CN102666512B - 对疾病治疗有用的mek抑制剂 - Google Patents
对疾病治疗有用的mek抑制剂 Download PDFInfo
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- CN102666512B CN102666512B CN201080053278.5A CN201080053278A CN102666512B CN 102666512 B CN102666512 B CN 102666512B CN 201080053278 A CN201080053278 A CN 201080053278A CN 102666512 B CN102666512 B CN 102666512B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (12)
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US25093609P | 2009-10-13 | 2009-10-13 | |
US61/250,936 | 2009-10-13 | ||
PCT/US2010/052514 WO2011047055A2 (en) | 2009-10-13 | 2010-10-13 | Novel mek inhibitors, useful in the treatment of diseases |
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CN102666512A CN102666512A (zh) | 2012-09-12 |
CN102666512B true CN102666512B (zh) | 2014-11-26 |
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US (1) | US9034861B2 (zh) |
EP (1) | EP2488507B1 (zh) |
JP (1) | JP5892612B2 (zh) |
KR (1) | KR20120094165A (zh) |
CN (1) | CN102666512B (zh) |
AU (1) | AU2010306830C1 (zh) |
BR (1) | BR112012008599A2 (zh) |
CA (1) | CA2814617C (zh) |
ES (1) | ES2534358T3 (zh) |
WO (1) | WO2011047055A2 (zh) |
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WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
EP3672603A1 (en) | 2017-08-23 | 2020-07-01 | Cell Receptor AG | Combination of a mapk/erk pathway inhibitor and a glycosaminoglycan for the treatment of cancer |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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-
2010
- 2010-10-13 WO PCT/US2010/052514 patent/WO2011047055A2/en active Application Filing
- 2010-10-13 US US13/501,442 patent/US9034861B2/en active Active
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- 2010-10-13 AU AU2010306830A patent/AU2010306830C1/en active Active
- 2010-10-13 EP EP10824026.8A patent/EP2488507B1/en active Active
- 2010-10-13 KR KR1020127012271A patent/KR20120094165A/ko not_active Application Discontinuation
- 2010-10-13 ES ES10824026.8T patent/ES2534358T3/es active Active
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- 2010-10-13 JP JP2012534327A patent/JP5892612B2/ja active Active
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EP2488507A4 (en) | 2013-05-01 |
CN102666512A (zh) | 2012-09-12 |
KR20120094165A (ko) | 2012-08-23 |
CA2814617A1 (en) | 2011-04-21 |
JP5892612B2 (ja) | 2016-03-23 |
US9034861B2 (en) | 2015-05-19 |
EP2488507A2 (en) | 2012-08-22 |
AU2010306830A1 (en) | 2012-05-31 |
EP2488507B1 (en) | 2014-12-17 |
BR112012008599A2 (pt) | 2019-09-24 |
AU2010306830C1 (en) | 2015-05-28 |
WO2011047055A3 (en) | 2011-08-18 |
AU2010306830B2 (en) | 2014-11-06 |
WO2011047055A8 (en) | 2012-05-24 |
CA2814617C (en) | 2017-12-19 |
JP2013507453A (ja) | 2013-03-04 |
ES2534358T3 (es) | 2015-04-21 |
US20120208859A1 (en) | 2012-08-16 |
WO2011047055A2 (en) | 2011-04-21 |
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