12c
|