UY24880A1 - Derivados de acido arilsulfonil hidroxamico - Google Patents

Derivados de acido arilsulfonil hidroxamico

Info

Publication number
UY24880A1
UY24880A1 UY24880A UY24880A UY24880A1 UY 24880 A1 UY24880 A1 UY 24880A1 UY 24880 A UY24880 A UY 24880A UY 24880 A UY24880 A UY 24880A UY 24880 A1 UY24880 A1 UY 24880A1
Authority
UY
Uruguay
Prior art keywords
aryl
alkyl
hydroxy
compounds
carboxylic acid
Prior art date
Application number
UY24880A
Other languages
English (en)
Inventor
Kim Francis Mcclure
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY24880A1 publication Critical patent/UY24880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invención se refiere a derivados de ácido arilsulfonil hidroxámico de fórmula (I), en donde la línea punteada representa un doble enlace opcional; X es C, O ó S; Y es C, S, SO, SO2, o N; R1, R2, R3, R4, R7, R8 y R9 se seleccionan del grupo formado por H, hidroxi y alquilo; R5 y R6 son seleccionados del grupo formado por H, alquilo, hidroxi, ácido carboxílico, ácido carbámico y sus respectivos alquil-ésteres; Q es arilo-arilo,arilo-alcoxi-arilo; y a sus sales farmacéuticamente aceptables. Ej. no limitante: ácido (2R,4R)-1-[4-(4-fluorobenciloxi) bencenosulfonil]-2-hidroxicarbamoil-piperidina-4-carboxílico Dichos compuestos son útiles en el tratamiento de artritis, cáncer, ulceración del tejido, degeneración macular, restenosis, enfermedad periodontal, epidermólisis vesicular, escleritis y otras enfermedades caracterizadas por la actividad de metaloproteínas de la matriz, SIDA, septicemia, choque séptico y otras enfermedades que implican la producción de factor de necrosis tumoral (TNF). Además, los compuestos se pueden usar en tratamiento de combinación con fármacos antiinflamatorios no esteroideos (AINE) y analgésicos convencionales, y en combinación con fármacos citotóxicos.
UY24880A 1997-02-11 1998-02-06 Derivados de acido arilsulfonil hidroxamico UY24880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3760097P 1997-02-11 1997-02-11

Publications (1)

Publication Number Publication Date
UY24880A1 true UY24880A1 (es) 2000-09-29

Family

ID=21895216

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24880A UY24880A1 (es) 1997-02-11 1998-02-06 Derivados de acido arilsulfonil hidroxamico

Country Status (37)

Country Link
US (1) US6599890B1 (es)
EP (1) EP0960098A1 (es)
JP (1) JP3710489B2 (es)
KR (1) KR20000070923A (es)
CN (1) CN1247531A (es)
AP (1) AP958A (es)
AR (1) AR011123A1 (es)
AU (1) AU722784B2 (es)
BG (1) BG63430B1 (es)
BR (1) BR9807678A (es)
CA (1) CA2280151C (es)
CO (1) CO4950619A1 (es)
DZ (1) DZ2416A1 (es)
EA (1) EA002546B1 (es)
GT (1) GT199800026A (es)
HN (1) HN1998000020A (es)
HR (1) HRP980070B1 (es)
HU (1) HUP0000657A3 (es)
ID (1) ID22809A (es)
IL (1) IL131123A0 (es)
IS (1) IS5130A (es)
MA (1) MA24469A1 (es)
NO (1) NO993836L (es)
NZ (1) NZ336836A (es)
OA (1) OA11142A (es)
PA (1) PA8446101A1 (es)
PE (1) PE58699A1 (es)
PL (1) PL334997A1 (es)
SA (1) SA98180856A (es)
SK (1) SK101399A3 (es)
TN (1) TNSN98025A1 (es)
TR (1) TR199901926T2 (es)
TW (1) TW502020B (es)
UY (1) UY24880A1 (es)
WO (1) WO1998034918A1 (es)
YU (1) YU37499A (es)
ZA (1) ZA981061B (es)

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