BR9807678A - Derivados de ácidos arilsulfonil-hidroxâmicos - Google Patents

Derivados de ácidos arilsulfonil-hidroxâmicos

Info

Publication number
BR9807678A
BR9807678A BR9807678-7A BR9807678A BR9807678A BR 9807678 A BR9807678 A BR 9807678A BR 9807678 A BR9807678 A BR 9807678A BR 9807678 A BR9807678 A BR 9807678A
Authority
BR
Brazil
Prior art keywords
cancer
derivatives
hydroxamic acids
combination
arylsulfonyl hydroxamic
Prior art date
Application number
BR9807678-7A
Other languages
English (en)
Inventor
Kim Francis Mcclure
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9807678A publication Critical patent/BR9807678A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção:<B>"DERIVADOS DE áCIDOS ARILSULFONIL-HIDROXâMICOS"<D>. Composto de fórmula no qual R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, R^ 9^ e Q estão acima definidos, útil no tratamento de um estado escolhido de um grupo consistindo em artrite, câncer, ulceração de tecidos, degeneração muscular, restenose, doença periodontal, epidermólise bolhosa, esclerite, e outras doenças caracterizadas pela atividade da metaloproteinase de matriz., AIDS, sepsia, choque séptico e outras doenças envolvendo a produção do TNF. Adicionalmente, os compostos da presente invenção podem ser utilizados em terapia combinada com medicamentos não-esteróides antiinflamatórios padrão (NSAID'S) e analgésicos, e em combinação com medicamentos citotóxidos tais como adriamicina, daunomicina, cis-platina, etoposido, taxol, taxotere e outros alcalóides, tais como vincristina, no tratamento do câncer.
BR9807678-7A 1997-02-11 1998-01-16 Derivados de ácidos arilsulfonil-hidroxâmicos BR9807678A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3760097P 1997-02-11 1997-02-11
PCT/IB1998/000064 WO1998034918A1 (en) 1997-02-11 1998-01-16 Arylsulfonyl hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
BR9807678A true BR9807678A (pt) 2000-02-15

Family

ID=21895216

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807678-7A BR9807678A (pt) 1997-02-11 1998-01-16 Derivados de ácidos arilsulfonil-hidroxâmicos

Country Status (37)

Country Link
US (1) US6599890B1 (pt)
EP (1) EP0960098A1 (pt)
JP (1) JP3710489B2 (pt)
KR (1) KR20000070923A (pt)
CN (1) CN1247531A (pt)
AP (1) AP958A (pt)
AR (1) AR011123A1 (pt)
AU (1) AU722784B2 (pt)
BG (1) BG63430B1 (pt)
BR (1) BR9807678A (pt)
CA (1) CA2280151C (pt)
CO (1) CO4950619A1 (pt)
DZ (1) DZ2416A1 (pt)
EA (1) EA002546B1 (pt)
GT (1) GT199800026A (pt)
HN (1) HN1998000020A (pt)
HR (1) HRP980070B1 (pt)
HU (1) HUP0000657A3 (pt)
ID (1) ID22809A (pt)
IL (1) IL131123A0 (pt)
IS (1) IS5130A (pt)
MA (1) MA24469A1 (pt)
NO (1) NO993836L (pt)
NZ (1) NZ336836A (pt)
OA (1) OA11142A (pt)
PA (1) PA8446101A1 (pt)
PE (1) PE58699A1 (pt)
PL (1) PL334997A1 (pt)
SA (1) SA98180856A (pt)
SK (1) SK101399A3 (pt)
TN (1) TNSN98025A1 (pt)
TR (1) TR199901926T2 (pt)
TW (1) TW502020B (pt)
UY (1) UY24880A1 (pt)
WO (1) WO1998034918A1 (pt)
YU (1) YU37499A (pt)
ZA (1) ZA981061B (pt)

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